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Protein found in humans
Paxillin is a protein that in humans is encoded by the PXN gene. Paxillin is expressed at focal adhesions of non-striated cells and at costameres of striated
Paxillin
Protein-coding gene in humans
components of focal adhesions include actin, filamin, vinculin, talin, paxillin, tensin and RSU-1. FAK is phosphorylated in response to integrin engagement
PTK2
Mammalian protein found in humans
phosphorylation site, while the tail region contains binding sites for F-actin, paxillin, and lipids. Essentially, there is an 835 amino acid N-terminal head, which
Vinculin
Protein-coding gene in the species Homo sapiens
Iwabuchi Y, Shibanuma M, Côté JF, Tremblay ML, Nose K (April 1999). "Hic-5, a paxillin homologue, binds to the protein-tyrosine phosphatase PEST (PTP-PEST) through
TGFB1I1
InterPro Domain
motifs. This group is limited to three different adaptor proteins: zyxin, paxillin, and PINCH. They each respectively have different number of LIM domains
LIM_domain
Area of the brain below the thalamus
Shiroor C, Taylor ME, et al. (July 2007). "Focal adhesion kinase and paxillin: novel regulators of brain sexual differentiation?". Endocrinology. 148
Hypothalamus
Protein domain
Leucine-Aspartate (LD)-repeat motif peptides in the related focal adhesion proteins paxillin (PXN), leupaxin (LPXN) and TGFB1I1/Hic-5. FAT domains with a similar 4-helix
Focal adhesion targeting region
Focal_adhesion_targeting_region
Indian-born American medical scientist
myelogenous leukemia. He was the first to fully clone the focal adhesion protein paxillin (human and chicken) and demonstrate its role in oncogenic transformation
Ravi_Salgia
Structural support for biological cells
(integrins) and signaling proteins (adhesion kinase (FAK), talin, vinculin, paxillin, α-actinin, GTPases etc.) which cause changes in cell shape and actomyosin
Extracellular_matrix
Involuntary non-striated muscle
phosphorylation of specific tyrosine residues on the focal adhesion adapter protein-paxillin by specific tyrosine kinases has been demonstrated to be essential to force
Smooth_muscle
British academic
the discovery of many adhesion proteins including vinculin, talin and paxillin, and ranks him in top 1% of the most cited scientist in the field of molecular
Keith_Burridge
Protein-coding gene in the species Homo sapiens
hematopoietic cells and is most homologous to the focal adhesion protein, paxillin. It may function in cell type-specific signaling by associating with PYK2
LPXN
Non-receptor tyrosine kinase and coding gene in humans
growth hormone accompanies tyrosine phosphorylation of Jak2, p125FAK, and paxillin". Journal of Immunology. 165 (4): 2116–23. doi:10.4049/jimmunol.165.4.2116
Janus_kinase_2
Mammalian protein found in Homo sapiens
chain or beta 7 chain. CD49d has been shown to interact with LGALS8 and Paxillin. Carotegrast methyl, an integrin alpha 4 antagonist used for the treatment
Integrin_alpha_4
Mammalian protein found in humans
the actin cytoskeleton through its stimulation of F-actin stress fibers, paxillin, RhoA, Rac1, Cdc42, and protein kinase C α (PKCα). mTORC2 also phosphorylates
MTOR
Species of bacterium
multocida toxin, a potent intracellularly acting mitogen, induces p125FAK and paxillin tyrosine phosphorylation, actin stress fiber formation, and focal contact
Pasteurella_multocida
Protein-coding gene in the species Homo sapiens
subunit requires the adaptor protein paxillin to inhibit cell spreading but promotes cell migration in a paxillin-independent manner". Mol. Biol. Cell
Integrin_alpha_9
Protein-coding gene in the species Homo sapiens
New Paxillin-binding Protein, PAG3/Papα/KIAA0400, Bearing an ADP-Ribosylation Factor GTPase-activating Protein Activity, Is Involved in Paxillin Recruitment
ASAP2
Gene on human chromosome 10
modification sites within the main isoform of BTBD16: LIG_FAT_LD1: part of the paxillin leucine-rich repeat motif family; recognized by focal adhesion proteins
BTBD16
Movement of cells according to local rigidity gradient
These proteins, such as focal adhesion kinase (FAK), talin, vinculin, paxillin, and α-actinin, interact with small GTPases (Rho, Rac, Cdc42) and other
Durotaxis
Protein-coding gene in the species Homo sapiens
factor. PTPrho also dephosphorylates paxillin on tyrosine 88. Higher levels of tyrosine 88 phosphorylation of paxillin are observed in colon cancers. When
PTPRT
Protein-coding gene in the species Homo sapiens
"Interaction of POB1, a downstream molecule of small G protein Ral, with PAG2, a paxillin-binding protein, is involved in cell migration". The Journal of Biological
DDEF1
Transmembrane receptors involved in cellular adhesion and signalling
consist of integrins and many cytoplasmic proteins, such as talin, vinculin, paxillin, and alpha-actinin. These act by regulating kinases such as FAK (focal
Integrin
Enzyme grouping
The B' subunit seems to interact specifically with and dephosphorylate paxillin in the focal adhesions of cancer cells (Janssens & Goris, 2001). When truncated
Ceramide-activated protein phosphatase
Ceramide-activated_protein_phosphatase
Protein-coding gene in humans
Yeast two Hybrid Zyxin LIM1 Yeast two Hybrid, Pull-down assay Actin PET? Pull-down assay α-Actinin PET? Pull-down assay Paxillin PET? Pull-down assay
Testin
Protein-coding gene in the species Homo sapiens
cell adhesion molecules, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin, which suggested its regulatory roles in controlling cell shape and mobility
PTPN12
Structures which transmit force and signals between a cell and the extracellular matrix
consist of integrin, and some of the adapter proteins, such as talin, paxillin and tensin. Many of these focal complexes fail to mature and are disassembled
Focal_adhesion
Protein-coding gene in the species Homo sapiens
gene, Dock2, EPOR, GAB1, GAB2, INPP5D, MAP4K1, MAP4K5, NEDD9, PIK3R2, Paxillin RAPGEF1, RICS, STAT5A, Syk, and WAS. Crk GRCh38: Ensembl release 89: ENSG00000099942
CRKL
Protein-coding gene in humans
breakpoint region 1, FYN, GRIN2A, Gelsolin, NPHP1, PITPNM1, PTPN11, PTPN6, Paxillin, RAS p21 protein activator 1, RB1CC1, SORBS2, Src, and TGFB1I1, VE-PTP
PTK2B
Protein-coding gene in the species Homo sapiens
Turner CE (2001). "Actopaxin, a new focal adhesion protein that binds paxillin LD motifs and actin and regulates cell adhesion". J. Cell Biol. 151 (7):
PARVA
Species of fungus
secoemestrin C, secoemestrin D, emericellenes A-E, desferritriacetylfusigen, paxillin, and violaceic acid. Horie, Y. 1978. A new species of Emericella from India
Aspergillus_foveolatus
Class of pharmaceutical drugs
signals. mTORC2 is activated by growth factors, phosphorylates PKCα, AKT and paxillin, and regulates the activity of the small GTPase, Rac, and Rho related to
MTOR_inhibitors
Protein-coding gene in humans
functionally distinct from its family members in that it interacts with FAK and paxillin (PXN) in the regulation of cell morphology and motility. Fyn is a protein
FYN
Protein-coding gene in the species Homo sapiens
PMID 9372968. Herreros L, Rodríguez-Fernandez JL, Brown MC, et al. (2000). "Paxillin localizes to the lymphocyte microtubule organizing center and associates
TUBA1B
Protein-coding gene in the species Homo sapiens
immortalized human keratinocytes results in increased invasiveness and decreased paxillin expression". The American Journal of Pathology. 161 (6): 2065–78. doi:10
Prostaglandin_EP2_receptor
Protein-coding gene in humans
PMID 11864573. Brown MC, West KA, Turner CE (2002). "Paxillin-dependent paxillin kinase linker and p21-activated kinase localization to focal
ARHGEF7
Protein-coding gene in the species Homo sapiens
regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions
RNF5
Species of bacterium
residues on focal adhesion kinase (FAK) and the focal adhesion proteins paxillin and p130. Since FAK phosphorylation is involved in uptake of yersiniae
Yersinia_pseudotuberculosis
Protein domain
Kansas GS, Sobhany ES, et al. (March 1995). "Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL". The Journal of
BCR_(gene)
Mammalian protein found in humans
MAPK VEGF IL-8 Shc Grb2/SOS Ras Raf MEK1 / MEK2 Erk1/2 FAK p190Rho/GAP Paxillin p130CAS RhoA JNK c-jun MLCK Myosin GRCh38: Ensembl release 89: ENSG00000197122
Proto-oncogene tyrosine-protein kinase Src
Proto-oncogene_tyrosine-protein_kinase_Src
Protein found in humans
Nikolopoulos SN, Turner CE (June 2001). "Integrin-linked kinase (ILK) binding to paxillin LD1 motif regulates ILK localization to focal adhesions". The Journal of
Integrin-linked_kinase
Protein-coding gene in the species Homo sapiens
autophosphorylated mammalian sterile 20-like kinase 3 (MST3) involves paxillin and protein-tyrosine phosphatase-PEST". The Journal of Biological Chemistry
STK24
Protein-coding gene in humans
Nikolopoulos SN, McDonald AR, Bagrodia S, Thomas S, Leventhal PS (May 1999). "Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP
GIT2
Species of fungus
desferritriacetylfusigen, dithiosilvatin, emindol SA, emindol SB, 7-Hydroxyemodin, paxillin, 1-O-acetylpaxillin, penicillin G, sterigmatocystin, violaceic acid, violaceol
Aspergillus_striatulus
Conversion of mechanical stimulus of a cell into electrochemical activity
addition, kinases (e.g., focal adhesion kinase and adapter proteins (e.g., paxillin, aka Pax, talin, aka Tal, and Shc) are recruited to this cluster, which
Mechanotransduction
Protein-coding gene in the species Homo sapiens
PMID 9566969. Herreros L, Rodríguez-Fernandez JL, Brown MC, et al. (2000). "Paxillin localizes to the lymphocyte microtubule organizing center and associates
TUBG2
American physician
P. M. (1997). "The bovine papillomavirus E6 oncoprotein interacts with paxillin and disrupts the actin cytoskeleton". Proceedings of the National Academy
Peter_M._Howley
Protein-coding gene in the species Homo sapiens
bind other proteins or nucleic acids. Between these two regions exists a paxillin leucine-aspartate repeat (LD) motif which is involved in protein–protein
Roxan
Protein-coding gene in the species Homo sapiens
truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation". The EMBO Journal. 19 (4): 562–71. doi:10.1093/emboj/19
PPP2R5C
Protein complex
the actin cytoskeleton through its stimulation of F-actin stress fibers, paxillin, RhoA, Rac1, Cdc42, and protein kinase C α (PKCα). mTORC2 also regulates
MTORC2
Mammalian protein found in Homo sapiens
MEK1-S298, CRKII-S41, MORC family CW-type zinc finger 2-S739, Paxillin-S258, and Paxillin-S273. PAK1 and/or PAK1-dependent signals modulate the expression
PAK1
Protein-coding gene in the species Homo sapiens
"Interaction of POB1, a downstream molecule of small G protein Ral, with PAG2, a paxillin-binding protein, is involved in cell migration". J. Biol. Chem. 277 (41):
REPS2
American cell biologist
Turner, CE; Beckerle, MC (2013). "LIM domains target actin regulators paxillin and zyxin to sites of stress fiber strain". PLOS ONE. 8 (8) e69378. Bibcode:2013PLoSO
Mary_Beckerle
Human protein-coding gene
receptor leads to cell spreading, phosphorylation of focal adhesion kinase, paxillin and ERK2 MAPK, and proliferation. In contrast, when these same cells use
Tenascin_C
Protein-coding gene in humans
truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation". The EMBO Journal. 19 (4): 562–71. doi:10.1093/emboj/19
PPP2CA
Protein-coding gene in the species Homo sapiens
New Paxillin-binding Protein, PAG3/Papα/KIAA0400, Bearing an ADP-Ribosylation Factor GTPase-activating Protein Activity, Is Involved in Paxillin Recruitment
ARF5
between and onto neighboring podosomes. Accumulation of F-actin, vinculin, paxillin, and α-actin within the podosomes of the coalescent band signals the development
Podosome
Pseudogene in the species Homo sapiens
"RNF5, a RING Finger Protein That Regulates Cell Motility by Targeting Paxillin Ubiquitination and Altered Localization". Mol. Cell. Biol. 23 (15): 5331–45
RNF5P1
Mammalian protein found in Homo sapiens
S30, T173 and S239 inhibits apoptotic activity in breast cancer cells, Paxillin phosphorylation at S272 and S274 activates ADAM10 protease, and STAT5 phosphorylation
PAK2
Protein-coding gene in the species Homo sapiens
Alonso-Lebrero JL, Cabañas C, Sánchez-Madrid F, et al. (August 2000). "Paxillin localizes to the lymphocyte microtubule organizing center and associates
TUBA8
Protein-coding gene in the species Homo sapiens
H, El Banayosy A, Körfer R, Wilmanns M, Ehler E, Fürst DO (Jun 2007). "Paxillin and ponsin interact in nascent costameres of muscle cells". Journal of
SORBS1
Protein-coding gene in humans
(2003). "Hic-5 interacts with GIT1 with a different binding mode from paxillin". J. Biochem. 132 (2): 279–89. doi:10.1093/oxfordjournals.jbchem.a003222
GIT1
The following is a partial list of the "D" codes for Medical Subject Headings (MeSH), as defined by the United States National Library of Medicine (NLM)
List_of_MeSH_codes_(D12.776)
Protein-coding gene in the species Homo sapiens
other proteins relevant to SRC kinase signaling, including CDCP1/Trask and Paxillin, in trastuzumab (Herceptin) resistant versus sensitive cells Importantly
Embryonal fyn-associated substrate
Embryonal_fyn-associated_substrate
Protein-coding gene in the species Homo sapiens
C, Sánchez-Madrid F, Longo N, Turner CE, Sánchez-Mateos P (Aug 2000). "Paxillin localizes to the lymphocyte microtubule organizing center and associates
Alpha-tubulin_3C
Protein-coding gene in the species Homo sapiens
discovered ArgBP2 in complex with alpha actinin-2, vinculin, spectrin, paxillin, Pyk2 and flotillin, suggesting that ArgBP2 may be involved in myofibril
SORBS2
Protein found in humans
factor receptor, Grb2, IRS4, MAP4K1, MAPK8, NEDD9, PDGFRA, PDGFRB, PTK2, Paxillin RAPGEF1, RICS, SH3KBP1, and SOS1. CrkL, "Crk-like" protein GRCh38: Ensembl
Adapter_molecule_crk
Protein-coding gene in the species Homo sapiens
1204785. PMID 11607844. Panetti TS (2002). "Tyrosine phosphorylation of paxillin, FAK, and p130CAS: effects on cell spreading and migration". Front. Biosci
BCAR1
Protein-coding gene in the species Homo sapiens
Hashimoto S, Sabe H (Mar 1997). "Monocyte cells and cancer cells express novel paxillin isoforms with different binding properties to focal adhesion proteins"
TLN1
Protein-coding gene in the species Homo sapiens
(1999). "The Csk homologous kinase, Chk, binds tyrosine phosphorylated paxillin in human blastic T cells". Biochem. Biophys. Res. Commun. 256 (3): 668–75
Megakaryocyte-associated tyrosine kinase
Megakaryocyte-associated_tyrosine_kinase
Medical condition
molecular signaling event activated by BCR/ABL. Some focal adhesion complex (PAXILLIN, FAK0 could be activated by BCR/ABL with adaptor molecule CRK-L. BCR/ABL
Biphenotypic_acute_leukaemia
The following is a partial list of the "D" codes for Medical Subject Headings (MeSH), as defined by the United States National Library of Medicine (NLM)
List of MeSH codes (D12.776.157)
List_of_MeSH_codes_(D12.776.157)
Protein-coding gene in the species Homo sapiens
adhesive substrate, CCN1 induces the activation of focal adhesion kinase, paxillin, RAC, and sustained activation of MAPK/ERK1-2. In macrophages, CCN1 also
CYR61
Protein-coding gene in the species Homo sapiens
(FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin". Nat. Struct. Biol. 9 (2): 101–6. doi:10.1038/nsb755. PMID 11799401. S2CID 19881447
NEDD9
The following is a partial list of the "D" codes for Medical Subject Headings (MeSH), as defined by the United States National Library of Medicine (NLM)
List of MeSH codes (D12.776.476)
List_of_MeSH_codes_(D12.776.476)
Protein-coding gene in humans
PMC 22359. PMID 10097102. Turner CE, Brown MC, Perrotta JA, et al. (1999). "Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP
CLTC
Protein-coding gene in the species Homo sapiens
Mazaki Y, Sabe H, Morley SJ, Critchley DR, Norman JC (February 2002). "Paxillin associates with poly(A)-binding protein 1 at the dense endoplasmic reticulum
PABPC1
Protein domain
phosphotyrosyl peptide-binding activity, allowing for recognition of p130Cas and paxillin. YopH from Yersinia sp. is essential for pathogenesis, as it allows the
YopH,_N-terminal
024.305 – pii nitrogen regulatory proteins MeSH D12.644.360.024.307 – paxillin MeSH D12.644.360.024.311 – protein inhibitors of activated STAT MeSH D12
List_of_MeSH_codes_(D12.644)
PAXILLIN
PAXILLIN
PAXILLIN
PAXILLIN
Boy/Male
Hindu, Indian
Excessive Joy; Pleasure; Delight; Happiness
Boy/Male
Afghan, Arabic, Muslim, Turkish
Built; Constructed; Senior
Surname or Lastname
English
English : variant of Whitemore.Thomas Whittemore came from England to Charlestown, MA, in or about 1639. Amos Whittemore, born in Cambridge, MA, in 1759 was an inventor and gunsmith, and another Thomas Whittemore was born in Boston in 1800; he was a Universalist clergyman and MA legislator.
Girl/Female
Arabic, Muslim
Made of Silk
Boy/Male
Tamil
Kundal in krishnas ear, Name of a sage
Girl/Female
Indian, Tamil
Intelligence
Girl/Female
American, Australian, Chinese, French, Greek
Victory of the People; Feminine of Nicholas; People's Victory
Boy/Male
Hindu, Indian
Soft; Loveable; Obedient; Good Nature; Innocent
Girl/Female
Muslim/Islamic
A narrator of Hadith
Girl/Female
Biblical, Danish, Finnish, German, Hebrew
Reckoned; Prepared; Will; Desire; Helmet; Protection
PAXILLIN
PAXILLIN
PAXILLIN
PAXILLIN
PAXILLIN