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Chemical compound
Atovaquone/proguanil, sold under the brand name Malarone among others, is a fixed-dose combination medication used to treat and prevent malaria, including
Atovaquone/proguanil
Chemical compound
Proguanil, also known as chlorguanide and chloroguanide, is a medication used to treat and prevent malaria. It is often used together with chloroquine
Proguanil
Antimicrobial and antiprotozoan drug
Pneumocystis jirovecii pneumonia (PCP), and malaria (in combination with proguanil), as well as for treatment of babesiosis (in combination with azithromycin)
Atovaquone
Chemical compound
antimalarial drug proguanil; its formation in vivo has been thought to be primarily responsible for the antimalarial activity of proguanil. However, more
Cycloguanil
Medication used to treat malaria and babesiosis
drugs, such as Fansidar (sulfadoxine with pyrimethamine) or Malarone (proguanil with atovaquone), are often used when oral therapy is required. Quinine
Quinine
Agents used in the treatment of malaria
side effects to proguanil, with slight hair loss and mouth ulcers being occasionally reported following prophylactic use. Proguanil hydrochloride is
Antimalarial_medication
Pharmaceutical drug classification
P01BA07 Tafenoquine P01BB01 Proguanil P01BB02 Cycloguanil embonate P01BB51 Proguanil and atovaquone P01BB52 Chloroquine and proguanil P01BC01 Quinine P01BC02
ATC_code_P01
Pharmaceutical drug
weeks before entering an area with malaria. Doxycycline and atovaquone/proguanil provide protection within one to two days and may be better tolerated
Mefloquine
Mosquito-borne disease
quinine, and mefloquine. Antifolate compounds include pyrimethamine, proguanil, and sulfadoxine. Other drugs include lumefantrine, atovaquone, doxycycline
Malaria
Class of antimetabolite medications
division, DNA/RNA synthesis and repair and protein synthesis. Some such as proguanil, pyrimethamine and trimethoprim selectively inhibit folate's actions in
Antifolate
Pharmaceutical drug
Antifolates DHFR inhibitors pyrimethamine cycloguanil biguanides chlorproguanil proguanil# Sulfonamides sulfadoxine sulfalene Co-formulation sulfadoxine/pyrimethamine
Primaquine
Cellular enzyme inhibitor
urothelial cancer. Cycloguanil, a metabolite of proguanil (a component of the oral antimalarial atovaquone-proguanil, or Malarone), although this has been called
Dihydrofolate reductase inhibitor
Dihydrofolate_reductase_inhibitor
Mammalian protein found in humans
as omeprazole, antiseizure drugs such as mephenytoin, the antimalarial proguanil, and the anxiolytic diazepam. CYP2C19 has been annotated as (R)-limonene
CYP2C19
Chemical compound
Antifolates DHFR inhibitors pyrimethamine cycloguanil biguanides chlorproguanil proguanil# Sulfonamides sulfadoxine sulfalene Co-formulation sulfadoxine/pyrimethamine
Piperaquine
Medical prevention of malaria
This disruption completely stopped the binding process. Chloroquine, proguanil, mefloquine, and doxycycline are suppressive prophylactics. This means
Malaria_prophylaxis
(INN) proglumetacin (INN) proglumide (INN) Proglycem Prograf proguanil (INN) proguanil hydrochloride (USAN) Prohance proheptazine (INN) Proketazine Prokine
List_of_drugs:_Pro–Prz
Tetracycline-class antibiotic
leaving a malarious area, compared with only seven days for atovaquone/proguanil. Doxycycline blocks protein production in the apicoplast (an organelle)
Doxycycline
Disinfectant and antiseptic
after other dental products. The structure is based on two molecules of proguanil, linked with a hexamethylenediamine spacer. Chlorhexidine topical is sold
Chlorhexidine
Species of single-celled organism
alternative and in some countries is more readily available. Atovaquone-proguanil is an effective alternative in patients unable to tolerate chloroquine
Plasmodium_vivax
Species of protozoan parasite
73, P<0.000001). The prescription of anti protozoans such atovaquone/proguanil, effective against T. gondii, has been found to be associated with a reduced
Toxoplasma_gondii
Chemical compound
inhibiting dihydrofolate reductase. Examples include:[citation needed] Proguanil (>cycloguanil) Chlorproguanil The disinfectants chlorhexidine, polyaminopropyl
Biguanide
Species of single-celled organism
treatment with chloroquine and primaquine. The combination atovaquone-proguanil may be used in those patients who are unable to take chloroquine for whatever
Plasmodium_ovale
Genus of parasitic protists that can cause malaria
antimalarial medications through the 20th century including chloroquine, proguanil, atovaquone, sulfadoxine/pyrimethamine, mefloquine, and artemisinin. In
Plasmodium
Combination of two antibiotic drugs
half-life of phenytoin is increased Antifolates like pyrimethamine, proguanil and methotrexate increase the risk of associated side effects like bone
Trimethoprim/sulfamethoxazole
Levitra (vardenafil HCI) Lynavoy (linerixibat) Malarone (atovaquone and proguanil hydrochloride) Mepron (atovaquone) Mivacron (mivacurium chloride) Naramig
List_of_GSK_plc_products
British biologist
also investigated the drugs pamaquine and atebrin, along with proguanil, though proguanil was the only one shown to cause the development of drug resistance
Ann_Bishop_(biologist)
Branch of medicine
weeks (chloroquine, doxycycline, or mefloquine) or seven days (atovaquone/proguanil or primaquine) after leaving the risk area. The traveler should have a
Travel_medicine
Protozoan species of malaria parasite
treatment fails. For travellers returning to nonendemic countries, atovaquone/proguanil, artemether/lumefantrineany and quinine plus doxycycline or clindamycin
Plasmodium_falciparum
French military school of Marseille
the school's researchers. Firstly, the combination of chloroquine and proguanil, used from 1990 onwards, then the use of doxycycline monohydrate at the
École_du_Pharo
Estrogen medication
mephenytoin, midazolam, nicotine, nifedipine, omeprazole, propranolol, proguanil, selegiline, theophylline, and tizanidine. One of the most notable interactions
Ethinylestradiol
Species of parasite
Lastly, some drugs, such as furazolidone, furoxone, benomyl, fumagillin, proguanil and clamoxyquine, have been shown to impede spore development, which reduces
Myxobolus_cerebralis
contributions to the development of malaria drugs, such as atovaquone-proguanil, amodiaquine artesunate, pyronaridine artesunate as well as malaria and
Institute for Tropical Medicine Tübingen
Institute_for_Tropical_Medicine_Tübingen
Antidepressant
dextromethorphan. Moclobemide may decrease metabolism of diazepam, omeprazole, proguanil, propranolol and others due to inhibition of CYP2C19. Irreversible MAOIs
Moclobemide
Health of populations in a global context
are advised chemoprophylaxis with antimalarial drugs like Atovaquone-proguanil, doxycycline, or mefloquine. Global consumption and international trade
Global_health
Professor of pathology in New Zealand
Breckenridge AM (1 June 1991). "The activation of the biguanide antimalarial proguanil co-segregates with the mephenytoin oxidation polymorphism--a panel study"
Nuala_Helsby
Medical fitness to function underwater
staining of developing teeth. Malarone (a combination of atovaquone and proguanil) seldom has side effects, but headache, nausea, vomiting and abdominal
Fitness_to_dive
Nigerian pharmacist and academic
when combined with some anti-malaria drugs. Her report on the use of proguanil suggested that some Nigerians are carriers of mutant CYP2C19 genes and
Chinedum_Babalola
Chemical compound
11 (1): 139. doi:10.1186/1475-2875-11-139. ISSN 1475-2875. PMC 3393623. PMID 22546009. Proguanil Chlorproguanil hydrochloride-dapsone-artesunate v t e
Chlorproguanil
Administering drugs to a whole population in order to prevent disease
Kenya. Ten thousand inhabitants of the tea estates received twice weekly proguanil from April to July 1948. The intervention was supplemented with DDT spraying
Mass_drug_administration
Austrian physician
principal investigator on key studies for the development of atovaquone/proguanil, artesunate/amodiaquine, artesunate/pyronaridine and parenteral artesunate
Peter_Gottfried_Kremsner
258450; POLG Progressive familial heart block, type IB; 604559; TRPM4 Proguanil poor metabolizer; 609535; CYP2C Prolidase deficiency; 170100; PEPD Proliferative
List_of_OMIM_disorder_codes
PROGUANIL
PROGUANIL
PROGUANIL
PROGUANIL
Girl/Female
Tamil
Flowers
Boy/Male
Tamil
Heart
Girl/Female
Spanish
Strong.
Boy/Male
Hindu, Indian, Kannada, Sanskrit, Tamil, Telugu
King
Boy/Male
Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Sanskrit
Sovereign
Biblical
who lays up treasures in secret
Girl/Female
Indian
Yafeen
Girl/Female
Assamese, Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Oriya, Punjabi, Sanskrit, Sikh, Sindhi, Tamil, Telugu
Brilliant; Beauty; Complete
Male
Italian
Italian form of Late Latin Jacomus (English James), GIACOMO means "supplanter."
Boy/Male
English
Harvest-time friend.
PROGUANIL
PROGUANIL
PROGUANIL
PROGUANIL
PROGUANIL