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C3a is one of the proteins formed by the cleavage of complement component 3; the other is C3b. C3a is a 77 residue anaphylatoxin that binds to the C3a
C3a_(complement)
Topics referred to by the same term
C3a may refer to: C3a (complement) C3a receptor C3A, or 3CaO·Al2O3, tricalcium aluminate in cement chemist notation, one of the 4 mineral phases of the
C3a
Part of the immune system that enhances the ability of antibodies and phagocytic cells
of Basic and Clinical Pharmacology. [corrected]. LXXXVII. Complement peptide C5a, C4a, and C3a receptors". Pharmacological Reviews. 65 (1): 500–43. doi:10
Complement_system
Protein-coding gene in humans
The C3a receptor also known as complement component 3a receptor 1 (C3AR1) is a G protein-coupled receptor protein involved in the complement system. The
C3a_receptor
Aspect of the immune system
the anaphylatoxin C3a interacts with its C3a receptor (C3aR) to recruit leukocytes, C3b contributes to further downstream complement activation. C3b binds
Classical_complement_pathway
Protein found in humans
releasing C3a anaphylatoxin and generating C3b (beta chain + alpha' (alpha prime) chain). C3 plays a central role in the activation of the complement system
Complement_component_3
Class of serine proteases
pathways. Cleavage of complement C3 by a free floating convertase, thrombin, plasmin or even a bacterial enzyme leads to formation of C3a and C3b fragments
C3-convertase
Protein domain
Anaphylatoxins, or complement peptides, are fragments (C3a, C4a and C5a) that are produced as part of the activation of the complement system. Complement components
Anaphylatoxin
Type of cascade reaction of the complement system
although only produced in small amounts, can cleave multiple C3 proteins into C3a and C3b. The complex is believed to be unstable until it binds properdin
Alternative complement pathway
Alternative_complement_pathway
Protein fragment
of Basic and Clinical Pharmacology. [corrected]. LXXXVII. Complement peptide C5a, C4a, and C3a receptors". Pharmacological Reviews. 65 (1): 500–543. doi:10
Complement_component_5a
Medical condition
involves the formation of a C3-convertase, which will cleave C3 molecules into C3a and C3b fragments. This is important because an unregulated C3-convertase
Complement_3_deficiency
Protein family
A complement receptor is a membrane-bound receptor belonging to the complement system, which is part of the innate immune system. Complement receptors
Complement_receptor
Protein found in humans
Complement component 5 is a protein that in humans is encoded by the C5 gene. Complement component 5 is involved in the complement system. It is cleaved
Complement_component_5
Protein involved in the immune system
microbes. All three pathways converge at a step in which complement protein C3 is cleaved into proteins C3a and C3b, which results in a lytic pathway and formation
Complement_component_4
Part of the innate immune system
cases treatment with the complement-inhibitory anti-C5 monoclonal antibody, eculizumab, is found to be highly effective. C3a - the other fragment C3 is
C3b
reaction Cleavage of Arg-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg- bond in complement component C5 alpha-chain to yield
Alternative-complement-pathway C3/C5 convertase
Alternative-complement-pathway_C3/C5_convertase
Immunity strategy in living beings
the complement system.This then activates C4 and C2 which will both combine to form C3 convertase. C3 convertase will then split into C3a and C3b. C3a aids
Innate_immune_system
Complication of blood transfusion
also activate the complement cascade via C3a and C5a, which then promote inflammatory cytokine release from white blood cells. C3a and C5a also activate
Acute hemolytic transfusion reaction
Acute_hemolytic_transfusion_reaction
Overview of and topical guide to immunology
Middle stage C3 - C3a / C3b / iC3b C5 - C5a C3-convertase C5-convertase Late stage Membrane attack complex (MAC) C6 C7 C8 C9 Complement pathway inhibitors
Outline_of_immunology
Protein in humans
Complement 3 (C3) through its interaction with factors B and D (adipsin) generates C3a. In the human body, C3a is rapidly cleaved by carboxypeptidase B
Acylation_stimulating_protein
Inflammation of small blood vessels, accompanied by skin bumps
vessel walls leading to activation of the complement system. C3a and C5a, proteins produced from the complement system, attract neutrophils to the vessels
Cutaneous small-vessel vasculitis
Cutaneous_small-vessel_vasculitis
Protein-coding gene in the species Homo sapiens
C3(H2O)Bb. C3(H2O)Bb can cleave additional C3 molecules, creating C3b and C3a. It is known that it participates in some specific immune responses. It plays
Properdin
Protein-coding gene in the species Homo sapiens
anaphylatoxins C3a and C5a are fragments of C3 and C5 generated via proteolytic cleavage by C3 convertases and C5 convertases during the complement cascade.
C5AR2
Mammalian protein found in Homo sapiens
of Basic and Clinical Pharmacology. [corrected]. LXXXVII. Complement peptide C5a, C4a, and C3a receptors". Pharmacological Reviews. 65 (1): 500–543. doi:10
C5a_receptor
Protein-coding gene in the species Homo sapiens
then be able to cleave C3 into C3a and C3b. However, MASP-1 is useful for biological pathways other than the complement pathway, such as blood clots. MASP-1
MASP1
Non-invasive analytical tool
(2017-05-31). "Europium-Labeled Synthetic C3a Protein as a Novel Fluorescent Probe for Human Complement C3a Receptor" (PDF). Bioconjugate Chemistry. 28
Lanthanide_probes
Physical effects resulting from activation of the immune system
the site. A variety of molecules behave as chemoattractants, for example, C3a or C5a (the anaphylatoxins), and cause the leukocytes to move along a chemotactic
Inflammation
relatively preserved. The consequent generation of potent chemotactic factors (C3a and C5a) provides the stimulus for a massive influx of inflammatory infiltrates
Endocapillary proliferative glomerulonephritis
Endocapillary_proliferative_glomerulonephritis
Medical condition
component of the complement system, encounters conformational change that leads to C3 convertase breaking C3 into C3a and C3b. C3a, C5a, IL-8 are all
Diffuse proliferative nephritis
Diffuse_proliferative_nephritis
Overreaction of the immune system to an antigen
or both. Type III, an immune complex-mediated reaction involving IgG, complement system and phagocytes. Type IV, a T cell-mediated, delayed hypersensitivity
Hypersensitivity
Protein-coding gene in the species Homo sapiens
bacteria-induced complement activation also causes the formation of complement component 3a (C3a) by cleavage from complement component 3; C3a is a neutrophil
Formyl_peptide_receptor_1
Blood disorder in which antibodies target red blood cells
are produced against the RBCs, which leads to complement activation. Complement fragments, such as C3a, C4a and C5a, activate granular leukocytes (e.g
Autoimmune_hemolytic_anemia
Type of immunotherapy
convertase to produce C5a and C5b for terminal complement components assembly. The formation of complement proteins (C3a, C3b, C5a, C5b, etc.) ultimately congregates
Passive_antibody_therapy
Protein domain
cysteines. The structure of an AT module was determined for the complement-derived anaphylatoxin C3a, and was found to be a compact alpha-helical fold that is
Fibulin
Widening of blood vessels
dysfunction, and respiratory dysfunction. Anaphylatoxins, specifically complement proteins C3a and C5a, bind to receptors on mast cells and basophils causing
Vasodilation
Mammalian protein found in Homo sapiens
deacetylase binding complement component C3a binding protein C-terminus binding proteinase activated receptor binding complement component C3b binding
Prohibitin
Extracellular metalloprotease expressed by S. aureus
by the host C3 convertase. The aureolysin derived C3a and C3b are further degraded by host complement inhibitor factor H and I. In the lectin pathway,
Aureolysin
Class of G protein-coupled receptors
FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin B1 B2 Chemerin
Trace amine-associated receptor
Trace_amine-associated_receptor
Military-run national youth program
rarely worn. Order of Dress C3A (Service Dress): C1A, but ribbons replace medals. Order of Dress C3B (Service Dress): C3A, minus the tunic Order of Dress
Royal_Canadian_Sea_Cadets
Page, KM; Parsons, M; Lambris, JD; Mayor, R (13 December 2011). "Complement fragment C3a controls mutual cell attraction during collective cell migration"
Collective_cell_migration
Type of white blood cell
gradients of molecules such as interleukin-8 (IL-8), interferon gamma (IFN-γ), C3a, C5a, and leukotriene B4, which these cells use to direct the path of their
Neutrophil
American physician, researcher, and inventor (born 1953)
Tippett, P. S.; Erickson, B. W.; and Hugli, T. E. (1980) The Active Site of C3a Anaphylatoxin. J. Biol. Chem. 255 10758–10763. Tippett, P. S. and Neet, K
Peter_Tippett
Movement of an organism or entity in response to a chemical stimulus
article, Formyl peptide receptors. Complement 3a (C3a) and complement 5a (C5a) are intermediate products of the complement cascade.[citation needed] Their
Chemotaxis
Computer simulations to discover and understand chemical properties
used to estimate the elastic properties of major clinker phases (C3S, C2S, C3A, and C4AF) and to evaluate the performance of different force fields in predicting
Molecular_dynamics
Class of cell surface receptors coupled to G-protein-associated intracellular signaling
binding side was even more easily accessible to the ligand. New structures complemented with biochemical investigations uncovered mechanisms of action of molecular
G_protein-coupled_receptor
Protein-coding gene in the species Homo sapiens
Taylor SM, Woodruff TM (Mar 2013). "C5L2: a controversial receptor of complement anaphylatoxin, C5a". FASEB Journal. 27 (3): 855–64. doi:10.1096/fj.12-220509
Formyl_peptide_receptor_3
Cellular molecules that help resolve inflammation
b) complement components C5a and C3a which are chemotactic factors formed during the activation of the host's blood complement system by invading
Specialized pro-resolving mediators
Specialized_pro-resolving_mediators
124.486.274.024.250 – complement c3a MeSH D12.776.124.486.274.024.260 – complement c4a MeSH D12.776.124.486.274.024.270 – complement c5a MeSH D12.776.124
List of MeSH codes (D12.776.124)
List_of_MeSH_codes_(D12.776.124)
Swedish-born artist duo
Milan 2021: Underneath. The Nordic House, Reykjavik. 2021: This Is Heaven. C3A Centro De Creacion Contemporanea De Andalucia, Cordoba, Spain. 2021: A Moon
Nathalie Djurberg and Hans Berg
Nathalie_Djurberg_and_Hans_Berg
Subtype of serotonin receptor
repair of 5-hydroxy-2'-deoxycytidine in Cockayne syndrome cells and its complementation by Escherichia coli formamidopyrimidine DNA glycosylase and endonuclease
5-HT2A_receptor
Biomedical engineering discipline
Extracorporeal Liver Assist Device (ELAD): The human hepatocyte cell line (C3A line) in a hollow fiber bioreactor can mimic the hepatic function of the
Tissue_engineering
1979 Star Trek board game
empires: Andromedans (bases), WYN ('fish' ships), Seltorians, and LDR. Module C3A: Andromedan Threat File (2011): Speculations of the Andromedan capabilities
Star_Fleet_Battles
Directed movement of cell motility via mechanical cues
Parsons, Maddy; Lambris, John D.; Mayor, Roberto (2011-12-13). "Complement Fragment C3a Controls Mutual Cell Attraction during Collective Cell Migration"
Mechanotaxis
Proteins and peptides: fractalkine (CX3CL1) interleukin-8 (IL-8) complement components C3a and C5a split tyrosyl tRNA synthetase (mini TyrRS) dimerized ribosomal
Find-me_signals
Protein-coding gene in the species Homo sapiens
cell attachment. However, unlike CD97 EMR2 does not interact with the complement regulatory protein, decay accelerating factor CD55, and indicating that
EMR2
Grammar of the Levantine Arabic variety
indistinguishable from an independent sentence. In formal speech, sentence complements can be introduced with the particle ʔǝnn ("that"), to which some speakers
Levantine_Arabic_grammar
skeletal muscle, the liver, and fat tissue. mGRs appear to cooperate with, complement, and synergize with classical nuclear GRs in various ways. Membrane steroid
Membrane glucocorticoid receptor
Membrane_glucocorticoid_receptor
Mammalian protein found in humans
mice. Decay accelerating factor (DAF/CD55), a regulatory protein of the complement cascade, interacts with the first and second EGF-like domains of CD97;
CD97
Protein-coding gene in humans
PMID 10878383. Campbell WD, Lazoura E, Okada N, Okada H (2002). "Inactivation of C3a and C5a octapeptides by carboxypeptidase R and carboxypeptidase N." Microbiol
CPN1
Human biochemical receptor
FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin B1 B2 Chemerin
GPR32
Canadian national youth military program
on a number of factors, may have some of the following teams/groups to complement mandatory training. This is not an exhaustive list. Drill team: The vast
Royal_Canadian_Air_Cadets
Protein-coding gene in the species Homo sapiens
FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin B1 B2 Chemerin
GPR33
Protein-coding gene in the species Homo sapiens
FF 1 2 S Y 1 2 4 5 Neuromedin B U 1 2 Neurotensin 1 2 Other Anaphylatoxin C3a C5a 1 2 Angiotensin 1 2 Apelin Bombesin BRS3 GRPR NMBR Bradykinin B1 B2 Chemerin
GABBR1
Protein-coding gene in the species Homo sapiens
Taylor SM, Woodruff TM (Mar 2013). "C5L2: a controversial receptor of complement anaphylatoxin, C5a". FASEB Journal. 27 (3): 855–864. doi:10.1096/fj.12-220509
Formyl_peptide_receptor_2
C3A COMPLEMENT
C3A COMPLEMENT
Surname or Lastname
English
English : habitational name, either from Pagham in Sussex or from Pakenham in Suffolk, named in Old English from the personal names Pæcga and Pacca respectively, + hÄm ‘homestead’.
Surname or Lastname
English (chiefly Devon)
English (chiefly Devon) : habitational name from Blatchford in Sourton, Devon, which is probably named with the Old English personal name Blæcca + Old English ford ‘ford’.
Female
Hungarian
Hungarian form of Latin Felicia, FELÃCIA means "happy" or "lucky."
Surname or Lastname
Irish
Irish : see Dignan.English : of uncertain derivation. Perhaps, as Reaney suggests, a habitational name for someone from Dagenham, formerly in Essex, now in Greater London, which gets its name from an Old English personal name Dæcca + genitive -n + hÄm ‘homestead’.
Surname or Lastname
English
English : habitational name from Crockford Bridge in the parish of Chertsey, Surrey. The place name is of uncertain origin; the first element may be Old English croc(ca) ‘pot’, used of a hollow in the ground or of a place where potsherds were found; the second is Old English ford ‘ford’.
Surname or Lastname
Irish and English
Irish and English : habitational name from Clare in Suffolk (probably named with a Celtic river name meaning ‘bright’, ‘gentle’, or ‘warm’). One of the first Normans in Ireland (1170–72) was Richard de Clare, Earl of Pembroke, better known as ‘Strongbow’, who took his surname from his estate in Suffolk.English : habitational name from Clare in Oxfordshire, named with Old English clÇ£g ‘clay’ + Åra ‘slope’.English : from the Middle English, Old French female personal name Cla(i)re (Latin Clara, from clarus ‘famous’), which achieved some popularity, greater on the Continent than in England, through the fame of St. Clare of Assisi. See also Sinclair.English : occupational name for a worker in clay, for example someone expert in building in wattle and daub, from Middle English clayere, an agent derivative of Old English clÇ£g ‘clay’.
Surname or Lastname
English
English : variant of the habitational name Bletchley, from places so named in Buckinghamshire and Shropshire. The first is named from the Old English personal name Blæcca + lēah ‘woodland clearing’; the second has the same second element combined with a personal name Blæcca or Blecci.
Surname or Lastname
English
English : habitational name from a place in Kent named Chesley, from the Old English personal name Cæcca + Old English lēah ‘woodland clearing’.Possibly an Americanized form of German Schüssler (see Schuessler).
Surname or Lastname
English
English : nickname from Middle English ca ‘jackdaw’, from an unattested Old Norse ká. See also Daw.English : nickname from Middle English cai, kay, kei ‘left-handed’, ‘clumsy’.English : metonymic occupational name for a locksmith, from Middle English keye, kaye ‘key’. Compare Care, Kear.English : topographic name for someone living on or near a quay, Middle English kay(e), Old French cay.English : from a Middle English personal name which figures in Arthurian legend. It is found in Old Welsh as Cai, Middle Welsh Kei, and is ultimately from the Latin personal name Gaius.Scottish and Irish : reduced form of McKay.French : variant of Quay, cognate with 2.Much shortened form of any of various names, mostly Eastern European, beginning with the letter K-.Variant of Danish and Frisian Kai.
Surname or Lastname
English
English : habitational name from any of various places, for example in Cheshire and North Yorkshire, so called from Old English pīc ‘point’, ‘peak’ (or the derived byname Pīca) + tūn ‘enclosure’, ‘settlement’.
Surname or Lastname
English
English : habitational name from Pashley in the parish of Ticehurst, Sussex, named with an unattested Old English personal name Pæcca or Pacca (see Packham) + Old English lēah ‘wood’, ‘clearing’. A district of Eastbourne, Sussex, bearing this name derives it from the surname; a family called Pashley had moved there from Ticehurst by the later part of the 13th century.English : possibly a variant of Parsley. The surname now occurs chiefly in southern Yorkshire.
Boy/Male
Hindu
Narang ca be used as a surname in various culture
Boy/Male
Hindu, Indian, Punjabi, Telugu, Thai
A Desire
Surname or Lastname
English (of Norman origin)
English (of Norman origin) : habitational name from any of the various places in Normandy, France, called Crèvecoeur (‘heartbreak’), from Old French creve(r) ‘to break or destroy’, ‘to die’ + ceur ‘heart’, a reference to the infertility and unproductiveness of the land.English : occupational name for a potter, Middle English crockere, an agent derivative of Middle English crock ‘pot’ (Old English croc(ca)).Americanized spelling of German Krocker.
Surname or Lastname
English
English : occupational name for someone who was employed in the private living quarters of his master, rather than in the public halls of the manor. The name represents a genitive or plural form of Middle English cha(u)mbre ‘chamber’, ‘room’ (Latin camera), and is synonymous in origin with Chamberlain, but as that office rose in the social scale, this term remained reserved for more humble servants of the bedchamber.
Surname or Lastname
English
English : habitational name from any of various places named Stanford, for example in Bedfordshire, Kent, and Norfolk, or Stanford Dingley in Berkshire, Stanford in the Vale in Oxfordshire, or Stanford le Hope in Essex, etc., all named from Old English stÄn ‘stone’ + ford ‘ford’.An early bearer, Thomas Stanford of England, settled in Charlestown, MA, in the mid 17th century and started a family line that includes Leland Stanford (1824–93), the railroad developer who was governor of CA, a U.S. senator, and the founding benefactor of Stanford University.
Boy/Male
Tamil
Narang ca be used as a surname in various culture
Surname or Lastname
English
English : variant of Black 1, meaning ‘swarthy’ or ‘dark-haired’, from a byform of the Old English adjective blæc, blac ‘black’, with change of vowel length.English : nickname from Old English blÄc ‘wan’, ‘pale’, ‘white’, ‘fair’. In Middle English the two words blac and blÄc, with opposite meanings, fell together as Middle English blake. In the absence of independent evidence as to whether the person referred to was dark or fair, it is now impossible to tell which sense was originally meant.Irish : Anglicized form of Gaelic Ó Bláthmhaic ‘descendant of Bláthmhac’, a personal name from bláth ‘flower’, ‘blossom’, ‘fame’, ‘prosperity’ + mac ‘son’. In some instances, however, the Irish name is derived from Old English blæc ‘dark’, ‘swarthy’, as in 1 above. Many bearers are descended from Richard Caddell, nicknamed le blac, sheriff of Connacht in the early 14th century. The English name has been Gaelicized de Bláca.
Surname or Lastname
English, northern Irish, and Scottish
English, northern Irish, and Scottish : from a pet form of the personal name Pate.The American general George Patton (1885–1945) was born in San Gabriel, CA, into a family with a long military tradition. His earliest American ancestor, Robert Patton, had emigrated from Scotland to VA c.1770.
Female
Hungarian
Short form of Hungarian FelÃcian, LÃCIA means "happy" or "lucky."
C3A COMPLEMENT
C3A COMPLEMENT
Boy/Male
German
Star
Boy/Male
Gujarati, Hindu, Indian, Kannada
Happy
Girl/Female
Hindu
Boy/Male
Tamil
Parasmaijyotishe | பரஸà¯à®®à¯ˆà®œà¯à®¯à¯‹à®¤à¯€à®·à¯‡
Most radiant
Girl/Female
Tamil
One who has only friends and no enemies
Boy/Male
Indian, Punjabi, Sikh
Charming Friend
Girl/Female
Anglo Saxon Irish Scottish
Bitter.
Boy/Male
American, Australian, Chinese, Hebrew, Jewish
Exalt; Praised; Son of Jacob and Leah
Girl/Female
Indian
Preety
Girl/Female
Indian
Beautiful
C3A COMPLEMENT
C3A COMPLEMENT
C3A COMPLEMENT
C3A COMPLEMENT
C3A COMPLEMENT
n.
A thing may be applied to another thing so as to fit perfectly, as a seal to its impression; hence, a thing which is adapted to another thing, or which supplements it; that which serves to complete or complement anything; hence, a person or thing having qualities lacking in another; an opposite.
n.
A band composed, for the largest part, of players of the various viol instruments, many of each kind, together with a proper complement of wind instruments of wood and brass; -- as distinguished from a military or street band of players on wind instruments, and from an assemblage of solo players for the rendering of concerted pieces, such as septets, octets, and the like.
v. t.
To match; to mate in contest; to furnish a complement to; as, to cap text; to cap proverbs.
a.
Serving to fill out or to complete; as, complementary numbers.
n. pl.
The third order of the Linnaean class Polygamia.
n.
A system of jurisprudence, supplemental to law, properly so called, and complemental of it.
v. t.
To assume; to adopt; to acquire, as shape; to permit to one's self; to indulge or engage in; to yield to; to have or feel; to enjoy or experience, as rest, revenge, delight, shame; to form and adopt, as a resolution; -- used in general senses, limited by a following complement, in many idiomatic phrases; as, to take a resolution; I take the liberty to say.
v. t.
To supply with men; to furnish with a sufficient force or complement of men, as for management, service, defense, or the like; to guard; as, to man a ship, boat, or fort.
n.
A luminous appearance, or an image seen after the eye has been exposed to an intense light or a strongly illuminated object. When the object is colored, the image appears of the complementary color, as a green image seen after viewing a red wafer lying on white paper. Called also ocular spectrum.
n.
A number of things of the same kind, ordinarily used or classed together; a collection of articles which naturally complement each other, and usually go together; an assortment; a suit; as, a set of chairs, of china, of surgical or mathematical instruments, of books, etc.
v. t.
The interval wanting to complete the octave; -- the fourth is the complement of the fifth, the sixth of the third.
n.
An elementary substance; a metal which combined with oxygen forms lime. It is of a pale yellow color, tenacious, and malleable. It is a member of the alkaline earth group of elements. Atomic weight 40. Symbol Ca.
a.
Having three sorts of flowers on the same or on different plants, some of the flowers being staminate, others pistillate, and others both staminate and pistillate; belonging to the order Tri/cia.
a.
Not having the full complement of tones; -- said of a chord of only two tones, which requires a third tone to be sounded with them to make the combination pleasing to the ear; as, a naked fourth or fifth.
a.
Not having a full complement of men; as, a vessel light-handed.
n.
The instruments employed by a full band, collectively; as, an orchestra of forty stringed instruments, with proper complement of wind instruments.
v. t.
To unite in couples; to form a pair of; to bring together, as things which belong together, or which complement, or are adapted to one another.
n.
The space included between the boundary lines of two similar parallelograms, the one within the other, with an angle in common; as, the gnomon bcdefg of the parallelograms ac and af. The parallelogram bf is the complement of the parallelogram df.