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Protein found in humans
Complement receptor type 2 (CR2), also known as complement C3d receptor, Epstein–Barr virus receptor, and CD21 (cluster of differentiation 21), is a protein
Complement_receptor_2
Protein found in humans
Complement receptor type 1 (CR1) also known as C3b/C4b receptor or CD35 (cluster of differentiation 35) is a protein that in humans is encoded by the
Complement_receptor_1
Protein family
complement receptor is a membrane-bound receptor belonging to the complement system, which is part of the innate immune system. Complement receptors bind
Complement_receptor
antigen (or integrin αMβ2 or macrophage integrin or Mac-1) is a complement receptor ("CR3") consisting of CD11b (integrin αM) and CD18 (integrin β2)
Macrophage-1_antigen
Mammalian protein found in Homo sapiens
The C5a receptor also known as complement component 5a receptor 1 (C5AR1) or CD88 (Cluster of Differentiation 88) is a G protein-coupled receptor for C5a
C5a_receptor
formed by the cleavage of complement component 3; the other is C3b. C3a is a 77 residue anaphylatoxin that binds to the C3a receptor (C3aR), a class A G protein-coupled
C3a_(complement)
Part of the immune system that enhances the ability of antibodies and phagocytic cells
proteins and protein fragments make up the complement system, including plasma proteins, and cell membrane receptors. They account for about 10% of the globulin
Complement_system
Protein found in humans
invader, the complement system becomes activated. This activation process involves complement component 2 protein attaching to complement component 4 protein
Complement_component_2
Aspect of the immune system
anaphylatoxin C3a interacts with its C3a receptor (C3aR) to recruit leukocytes, C3b contributes to further downstream complement activation. C3b binds to the C3
Classical_complement_pathway
Type of white blood cell
Szakonyi G, Chen XS, Holers VM (January 2013). "Human complement receptor 2 (CR2/CD21) as a receptor for DNA: implications for its roles in the immune response
B_cell
Biomarker for B cell lineage
complex bound to the antigen-complement complex can decrease the threshold for B cell activation. CD21, complement receptor 2, can bind fragments of C3 that
CD19
Antigen which strongly activates the immune system
Transactivates the HERV-K18 Superantigen by Docking to the Human Complement Receptor 2 (CD21) on Primary B Cells". The Journal of Immunology. 177 (4):
Superantigen
Protein-coding gene in humans
The C3a receptor also known as complement component 3a receptor 1 (C3AR1) is a G protein-coupled receptor protein involved in the complement system. The
C3a_receptor
Topics referred to by the same term
Singapore, station code CR2 Complement receptor 2, an immunological cell surface receptor for a complement component Conserved Region 2, the second conserved
CR2
Protein-coding gene in the species Homo sapiens
Complement component 5a receptor 2 is a protein of the complement system that in humans is encoded by the C5AR2 gene. It is highly expressed in the blood
C5AR2
Protein fragment
Basic and Clinical Pharmacology. [corrected]. LXXXVII. Complement peptide C5a, C4a, and C3a receptors". Pharmacological Reviews. 65 (1): 500–543. doi:10.1124/pr
Complement_component_5a
Membrane-bound complement regulators Membrane Cofactor Protein, MCP (CD46) Decay Accelerating Factor, DAF (CD55) Protectin (CD59) Complement C3b/C4b Receptor 1, CR1
Complement_control_protein
Type of allergic reaction
mechanisms such as complement activation via the classical complement pathway Antibody-dependent cellular cytotoxicity or anti-receptor activity. The activation
Type_II_hypersensitivity
Cell surface molecules of the immune system triggering changes in the behavior of cells
inhibitor receptors (KARs and KIRs), complement receptors, Fc receptors, B cell receptors and T cell receptors. Antigen Lippincott's Illustrated Reviews:
Immune_receptor
Cell surface receptor found in humans
Toll-like receptor 2 also known as TLR2 is a protein that in humans is encoded by the TLR2 gene. TLR2 has also been designated as CD282 (cluster of differentiation
Toll-like_receptor_2
Protein complex
structure, function, and receptors. Kishore U1, Reid KB. Immunopharmacology. 2000 Aug;49(1-2):159-70. Functional Complement C1q Abnormality Leads to Impaired
Complement_component_1q
Antibody isotype
human and mouse antibodies have different abilities to fix complement and to bind to Fc receptors.[citation needed] The measurement of immunoglobulin G can
Immunoglobulin_G
Mammalian protein found in humans
inhibitory complement receptor. CD46 is found in a cluster on chromosome 1q32 with other genes encoding structural components of the complement system. At
Membrane_cofactor_protein
Cell membrane engulfing a large particle
Macrophages initiate phagocytosis by mannose receptors, scavenger receptors, Fcγ receptors and complement receptors 1, 3 and 4. Macrophages are long-lived and
Phagocytosis
Protein molecule receiving signals for a cell
toll-like receptors (TLRs), killer activated and killer inhibitor receptors (KARs and KIRs), complement receptors, Fc receptors, B cell receptors and T cell
Receptor_(biochemistry)
Surface protein important to the immune system
In immunology, an Fc receptor is a protein found on the surface of certain cells – including, among others, B lymphocytes, follicular dendritic cells,
Fc_receptor
Protein found in humans
leucocyte C5a receptors". Immunology. 82 (4): 516–21. PMC 1414921. PMID 7835913. Süsal C, Kirschfink M, Kröpelin M, et al. (1994). "Complement activation
Complement_component_5
Overview of and topical guide to immunology
FCN2 FCN3 Complement receptor CR1 (CD35) CR2 (CD21) CR3 - Heterodimer: CD11b / CD18 CR4 - Heterodimer: CD11c / CD18 CRIg (Complement receptor of the immunoglobulin
Outline_of_immunology
Family of cell surface receptors
Pattern recognition receptors (PRRs) play a crucial role in the proper function of the innate immune system. PRRs are germline-encoded host sensors, which
Pattern_recognition_receptor
Protein domain
for fragments of the complement system. C3, C4A, C4B, C4B-1, C5, FBLN1, FBLN2 Allergy Anaphylatoxin receptors Anaphylaxis Complement system Inflammation
Anaphylatoxin
Drug that blocks histamine or histamine agonists
antihistamines that act on H1-receptors. In 2014, antihistamines such as desloratadine were found to be effective to complement standardized treatment of
Antihistamine
Chemical compound
anti-neutrophil cytoplasmic autoantibody-associated vasculitis. Avacopan is a complement 5a receptor antagonist and a cytochrome P450 3A4 inhibitor. The most common
Avacopan
Cell receptor found in humans
The insulin receptor (IR) is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of receptor tyrosine kinase
Insulin_receptor
Antibodies rarely making an infection worse instead of better
FcγR or complement pathway. After interaction with a virus, the antibodies bind Fc receptors (FcR) expressed on certain immune cells or complement proteins
Antibody-dependent enhancement
Antibody-dependent_enhancement
Aspect of immunity
macrophages and other cells, block viral receptors, and stimulate other immune responses, such as the complement pathway. An incompatible blood transfusion
Humoral_immunity
Type of cascade reaction of the complement system
regulatory proteins that disrupt the complement activation process: Complement Receptor 1 (CR1 or CD35) and DAF (decay accelerating factor also known as
Alternative complement pathway
Alternative_complement_pathway
Medication class that inhibits leukotriene synthesis and/or activity
receptor antagonist, is a medication which functions as a leukotriene-related enzyme inhibitor (arachidonate 5-lipoxygenase) or leukotriene receptor antagonist
Antileukotriene
Class of cell surface receptors coupled to G-protein-associated intracellular signaling
protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G
G_protein-coupled_receptor
Subtype of serotonin receptor
5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and functions as a G protein-coupled receptor (GPCR)
5-HT2A_receptor
Immunity strategy in living beings
of pattern recognition receptor, that exists in all coelomates (animals with a body-cavity), including humans. The complement system exists in most life
Innate_immune_system
Tail region of an antibody
antibody that interacts with cell surface receptors called Fc receptors and some proteins of the complement system. This region allows antibodies to activate
Fragment crystallizable region
Fragment_crystallizable_region
Mammalian protein found in Homo sapiens
heterodimeric integrin alpha-M beta-2 (αMβ2) molecule, also known as macrophage-1 antigen (Mac-1) or complement receptor 3 (CR3). ITGAM is also known as CR3A
Integrin_alpha_M
Protein complex on the surface of T cells that recognizes antigens
the structure of the human T-cell receptor using anti-idiotypic monoclonal antibodies to T-cell clones, complemented by studies in the mouse by Philippa
T-cell_receptor
Mammalian protein found in humans
binds to the Fc-gamma receptor IIa, to which IgG isotype antibodies also bind. In addition, CRP activates the classical complement pathway via C1q binding
C-reactive_protein
Protein-coding gene in the species Homo sapiens
ICAM-1 and reduced expression and/or function of complement receptors, FcgammaRII and the mannose receptor". Microbiology. 148 (Pt 10): 3161–71. doi:10
Mannose_receptor_C-type_1
Overreaction of the immune system to an antigen
FcγRs is shown to be increased by C5a receptor signaling. Additionally, there are instances in which complement does appear to be key to the pathogenesis
Hypersensitivity
Lymphotoxin beta receptor (LTBR), also known as tumor necrosis factor receptor superfamily member 3 (TNFRSF3), is a cell surface receptor for lymphotoxin
Lymphotoxin_beta_receptor
Topics referred to by the same term
(psychedelics), a family of psychedelic phenethylamines Alpha-2C adrenergic receptor in biochemistry Apple IIc, a personal computer introduced by Apple Computer
2C
Biological system protecting an organism against disease
phagocytosis, antimicrobial peptides called defensins, RNA interference, and the complement system. Jawed vertebrates, including humans, have a more sophisticated
Immune_system
Protein
C3b or C4b) and a cofactor protein (Factor H, C4b-binding protein, complement receptor 1, and membrane cofactor protein). Upon binding of the enzyme to
Complement_factor_I
Mammalian protein found in Homo sapiens
Complement decay-accelerating factor, also known as CD55 or DAF, is a protein that, in humans, is encoded by the CD55 gene. DAF regulates the complement
Decay-accelerating_factor
Mammalian protein found in Homo sapiens
density lipoprotein receptor-related protein 1 (LRP1), also known as alpha-2-macroglobulin receptor (A2MR), apolipoprotein E receptor (APOER) or cluster
LRP1
Protein-coding gene in the species Homo sapiens
Formyl peptide receptor 1 (FPR1, FPR1 receptor, fMet-Leu-Phe receptor 1, FMLP receptor 1, or N-formylmethionyl-leucyl-phenylalanine receptor 1) is a cell
Formyl_peptide_receptor_1
Mammalian protein found in Homo sapiens
CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a gene that encodes for CD11c . CD11c is an integrin alpha
Integrin_alpha_X
Lack of or compromised immune system
Asplenia, where there is no function of the spleen Complement deficiency is where the function of the complement system is deficient In reality, immunodeficiency
Immunodeficiency
Class of proteins involved in inflammation
upregulation of transferrin receptors, but the latter does not appear to change with inflammation. While the production of C3 (a complement factor) increases in
Acute-phase_protein
Mammalian protein found in Homo sapiens
R (1996). "The continuing saga of complement receptor type 3 (CR3)". Journal of Clinical Investigation. 98 (1): 1–2. doi:10.1172/jci118752. PMC 507390
Integrin_beta_2
Jonathan; Kabashima, Kenji; XCIMA Study Group (2017). "Anti–Interleukin-31 Receptor a Antibody for Atopic Dermatitis". New England Journal of Medicine. 376
List of therapeutic monoclonal antibodies
List_of_therapeutic_monoclonal_antibodies
Chemical compound
(May 2021). "Zilucoplan: An Investigational Complement C5 Inhibitor for the Treatment of Acetylcholine Receptor Autoantibody-Positive Generalized Myasthenia
Zilucoplan
Antibody that plays a crucial role in the immune function of mucous membranes
still attached to the receptor. Proteolysis of the receptor occurs, and the dimeric IgA molecule, along with a portion of the receptor known as the secretory
Immunoglobulin_A
Pattern of the immune system
are products of tissue damage. Toll-like receptors (TLR), complement receptors (CR), and scavenger receptors are among the many types of PRRs that monitor
Pathogen-associated molecular pattern
Pathogen-associated_molecular_pattern
Medical condition
suggested, including complement receptors (CR3, CR4, CR3a, CR5a) activated by the respective complement factors; toll-like receptors activated by bacterial
Pseudoallergy
Medical condition
involving the inability to respond to androgens, typically due to androgen receptor dysfunction. It affects 1 in 20,000 to 64,000 XY (karyotypically male)
Androgen insensitivity syndrome
Androgen_insensitivity_syndrome
Class of G protein-coupled receptors
amine-associated receptors (TAARs), sometimes referred to as trace amine receptors (TAs or TARs), are a class of G protein-coupled receptors that were discovered
Trace amine-associated receptor
Trace_amine-associated_receptor
Norwegian immunologist
Espevik, T., & Mollnes, T. E. (2017). Dual inhibition of complement and Toll-like receptors as a novel approach to treat inflammatory diseases—C3 or C5
Tom_Mollnes
Rare disease which results in brain inflammation
Anti-NMDA receptor encephalitis is a type of brain inflammation caused by antibodies. Early symptoms may include fever, headache, and feeling tired. This
Anti-NMDA receptor encephalitis
Anti-NMDA_receptor_encephalitis
Mammalian protein found in Homo sapiens
neonatal fragment crystallizable (Fc) receptor (also FcRn, IgG receptor FcRn large subunit p51, or Brambell receptor) is a protein that in humans is encoded
Neonatal fragment crystallizable receptor
Neonatal_fragment_crystallizable_receptor
Signal to activate immune cells
is provided alternatively by complement receptors. Microbes may activate the complement system directly and complement component C3b bind to microbes
Co-stimulation
Protein-coding gene in the species Homo sapiens
peptide receptor 2 (FPR2) is a G-protein coupled receptor (GPCR) located on the surface of many cell types of various animal species. The human receptor protein
Formyl_peptide_receptor_2
Mammalian protein found in Homo sapiens
Hepatocyte growth factor receptor (HGF receptor) is a protein that in humans is encoded by the MET gene. The protein possesses tyrosine kinase activity
Hepatocyte growth factor receptor
Hepatocyte_growth_factor_receptor
Cholesterol-transporting protein most notably implicated in Alzheimer's disease
transports cholesterol to neurons via Apo-E receptors, which are members of the low density lipoprotein receptor gene family. Apo-E is the principal cholesterol
Apolipoprotein_E
DNA or RNA sequence that matches its complement when read backwards
equal to its reverse complement. For example, the DNA sequence ACCTAGGT is palindromic with its nucleotide-by-nucleotide complement TGGATCCA because reversing
Palindromic_sequence
Protein involved in the immune system
the human leukocyte antigen (HLA) system, which when paired with complement component 2 (C2) is imperative in generating an immune response. C4 serves a
Complement_component_4
Aggressive type of brain cancer
tumors in this subtype carry extra copies of the epidermal growth factor receptor (EGFR) gene, and most have higher than normal expression of EGFR, whereas
Glioblastoma
Movement of an organism or entity in response to a chemical stimulus
ligands and receptors related to formyl peptides are summarized in the related article, Formyl peptide receptors. Complement 3a (C3a) and complement 5a (C5a)
Chemotaxis
Atypical antipsychotic medication
agonists may induce structural changes in receptor conformations that are differentially "sensed" by the local complement of G proteins to induce a variety of
Aripiprazole
Protein
also inhibits the membrane-damaging effect of the terminal cytolytic complement pathway and binds to several serpins (serine protease inhibitors). It
Vitronectin
infections) MBP deficiency (pyogenic infections) MASP2 deficiency Complement receptor 3 deficiency Membrane cofactor protein (CD46) deficiency Membrane
List of primary immunodeficiencies
List_of_primary_immunodeficiencies
Protein(s) forming a major part of an organism's immune system
natural killer cells) bind via their Fc receptors (FcR) to the Fc region of an antibody, while the complement system is activated by binding the C1q protein
Antibody
Psychoactive chemical
natural substances found in the opium poppy plant. Opioids work on opioid receptors in the brain and other organs to produce a variety of morphine-like effects
Opioid
Anti-inflammatory cytokine
signals through a receptor complex consisting of two IL-10 receptor-1 and two IL-10 receptor-2 proteins. Consequently, the functional receptor consists of four
Interleukin_10
Proteins similar to insulin that stimulate cell proliferation
insulin receptor, it can also complement for the effects of insulin. Receptors for IGF-1 are found in vascular smooth muscle, while typical receptors for
Insulin-like_growth_factor
Country in North America
genetics, which include stem cells, site-directed mutagenesis, T-cell receptor, and the identification of the genes that cause Fanconi anemia, cystic
Canada
the surface of the microbe. Because primate erythrocytes express complement receptor 1 (CR1) on their surface and having binding specificity to C4b, C3b
Immune_adherence
Cell surface proteins, part of the acquired immune system
lymphocytes (CTLs). A CTL expresses CD8 receptors, in addition to T-cell receptors (TCRs). When a CTL's CD8 receptor docks to a MHC class I molecule, if the
Major histocompatibility complex
Major_histocompatibility_complex
Antibodies targeted against the thyroid
anti-thyroid peroxidase antibodies (anti-TPO antibodies, TPOAb), thyrotropin receptor antibodies (TRAb) and thyroglobulin antibodies (TgAb). TRAb's are subdivided
Antithyroid_autoantibodies
factor 1 receptor - colorimeter - comparative biochemistry - competitive inhibition - complement 3A - complement 5A - complement factor B - complement membrane
Index of biochemistry articles
Index_of_biochemistry_articles
Mammalian protein found in Homo sapiens
activity as a virus receptor protein, having been identified as a receptor for Chikungunya Virus (CHIKV) and Dengue Virus 2 (DENV-2). Little else is known
Prohibitin
Technology used to validate protein interactions
Bimolecular fluorescence complementation (also known as BiFC) is a technology typically used to validate protein interactions. It is based on the association
Bimolecular fluorescence complementation
Bimolecular_fluorescence_complementation
Physiological capacity
information to and from the brain and body), the different types of sensory receptor cells (such as mechanoreceptors, photoreceptors, chemoreceptors, thermoreceptors)
Sense
Subsystem of the immune system
attached antibodies activate complement, and complement C3 fragments are opsonins recognized by the CR1 complement receptor on phagocytic cells. A population
Adaptive_immune_system
Activation of coagulation cascade
peptide known as bradykinin (BK). BK and its derivatives bind to bradykinin receptors B1 and B2 to mediate inflammation. Artificial negatively charged substances
Contact_activation_system
Blood antigen set classification systems
antibodies produced by the patient can be detected by mixing patient serum with 2 to 4 "screening" or "control" red blood cells that together display essentially
Human_blood_group_systems
Protein-coding gene in the species Homo sapiens
peptide receptor 3 (FPR3) is a receptor protein that in humans is encoded by the FPR3 gene. Confusingly, there are two nomenclatures for FPR receptors and
Formyl_peptide_receptor_3
Chemical compound
SD, Olsen E, Kimball B, Cohn ZA (September 1987). "Aggregation of complement receptors on human neutrophils in the absence of ligand". The Journal of Cell
N-Formylmethionine
Vision loss due to damage to the macula of the eye
location 10q26 Complement factor B/complement component 2 (CFB/CC2) on chromosome 6 at 6p21.3[citation needed] Polymorphisms in genes for complement system proteins:
Macular_degeneration
Genus of flowering plants
cannabidiol modulates and directly activates alpha-1 and alpha-1-Beta glycine receptor function". Pharmacology. 83 (4): 217–22. doi:10.1159/000201556. PMID 19204413
Cannabis
Synthetic Opioid pain medication
isomers complement each other's analgesic activities. The (+)-isomer is predominantly active as an opiate with a higher affinity for the μ-opiate receptor (20
Tramadol
Autoimmune disease resulting in skeletal muscle weakness
addition of pathogenic antibodies against the acetylcholine receptor and activation of the complement system, the neuromuscular co-culture shows symptoms such
Myasthenia_gravis
Macrophages located in the liver
identified a receptor present in Kupffer cells, the complement receptor of the immunoglobulin family (CRIg). Mice without CRIg could not clear complement system-coated
Kupffer_cell
COMPLEMENT RECEPTOR-2
COMPLEMENT RECEPTOR-2
Boy/Male
Hindu
Preceptor of all
Boy/Male
Hindu
Preceptor of Skanda
Boy/Male
Anglo Saxon
Competent.
Girl/Female
Indian
Competent
Boy/Male
Tamil
Sarvacharya | ஸரà¯à®µà®¾à®šà®¾à®°à¯à®¯
Preceptor of all
Sarvacharya | ஸரà¯à®µà®¾à®šà®¾à®°à¯à®¯
Boy/Male
Indian, Sanskrit
The Preceptor
Boy/Male
Tamil
Skandaguru | ஸà¯à®•à¯à®¨à¯à®¤à®•à¯à®°à¯à®‚
Preceptor of Skanda
Skandaguru | ஸà¯à®•à¯à®¨à¯à®¤à®•à¯à®°à¯à®‚
Boy/Male
Arabic, Muslim
Competent
Boy/Male
Indian
Compliments, Happiness
Boy/Male
Muslim/Islamic
Compliments happiness
Boy/Male
Arabic
Educator; Preceptor
Boy/Male
Muslim
Competent
Boy/Male
Arabic, Muslim
Competent
Boy/Male
Arabic, Muslim
Competent
Boy/Male
Japanese
Complacent; satisfied.
Girl/Female
Indian
Competent.
Boy/Male
Muslim
Compliments, Happiness
Boy/Male
Hindi
Competent.
Boy/Male
Indian, Sanskrit
Competent
Boy/Male
Arabic, Muslim
Competent
COMPLEMENT RECEPTOR-2
COMPLEMENT RECEPTOR-2
Girl/Female
Tamil
Pleasant, Wonderful, Happy or full of laughter
Surname or Lastname
English
English : ethnic name (see English 1).Norwegian : habitational name from any of various farmsteads, so named from Old Norse eng ‘meadow’ + land ‘land’.Swedish : ornamental name with the same meaning as 2.
Biblical
fugitive
Male
African
witness.
Girl/Female
Hindu, Indian, Telugu
Judicial
Boy/Male
Hindu
The cupid, The God of Love
Boy/Male
Arabic, Farsi, Urdu
Resident of City Madeena; Old Name Yasrib
Boy/Male
Arabic, Muslim
Crown of a King; Like a King
Boy/Male
Biblical
Bramble of destruction.
Surname or Lastname
English
English : unexplained.
COMPLEMENT RECEPTOR-2
COMPLEMENT RECEPTOR-2
COMPLEMENT RECEPTOR-2
COMPLEMENT RECEPTOR-2
COMPLEMENT RECEPTOR-2
v. t.
To provide with an implement or implements; to cause to be fulfilled, satisfied, or carried out, by means of an implement or implements.
v. i.
To pass compliments; to use conventional expressions of respect.
v. t.
To praise, flatter, or gratify, by expressions of approbation, respect, or congratulation; to make or pay a compliment to.
n.
An expression, by word or act, of approbation, regard, confidence, civility, or admiration; a flattering speech or attention; a ceremonious greeting; as, to send one's compliments to a friend.
v. t.
A second quantity added to a given quantity to make it equal to a third given quantity.
v. t.
A compliment.
v. t.
The whole working force of a vessel.
v. t.
To compliment.
v. t.
That which is required to supply a deficiency, or to complete a symmetrical whole.
v. t.
Something added for ornamentation; an accessory.
n.
The chief elective officer of some universities, as in France and Scotland; sometimes, the head of a college; as, the Rector of Exeter College, or of Lincoln College, at Oxford.
n.
The act of receiving; receipt; admission; as, the reception of food into the stomach; the reception of a letter; the reception of sensation or ideas; reception of evidence.
n.
Compliments; greetings.
v. t.
The interval wanting to complete the octave; -- the fourth is the complement of the fifth, the sixth of the third.
v. t.
To supply a lack; to supplement.
v. t.
That which fills up or completes; the quantity or number required to fill a thing or make it complete.
v. t.
Full quantity, number, or amount; a complete set; completeness.
n.
The head of a preceptory among the Knights Templars.
a.
Self-satisfied; contented; kindly; as, a complacent temper; a complacent smile.
n.
The act or manner of receiving, esp. of receiving visitors; entertainment; hence, an occasion or ceremony of receiving guests; as, a hearty reception; an elaborate reception.