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Class of compounds
Sulfatide, also known as 3-O-sulfogalactosylceramide, SM4, or sulfated galactocerebroside, is a class of sulfolipids, specifically a class of sulfoglycolipids
Sulfatide
Medical condition
enzyme, sulfatides build up in many tissues of the body, eventually destroying the myelin sheath of the nervous system. The excess sulfatides stored in
Metachromatic_leukodystrophy
Formation of myelin sheaths in the nervous system
rise in the production of various lipids – cholesterol, cerebroside, and sulfatide. As researchers began to do postnatal research, they found that myelinogenesis
Myelination
important members of the sulfur cycle. Other important sulfolipids include sulfatide and seminolipid, each of which are sulfated glycolipids. Sulfolipids have
Sulfolipid
Class of chemical compounds
galactosphingolipid galactocerebroside (GalC) and its sulfated derivative sulfatide are also in abundance present (together with a small group of proteins)
Galactolipid
Mammalian protein found in Homo sapiens
Arylsulfatase A (or cerebroside-sulfatase) is an enzyme that breaks down sulfatides, namely cerebroside 3-sulfate into cerebroside and sulfate. In humans
Arylsulfatase_A
Protein-coding gene in the species Homo sapiens
hydrolysis of sulfatides by arylsulfatase A. It is known by many different names, such as, sphingolipid activator protein-1 (SAP-1), sulfatide activator protein
Prosaposin
Group of disorders characterised by degeneration of white matter in the brain
A (ASA or sometimes ARSA), also called sulfatide sulfatase. ASA is responsible for the breakdown of sulfatides, sphingolipids present in neuronal membranes
Leukodystrophy
Chemical compound
C18H39NO2 Molar mass 301.515 g·mol−1 Related compounds Related sphingolipids Sulfatide Ceramide Sphingosine Phytosphingosine Sphingosine-1-phosphate Related
Sphinganine
Family of chemical compounds
Cerebrosides have a single glucose or galactose at the 1-hydroxy position. Sulfatides are sulfated cerebrosides. Gangliosides have at least three sugars, one
Sphingolipid
Medical technology
expected to start producing the ARSA enzyme that breaks down the build-up of sulfatides in the nerve cells and other cells of the patient's body. Libmeldy was
Gene_therapy
Swedish chemist
thesis concerned the blood lipids in diabetics. In 1933 he discovered that sulfatide in the brain contained amide-bound fatty acid and 4-sphingenine. Along
Gunnar_Blix
Blood thinning drugs
(1989). "Antistasin, an inhibitor of coagulation and metastasis, binds to sulfatide (Gal(3-SO4) beta 1-1Cer) and has a sequence homology with other proteins
Direct_factor_Xa_inhibitors
Family of glycoproteins
α-GalCer-CD1D. Instead, they respond to a diverse set of antigens such as sulfatide-CD1d and mycobacterial lipid-CD1d. CD1 antigens are expressed on cortical
CD1
Medical condition
Tay–Sachs Metachromatic leukodystrophy (MLD) Arylsulfatase A or prosaposin Sulfatide compounds in neural tissue Demyelination in CNS and PNS: Intellectual
Sphingolipidoses
Protein-coding gene in the species Homo sapiens
ontology Molecular function growth factor activity RNA binding lipid binding sulfatide binding Cellular component nucleus extracellular region extracellular
MANF
Chemical compound
P305+P351+P338, P310, P391, P501 Related compounds Related sphingolipids Sulfatide Ceramide Sphingosine Sphinganine Sphingosine-1-phosphate Except where
Phytosphingosine
Lipid with a carbohydrate attached to a ceramide
means of the charge carrier: gangliosides, which have sialic acids; and sulfatides, which have a sulfate group. The structural similarity of most glycolipids
Glycosphingolipid
Addition of a sulfate group to a compound
polycyclic aromatic hydrocarbons). Sulfate is part of sulfolipids, such as sulfatides, which constitute 20% of the galactolipids in myelin. Another example
Sulfation
American neuroscientist and academic
sulfatides. During her doctoral research, Lees identified that it was possible to extract sulfatide using chloroform. and that extracts of sulfatide including
Marjorie_Lees
Class of chemical compounds
with glucose as the saccharide moiety; often found in non-neural tissue. Sulfatides: a class of glycolipids containing a sulfate group in the carbohydrate
Glycolipid
Species of bacterium causing pertussis or whooping cough
surface protein, filamentous haemagglutinin adhesin, which binds to the sulfatides found on cilia of epithelial cells. Other adhesins are fimbriae and petractin
Bordetella_pertussis
Gene therapy for leukodystrophy
produce the ARSA enzyme, which helps break down the harmful build-up of sulfatides and may stop the progression of MLD. Prior to treatment, recipients must
Atidarsagene_autotemcel
Medical condition
is a form of lysosomal storage disease resulting in a proliferation of sulfatide. It is caused by a genetic insufficiency of sulfatase enzymes. Metachromatic
Sulfatidosis
Class of enzymes
Levy R, Ho W (1965). "Metabolism of sulfatides. I. The effect of galactocerebrosides on the synthesis of sulfatides". Biochem. Biophys. Res. Commun. 20
Galactosylceramide sulfotransferase
Galactosylceramide_sulfotransferase
Type-1 transmembrane protein
2007). "P-selectin mediates metastatic progression through binding to sulfatides on tumor cells". Glycobiology. 17 (2): 185–196. doi:10.1093/glycob/cwl059
P-selectin
Lipid classification
lactosylceramide. Cerebrosides containing a sulfuric ester (sulfate) group, known as sulfatides, also occur in the myelin sheath of nerves. These compounds are preferably
Cerebroside
Unconventional T cell
NKT cells. Some type II NKT cells recognize the mammalian glycolipid sulfatide (produced at high concentrations in neuroendocrine tissue) phospholipid
Cd1-restricted_T_cell
Protein-coding gene in the species Homo sapiens
Srikanthan V, Williams WV, Weiner DB (1993). "The galactosyl ceramide/sulfatide receptor binding region of HIV-1 gp120 maps to amino acids 206-275". AIDS
UGT8
American medical researcher born in Bern, Switzerland (1924–2007)
established a neurochemistry program. Hugo set up the test for urinary sulfatides and compared the composition of urinary lipids with that of brain in metachromatic
Hugo_Moser_(scientist)
Component of MHC class I molecules
(RESIDUES 400-408) 1onq: Crystal Structure of CD1a in Complex with a Sulfatide 1p7q: Crystal Structure of HLA-A2 Bound to LIR-1, a Host and Viral MHC
Beta-2_microglobulin
Protein covalently bonded to lipids
serendipitously in 1951 by Jordi Folch Pi and Marjorie Lees while extracting sulfatides from brain lipids. They are not to be confused with lipoproteins, a kind
Proteolipid
Protein-coding gene in humans
spectrometric analysis reveals changes in phospholipid, neutral sphingolipid and sulfatide molecular species in progressive epilepsy with mental retardation, EPMR
CLN8
Protein-coding gene in humans
v t e PDB gallery 1onq: Crystal Structure of CD1a in Complex with a Sulfatide 1xz0: Crystal structure of CD1a in complex with a synthetic mycobactin lipopeptide
CD1A
American immunologist and geneticist
X-ray crystallography combined with biological assays, that endogenous sulfatides are capable of binding to the TLR4-MD2 complex, causing its activation
Bruce_Beutler
Protein-coding gene in the species Homo sapiens
PMC 1151101. PMID 2049067. Taraboletti G, Rao CN, Krutzsch HC, et al. (1990). "Sulfatide-binding domain of the laminin A chain". J. Biol. Chem. 265 (21): 12253–8
Laminin_subunit_alpha-1
endogenous lipids, including gangliosides (GM1,GD1a, GD1b, GT1b, and GQ1b), sulfatides, sphingomyelin, phophatidylglycerol, lysophospholipids, squalene, wax
Group 1 CD1-restricted T cells
Group_1_CD1-restricted_T_cells
Class of chemical compounds
forerunner of the greater part of the impartial oligoglycosylceramides, sulfatides and gangliosides. In tissues, biosynthesis of lactosylceramide includes
Lactosylceramide
Indian neurochemist and glycobiologist
absence of Arylsulfatase A, an enzyme responsible for the breaking down on sulfatides. This discovery assisted other scientists in the elucidation of similar
Bimal_Kumar_Bachhawat
Protein-coding gene in the species Homo sapiens
PMID 15546874. Delacour D, Gouyer V, Zanetta JP, et al. (2005). "Galectin-4 and sulfatides in apical membrane trafficking in enterocyte-like cells". J. Cell Biol
Galectin-4
Protein-coding gene in the species Homo sapiens
(1996). "Interferon induction by HIV-1-infected cells: a possible role of sulfatides or related glycolipids". Virology. 221 (1): 113–9. doi:10.1006/viro.1996
IFNA7
Overview of and topical guide to organic chemistry
Acids Glycolipids Glycoglycerolipids Glycosphingolipids Cerebrosides Sulfatides Gangliosides Globosides Glycophosphatidylinositols Isoprenoids Phospholipids
Outline_of_organic_chemistry
Protein-coding gene in humans
β-catenin and nuclear factor of activated T-cells (NFAT). In several sulfatide and cholesterol-3-sulfate (SCS)-binding proteins the consensus motif
CSNK1D
as a precursor for more complex glycosphingolipids, like globosides, sulfatides, gangliosides, and other neutral glycosphingolipids. LacCer also acts
CDw17_antigen
Protein-coding gene in the species Homo sapiens
(1996). "Interferon induction by HIV-1-infected cells: a possible role of sulfatides or related glycolipids". Virology. 221 (1): 113–9. doi:10.1006/viro.1996
IFNA16
SULFATIDE
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Boy/Male
Hindu, Indian
Lord Shiva
Girl/Female
Arabic, Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Muslim, Sikh, Sindhi, Telugu
Sweet Smell; Aura; Fragrance
Girl/Female
Tamil
Veneration, Goddess chamundi
Female
Hungarian
Pet form of Hungarian Dorottya, DÓRA means "gift of God."
Boy/Male
Indian
Ruler
Biblical
that cuts or divides; a nail; a gryphon; a horseman
Girl/Female
Tamil
Bunch of flower
Male
Spanish
Portuguese and Spanish form of Roman Latin Maximinus, MAXIMINO means "the greatest."
Boy/Male
Hindu, Indian
Lord Hanuman
Girl/Female
Arabic, Muslim
Sultana
SULFATIDE
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