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Family of proteins involved in anatomical development
Fibroblast growth factors (FGF) are a family of cell signalling proteins produced by the macrophages. They are involved in a wide variety of processes
Fibroblast_growth_factor
Growth factor and signaling protein otherwise known as FGF2
Fibroblast growth factor 2 (FGF-2), also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling protein encoded by
Fibroblast_growth_factor_2
Family of proteins that bind to fibroblast growth factors
The fibroblast growth factor receptors (FGFR) are, as their name implies, receptors that bind to members of the fibroblast growth factor (FGF) family of
Fibroblast growth factor receptor
Fibroblast_growth_factor_receptor
Protein-coding gene in mammals
Fibroblast growth factor 21 (FGF-21) is a protein found in humans and other mammals that is encoded by the FGF21 gene. This protein is a member of the
Fibroblast_growth_factor_21
Protein found in humans
Fibroblast growth factor 23 (FGF-23) is a protein and member of the fibroblast growth factor (FGF) family which participates in the regulation of phosphate
Fibroblast_growth_factor_23
Gene involved in the most common form of dwarfism
Fibroblast growth factor receptor 3 (FGFR-3) is a protein that in humans is encoded by the FGFR3 gene. FGFR3 has also been designated as CD333 (cluster
Fibroblast growth factor receptor 3
Fibroblast_growth_factor_receptor_3
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor 1 (FGF-1) also known as acidic fibroblast growth factor (aFGF), is a growth factor and signaling protein encoded by the FGF1
Fibroblast_growth_factor_1
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor 8 (FGF-8) is a protein that in humans is encoded by the FGF8 gene. The protein encoded by this gene belongs to the fibroblast
Fibroblast_growth_factor_8
Protein found in humans
Fibroblast growth factor receptor 1 (FGFR-1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome
Fibroblast growth factor receptor 1
Fibroblast_growth_factor_receptor_1
Protein or other substance that stimulates cellular proliferation
Ephrin Fibroblast growth factor (FGF) Foetal Bovine Somatotrophin (FBS) GDNF family of ligands Growth differentiation factor-9 (GDF9) Hepatocyte growth factor
Growth_factor
Mammalian protein found in Homo sapiens
Fibroblast growth factor 18 (FGF-18) is a protein that is encoded by the FGF18 gene in humans. The protein was first discovered in 1998, when two newly-identified
Fibroblast_growth_factor_18
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor receptor 2 (FGFR-2) also known as CD332 (cluster of differentiation 332) is a protein that in humans is encoded by the FGFR2 gene
Fibroblast growth factor receptor 2
Fibroblast_growth_factor_receptor_2
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor receptor 4 (FGFR-4) is a protein that in humans is encoded by the FGFR4 gene. FGFR4 has also been designated as CD334 (cluster
Fibroblast growth factor receptor 4
Fibroblast_growth_factor_receptor_4
Mammalian protein found in Homo sapiens
Fibroblast growth factor 5 is a protein that in humans is encoded by the FGF5 gene. The majority of FGF family members are glycosaminoglycan binding proteins
FGF5
Tumour-promoting cell type
secreting growth factors such as Vascular Endothelial Growth Factor (VEGF), Platelet Derived Growth Factor (PDGF) and Fibroblast Growth Factor (FGF) and other
Cancer-associated_fibroblast
Form of localized cell signaling
similar structures: fibroblast growth factor (FGF) family, Hedgehog family, Wnt family, and TGF-β superfamily. Binding of a paracrine factor to its respective
Paracrine_signaling
Genetic condition, the most common form of dwarfism
immunodeficiency. Achondroplasia is caused by a mutation in the fibroblast growth factor receptor 3 (FGFR3) gene (located in chromosome 4) that results
Achondroplasia
Factor that stimulates the growth of bone tissue
insulin-like growth factor-2 (IGF-2), transforming growth factor beta (TGF-β), fibroblast growth factors (FGFs), platelet-derived growth factor (PDGF), parathyroid
Bone_growth_factor
Measurable indicators of diabetes
Endothelin-1 Nesfatin-1 Irisin Betatrophin Hepatocyte growth factor (HGF) Fibroblast growth factor -Biomarkers with insulin-sensitizing properties (irisin
Biomarkers_of_diabetes
Human recombinant FGF18
Sprifermin (INN; development code AS-902330) is a recombinant human fibroblast growth factor 18 (rhFGF18) analog, originally developed by Merck, and now being
Sprifermin
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor 19 is a protein that in humans is encoded by the FGF19 gene. It functions as a hormone, regulating bile acid synthesis, with effects
FGF19
Class of enzymes
critical factors in the development and malignancy of these tumors. Fibroblast growth factors comprise the largest family of growth factor ligands at
Receptor_tyrosine_kinase
Formation of blood vessels
These growth factors often act in a paracrine or autocrine fashion; they include fibroblast growth factor, placental growth factor, insulin-like growth factor
Vascularisation
This article is about the role of fibroblast growth factor signaling in mesoderm formation. Mesoderm formation is a complex developmental process involving
Fibroblast growth factor and mesoderm formation
Fibroblast_growth_factor_and_mesoderm_formation
Human enzyme
be a circulating factor detectable in serum that declines with age. β-Klotho: The binding of the endocrine fibroblast growth factors (FGF's, viz., FGF19
Klotho_(biology)
fibroblast growth factor (FGF). Fibroblasts do not appear to be fully differentiated or specialized. After examining the CD markers of the fibroblast
Dermal_fibroblast
Genetic disorder of the skull
and big toes. Pfeiffer syndrome is caused by mutations in the fibroblast growth factor receptors FGFR1 and FGFR2. The syndrome is grouped into three types:
Pfeiffer_syndrome
Chemical compound
an anti-cancer medication. It is a small molecule inhibitor of fibroblast growth factor receptor (FGFR) used for the treatment of cancer. FGFRs are a subset
Erdafitinib
Pharmaceutical compound
including vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR), platelet-derived growth factor receptors (PDGFR), and
Catequentinib
Blood vessel formation, when new vessels emerge from existing vessels
integrins and prostaglandins, including several growth factors e.g. VEGF, FGF. The fibroblast growth factor (FGF) family with its prototype members FGF-1
Angiogenesis
Signaling glycoprotein regulating cell proliferation
the growth of blood vessels from already-existing blood vessel tissue, mitogenesis, i.e. proliferation, of mesenchymal cells such as fibroblasts, osteoblasts
Platelet-derived growth factor
Platelet-derived_growth_factor
Protein-coding gene in the species Homo sapiens
associated with an atypical myeloproliferative disorder fuses the fibroblast growth factor receptor 1 gene to a novel gene RAMP". Human Molecular Genetics
ZMYM2
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor 14 is a biologically active protein that in humans is encoded by the FGF14 gene. The protein encoded by this gene is a member
FGF14
Investigational drug
Loxo Oncology for the treatment of genitourinary cancer. It is a fibroblast growth factor receptor 3 antagonist. "Vepugratinib". AdisInsight. Springer Nature
Vepugratinib
Biomarker indicative of breast cancer patients' prognosis
cell culture system, rat kidney fibroblasts. Application of the transforming growth factors to normal rat kidney fibroblasts induces the cultured cells to
Transforming_growth_factor
Genetic disorder of the skull and face
a gene on chromosome 10 that controls the body's production of fibroblast growth factor receptor 2 (FGFR2). Crouzon syndrome is named for Octave Crouzon
Crouzon_syndrome
Protein found in humans
Fibroblast growth factor receptor-like 1 is a protein that in humans is encoded by the FGFRL1 gene. The protein encoded by this gene is a member of the
Fibroblast growth factor receptor-like 1
Fibroblast_growth_factor_receptor-like_1
Chemical compound
targeting vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Ofev was developed
Nintedanib
Fibroblast growth factor gene
Fibroblast growth factor 4 is a protein that in humans is encoded by the FGF4 gene. The protein encoded by this gene is a member of the fibroblast growth
FGF4
InterPro family
the epithelium. KGF is a small signaling molecule that binds to fibroblast growth factor receptor 2b (FGFR2b). For signalling to occur, a dimer is required
Keratinocyte_growth_factor
Investigational drug
for the treatment of achondroplasia and solid tumors. It is a fibroblast growth factor receptor 3 receptor antagonist. "Dabogratinib - TYRA Biosciences"
Dabogratinib
Protein-coding gene in humans
Fibroblast growth factor 6 is a protein that in humans is encoded by the FGF6 gene. The protein encoded by this gene is a member of the fibroblast growth
FGF6
Medication
as recombinant human basic fibroblast growth factor (rhbFGF), is a recombinant form of human basic fibroblast growth factor (bFGF) which is marketed in
Trafermin
Premature fusion of bones in the skull
been found in the fibroblast growth factor receptor 3 (FGFR3) and TWIST genes. Fibroblast growth factor and fibroblast growth factor receptors regulate
Craniosynostosis
Protein
Fibroblast growth factor 20 is a protein which in humans is encoded by the FGF20 gene. The protein encoded by this gene is a member of the fibroblast
FGF20
Protein-coding gene in humans
Fibroblast growth factor 10 is a protein that in humans is encoded by the FGF10 gene. It is a polypeptide of 208 amino acids. Human FGF10 gene is highly
FGF10
Protein-coding gene in the species Homo sapiens
growth factor is a protein that in humans is encoded by the FGF7 gene. The protein encoded by this gene is a member of the fibroblast growth factor (FGF)
FGF7
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor-binding protein 1 is a protein that in humans is encoded by the FGFBP1 gene. FGFBP1, or HBP17, binds to both acidic FGF1 and basic
FGFBP1
Protein-coding gene in the species Homo sapiens
the SHB gene. SHB (gene) has been shown to interact with: EPS8, Fibroblast growth factor receptor 1, Linker of activated T cells, Lymphocyte cytosolic protein
SH2 domain-containing adapter protein B
SH2_domain-containing_adapter_protein_B
Pharmaceutical compound
(AZD4547) is an experimental drug which acts as an inhibitor of the fibroblast growth factor receptors, having high affinity for FGFR1, FGFR2 and FGFR3 and
Fexagratinib
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor receptor substrate 3 is a protein that in humans is encoded by the FRS3 gene. The protein encoded by this gene is a substrate
FRS3
Hormone whose molecules are peptides
cellular responses. Certain peptides, such as angiotensin II, basic fibroblast growth factor-2, and parathyroid hormone-related protein, can also interact with
Peptide_hormone
Large plasma protein found in the blood
it also binds to numerous growth factors and cytokines, such as platelet-derived growth factor, basic fibroblast growth factor, TGF-β, insulin, and IL-1β
Alpha-2-Macroglobulin
Protein
(November 1991). "Fibroblast growth factor 5 proto-oncogene is expressed in normal human fibroblasts and induced by serum growth factors". Oncogene. 6 (11):
TGF_alpha
Mammalian protein found in humans
(such as hypocalcemia). Calcitriol Increase in serum phosphate. Fibroblast growth factor-23 (FGF23) is produced in osteoblasts (from bone) in response to
Parathyroid_hormone
Experimental drug for the treatment of achondroplasia
disproportionate growth. Achondroplasia is caused by a genetic mutation that increases the activity of a certain growth regulation gene called fibroblast growth factor
Vosoritide
Abdominal wall birth defect
indicated that mutations in the fibroblast growth factor receptors 1 and 2 (Fgfr1, Fgfr2) cause exomphalos. Fibroblast growth factor (FBGF) encourages the migration
Omphalocele
Medical condition
disorder caused by an autosomal dominant genetic defect in the fibroblast growth factor receptor 3 gene (FGFR3) that results in a disproportionately short
Hypochondroplasia
Medication
hypochondroplasia. Infigratinib is an oral small molecule that targets the fibroblast growth factor receptors FGFR1, FGFR2, and FGFR3. Unlike other therapeutics in
Infigratinib
Protein found in humans
Insulin-like growth factor 1 (IGF1), also called somatomedin C, is a hormone similar in molecular structure to insulin which plays an important role in
Insulin-like_growth_factor_1
Biological process in primates
induce the expression of growth factors, such as amphiregulin, epidermal growth factor (EGF), IGF-1, and fibroblast growth factor (FGF), which in turn have
Breast_development
Study of inheritance in domestic cats
of dark pigmentation. Hair length is determined by the gene for fibroblast growth factor 5, with inactive copies of this gene causing long hair. The Cat
Cat_genetics
Chemical compound
treatment of other types of solid tumors. Surufatinib targets fibroblast growth factor receptor 1 (FGFR1). Syed YY (April 2021). "Surufatinib: First Approval"
Surufatinib
Family of biomolecules
factors include: glia maturation factor, insulin, insulin-like growth factor 1 (IGF-1), vascular endothelial growth factor (VEGF), fibroblast growth factor
Neurotrophic_factors
Human chromosome
FAM47E-STBD1 readthrough FGF2: Fibroblast growth factor 2 (basic fibroblast growth factor) FGFR3: fibroblast growth factor receptor 3 (achondroplasia, thanatophoric
Chromosome_4
Russian biochemist
researcher best known for his discoveries of endocrine functions of Fibroblast Growth Factor 21 (FGF21) and its prospects in developing novel therapies for
Alexei_Kharitonenkov
Variety of genetically modified laboratory mice
as golden-colored fur. This included FGF5 (fibroblast growth factor 5), that is involved with the hair growth cycle, and MC1R (melanocortin 1 receptor)
Woolly_mouse
Cell that composes cartilage
proteins. Two proteins, bone morphogenetic protein 4 (BMP-4) and fibroblast growth factor 2 (FGF2) have been seen to influence the amount of differentiation
Chondrocyte
Rare genetic skeletal dysplasia
associated with pathogenic variants in FGFR2, the gene encoding fibroblast growth factor receptor 2. Bent bone dysplasia syndrome 2 has been linked to biallelic
Bent_bone_dysplasia_syndrome
Experimental drug
investigational drug developed by Akero Therapeutics, acting as a fibroblast growth factor 21 (FGF21) analog developed to treat metabolic dysfunction-associated
Efruxifermin
Protein-coding gene in the species Homo sapiens
Acidic fibroblast growth factor intracellular-binding protein is a protein that in humans is encoded by the FIBP gene. Acidic fibroblast growth factor is
FIBP
Cytokine
Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes three different
Transforming growth factor beta
Transforming_growth_factor_beta
First stage of pregnancy
histamine-releasing factor Tissue plasminogen activator as well as its inhibitors Estradiol β1-integrins Fibroblast growth factor Transforming growth factor alpha Inhibin
Implantation_(embryology)
Pharmaceutical drug
(targets) called fibroblast growth factor receptors (FGFRs). FGFRs are found on the surface of cancer cells and are involved in the growth and spread of
Pemigatinib
Type of cartilage in humans
Gerald; Buschmann, Michael D.; Henderson, Janet E. (27 May 2005). "Fibroblast growth factor (FGF) 18 signals through FGF receptor 3 to promote chondrogenesis"
Hyaline_cartilage
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor 16 is a protein which in humans is encoded by the FGF16 gene. The protein encoded by this gene is a member of the fibroblast
FGF16
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor 12 is a protein that in humans is encoded by the FGF12 gene. The protein encoded by this gene is a member of the fibroblast growth
FGF12
Enzyme in humans
Substance P (SP), and B-type natriuretic peptide (BNP), human fibroblast growth factor 21 (FGF-21), human alpha2 antiplasmin and denatured collagen I
Fibroblast activation protein, alpha
Fibroblast_activation_protein,_alpha
Chemical compound
Specifically, it inhibits fibroblast growth factor receptors (FGFRs) 1–3, janus kinase (JAK) 1/2, vascular endothelial growth factor receptors (VEGFRs), and
Tinengotinib
Novel gene
Fibroblast growth factor receptor oncogene partner 2 (FGFR1OP2) was identified in a study on myeloproliferative syndrome (EMS). The study aimed to identify
FGFR1OP2
Genetics responsible for the appearance of a cat's fur
shorthaired offspring. The Length gene has been identified as the fibroblast growth factor 5 (FGF5; M3X9S6) gene. The dominant allele codes for the short
Cat_coat_genetics
Neural stem cell culture system
substrates but containing necessary growth factors, such as epidermal growth factor and fibroblast growth factor. This allows the neural stem cells to
Neurosphere
Mammalian protein found in Mus musculus
Fibroblast growth factor 15 is a protein in mouse encoded by the Fgf15 gene. It is a member of the fibroblast growth factor (FGF) family but, like FGF19
FGF15
Medical condition
Kuo, Ann; Leder, Philip (March 1996). "Fibroblast Growth Factor Receptor 3 Is a Negative Regulator of Bone Growth". Cell. 84 (6): 911–921. doi:10
Camptodactyly, tall stature, and hearing loss syndrome
Camptodactyly,_tall_stature,_and_hearing_loss_syndrome
Protein-coding gene in the species Homo sapiens
Glia-activating factor is a protein that in humans is encoded by the FGF9 gene. The protein encoded by this gene is a member of the fibroblast growth factor (FGF)
FGF9
Protein in humans
ubiquitination results in reduced levels of fibroblast growth factor 8 (FGF8) and fibroblast growth factor 10 (FGF10). FGF8 in turn regulates a number
Cereblon
Outer layer of the cerebrum of the mammalian brain
a 'protomap', which is regulated by molecular signals such as fibroblast growth factor FGF8 early in embryonic development. These signals regulate the
Cerebral_cortex
Chemical compound
receptors 1, 2 and 3, as well as the fibroblast growth factor receptors 1 and 2, and the platelet-derived growth factor receptors alpha and beta. Soria JC
Lucitanib
Protein-coding gene in the species Homo sapiens
"Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation". Molecular and Cellular Biology
GRB2
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor 13 is a protein that in humans is encoded by the FGF13 gene. The protein encoded by this gene is a member of the fibroblast growth
FGF13
Mass formed in response to injury to the nervous system
family of glial scar inducers include interferon-γ (IFNγ) and fibroblast growth factor 2 (FGF2). IFNγ has been shown to induce astrocyte proliferation
Glial_scar
Type of adipose tissue
not only in vascular disorders but also in life span modulation. Fibroblast growth factor 21 (FGF-21) production has been documented as a pathway to longevity
Brown_adipose_tissue
Protein-coding gene in the species Homo sapiens
receptors for fibroblast growth factor (FGF), epidermal growth factor (EGF), and hepatocyte growth factor (HGF). Antagonization of growth factor mediated pathways
SPRY2
Fibroblast growth factor 11 also known as FGF11 is a human gene. The protein encoded by this gene is a member of the intracellular fibroblast growth factor
FGF11
Pharmaceutical compound
Aldafermin is a fibroblast growth factor 19 (FGF19) analogue developed for non-alcoholic steatohepatitis. Babu, A.F.; Iannone, V.; Lok, J.; Gomez-Gallego
Aldafermin
Genetic disorder of sheep
found on ovine chromosome 6, and involves the inactivation of fibroblast growth factor receptor 3. It has been compared to dwarfism in beef cattle. Afflicted
Spider_lamb_syndrome
cells are brought into the neural folds. Molecules such as Wnt, fibroblast growth factor (FGF) and bone morphogenetic protein (BMP) provide signals which
Cardiac_neural_crest
Pharmaceutical compound
Efimosfermin alfa (development code BOS-580) is a long-acting fibroblast growth factor 21 analog that can be injected once monthly. It was acquired by
Efimosfermin_alfa
Protein-coding gene in humans
of the fibroblast growth factor family. FGF3 binds to Fibroblast Growth Factor Receptor 3 (FGFR3) to serve as a negative regulator of bone growth during
FGF3
Medical condition
of a new skeletal dysplasia caused by a Lys650Met mutation in fibroblast growth factor receptor 3". Am J Med Genet. 85 (1): 53–65. doi:10
Severe achondroplasia with developmental delay and acanthosis nigricans
Severe_achondroplasia_with_developmental_delay_and_acanthosis_nigricans
FIBROBLAST GROWTH-FACTOR
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FIBROBLAST GROWTH-FACTOR