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ANAPHYLATOXIN

• Anaphylatoxin

Protein domain

Anaphylatoxins, or complement peptides, are fragments (C3a, C4a and C5a) that are produced as part of the activation of the complement system. Complement

Anaphylatoxin



Anaphylatoxin

• C5a receptor

Mammalian protein found in Homo sapiens

U.S. National Library of Medicine. Gerard C, Gerard NP (1994). "C5A anaphylatoxin and its seven transmembrane-segment receptor". Annual Review of Immunology

C5a receptor



C5a_receptor

• Anaphylatoxin receptors

Group of G-protein coupled receptors

The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins. Members of this family include: C3a receptor C3AR1 C5a

Anaphylatoxin receptors

Anaphylatoxin_receptors

• C3a receptor

Protein-coding gene in humans

1016/0167-4781(95)00209-x. PMID 8605247. Ali H, Panettieri RA (February 2005). "Anaphylatoxin C3a receptors in asthma". Respiratory Research. 6 (1): 19. doi:10.1186/1465-9921-6-19

C3a receptor



C3a_receptor

• Lysine carboxypeptidase

Class of enzymes

enzyme found in plasma. It inactivates proteins such as bradykinin and anaphylatoxins in the blood in order to prevent toxic buildup. Lysine carboxypeptidase

Lysine carboxypeptidase

Lysine_carboxypeptidase

• Complement component 5

Protein found in humans

linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived

Complement component 5



Complement_component_5

• C3a (complement)

cleavage of complement component 3; the other is C3b. C3a is a 77 residue anaphylatoxin that binds to the C3a receptor (C3aR), a class A G protein-coupled receptor

C3a (complement)



C3a_(complement)

• C5AR2

Protein-coding gene in the species Homo sapiens

expressed in the blood and spleen, predominantly by myeloid cells. The anaphylatoxins C3a and C5a are fragments of C3 and C5 generated via proteolytic cleavage

C5AR2



C5AR2

• Complement system

Part of the immune system that enhances the ability of antibodies and phagocytic cells

usually rapidly cleaved by carboxypeptidase B. Both C3a and C5a have anaphylatoxin activity, directly triggering degranulation of mast cells as well as

Complement system



Complement_system

• Fibulin

Protein domain

structures. The amino-terminal domain I of fibulin consists of three anaphylatoxin-like (AT) modules, each approximately 40 residues long and containing

Fibulin



Fibulin

• Complement component 5a

Protein fragment

may cause local increase of C5a. C5a is a chemotactic agent and an anaphylatoxin; it is essential in the innate immunity but it is also linked with the

Complement component 5a



Complement_component_5a

• Complement component 3

Protein found in humans

activation by C3 convertase, the α-chain is cleaved, releasing the anaphylatoxin C3a and generating C3b, which exposes the reactive thioester group.

Complement component 3



Complement_component_3

• Ernst Friedberger

German immunologist

antigen, antibody, and complement is accompanied by the manufacture of anaphylatoxin, a word he used for the poison that was supposed to be the same with

Ernst Friedberger



Ernst_Friedberger

• Arthus reaction

Medical condition

Subsequent investigation demonstrated that complement, specifically the anaphylatoxin C5a, can drive the Arthus reaction indirectly because the resultant

Arthus reaction

Arthus_reaction

• Bronchospasm

Lower respiratory tract disease that affects the airways leading into the lungs

(degranulation) of substances from mast cells or basophils under the influence of anaphylatoxins. It causes difficulty in breathing which ranges from mild to severe

Bronchospasm



Bronchospasm

• G protein-coupled receptor

Class of cell surface receptors coupled to G-protein-associated intracellular signaling

factor, and leukotrienes); peptide hormones (e.g., calcitonin, C5a anaphylatoxin, follicle-stimulating hormone [FSH], gonadotropin-releasing hormone

G protein-coupled receptor



G_protein-coupled_receptor

• Complement component 4B

Protein-coding gene in the species Homo sapiens

complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated

Complement component 4B



Complement_component_4B

• Opioid receptor

Group of biological receptors

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Opioid receptor



Opioid_receptor

• 5-HT2A receptor

Subtype of serotonin receptor

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

5-HT2A receptor



5-HT2A_receptor

• Rhodopsin

Light-sensitive receptor protein

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Rhodopsin



Rhodopsin

• Orexin receptor

G-protein-coupled receptor

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Orexin receptor

Orexin_receptor

• Adrenergic receptor

Class of G protein-coupled receptors

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Adrenergic receptor



Adrenergic_receptor

• VN1R1

Protein-coding gene in the species Homo sapiens

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

VN1R1



VN1R1

• Gonadotropin receptor

Class of receptors

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Gonadotropin receptor

Gonadotropin_receptor

• Membrane estrogen receptor

Receptor group

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Membrane estrogen receptor



Membrane_estrogen_receptor

• Inflammation

Physical effects resulting from activation of the immune system

molecules behave as chemoattractants, for example, C3a or C5a (the anaphylatoxins), and cause the leukocytes to move along a chemotactic gradient towards

Inflammation



Inflammation

• Alpha-2 adrenergic receptor

Protein family

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Alpha-2 adrenergic receptor



Alpha-2_adrenergic_receptor

• Adenosine receptor

Class of four receptor proteins to the molecule adenosine

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Adenosine receptor



Adenosine_receptor

• GPR68

Protein-coding gene in the species Homo sapiens

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

GPR68



GPR68

• Prokineticin receptor 1

Protein-coding gene in the species Homo sapiens

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Prokineticin receptor 1



Prokineticin_receptor_1

• Leukotriene receptor

Protein family

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Leukotriene receptor

Leukotriene_receptor

• Classical complement pathway

Aspect of the immune system

able to more easily recognize and engulf pathogen molecules. While the anaphylatoxin C3a interacts with its C3a receptor (C3aR) to recruit leukocytes, C3b

Classical complement pathway



Classical_complement_pathway

• Hypersensitivity

Overreaction of the immune system to an antigen

classical pathway, causing formation of the membrane attack complex, anaphylatoxin production, and opsonization. Fc-mediated effector functions (e.g.,

Hypersensitivity



Hypersensitivity

• TAAR3

Human pseudogene

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

TAAR3



TAAR3

• GPR75

Protein-coding gene in humans

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

GPR75



GPR75

• GPR6

Protein-coding gene in the species Homo sapiens

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

GPR6



GPR6

• Hydroxycarboxylic acid receptor 2

Protein-coding gene in the species Homo sapiens

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Hydroxycarboxylic acid receptor 2



Hydroxycarboxylic_acid_receptor_2

• Luteinizing hormone/choriogonadotropin receptor

Transmembrane receptor found in humans

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Luteinizing hormone/choriogonadotropin receptor



Luteinizing_hormone/choriogonadotropin_receptor

• Corticotropin-releasing hormone receptor 2

Protein found in humans

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Corticotropin-releasing hormone receptor 2



Corticotropin-releasing_hormone_receptor_2

• OPN5

Protein-coding gene in the species Homo sapiens

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

OPN5



OPN5

• C3-convertase

Class of serine proteases

smaller fragments of proteolysis, C4a and C2a are released. C4a is an anaphylatoxin. C3 convertases are unstable (half-life 10 – 20 min) – respectively

C3-convertase



C3-convertase

• Muscarinic acetylcholine receptor M5

Protein-coding gene in the species Homo sapiens

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Muscarinic acetylcholine receptor M5



Muscarinic_acetylcholine_receptor_M5

• Neuromedin U receptor

InterPro Family

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Neuromedin U receptor

Neuromedin_U_receptor

• GPR158

Protein-coding gene in the species Homo sapiens

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

GPR158



GPR158

• Parathyroid hormone 2 receptor

Protein-coding gene in the species Homo sapiens

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Parathyroid hormone 2 receptor



Parathyroid_hormone_2_receptor

• Adenosine A3 receptor

Cell surface receptor found in humans

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Adenosine A3 receptor



Adenosine_A3_receptor

• Neurotensin receptor

InterPro Family

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Neurotensin receptor



Neurotensin_receptor

• Type III hypersensitivity

Type of allergic reaction

the response which can be augmented by the complement system via the anaphylatoxin C5a. Ligation of Fc receptors on the surfaces of immune effector cells

Type III hypersensitivity



Type_III_hypersensitivity

• GPR114

Protein-coding gene in the species Homo sapiens

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

GPR114



GPR114

• CELSR3

Protein-coding gene in the species Homo sapiens

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

CELSR3



CELSR3

• Muscarinic acetylcholine receptor

Acetylcholine receptors named for their selective binding of muscarine

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Muscarinic acetylcholine receptor



Muscarinic_acetylcholine_receptor

• VIPR1

Protein-coding gene in humans

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

VIPR1



VIPR1

• S1PR4

Protein-coding gene in the species Homo sapiens

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

S1PR4



S1PR4

• Pyroglutamylated RFamide peptide receptor

Protein-coding gene in the species Homo sapiens

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Pyroglutamylated RFamide peptide receptor



Pyroglutamylated_RFamide_peptide_receptor

• Thyrotropin receptor

Mammalian protein found in Homo sapiens

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Thyrotropin receptor



Thyrotropin_receptor

• Melanocortin 3 receptor

Mammalian protein found in humans

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Melanocortin 3 receptor



Melanocortin_3_receptor

• Prostaglandin EP4 receptor

Protein-coding gene in the species Homo sapiens

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Prostaglandin EP4 receptor



Prostaglandin_EP4_receptor

• Capillary

Smallest type of blood vessel

permeability can be increased by the release of certain cytokines, anaphylatoxins, or other mediators (such as leukotrienes, prostaglandins, histamine

Capillary



Capillary

• Taste receptor

Type of cellular receptor that facilitates taste

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Taste receptor



Taste_receptor

• P2Y receptor

Subclass of purinergic P2 receptors

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

P2Y receptor



P2Y_receptor

• Cholecystokinin receptor

G-protein coupled receptor

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Cholecystokinin receptor

Cholecystokinin_receptor

• Eicosanoid receptor

Integral membrane protein G protein-coupled receptor

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Eicosanoid receptor

Eicosanoid_receptor

• GPR64

Protein-coding gene in humans

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

GPR64



GPR64

• Ludwik Hirszfeld

Polish microbiologist and serologist

made an academic lecturer on the basis of his work on anaphylaxis and anaphylatoxin and their relationships to coagulation; he was also named "Privatdozent

Ludwik Hirszfeld



Ludwik_Hirszfeld

• Galanin receptor 2

Protein-coding gene in the species Homo sapiens

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Galanin receptor 2



Galanin_receptor_2

• CPN1

Protein-coding gene in humans

regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer

CPN1



CPN1

• Vasodilation

Widening of blood vessels

vasodilation, gastrointestinal dysfunction, and respiratory dysfunction. Anaphylatoxins, specifically complement proteins C3a and C5a, bind to receptors on

Vasodilation



Vasodilation

• Cannabinoid receptor

Group of receptors to cannabinoid compounds

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Cannabinoid receptor



Cannabinoid_receptor

• Formyl peptide receptor 1

Protein-coding gene in the species Homo sapiens

activated by complement component 5a (C5a) and GPR77, a second C5a anaphylatoxin chemotactic receptor C5a2 (C5L2), a second C5a receptor of debated function

Formyl peptide receptor 1



Formyl_peptide_receptor_1

• Cannabinoid receptor 2

Mammalian protein found in Homo sapiens

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Cannabinoid receptor 2



Cannabinoid_receptor_2

• Glutamate receptor

Neuron membrane protein

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Glutamate receptor



Glutamate_receptor

• Thromboxane receptor

Mammalian protein found in Homo sapiens

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Thromboxane receptor



Thromboxane_receptor

• MRGPRG

Protein-coding gene in the species Homo sapiens

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

MRGPRG



MRGPRG

• Vertebrate visual opsin

Vision proteins

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Vertebrate visual opsin



Vertebrate_visual_opsin

• TAS2R38

Protein-coding gene in the species Homo sapiens

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

TAS2R38



TAS2R38

• Cannabinoid receptor 1

Mammalian protein found in humans

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Cannabinoid receptor 1



Cannabinoid_receptor_1

• Membrane steroid receptor

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Membrane steroid receptor

Membrane_steroid_receptor

• 5-HT1A receptor

Serotonin receptor protein distributed in the cerebrum and raphe nucleus

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

5-HT1A receptor



5-HT1A_receptor

• Histamine receptor

Class of receptor proteins that bind histamine

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Histamine receptor



Histamine_receptor

• GHB receptor

GHB receptor coding gene in the species Homo sapiens

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

GHB receptor



GHB_receptor

• Peter Tippett

American physician, researcher, and inventor (born 1953)

S.; Erickson, B. W.; and Hugli, T. E. (1980) The Active Site of C3a Anaphylatoxin. J. Biol. Chem. 255 10758–10763. Tippett, P. S. and Neet, K. E. (1982)

Peter Tippett



Peter_Tippett

• Glucagon receptor

Protein-coding gene in the species Homo sapiens

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Glucagon receptor



Glucagon_receptor

• D1-like receptor

Subfamily of dopamine receptors

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

D1-like receptor

D1-like_receptor

• Opsin

Class of light-sensitive proteins

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Opsin



Opsin

• Alpha-1 adrenergic receptor

G protein-coupled receptor

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Alpha-1 adrenergic receptor

Alpha-1_adrenergic_receptor

• Glucagon-like peptide-1 receptor

Receptor activated by peptide hormone GLP-1

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Glucagon-like peptide-1 receptor



Glucagon-like_peptide-1_receptor

• Muscarinic acetylcholine receptor M3

Protein and coding gene in humans

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Muscarinic acetylcholine receptor M3



Muscarinic_acetylcholine_receptor_M3

• LGR5

Protein-coding gene in humans

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

LGR5



LGR5

• Eculizumab

Pharmaceutical drug

inhibits the cleavage of C5 by the C5 convertase into C5a, a potent anaphylatoxin with prothrombotic and proinflammatory properties, and C5b, which then

Eculizumab

Eculizumab

• OPN1MW2

Human protein

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

OPN1MW2

OPN1MW2

• Κ-opioid receptor

Protein-coding gene in the species Homo sapiens, named for ketazocine

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Κ-opioid receptor



Κ-opioid_receptor

• Peanut allergy

Type of food allergy caused by peanuts

allergy are related to the action of immunoglobulin E (IgE) and other anaphylatoxins which act to release histamine and other mediator substances from mast

Peanut allergy



Peanut_allergy

• 5-HT1 receptor

Transmembrane protein

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

5-HT1 receptor

5-HT1_receptor

• Acetylcholine receptor

Integral membrane protein

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Acetylcholine receptor



Acetylcholine_receptor

• GABA receptor

Receptors that respond to gamma-aminobutyric acid

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

GABA receptor



GABA_receptor

• 5-HT receptor

Class of transmembrane proteins

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

5-HT receptor



5-HT_receptor

• Dopamine receptor D4

Protein-coding gene in the species Homo sapiens

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Dopamine receptor D4



Dopamine_receptor_D4

• Δ-opioid receptor

Opioid receptor

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Δ-opioid receptor



Δ-opioid_receptor

• Metabotropic glutamate receptor

Type of glutamate receptor

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

Metabotropic glutamate receptor



Metabotropic_glutamate_receptor

• TAS2R4

Protein-coding gene in the species Homo sapiens

B/W 1 2 FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin

TAS2R4



TAS2R4

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