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Protein-coding gene in humans
Structural maintenance of chromosomes protein 3 (SMC3) is a protein that in humans is encoded by the SMC3 gene. SMC3 is a subunit of the Cohesin complex which
SMC3
Medical condition
when it is mutated. Since then, additional genes have been found (SMC1A, SMC3 and HDAC8, RAD21) that cause CdLS when changed. In July 2012, the fourth
Cornelia_de_Lange_syndrome
Protein complex that regulates the separation of sister chromatids during cell division
cohesion, homologous recombination, and DNA looping. Cohesin is formed of SMC3, SMC1, SCC1 and SCC3 (SA1 or SA2 in humans). Cohesin holds sister chromatids
Cohesin
three distinct heterodimers with specialized functions: SMC1-SMC3: A pair of SMC1 and SMC3 constitutes the core subunits of the cohesin complexes involved
SMC_protein
Protein-coding gene in humans
component of the highly conserved cohesin complex consisting of RAD21, SMC1A, SMC3, and SCC3 [ STAG1 (SA1) and STAG2 (SA2) in multicellular organisms] proteins
RAD21
Protein-coding gene in the species Homo sapiens
somatic cells cohesin is formed of SMC3, SMC1, RAD21 and either SA1 or SA2 whereas in meiosis, cohesin is formed of SMC3, SMC1B, REC8 and SA3. There is a
STAG1
Protein-coding gene in the species Homo sapiens
cohesion, homologous recombination and DNA looping. Cohesin is formed of SMC3, SMC1, RAD21 and either SA1 or SA2. Cohesin has a ring-like arrangement and
WAPAL
Protein-coding gene in humans
cells, cohesin is formed of SMC1A, SMC3, RAD21 and either SA1 or SA2 whereas in meiosis, cohesin is formed of SMC3, SMC1B, REC8 and SA3. SMC1A is a member
SMC1A
Protein-coding gene in humans
somatic cells cohesin is formed of SMC3, SMC1, RAD21 and either SA1 or SA2 whereas in meiosis, cohesin is formed of SMC3, SMC1B, REC8 and SA3. STAG2 is frequently
STAG2
residues in the Smc3 subunit of cohesin. Smc3 remains acetylated until at least anaphase. Once cohesin has been removed from the chromatin, Smc3 is deacetylated
Establishment of sister chromatid cohesion
Establishment_of_sister_chromatid_cohesion
Protein-coding gene in the species Homo sapiens
eukaryotes the structural maintenance chromosomes consists of cohesin (SMC1 AND SMC3), condensin (SMC2 and SMC4), and SMC5/6 complexes. The Smc5/6 complex was
SMC5
Other Chromatin Dot (PML body) Paraspeckle SMC protein: Cohesin SMC1A SMC1B SMC3 Condensin NCAPD2 NCAPD3 NCAPG NCAPG2 NCAPH NCAPH2 SMC2 SMC4 DNA repair SMC5
Perinucleolar_compartment
Protein-coding gene in humans
have not been verified experimentally. MXI1 has been shown to interact with SMC3 and MAX. GRCh38: Ensembl release 89: ENSG00000119950 – Ensembl, May 2017
MXI1
Protein-coding gene in the species Homo sapiens
SMC1B protein appears to participate with other cohesins REC8, STAG3 and SMC3 in sister-chromatid cohesion throughout the whole meiotic process in human
SMC1B
Protein-coding gene in the species Homo sapiens
from the ring shaped cohesin complex consisting of 4 subunits (SMC1A/B, SMC3, SCC1, and SA1/2 in humans). This complex encircles the two sister chromatids
Shugoshin_1
Biomolecular condensates of mRNA and RNA binding proteins found in eukaryotic cells
IGF2BP2 IF2B2 Yes DDX21 DDX21 Yes DSC1 DSC1 No NKRF NKRF No DCP1B DCP1B No SMC3 SMC3 No RPS3 RS3 Yes PUM1 PUM1 Yes PIP PIP No RPL26 RL26 No GTPBP4 NOG1 No
P-bodies
Protein-coding gene in the species Homo sapiens
homologous recombination and DNA looping. The core cohesin complex is formed of SMC3, SMC1, RAD21 and either SA1 or SA2. PDS5 associates with WAPL to stimulate
PDS5B
Protein complex
condensins: SMCc, canonical SMC; SMCnc, non-canonical SMC; SMC14, ancestor of SMC1 & SMC4; SMC23, ancestor of SMC2 & SMC3; SMC556, ancestor of SMC5 & SMC6
Condensin
Protein-coding gene in the species Homo sapiens
REC8 protein appears to participate with other cohesins STAG3, SMC1B and SMC3 in sister chromatid cohesion throughout the whole meiotic process in human
REC8
Protein-coding gene in the species Homo sapiens
unstable stalk coiled-coil. KIFAP3 has been shown to interact with APC, SMC3 and RAP1GDS1. GRCh38: Ensembl release 89: ENSG00000075945 – Ensembl, May
Kinesin-associated_protein_3
cohesin, which is a multisubunit complex composed of Scc1, Scc3, Smc2, and Smc3. In yeast at the metaphase-to-anaphase transition, Scc1 dissociates from
Biochemical switches in the cell cycle
Biochemical_switches_in_the_cell_cycle
Protein-coding gene in the species Homo sapiens
"RPGR-ORF15, which is mutated in retinitis pigmentosa, associates with SMC1, SMC3, and microtubule transport proteins". J. Biol. Chem. 280 (39): 33580–7. doi:10
IFT88
Spatial distribution of chromatin within a cell nucleus
architecture. Cohesin is a heterodimer composed of the proteins SMC1 and SMC3 in combination with the SCC1 and SCC3 proteins. The entire complex is loaded
Nuclear_organization
Protein-coding gene in humans
including: TP53, RUNX1, FLT3, ERG, DYRK1A, CHAF1B, HLCS, CTCF, STAG2, RAD21, SMC3, SMC1A, NIPBL, SUZ12, PRC2, JAK1, JAK2, JAK3, MPL, KRAS, NRAS, SH2B3, and
GATA1
Mechanism of nuclear organization
highly conserved ring-like structure. Two SMC proteins (usually, SMC1 and SMC3) are connected via a hinge region and linked at their heads by a kleisin
Loop_extrusion
Definition of scientific term
Aggregates of chromomeres are known as chromonemata. Cohesive proteins SMC3 and hRAD21(plays a role in sister chromatid cohesion) are found within chromomeres
Chromomere
Q14683 15314 SMC1B HGNC:11112; Q8NDV3 15315 SMC2 HGNC:14011; O95347 15316 SMC3 HGNC:2468; Q9UQE7 15317 SMC4 HGNC:14013; Q9NTJ3 15318 SMC5 HGNC:20465; Q8IY18
List of human protein-coding genes 7
List_of_human_protein-coding_genes_7
Medical condition
RUNX1, MIR125B2 (which is the gene for microRNA MiR125B2CTCF, STAG2, RAD21, SMC3, SMC1A, NIPBL, SUZ12, PRC2, JAK1, JAK2, JAK3, MPL, KRAS, NRAS, and SH2B3
Transient myeloproliferative disease
Transient_myeloproliferative_disease
CSPG4 (melanoma-associated chondroitin sulfate proteoglycan, NG2) CSPG5 SMC3 (CSPG6, structural maintenance of chromosomes 3) Brevican (CSPG7) CD44 (CSPG8
Chondroitin sulfate proteoglycan
Chondroitin_sulfate_proteoglycan
Blood marrow cancer originating in megakaryoblast cells
RUNX1, MIR125B2 (which is the gene for microRNA MiR125B2CTCF, STAG2, RAD21, SMC3, SMC1A, NIPBL, SUZ12, PRC2, JAK1, JAK2, JAK3, MPL, KRAS, NRAS, and SH2B3
Acute megakaryoblastic leukemia
Acute_megakaryoblastic_leukemia
Mammalian protein found in Homo sapiens
"RPGR-ORF15, which is mutated in retinitis pigmentosa, associates with SMC1, SMC3, and microtubule transport proteins". The Journal of Biological Chemistry
Mitochondrial dicarboxylate carrier
Mitochondrial_dicarboxylate_carrier
Culture in Sydney, Australia
interest to have graffitied walls transformed by renowned street artists. 'SMC3', St Peters 2016 Several novel street art developments have recently appeared
Newtown area graffiti and street art
Newtown_area_graffiti_and_street_art
Protein-coding gene in the species Homo sapiens
suppressor. MXD1 has been shown to interact with Histone deacetylase 2, SMC3, MLX, SIN3A and MAX. GRCh38: Ensembl release 89: ENSG00000059728 – Ensembl
MXD1
Chromosome with multiple kinetochores along its length
proteins, termed cohesin, that is composed of the core subunits Scc3, Smc1, Smc3 and Scc1. They play the same function in organisms with monocentric chromosomes
Holocentric_chromosome
British biochemist
November 2014). "Closing the cohesin ring: structure and function of its Smc3-kleisin interface". Science. 346 (6212): 963–967. Bibcode:2014Sci...346.
Kim_Nasmyth
Protein-coding gene in the species Homo sapiens
matrix realignment and degradation. KIF3B has been shown to interact with the SMC3 subunit of the cohesin complex and with RAB4A. GRCh38: Ensembl release 89:
KIF3B
SMC3
SMC3
SMC3
SMC3
Boy/Male
Arabic, Muslim
Protector of the Faith
Girl/Female
Australian, German, Hawaiian, Hebrew
Sweet-natured; Cypress Tree; Pleasantness; Delightful; Favorable
Girl/Female
Indian
Girl/Female
Indian
Early bird, Pure, Richness
Boy/Male
Czechoslovakian, German, Polish
Spring Peace; Famous Spring
Girl/Female
German, Hebrew, Hindu, Indian, Marathi, Tamil
A Bird
Girl/Female
American, Arabic, Australian, Chinese, Danish, Dutch, Finnish, German, Hebrew, Latin, Muslim, Swedish
Moon; Lovely
Boy/Male
Hindu
Able daughter
Girl/Female
Indian
Happy
Boy/Male
Biblical
Paternal; that pursues the steps of his father.
SMC3
SMC3
SMC3
SMC3
SMC3