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Protein involved in the immune system
Complement component 4 (C4), in humans, is a protein involved in the intricate complement system, originating from the human leukocyte antigen (HLA) system
Complement_component_4
Protein found in humans
invader, the complement system becomes activated. This activation process involves complement component 2 protein attaching to complement component 4 protein
Complement_component_2
Protein found in humans
Complement component 3, often simply called C3, is a protein of the immune system that is found primarily in the blood. It plays a central role in the
Complement_component_3
Protein found in humans
Complement component 1s (EC 3.4.21.42, C1 esterase, activated complement C1s, complement C overbar 1r, C1s) is a protein involved in the complement system
Complement_component_1s
Protein found in humans
Complement component 5 is a protein that in humans is encoded by the C5 gene. Complement component 5 is involved in the complement system. It is cleaved
Complement_component_5
Protein-coding gene in the species Homo sapiens
Complement component 4B (Chido blood group) is a kind of the Complement component 4 protein that in humans is encoded by the C4B gene. This gene encodes
Complement_component_4B
Protein fragment
cleavage of complement component C5 by protease C5-convertase into C5a and C5b fragments. C5b is important in late events of the complement cascade, an
Complement_component_5a
Protein found in humans
Complement component 9 (C9) is a MACPF protein involved in the complement system, which is part of the innate immune system. Once activated, about 12-18
Complement_component_9
Autoimmune disease in which the immune system attacks healthy tissue
Complement component 1qA, Complement component 1qB, Complement component 1r, Complement component 1s, Complement component 2, Complement component 3
Lupus
Protein-coding gene in humans
Complement C1r subcomponent (EC 3.4.21.41, activated complement C1r, C overbar 1r esterase, C1r) is a protein involved in the complement system of the
Complement_component_1r
Protein found in humans
Complement component 6 is a protein that in humans is encoded by the C6 gene. Complement component 6 is a protein involved in the complement system. It
Complement_component_6
Medical condition
Deficiencies of the terminal complement components increases susceptibility to infections by Neisseria. The cause of complement deficiency is genetics (though
Complement_deficiency
Protein-coding gene in the species Homo sapiens
Complement C4-A is a kind of the Complement component 4 protein that in humans is encoded by the C4A gene. This gene encodes the acidic form of complement
C4A
Part of the immune system that enhances the ability of antibodies and phagocytic cells
component of fresh serum. Ehrlich, therefore, named this heat-labile component "complement," because it is something in the blood that "complements"
Complement_system
Process of synapse elimination
pruning. Genes in the Complement Component 4 (C4) locus of the major histocompatibility complex (MHC), which encode for complement factors, have also been
Synaptic_pruning
Medical condition
Complement 4 deficiency is a genetic condition affecting complement component 4. It can present with lupus-like symptoms. Parija (2009). Textbook of Microbiology
Complement_4_deficiency
Topics referred to by the same term
column C04, oral cancer ICD-10 code Complement component 4, a protein involved in the intricate complement system, encoded by C4A or C4B gene in humans
C4
Protein family
express complement receptors on their surface. All four complement receptors can bind to fragments of complement component 3 or complement component 4 coated
Complement_receptor
Proteins present in blood serum
functioning of the immune system. Other blood proteins act as enzymes, complement, components, protease inhibitors or kinin precursors. Contrary to popular belief
Plasma_protein
Protein complex involved in the complement system
C4b-binding protein (C4BP) is a protein complex involved in the complement system where it acts as inhibitor. C4BP has an octopus-like structure with a
C4b-binding_protein
Human genetic cluster on chromosome 6
and differentiation. The C4 gene encodes the complement component 4, which is involved in the complement system and is an important part of the innate
RCCX
Clumping of abnormal cold-sensitive proteins in blood
are abnormal proteins composed of immunoglobulins and sometimes complement components. Cryoglobulins specifically form gel-like solids by clumping together
Cryoglobulinemia
Medical condition
Complement component 1qA, Complement component 1qB, Complement component 1r, Complement component 1s, Complement component 2, Complement component 3
Childhood-onset systemic lupus erythematosus
Childhood-onset_systemic_lupus_erythematosus
Topics referred to by the same term
may refer to: C4S (gene), a gene variant for encoding the protein complement component 4 Clips4Sale, adult video site SAP Cloud for Services (C4S), an application
C4S
Genetic trait
(February 2016). "Schizophrenia risk from complex variation of complement component 4". Nature. 530 (7589): 177–83. Bibcode:2016Natur.530..177.. doi:10
Complex_traits
Protein complex
cells, leading to cell lysis and death. The MAC is composed of the complement components C5b, C6, C7, C8 and several C9 molecules. A number of proteins participate
Complement membrane attack complex
Complement_membrane_attack_complex
Biotechnological procedure
(February 2016). "Schizophrenia risk from complex variation of complement component 4". Nature. 530 (7589): 177–183. Bibcode:2016Natur.530..177.. doi:10
Digital polymerase chain reaction
Digital_polymerase_chain_reaction
Mycobacterium tuberculosis is mediated by human monocyte complement receptors and complement component C3". J. Immunol. 144 (7): 2771–80. doi:10.4049/jimmunol
Macrophage-1_antigen
Medical condition
antigens (HLA) HLA-DR4 and DRB1/DQA1, copy-number variations of complement component 4, a variant IL-23R locus and with various other non-HLA genes. HLA-DRB1*0405
Vogt–Koyanagi–Harada_disease
Maturational stage in the lifespan of an organism
visual cortex critical period. More recently, the expression of the complement component 4 gene has been found to significantly contribute to abnormally high
Critical_period
Genomic alterations, varying between individuals
This study found that the association is caused partly by the complement component 4 (C4) genes and therefore implying that allele variants of the C4
Structural variation in the human genome
Structural_variation_in_the_human_genome
American geneticist and neuroscientist
Research in his lab has explored the contribution of variation in complement component 4 to schizophrenia risk, revealed a mechanism by which CAG repeat
Steven_McCarroll
Medical condition
proteins in the complement cascade are activated, including complement component 2 (C2), complement component 3 (C3), and complement component 4 (C4). When
Acquired C1 esterase inhibitor deficiency
Acquired_C1_esterase_inhibitor_deficiency
Class of enzymes
Factor D (EC 3.4.21.46, C3 proactivator convertase, properdin factor D esterase, factor D (complement), complement factor D, CFD, adipsin) is a protein
Factor_D
Medical condition
major histocompatibility complex III (MHC class III) close to the Complement component 4 genes C4A and C4B, the Tenascin X gene TNXB and STK19. MHC class
Congenital adrenal hyperplasia due to 21-hydroxylase deficiency
Congenital_adrenal_hyperplasia_due_to_21-hydroxylase_deficiency
Protein-coding gene in the species Homo sapiens
Complement factor B is a protein that in humans is encoded by the CFB gene. This gene encodes complement factor B, a component of the alternative pathway
Complement_factor_B
Neuroscientist
proteins of the classical complement pathway were required for synapse elimination. She has explored the role of complement components in schizophrenia, Alzheimer's
Beth_Stevens
Human genotype
genetic risk for all types of myositis. Complement component 4 Complement component 4A Complement component 4B Price P, Witt C, Allcock R, et al. (February
HLA_A1-B8-DR3-DQ2
Aspect of the immune system
classical complement pathway is one of three pathways which activate the complement system, which is part of the immune system. The classical complement pathway
Classical_complement_pathway
Czech-American immunologist (1936–2023)
loci was the Ss locus, which was later identified as coding for complement component 4. The C4 protein was indeed involved in immunity by being one in
Jan_Klein
Human enzyme that hydroxylates steroids
major histocompatibility complex III (MHC class III) close to the Complement component 4 genes C4A and C4B, the Tenascin X gene TNXB and STK19. MHC class
21-Hydroxylase
Enzyme
and Factor VIII, gastrin, the leech enzyme hirudin, fibrinogen, Complement component 4, follicle-stimulating hormone receptor (FSHR), and other chemokine
Tyrosylprotein sulfotransferase
Tyrosylprotein_sulfotransferase
Graph formed by complementation and disjoint union
cograph, or complement-reducible graph, or P4-free graph, is a graph that can be generated from the single-vertex graph K1 by complementation and disjoint
Cograph
C3a is one of the proteins formed by the cleavage of complement component 3; the other is C3b. C3a is a 77 residue anaphylatoxin that binds to the C3a
C3a_(complement)
Protein
and its effect on the third component of complement". Journal of Immunology. 100 (4): 691–8. doi:10.4049/jimmunol.100.4.691. PMID 5645214. Nilsson SC
Complement_factor_I
Protein found in humans
Lippincott Williams & Wilkins, ISBN 0-7817-2120-2. "Entrez Gene: CR2 complement component (3d/Epstein Barr virus) receptor 2". Bradbury LE, Kansas GS, Levy
Complement_receptor_2
Protein found in humans
Complement receptor type 1 (CR1) also known as C3b/C4b receptor or CD35 (cluster of differentiation 35) is a protein that in humans is encoded by the CR1
Complement_receptor_1
Form of musical chord
either up or down to create more tension and dissonance. Fétis tuned the chord 4:5:6:7:9. In the common practice period, "the root, 3rd, 7th, and 9th are the
Ninth_chord
Macrophage-1 antigen (CR3) and αMβ2 integrin. CD11c/CD18 also called complement receptor 4 (CR4) and αXβ2 integrin. Wilkes, D.S.; Webb, T.J. (2006). "Cd11/18"
CD11
Alternative-complement-pathway C3/C5 convertase (EC 3.4.21.47, complement component C3/C5 convertase (alternative), proenzyme factor B, properdin factor
Alternative-complement-pathway C3/C5 convertase
Alternative-complement-pathway_C3/C5_convertase
Complement control proteins are proteins that interact with components of the complement system. The complement system is tightly regulated by a network
Complement_control_protein
Type of cascade reaction in the complement system
Schwaeble, Wilhelm J. (5 July 2012). "The Lectin Pathway of Complement Activation Is a Critical Component of the Innate Immune Response to Pneumococcal Infection"
Lectin_pathway
Medical condition
component of complement associated with anaphylactoid purpura and presence of mycoplasma in the serum". Clinical and Experimental Immunology. 14 (4)
Complement_2_deficiency
Serine protease that plays key role in innate immunity
The complement component C5 can be also activated by fluid phase C5 convertase. C5 is activated by CVFBb in the presence of complement component C6 and
C5-convertase
Largest structure in the nucleus of eukaryotic cells
Three major components of the nucleolus are recognized: the fibrillar center (FC), the dense fibrillar component (DFC), and the granular component (GC). Transcription
Nucleolus
Aspect of immunity
microorganisms. Alexins, later redefined as "complements" by Paul Ehrlich, were shown to be the soluble components of the innate response that leads to a combination
Humoral_immunity
deficiency; 611721; PSAP Complement component 4, partial deficiency of; 120790; C1NH Complement factor H deficiency; 609814; HF1 Complement factor I deficiency;
List_of_OMIM_disorder_codes
Protein-coding gene in the species Homo sapiens
regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple
V-set and immunoglobulin domain containing 4
V-set_and_immunoglobulin_domain_containing_4
Pathological embedding of the sphere in 3D space
R n {\displaystyle \mathbb {R} ^{n}} such that the unbounded component of its complement is not simply connected. These are often referred to as higher-dimensional
Alexander_horned_sphere
Chord used prominently in the works of La Monte Young
des télécommunications de l'entreprise (1977). Contact. The Alliance. p. 4. Retrieved October 5, 2010. Strickland, Edward (2000). Minimalism--origins
Dream_chord
Protein found in humans
regulate the alternative pathway of the complement system, a key component of innate immunity. It ensures that complement activation is directed against pathogens
Factor_H
Medication
human complement split product C5a after cleavage from C5 to block its interaction with the C5a receptor, both of which are components of the complement system
Vilobelimab
Protein-coding gene in the species Homo sapiens
Complement component 5a receptor 2 is a protein of the complement system that in humans is encoded by the C5AR2 gene. It is highly expressed in the blood
C5AR2
Protein-coding gene in the species Homo sapiens
recognition immune clearance, SAP binds in a calcium dependent manner to complement component C1q and the antibody binding region of immunoglobulins (Fab). SAP
Serum_amyloid_P_component
Mammalian protein found in Homo sapiens
Complement decay-accelerating factor, also known as CD55 or DAF, is a protein that, in humans, is encoded by the CD55 gene. DAF regulates the complement
Decay-accelerating_factor
Life-threatening immune-related blood disease
that frequently has a genetic component. In most cases, it can be effectively controlled by interruption of the complement cascade. Particular monoclonal
Atypical hemolytic uremic syndrome
Atypical_hemolytic_uremic_syndrome
Mammalian protein found in Homo sapiens
in androgen regulation of prostate tumours". Endocrine-Related Cancer. 16 (4): 1157–1169. doi:10.1677/ERC-09-0028. PMC 2782800. PMID 19635783. Tatsuta
Prohibitin
Heptatonic music scale
Hungarian major scale Component pitches C, D♯, E, F♯, G, A, B♭ Qualities Number of pitch classes 7 Forte number 7-31 Complement 5-31 Interval vector <3
Hungarian_major_scale
Genetic disease causing anemia, birth defects, and cancers
of complementation group D1, N, and S, are embryonically lethal in most cases, which might account for the rare observation of these complementation groups
Fanconi_anemia
Antibody that plays a crucial role in the immune function of mucous membranes
the component of IgA can associate with the mucus layer that sits atop epithelial cells. Since sIgA is a poor opsonin and activator of complement, simply
Immunoglobulin_A
cleavage after Arg223 in complement component C2 (-Ser-Leu-Gly-Arg-Lys-Ile-Gln-Ile) and after Arg76 in complement component C4 (-Gly-Leu-Gln-Arg-Ala-Leu-Glu-Ile)
Mannan-binding lectin-associated serine protease-2
Mannan-binding_lectin-associated_serine_protease-2
Monoclonal antibody
disease (CAD). It is given by intravenous infusion. Sutimlimab prevents complement-enhanced activation of autoimmune human B cells in vitro. The most common
Sutimlimab
Sixth-generation strike fighter program
and complement the F-35C beginning in the 2030s. A requirement was first identified in June 2008. The F/A-XX is the crewed combat aircraft component and
F/A-XX_program
Mammalian protein found in Homo sapiens
The C5a receptor also known as complement component 5a receptor 1 (C5AR1) or CD88 (Cluster of Differentiation 88) is a G protein-coupled receptor for C5a
C5a_receptor
Administrative division of the Philippines
legislative body. Upon receiving their charters, cities also receive a full complement of executive departments to better serve their constituents. Some departments
Cities_of_the_Philippines
Mathematical set formed from two given sets
\\X_{1}&X_{2}&\dots &A_{n-1}^{\complement }&X_{n}\\X_{1}&X_{2}&\dots &X_{n-1}&A_{n}^{\complement }\end{array}}\right]} . The diagonal components of this matrix A i
Cartesian_product
Mammalian protein found in humans
or dying cells (and some types of bacteria) in order to activate the complement system via C1q. CRP is synthesized by the liver in response to factors
C-reactive_protein
Chord
Viennese trichord Component intervals from root tritone minor second root Tuning 8:12:17 Forte no. / Complement 3-5 / 9-5 Interval vector <1,0,0,0,1,1>
Viennese_trichord
Scientific study of how the component parts of fish function together in the living fish
fish anatomy and physiology complement each other, the former dealing with the structure of a fish, its organs or component parts and how they are put
Fish_physiology
Type of hexachord
the augmented triad. Its only five-note subset is 5-21 (0,1,4,5,8), the complement of which is 7-21 (0,1,2,4,5,8,9), the only superset of 6-20. The only
"Ode-to-Napoleon"_hexachord
Chemical compound
complement inhibitor that is injected subcutaneously (under the skin). Zilucoplan is a cyclic peptide that binds to the protein complement component 5
Zilucoplan
Musical motif forming Paul Sacher's name
Sur Incises all use tone rows with the same pitches. The hexachord's complement is its Z-relation, 6-Z40. Schoenberg hexachord Arnold Whittall, The Cambridge
Sacher_hexachord
2010 smartphone by Apple
doubled as an antenna, with internal components situated between two panels of aluminosilicate glass. The iPhone 4 introduced Apple's new high-resolution
IPhone_4
Seventh mode of the melodic minor scale
the altered scale, altered dominant scale, or super-Locrian scale (Locrian ♭4 scale) is a seven-note scale that is a dominant scale where all non-essential
Altered_scale
Partition of vertices of a directed graph
In graph theory, the weak components of a directed graph partition the vertices of the graph into subsets that are totally ordered by reachability. They
Weak_component
Mammalian protein found in Homo sapiens
cellular activation. It is involved in the complement system due to its capacity to bind inactivated complement component 3b (iC3b). The ITGAM (alpha) subunit
Integrin_alpha_M
Type of chord in music
Cmaj7, has pitches C–E–G–B: It can be represented by the integer notation {0, 4, 7, 11}. According to Forte, the major seventh chord is exemplified by IV7
Major_seventh_chord
Chord
seventh Component intervals from root major seventh diminished fifth (tritone) minor third root Tuning 200:240:288:375 Forte no. / Complement 4-18 / 8-18
Diminished major seventh chord
Diminished_major_seventh_chord
Protein-coding gene in the species Homo sapiens
encoded by the CFP (complement factor properdin) gene. Properdin and factor H are regulatory proteins in the alternative complement pathway. Properdin
Properdin
Compass that senses direction electronically
magnetic material, to directly sense the direction of the horizontal component of the Earth's magnetic field. The advantages of this mechanism over a
Fluxgate_compass
Early mechanical calculator
d is 9-d. So the 9's complement of 4 is 5 and the 9's complement of 7 is 2. In a decimal machine with n dials, the 9's complement of a number A is: C 9
Pascaline
Mathematical theory
cohomology of the complement only depends on the homology of L {\displaystyle L} , that is the number of its connected components (or number of strands)
Alexander_duality
Country primarily in North America
individuals or families. Major cities often have alternative newspapers to complement the mainstream daily papers, such as The Village Voice in New York City
United_States
Fractal named after mathematician Benoit Mandelbrot
constructed an explicit conformal isomorphism between the complement of the Mandelbrot set and the complement of the closed unit disk. Mandelbrot had originally
Mandelbrot_set
Color model based on red, green and blue
secondary color is the complement of one primary color: cyan complements red, magenta complements green, and yellow complements blue. When all the primary
RGB_color_model
Unique knot with a crossing number of four
Therefore its complement fibers over the circle, the fibers being Seifert surfaces which are 2-dimensional tori with one boundary component. The monodromy
Figure-eight knot (mathematics)
Figure-eight_knot_(mathematics)
Theorem in topology
its complement. If X is an n-dimensional compact connected submanifold of Rn+1 (or Sn+1) without boundary, its complement has 2 connected components. There
Jordan_curve_theorem
Embedding of the circle in three dimensional Euclidean space
splits the complement into the union of three manifolds: two trefoil complements and the complement of the Borromean rings. The trefoil complement has the
Knot_(mathematics)
Protein-coding gene in the species Homo sapiens
a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the
MASP1
Protein-coding gene in the species Homo sapiens
The complement component 1, q subcomponent-like 1 (or C1QL1) is encoded by a gene located at chromosome 17q21.31. It is a secreted protein and is 258 amino
C1QL1
COMPLEMENT COMPONENT-4
COMPLEMENT COMPONENT-4
Girl/Female
Tamil
Fit, Competent, Administrator
Girl/Female
Hindu
Fit, Competent, Administrator
Boy/Male
Anglo Saxon
Competent.
Boy/Male
Arabic, Muslim
Competent
Boy/Male
Arabic, Muslim
Competent
Boy/Male
Muslim
Competent. Well disposed.
Boy/Male
Hindu
Raft, Boat, Compelent person, The ocean
Boy/Male
Hindu, Indian, Marathi
Raft; Boat; A Competent Person; The Ocean
Boy/Male
Tamil
Raft, Boat, Compelent person, The ocean
Boy/Male
Muslim
Competent. Well disposed.
Boy/Male
Arabic, Muslim
Competent
Boy/Male
Arabic, Muslim
Deserving; Competent; Capable
Boy/Male
Tamil
Sakshain | ஸாகà¯à®·à¯€à®¨
Competent, Powerful
Sakshain | ஸாகà¯à®·à¯€à®¨
Boy/Male
Hindu
Competent, Powerful
Boy/Male
Muslim
Competent
Boy/Male
Arabic, Muslim
Competent
Boy/Male
Hindi
Competent.
Girl/Female
Indian
Competent.
Boy/Male
Indian, Sanskrit
Competent
Girl/Female
Indian
Competent
COMPLEMENT COMPONENT-4
COMPLEMENT COMPONENT-4
Boy/Male
Tamil
Girl/Female
Tamil
Kshanika | கà¯à®·à®£à®¿à®•à®¾
Momentary
Girl/Female
Indian, Telugu
Nectar Queen
Girl/Female
Hindu
Name of a river
Girl/Female
Irish
Pearl.
Surname or Lastname
English
English : variant spelling of Reader.Dutch : occupational name for someone who dressed new cloth, Middle Dutch reder.Dutch and German : variant of Reder 3.
Boy/Male
English Anglo Saxon German
Wealthy friend.
Boy/Male
Tamil
Veeramanikanta | விரமாஂநீகாநதாÂ
Brave one with a bell around his neck
Girl/Female
Hindu, Indian
Singer
Boy/Male
Hindu, Indian
Part of Love
COMPLEMENT COMPONENT-4
COMPLEMENT COMPONENT-4
COMPLEMENT COMPONENT-4
COMPLEMENT COMPONENT-4
COMPLEMENT COMPONENT-4
adv.
In a competent manner; adequately; suitably.
v. t.
A compliment.
n.
Competent power; validity; efficacy; as, the availableness of a title.
n.
A constituent part; an ingredient.
n.
An expression, by word or act, of approbation, regard, confidence, civility, or admiration; a flattering speech or attention; a ceremonious greeting; as, to send one's compliments to a friend.
a.
Having a sound, strong body; physically competent; robust.
a.
Not capable of making a will; not legally qualified or competent to make a testament.
v. t.
To praise, flatter, or gratify, by expressions of approbation, respect, or congratulation; to make or pay a compliment to.
a.
Possessing adequate talents or accomplishments; of competent power or ability; qualified; fit.
a.
Self-satisfied; contented; kindly; as, a complacent temper; a complacent smile.
a.
Rightfully or properly belonging; incident; -- followed by to.
v. t.
Serving, or helping, to form; composing; constituting; constituent.
adv.
In an competent manner; inadequately; unsuitably.
a.
Conformable to law; allowed by law; legitimate; competent.
v. t.
To provide with an implement or implements; to cause to be fulfilled, satisfied, or carried out, by means of an implement or implements.
v. t.
The interval wanting to complete the octave; -- the fourth is the complement of the fifth, the sixth of the third.
n.
The state of being competent; fitness; ability; adequacy; power.
v. i.
To pass compliments; to use conventional expressions of respect.
a.
Answering to all requirements; adequate; sufficient; suitable; capable; legally qualified; fit.
v. t.
To compliment.