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Chemical compound
Sphinganine is a chemical compound of the sphingolipid class with molecular formula C18H39NO2. Via the action of sphingosine kinase enzymes, it is converted
Sphinganine
Chemical compound
condensation required to yield sphinganine (dihydrosphingosine). Dehydrosphingosine is then reduced by NADPH to sphinganine, acylated to dihydroceramide
Sphingosine
Family of waxy lipid molecules
Chemotherapeutic agents Fas ligand Endotoxin Homocysteine Heat Hydroxypalmitoyl Sphinganine Gamma interferon Ionizing radiation Matrix metalloproteinases Niacinamide
Ceramide
Class of enzymes
forming 3-ketosphinganine (Fig. 1). This product is then reduced to sphinganine, also known as dihydrosphingosine (dihydro-Sph; 2-amino-1,3-dihydroxy-octadecane)
Sphingosine_kinase
The enzyme sphinganine-1-phosphate aldolase (EC 4.1.2.27) catalyzes the chemical reaction sphinganine 1-phosphate ⇌ {\displaystyle \rightleftharpoons }
Sphinganine-1-phosphate aldolase
Sphinganine-1-phosphate_aldolase
Class of enzymes
3-dehydro-D-sphinganine + CO2 Thus, the two substrates of this enzyme are palmitoyl-CoA and L-serine, whereas its 3 products are CoA, 3-dehydro-D-sphinganine, and
Serine_C-palmitoyltransferase
Class of enzymes
Sphinganine C4-monooxygenase (EC 1.14.13.169, sphingolipid C4-hydroxylase, SUR2 (gene), SBH1 (gene), SBH2 (gene)) is an enzyme with systematic name sphinganine
Sphinganine_C4-monooxygenase
Chemical compound
sphinganine, sphingosine and their 1-phosphate metabolites and in decreased concentrations of complex sphingolipids. The accumulation of sphinganine and
Fumonisin_B1
Chemical compound
CS-2100 CYM-5442 CYM-5520 CYM 5541 CYM-50260 CYM-50308 Dihydro-S1P (sphinganine 1-phosphate) Fingolimod Fingolimod phosphate KRP-203 Mocravimod Ozanimod
Fingolimod
Family of chemical compounds
specifically known as phytosphingosine and dihydrosphingosine (also known as sphinganine, although this term is less common), are mainly C18 compounds, with somewhat
Sphingolipid
Drug class
CS-2100 CYM-5442 CYM-5520 CYM 5541 CYM-50260 CYM-50308 Dihydro-S1P (sphinganine 1-phosphate) Fingolimod Fingolimod phosphate KRP-203 Mocravimod Ozanimod
Sphingosine-1-phosphate receptor modulator
Sphingosine-1-phosphate_receptor_modulator
Index of chemical compounds with the same name
two isomeric chemical compounds: Safingol (threo-dihydrosphingosine) Sphinganine (erythro-dihydrosphingosine) This set index article lists chemical compounds
Dihydrosphingosine
Amino acid
CS-2100 CYM-5442 CYM-5520 CYM 5541 CYM-50260 CYM-50308 Dihydro-S1P (sphinganine 1-phosphate) Fingolimod Fingolimod phosphate KRP-203 Mocravimod Ozanimod
Serine
Chemical compound
Related compounds Related sphingolipids Sulfatide Ceramide Sphingosine Sphinganine Sphingosine-1-phosphate Except where otherwise noted, data are given
Phytosphingosine
Chemical compound
CS-2100 CYM-5442 CYM-5520 CYM 5541 CYM-50260 CYM-50308 Dihydro-S1P (sphinganine 1-phosphate) Fingolimod Fingolimod phosphate KRP-203 Mocravimod Ozanimod
Palmitoyl-CoA
Marine biotoxin
toxin found in mussels appears to contain two fractions, namely C17-sphinganine analog mycotoxin (C17-SAMT) and MTP. C17-SAMT has been found earlier
Mussel_toxic_peptide
Medication
CS-2100 CYM-5442 CYM-5520 CYM 5541 CYM-50260 CYM-50308 Dihydro-S1P (sphinganine 1-phosphate) Fingolimod Fingolimod phosphate KRP-203 Mocravimod Ozanimod
Etrasimod
Class of chemically related vitamins
reaction, serine is decarboxylated and combined with palmitoyl-CoA to form sphinganine, which is combined with a fatty acyl-CoA to form dihydroceramide. This
Vitamin_B6
Medication
CS-2100 CYM-5442 CYM-5520 CYM 5541 CYM-50260 CYM-50308 Dihydro-S1P (sphinganine 1-phosphate) Fingolimod Fingolimod phosphate KRP-203 Mocravimod Ozanimod
Ozanimod
L-fuculose-phosphate aldolase Phenylserine aldolase Rhamnulose-1-phosphate aldolase Sphinganine-1-phosphate aldolase Tagatose-bisphosphate aldolase Threonine aldolase
List_of_aldolases
Chemical compound
CS-2100 CYM-5442 CYM-5520 CYM 5541 CYM-50260 CYM-50308 Dihydro-S1P (sphinganine 1-phosphate) Fingolimod Fingolimod phosphate KRP-203 Mocravimod Ozanimod
Lysophosphatidic_acid
Signaling sphingolipid
CS-2100 CYM-5442 CYM-5520 CYM 5541 CYM-50260 CYM-50308 Dihydro-S1P (sphinganine 1-phosphate) Fingolimod Fingolimod phosphate KRP-203 Mocravimod Ozanimod
Sphingosine-1-phosphate
Chemical compound
CS-2100 CYM-5442 CYM-5520 CYM 5541 CYM-50260 CYM-50308 Dihydro-S1P (sphinganine 1-phosphate) Fingolimod Fingolimod phosphate KRP-203 Mocravimod Ozanimod
Myriocin
Chemical compound
CS-2100 CYM-5442 CYM-5520 CYM 5541 CYM-50260 CYM-50308 Dihydro-S1P (sphinganine 1-phosphate) Fingolimod Fingolimod phosphate KRP-203 Mocravimod Ozanimod
Oleoylethanolamide
Protein-coding gene in the species Homo sapiens
activity protein binding ATP binding D-erythro-sphingosine kinase activity sphinganine kinase activity NAD+ kinase activity Cellular component cytoplasm lysosome
SPHK2
Class of toxic sphingolipids involved in neurological and metabolic disorders
it has 18 carbons. It is a bioactive sphingoid which derives from the sphinganine. It is formed by a sphingoid and an amino alcohol and it constitutes
1-Deoxysphingolipids
Protein-coding gene in the species Homo sapiens
of the yeast longevity assurance gene 1 (LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner
Ceramide_synthase_1
Medication for the treatment of multiple sclerosis
CS-2100 CYM-5442 CYM-5520 CYM 5541 CYM-50260 CYM-50308 Dihydro-S1P (sphinganine 1-phosphate) Fingolimod Fingolimod phosphate KRP-203 Mocravimod Ozanimod
Ponesimod
Index of chemical compounds with the same molecular formula
molecular formula C18H39NO2 may refer to: Ammonium stearate Safingol Sphinganine This set index page lists chemical structure articles associated with
C18H39NO2
Index of articles associated with the same name
CS-2100 CYM-5442 CYM-5520 CYM 5541 CYM-50260 CYM-50308 Dihydro-S1P (sphinganine 1-phosphate) Fingolimod Fingolimod phosphate KRP-203 Mocravimod Ozanimod
Lysophosphatidic acid receptor
Lysophosphatidic_acid_receptor
90: diphosphate—fructose-6-phosphate 1-phosphotransferase EC 2.7.1.91: sphinganine kinase EC 2.7.1.92: 5-dehydro-2-deoxygluconokinase EC 2.7.1.93: alkylglycerol
List_of_EC_numbers_(EC_2)
Class of compounds
CS-2100 CYM-5442 CYM-5520 CYM 5541 CYM-50260 CYM-50308 Dihydro-S1P (sphinganine 1-phosphate) Fingolimod Fingolimod phosphate KRP-203 Mocravimod Ozanimod
Lysophosphatidylcholine
Chemical compound
which have been implicated in autophagic induction and ROS production. Sphinganine, a related sphingolipid DL-threo-Dihydrosphingosine at Sigma-Aldrich
Safingol
synthesis pathway of ceramides. Their role is acylation coupling of sphinganine to a long-chain fatty acid to form a dihydroceramide, before the double
Sphingosine_N-acyltransferase
Type of enzyme
CS-2100 CYM-5442 CYM-5520 CYM 5541 CYM-50260 CYM-50308 Dihydro-S1P (sphinganine 1-phosphate) Fingolimod Fingolimod phosphate KRP-203 Mocravimod Ozanimod
Ceramidase
dihydroneopterin aldolase EC 4.1.2.26: phenylserine aldolase EC 4.1.2.27: sphinganine-1-phosphate aldolase EC 4.1.2.28: 2-dehydro-3-deoxy-D-pentonate aldolase
List_of_EC_numbers_(EC_4)
Medical condition
formation of two aberrant sphingolipid metabolites 1-deoxy-sphinganine and 1-deoxymethyl-sphinganine, respectively. As the metabolites lack a hydroxyl group
Hereditary sensory and autonomic neuropathy type I
Hereditary_sensory_and_autonomic_neuropathy_type_I
Chemical compound
CS-2100 CYM-5442 CYM-5520 CYM 5541 CYM-50260 CYM-50308 Dihydro-S1P (sphinganine 1-phosphate) Fingolimod Fingolimod phosphate KRP-203 Mocravimod Ozanimod
Siponimod
Protein-coding gene in the species Homo sapiens
These mice showed no decrease in overall ceramide level, but levels of sphinganine were elevated. They also developed severe liver disease, but there was
Ceramide_synthase_2
Protein-coding gene in the species Homo sapiens
binding protein phosphatase 2A binding ATP binding magnesium ion binding sphinganine kinase activity D-erythro-sphingosine kinase activity NAD+ kinase activity
Sphingosine_kinase_1
Topics referred to by the same term
SUR2 may refer to: Sulfonylurea receptor Sphinganine C4-monooxygenase This disambiguation page lists articles associated with the same title formed as
SUR2
Protein-coding gene in the species Homo sapiens
chemical reaction: sphinganine + NADP+ H+ H+ 3-ketosphinganine + NADPH The two substrates of this enzyme are sphinganine and oxidised nicotinamide
3-dehydrosphinganine reductase
3-dehydrosphinganine_reductase
CS-2100 CYM-5442 CYM-5520 CYM 5541 CYM-50260 CYM-50308 Dihydro-S1P (sphinganine 1-phosphate) Fingolimod Fingolimod phosphate KRP-203 Mocravimod Ozanimod
Sphingosine-1-phosphate receptor
Sphingosine-1-phosphate_receptor
Protein-coding gene in the species Homo sapiens
biosynthetic process extrinsic apoptotic signaling pathway dephosphorylation sphinganine-1-phosphate metabolic process sphingolipid metabolic process ER to Golgi
SGPP1
Type of G protein-coupled receptor
CS-2100 CYM-5442 CYM-5520 CYM 5541 CYM-50260 CYM-50308 Dihydro-S1P (sphinganine 1-phosphate) Fingolimod Fingolimod phosphate KRP-203 Mocravimod Ozanimod
Lysophospholipid_receptor
Protein-coding gene in the species Homo sapiens
endoplasmic reticulum Biological process sphingolipid metabolic process sphinganine biosynthetic process sphingosine biosynthetic process sphingomyelin biosynthetic
SPTLC1
Chemical compound
forms in the skin of humans and rodents. This hepoxilin is esterified to sphinganine in a lipid complex termed EOS i.e. esterified omega-hydroxyacyl-sphingosine
Hepoxilin
Protein-coding gene in the species Homo sapiens
endoplasmic reticulum mitochondrion Biological process lipid metabolism sphinganine biosynthetic process sphingosine biosynthetic process sphingolipid biosynthetic
SPTLC2
Enzyme
activity lyase activity pyridoxal phosphate binding carboxy-lyase activity sphinganine-1-phosphate aldolase activity Cellular component integral component of
SGPL1
Enzyme
Stoffel W, LeKim D, Heyn G (1970). "Metabolism of sphingosine bases. XIV. Sphinganine (dihydrosphingosine), an effective donor of the alk-1-enyl chain of plasmalogens"
Hexadecanol_dehydrogenase
Protein-coding gene in humans
reticulum membrane Biological process sphingolipid biosynthetic process sphinganine metabolic process lipid metabolism ceramide biosynthetic process Sources:Amigo
DEGS2
Chemical compound
CS-2100 CYM-5442 CYM-5520 CYM 5541 CYM-50260 CYM-50308 Dihydro-S1P (sphinganine 1-phosphate) Fingolimod Fingolimod phosphate KRP-203 Mocravimod Ozanimod
N,N-Dimethylsphingosine
SPHINGANINE
SPHINGANINE
SPHINGANINE
SPHINGANINE
Boy/Male
Hindu, Indian, Marathi
Happy
Female
English
Old Scottish name, possibly meant to be a feminine form of English/Scottish Ronald, RHONA means "wise ruler."Â
Girl/Female
Arabic, Muslim, Nigerian
Piece of Moon
Boy/Male
Hindu, Indian, Tamil
Lord Krishna
Girl/Female
British, English
Elf; Power
Male
Romanian
Romanian name, possibly derived from the word alina, ALIN means "to soothe."Â
Boy/Male
Hebrew
Life.
Girl/Female
Muslim
Lovely, Charming
Girl/Female
British, English
Female Version of Edwin; Prosperous Friend
Girl/Female
Biblical
House of the vineyard.
SPHINGANINE
SPHINGANINE
SPHINGANINE
SPHINGANINE
SPHINGANINE