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Chemical compound
Buformin (1-butylbiguanide) is an oral antidiabetic drug of the biguanide class, chemically related to metformin and phenformin. Buformin was marketed
Buformin
Chemical compound
Phenformin - withdrawn from the market in most countries due to toxic effects Buformin - withdrawn from the market due to toxic effects bioactive biguanidines
Biguanide
Gastrointestinal peptide hormone involved in glucose homeostasis
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Glucagon-like_peptide-1
Chemical compound
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Retatrutide
Drugs that lower blood glucose levels to treat diabetes
from 1960s through 1980s, but was withdrawn due to lactic acidosis risk. Buformin also was withdrawn due to lactic acidosis risk. Metformin is a first-line
Diabetes_medication
Anti-diabetic and anti-obesity medication
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Semaglutide
Diabetes medication
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Dapagliflozin
Medication used to treat diabetes
antidiabetic medications, which also includes the withdrawn agents phenformin and buformin, originates from research on Goat's rue (Galega officinalis) also known
Metformin
Pharmaceutical compound
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Brenipatide
Enzyme blocker and diabetes treatment drug
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Dipeptidyl peptidase-4 inhibitor
Dipeptidyl_peptidase-4_inhibitor
Long-acting insulin
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Insulin_glargine
Diabetes medication
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Empagliflozin
Species of flowering plant in the pea family
biguanide class of antidiabetic drugs, which also included phenformin and buformin (both discontinued). G. officinalis contains the phytochemicals, galegine
Galega_officinalis
Anti-obesity medication
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Orforglipron
Chemical compound
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Lotiglipron
Oral anti-diabetic drugs
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Alpha-glucosidase_inhibitor
Ultralong-acting basal insulin analogue
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Insulin_degludec
Anti-diabetic and anti-obesity medication
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Tirzepatide
Chemical compound
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Sorbinil
Diabetes medication
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Sitagliptin
Ultralong-acting basal insulin analogue
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Insulin_icodec
Class of drugs used to treat diabetes
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
GLP1_poly-agonist_peptides
Chemical compound
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Pioglitazone
Chemical compound
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Fidarestat
Class of organic compounds used in medicine and agriculture
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Sulfonylurea
Chemical compound
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Sotagliflozin
Class of medication
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
SGLT2_inhibitor
Rapid-acting insulin analogue
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Insulin_glulisine
Intermediate acting insulin formulation
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
NPH_insulin
Pharmaceutical drug classification
semaglutide A10AF01 Insulin (human) A10BA01 Phenformin A10BA02 Metformin A10BA03 Buformin A10BB01 Glibenclamide A10BB02 Chlorpropamide A10BB03 Tolbutamide A10BB04
ATC_code_A10
Class of chemical compounds
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Thiazolidinedione
Anti-diabetic medication
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Liraglutide
Rapid-acting man-made insulin
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Insulin_aspart
Chemical compound
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Linagliptin
Chemical compound
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Vildagliptin
Combination drug
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Empagliflozin/linagliptin/metformin
Empagliflozin/linagliptin/metformin
Anti-diabetic drug
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Alogliptin
Powdered insulin delivered with an inhaler
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Inhalable_insulin
Medication
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Exenatide
Antidiabetic medication
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Bexagliflozin
Chemical compound
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Glipizide
Modified forms of synthetic insulin
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Insulin_analogue
Chemical compound
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Enavogliflozin
Use of insulin protein and analogs as medical treatment
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Insulin_(medication)
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
List of commercially available insulins
List_of_commercially_available_insulins
Chemical compound
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Canagliflozin
Long-acting man-made insulin
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Insulin_detemir
Diabetes medication
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Dulaglutide
Medication
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Dapagliflozin/sitagliptin
Dopamine agonist medication
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Bromocriptine
bufexamac (INN) bufezolac (INN) Bufferin buflomedil (INN) bufogenin (INN) buformin (INN) bufrolin (INN) bufuralol (INN) bulevirtide (USAN, INN) bulevirtide-gmod
List_of_drugs:_Bs–Bz
Medication
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Insulin_efsitora_alfa
Cellular therapy medication
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Donislecel
Chemical compound
acids Asymmetric dimethylarginine N-Propyl-L-arginine Related compounds Buformin Acecarbromal Except where otherwise noted, data are given for materials
Methylarginine
Chemical compound
fights multiple viruses by disrupting the resources they need to replicate. Buformin McKendry JB, Kuwayti K, Rado PP (May 1959). "Clinical experience with DBI
Phenformin
Chemical compound
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Ertugliflozin
failure (requiring transplantation) Bucetin 1986 Germany Kidney damage Buformin 1978 Germany Metabolic toxicity Bunamiodyl 1963 Canada, UK, US Nephropathy
List_of_withdrawn_drugs
Chemical compound
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Acarbose
Experimental insulin analogue
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Selenoinsulin
Rapid-acting insuline analog
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Insulin_lispro
Chemical compound
Related compounds Related compounds Tetramethylurea Noxytiolin Metformin Buformin Allantoic acid Carmustine Except where otherwise noted, data are given
1,1,3,3-Tetramethylguanidine
Drug used for the treatment of symptoms of metabolic syndrome
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
PPAR_agonist
Pharmaceutical compound
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Insulin_tregopil
Alpha-glucosidase inhibitor
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Voglibose
Chemical compound
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Danuglipron
GLP1 poly-agonist drug
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Mazdutide
Chemical compound
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Gliclazide
Pharmaceutical compound
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Conveglipron
Chemical compound
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Saroglitazar
Combination drug
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Insulin_glargine/lixisenatide
Medication
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Glimepiride
Chemical compound
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Epalrestat
Chemical compound
In general: ℞ (Prescription only) Related compounds Related compounds Buformin Methylarginine Asymmetric dimethylarginine N-Propyl-L-arginine Except where
Acecarbromal
Pharmaceutical drug
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Vildagliptin/metformin
Chemical compound
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Teneligliptin
Chemical compound
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Miglitol
Two drugs combined to treat diabetes
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Dapagliflozin/metformin
Chemical compound
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Glibenclamide
Pharmaceutical drug
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Empagliflozin/metformin
Combination drug
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Glibenclamide/metformin
Chemical compound
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Saxagliptin
Chemical compound
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Tofogliflozin
Medication
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Dasiglucagon
Chemical compound
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Rosiglitazone
Chemical compound
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Repaglinide
Experimental anti-diabetic drug
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
RX871024
Chemical compound
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Ipragliflozin
Short-acting insulin formulation
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Regular_insulin
Pharmaceutical drug
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Sitagliptin/metformin
Chemical compound
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Trelagliptin
Chemical compound
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Imeglimin
Chemical compound
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Remogliflozin_etabonate
Chemical compound
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Gemigliptin
Chemical substance
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Meglitinide
Combination drug
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Dapagliflozin/saxagliptin/metformin
Dapagliflozin/saxagliptin/metformin
Diabetes drug
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Lixisenatide
Medication
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Velagliflozin
Chemical compound
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Rivoglitazone
Historical formulation of insulin as medication
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Lente_insulin
Chemical compound
†Phase III §Never to phase III Non-insulins Insulin sensitizers Biguanides Buformin‡ Metformin# Phenformin‡ TZDs ("-glitazones") and PPAR agonists Ciglitazone§
Luseogliflozin
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