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Protein family
Myelin basic protein (MBP) is a protein important in the process of myelination of nerves in the nervous system. The myelin sheath is a multi-layered
Myelin_basic_protein
American chemist
biochemist and neuroscientist known for purifying and characterizing myelin basic protein (MBP), investigating its potential role in the neurodegenerative
Elizabeth_Roboz_Einstein
Fatty substance insulating nerve cell axons
includes myelin basic protein (MBP), which is abundant in the CNS where it plays a critical, non-redundant role in formation of compact myelin; myelin oligodendrocyte
Myelin
Index of enzymes associated with the same name
Protein methylase I may refer to the following enzymes: Histone-arginine N-methyltransferase (Myelin basic protein)-arginine N-methyltransferase This set
Protein_methylase_I
Protein-coding gene in the species Homo sapiens
Myelin protein zero (MPZ), also Myelin protein P0, is a single membrane glycoprotein which in humans is encoded by the MPZ gene. P0 is a major structural
Myelin_protein_zero
Medication
acids found in myelin basic protein, namely glutamic acid, lysine, alanine, and tyrosine. Myelin basic protein is the antigen in the myelin sheaths of the
Glatiramer_acetate
Class of enzymes
[myelin basic protein]-arginine N-methyltransferase (EC 2.1.1.126) is an enzyme that catalyzes the chemical reaction S-adenosyl-L-methionine + [myelin
(Myelin basic protein)-arginine N-methyltransferase
(Myelin_basic_protein)-arginine_N-methyltransferase
Type of myelin-associated protein
Proteolipid protein 1 (PLP1) is a form of myelin proteolipid protein (PLP). Mutations in PLP1 are associated with Pelizaeus–Merzbacher disease. It is a
Proteolipid_protein_1
Biological process
embryo, deimination of myelin basic protein plays a major role in myelin assembly. In adults, deimination myelin basic protein occurs in demyelinating
Citrullination
Protein-coding gene in the species Homo sapiens
expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and
PADI2
Formation of myelin sheaths in the nervous system
axons in organized, multilamellar myelin sheaths that contain myelin basic protein (MBP) and myelin proteolipid protein (PLP). Myelinogenesis thus encompasses
Myelination
Topics referred to by the same term
Milk basic protein, a milk protein fraction Myc-binding protein-1, a protein encoded by the alpha-enolase glycolytic enzyme Myelin basic protein, a protein
MBP
Italian neuroscientist
Marin-Husstege M, Miskimins WK, Casaccia-Bonnefil P. p27(Kip1) enhances myelin basic protein gene promoter activity. Journal of Neuroscience Research. 67: 100–5
Patrizia_Casaccia
Central organ of the human nervous system
expressed in interneurons. Proteins expressed in glial cells include astrocyte markers GFAP and S100B whereas myelin basic protein and the transcription factor
Human_brain
Poisoning caused by mercury chemicals
antibodies sent to myelin basic protein (MBP), which is involved in the myelination of neurons, and glial fibrillary acidic protein (GFAP), which is essential
Mercury_poisoning
Neural cell type
oligodendroglia, are a type of neuroglia whose main function is to provide the myelin sheath to neuronal axons in the central nervous system (CNS). Myelination
Oligodendrocyte
Informal grouping of viruses
mimicry hypothesis, in which T cells confuse an HHV-6 viral protein with myelin basic protein, first appeared around this time. Early on in the development
Human_herpesvirus_6
American neurologist (1940–2001)
field of neuroimmunology and contributed with the identification of myelin basic protein production in urine. Whitaker was born in Memphis, Tennessee. He
John_N._Whitaker
Topics referred to by the same term
also spelled as "Golli" Golli myelin basic protein (Golli-MBP; or "golli"), an expression of MBP, myelin basic protein Ramesh Golli, a sprint kayaker
Golli
Long projection on a neuron that conducts signals to other neurons
composition of myelin is different in the two types. In the CNS the major myelin protein is proteolipid protein, and in the PNS it is myelin basic protein. Nodes
Axon
Chemical compound
ions. Proteins that normally contain citrulline residues include myelin basic protein, filaggrin, and several histone proteins, whereas other proteins, such
Citrulline
Central nervous system disease
to the release of antigens such as myelin oligodendrocyte glycoprotein, myelin basic protein, and proteolipid protein, causing an autoimmune response. This
Neurodegenerative_disease
Ability of a firearm or other weapon to cause immediate incapacitation
PMID 2313748. Wang Q, Wang Z, Zhu P, Jiang J (2004). "Alterations of the Myelin Basic Protein and Ultrastructure in the Limbic System and the Early Stage of Trauma-Related
Stopping_power
Emerging treatment for multiple sclerosis
especially those responsive to myelin antigens like MOG (Myelin Oligodendrocyte Glycoprotein) and MBP (Myelin Basic Protein). First, the reduced stability
CAR Treg therapy in multiple sclerosis
CAR_Treg_therapy_in_multiple_sclerosis
Chemical compound
c-Jun N-terminal Kinase (JNK), p38 mitogen-activated protein kinase (MAPK), and p36 myelin basic protein (MBP) kinase. Cytotrienin A is an ansamycin with
Cytotrienin_A
Protein-coding gene in the species Homo sapiens
HLA class II histocompatibility antigen, DRB1 beta chain is a protein that in humans is encoded by the HLA-DRB1 gene. DRB1 encodes the most prevalent
HLA-DRB1
Medical condition
ubiquitin, amyloid precursor protein, and neurofilament to characterize axonal changes and myelin basic protein for myelin pathology. Immunohistochemical
Hereditary diffuse leukoencephalopathy with spheroids
Hereditary_diffuse_leukoencephalopathy_with_spheroids
Cancer affecting Tasmanian devils
Schwann cells, revealing high activity in many of the genes coding for myelin basic protein production. Several specific markers were identified, including the
Devil_facial_tumour_disease
Biochemical test for a protein or other molecule using an antibody
S2CID 206490102. Georgios Tsekenis (2008). "Label-free immunosensor assay for myelin basic protein based upon an ac impedance protocol". Analytical Chemistry. 80 (6):
Immunoassay
Mammalian protein found in Homo sapiens
Myelin regulatory factor (MRF), Myelin gene regulatory factor, is a protein that in humans is encoded by the MYRF gene. Myelin regulatory factor is encoded
Myelin_regulatory_factor
proteins. But there is a diverse group of proteins which interact directly with the surface of the lipid bilayer. Some, such as myelin basic protein,
Protein–lipid_interaction
Biological system of neurotransmitters
an increase in the expression of transcripts encoding myelin basic protein, endoplasmic proteins, cytochrome oxidase, and two cell adhesion molecules:
Endocannabinoid_system
Ferra F, Hudson L, Lazzarini RA (1986). "Recombination within the myelin basic protein gene created the dysmyelinating shiverer mouse mutation". Proc Natl
Shiverer_mouse
Class of proteins
MIM MAYP Mycalolide (a macroglide drug) Mayven Myelin basic protein Naphthylphthalamic acid binding protein (NPA) N-RAP Nebulin N-WASP Neurabin Nullo Neurexins
Actin-binding_protein
Professor of biochemistry and medicine
(2026). "Peripheral Myelin Protein-22 and Its Prominence in Charcot-Marie-Tooth Disease." "VUMC - bio". "Charles Sanders - Basic Sciences". "Charles R
Charles_R._Sanders
Animal model of brain inflammation
produced by injection of brain extracts, CNS proteins (such as myelin basic protein), or peptides from such protein emulsified in an adjuvant such as complete
Experimental autoimmune encephalomyelitis
Experimental_autoimmune_encephalomyelitis
injected with activated T cells which are specific for myelin basic protein (MBP, a common protein in the CNS) retained 3-fold more retinal ganglion cells
Protective_autoimmunity
Antibody in molecular biology and neuroscience
(Fox-3, Rbfox3, or Hexaribonucleotide Binding Protein-3), a protein which is a homologue to the protein product of a sex-determining gene in Caenorhabditis
NeuN
Medical condition
Grinker's myelinopathy through an elevation in the concentrations of a myelin basic protein in the cerebrospinal fluid . Because this disease shares many of
Grinker_myelinopathy
Structure in the brain
parvalbumin-expressing inhibitory cell types. In recent studies, the use of myelin basic protein (MBP) and retrogradely traveling cholera toxin have additionally
Claustrum
Type of allergic reaction
PMID 22165815. Kumar, Vinay; Abbas, Abul K.; Aster, Jon C. (1 May 2012). Robbins Basic Pathology. Elsevier Health Sciences. ISBN 978-1455737871. "Hypersensitivity
Type_IV_hypersensitivity
Immunologist and neurologist, professor of pediatrics
antigen-specific tolerance for MS, where an engineered DNA plasmid encoding myelin basic protein showed promising results in a phase 2 trial. He also demonstrated
Lawrence_Steinman
American biologist (born 1938)
neurobiology, Hood and his colleagues were the first to clone and study the myelin basic protein (MBP) gene. The MBP is a central component in the sheath that wraps
Leroy_Hood
Controversial theory in terminal ballistics
Wang, Q; Wang, Z; Zhu, P; Jiang, J (2004). "Alterations of the Myelin Basic Protein and Ultrastructure in the Limbic System and the Early Stage of Trauma-Related
Hydrostatic_shock
Medical condition
gene. tRNA genes might participate in MBP (Myelin Basic Protein is a protein that participates in building myelin sheath, which is necessary for nerve conduction)
POLR3-related_leukodystrophy
Medical condition
indicated the signature autoantibodies (potassium channel antibodies, myelin basic protein antibodies and calcium channel antibodies) were present in experimental
Progressive inflammatory neuropathy
Progressive_inflammatory_neuropathy
Autoimmune disease
Giffels JJ, Johnson RT, Moser AB, Phanuphak P (February 1987). "Myelin basic protein as an encephalitogen in encephalomyelitis and polyneuritis following
Acute disseminated encephalomyelitis
Acute_disseminated_encephalomyelitis
Species of fluke
localised in intestines of migrating schistosomula is capable of myelin basic protein degradation, thus probably serving for nervous tissue digestion.
Trichobilharzia_regenti
Class of 33 human protein receptors
fish no myelin basic protein can be detected. In fish this can be rescued by adding forskolin during development, which rescues myelin basic protein expression
Adhesion G protein-coupled receptor
Adhesion_G_protein-coupled_receptor
Structural Linker of the CNS: Solid-State NMR and FTIR Spectroscopy of Myelin Basic Protein Bound to Actin". Biophysical Journal. 96 (1): 180–91. Bibcode:2009BpJ
Fuzzy_complex
Complex of different phospholipids and proteins
a surface-active complex of phospholipids and proteins formed by type II alveolar cells. The proteins and lipids that make up the surfactant have both
Pulmonary_surfactant
biochemist and neuroscientist known for purifying and characterizing myelin basic protein T. S. Kanaka (1932–2018), Asia's first female neurosurgeon Sandhya
List_of_women_neuroscientists
Protein-coding gene in the species Homo sapiens
antigenic relationship with the major encephalitogenic domain of myelin basic protein". The Biochemical Journal. 259 (1): 283–90. doi:10.1042/bj2590283
MBD3
American neurologist
patients after stroke and found that increases in autoantibodies to myelin basic protein were associated with cognitive decline after stroke. 1991 March of
Marion_Buckwalter
Index of enzymes associated with the same name
N-methyltransferase (cytochrome c)-arginine N-methyltransferase (Myelin basic protein)-arginine N-methyltransferase Calmodulin-lysine N-methyltransferase
N-methyltransferase
American medical doctor and academic
Garrison. (1992) Amelioration of autoimmune encephalomyelitis by myelin basic protein synthetic peptide-induced anergy. Science 258:1491-1494. Yang, Yang
C._Garrison_Fathman
German neurobiologist
S2CID 44482733. Fontana, A; Fierz, W; Wekerle, H (1984). "Astrocytes present myelin basic protein to encephalitogenic T-cell lines". Nature. 307 (5948): 273–6. Bibcode:1984Natur
Hartmut_Wekerle
RNA that is read by the ribosome to produce a protein
Carson JH (September 1997). "Transport and localization elements in myelin basic protein mRNA". The Journal of Cell Biology. 138 (5): 1077–1087. doi:10.1083/jcb
Messenger_RNA
Protein family
"Membrane-associated metalloproteinase recognized by characteristic cleavage of myelin basic protein: Assay and isolation". Proteolytic Enzymes: Aspartic and Metallo
Notch_proteins
Neuroimmunologist
Immunology and Immunopathology reporting the presence of antibodies to myelin basic protein in autistic children and arguing that a virally triggered autoimmune
Vijendra_K._Singh
Disease pathology and physiology
demyelination has occurred, the degraded myelin sheath components, such as myelin basic proteins and Myelin oligodendrocyte glycoproteins, are then used
Pathophysiology of multiple sclerosis
Pathophysiology_of_multiple_sclerosis
Transcription factor gene of the SOX family
(December 2007). "Olig1 and Sox10 Interact Synergistically to Drive Myelin Basic Protein Transcription in Oligodendrocytes". The Journal of Neuroscience.
SOX10
Combination of acute aseptic meningitis and urinary retention
underlying mechanism of MRS, because some patients show elevated myelin basic protein in the CSF and a reversible splenial lesion on brain magnetic resonance
Meningitis-retention_syndrome
Pediatric neurologist and academic
"Detection of brain-specific autoantibodies to myelin oligodendrocyte glycoprotein, S100beta and myelin basic protein in patients with Devic's neuromyelitis optica"
Brenda_Banwell
Israeli immunologist (1924–2022)
"Copolymer 1 induces T cells of the T helper type 2 that crossreact with myelin basic protein and suppress experimental autoimmune encephalomyelitis". Proc. Natl
Michael_Sela
set of 2006 MeSH Trees from the NLM. MeSH D12.776.641.580.510.500 – myelin p2 protein MeSH D12.776.641.600.381.500 – glial cell line-derived neurotrophic
List of MeSH codes (D12.776.641)
List_of_MeSH_codes_(D12.776.641)
Approaches to managing the disease
amino acids which is antigenically similar to the myelin basic protein, a component of the myelin sheath of nerves with which it competes for presentation
Management of multiple sclerosis
Management_of_multiple_sclerosis
Substances isolated from the mycelium of lion's mane mushrooms
compounds promote oligodendrocyte maturation with an increase in myelin basic protein". Scientific Reports. 11 (1) 6551. Bibcode:2021NatSR..11.6551H. doi:10
Erinacine
Pathogenic type of misfolded protein
myelin repair in Schwann cells, and that the lack of PrP proteins causes demyelination in those cells. MAVS, RIP1, and RIP3 are prion-like proteins found
Prion
Chemical compound
acids linked in a sequence identical to that of a portion of human myelin basic protein (MBP). The sequence of these 17 amino acids is
Dirucotide
Protein-coding gene in the species Homo sapiens
Myelin transcription factor 1 like is a protein that in humans is encoded by the MYT1L gene. This gene encodes a member of the zinc finger superfamily
MYT1L
Visual impairment
CRP/inflammation markers immunoglobin G index insulin-like growth factors myelin basic protein oligoclonal bands platelet count S-100 somatostatin tet-transactivator
Spaceflight associated neuro-ocular syndrome
Spaceflight_associated_neuro-ocular_syndrome
Biological process of axonal degeneration
continue to clear up the myelin debris by degrading their own myelin, phagocytose extracellular myelin and attract macrophages to myelin debris for further
Wallerian_degeneration
Protein-coding gene in the species Homo sapiens
A, Johnson EM, Khalili K, Amini S (October 1999). "Regulation of myelin basic protein gene transcription by Sp1 and Puralpha: evidence for association
PURA
Protein-coding gene in the species Homo sapiens
et al. (February 2004). "Identification of a protein that interacts with the golli-myelin basic protein and with nuclear LIM interactor in the nervous
CTDSP1
Subtype of glial cell in the central nervous system
characterized by the emergence of the expression of myelin basic protein (MBP), proteolipid protein (PLP), or myelin-associated glycoprotein (MAG). Following terminal
Oligodendrocyte progenitor cell
Oligodendrocyte_progenitor_cell
Synchrotron Radiation Circular Dichroism
specific proteins within the myelin components whose roles are to structure the myelin into linked layers. Two of these proteins are myelin basic protein (MBP)
Synchrotron radiation circular dichroism spectroscopy
Synchrotron_radiation_circular_dichroism_spectroscopy
Protein-coding gene in humans
(SCS)-binding proteins the consensus motif Lys/Arg-X-Lys/Arg-X-X-Ser/Thr has been identified and phosphorylation of this motif has been demonstrated for myelin basic
CSNK1D
Pathologic overview
This MTR parameter is related to axonal density. It also seems that myelin basic protein (MBP) from multiple sclerosis (MS) patients contains lower levels
Pathology of multiple sclerosis
Pathology_of_multiple_sclerosis
Canadian neuroscientist
Balsor, Justin L.; Murphy, Kathryn M. (2015). "Classic and Golli Myelin Basic Protein have distinct developmental trajectories in human visual cortex"
Kathryn_Mary_Murphy
Histopathologist
TL, et al. (2021). Dysregulation in subcellular localization of myelin basic protein mRNA does not result in altered myelination in ALS. Frontiers in
Jenna_Gregory
Swedish physician, microbiologist and immunologist
"Treatment of experimental autoimmune encephalomyelitis by feeding myelin basic protein conjugated to cholera toxin B subunit". Proceedings of the National
Jan_Holmgren
Foundation grammar school in Canterbury, Kent, England
plasma physics project, the Faulkes Telescope Project, and MBP2 (Myelin Basic Protein Project) with the help of the University of Kent in support of the
Simon Langton Grammar School for Boys
Simon_Langton_Grammar_School_for_Boys
American neurologist
Science in biochemistry. His master's thesis was on fragments of myelin basic protein. In 1978, he received his MD degree from the University of Miami
David_A._Hafler
Wang, Q.; Wang, Z.; Zhu, P.; Jiang, J. (2004). "Alterations of myelin basic protein and ultrastructure in the limbic system at the early stage of trauma-related
Handgun_effectiveness
research is on neuron-glia interactions that result in the assembly of myelin in the nervous system. Neuronal processes (axons) exhibit signaling molecules
Max Planck Institute for Experimental Medicine
Max_Planck_Institute_for_Experimental_Medicine
Protein-coding gene in the species Homo sapiens
Uncharacterized protein C1orf21, also known as Proliferation-Inducing Protein 13, is a protein that in humans is encoded by the C1orf21 gene. C1orf21 is
C1orf21
Category of memory stabilizing processes
neuronal axons are insulated by myelin which can also change over time. Current studies have established that myelin has a high rate of change in the
Memory_consolidation
Line of stem cells for research
generation could be accelerated further. Using a novel protocol, myelin basic protein (MBP), a marker for oligodendrocyte differentiation and myelination
Myelinoid
Group of disorders characterised by degeneration of white matter in the brain
by imperfect growth or development of the glial cells which produce the myelin sheath, the fatty insulating covering around nerve fibers. Leukodystrophies
Leukodystrophy
muscarinic receptor - muscle - muscle protein - mutagen - mutation - myc gene - mycology - myelin basic protein - myeloma protein - myosin N-formylmethionine -
Index of biochemistry articles
Index_of_biochemistry_articles
Nadj, I; et al. (2008). "Phase 2 trial of a DNA vaccine encoding myelin basic protein for multiple sclerosis". Annals of Neurology. 63 (5): 611–20. CiteSeerX 10
Peptide_microarray
Human protein and coding gene
Basic helix-loop-helix ARNT-like protein 1 or aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL), or brain and muscle ARNT-like 1 is
Basic helix-loop-helix ARNT-like protein 1
Basic_helix-loop-helix_ARNT-like_protein_1
Small structural protein motif found mostly in transcriptional proteins
finger domain found in eukaryotes. Proteins containing these domains include: MYST family histone acetyltransferases Myelin transcription factor Myt1 Suppressor
Zinc_finger
Protein-coding gene in the species Homo sapiens
the asparagine-specific endoprotease, controls the processing of myelin basic protein in lysosomes from human B lymphocytes". J. Immunol. 172 (9): 5495–503
LGMN
Proposed cause of autoimmunity
proteolipid protein (myelin protein) and the Epstein-Barr virus mimicking anti-myelin oligodendrocyte glycoprotein (contributes to a ring of myelin around
Molecular_mimicry
Protein-coding gene in the species Homo sapiens
HLA class II histocompatibility antigen, DR alpha chain is a protein that in humans is encoded by the HLA-DRA gene. HLA-DRA encodes the alpha subunit
HLA-DRA
Italian neurophysiologist
Bernardi, R; Durante, M; Brunelli, M (26 May 2011). "Modulation of Myelin Basic Protein Gene Expression by Acetyl-l-Carnitine". Molecular Neurobiology. 44
Marcello_Brunelli
Use of stem cells to treat or prevent a disease or condition
cells to the site of lesion, increased remyelination detected by Myelin Basic Proteins, positive differentiation into Olig2 positive oligodendrocytes,
Stem-cell_therapy
Polymer in bacterial cell walls
(also called MurNAc or NAMA). Gram-positive cell wall Penicillin binding protein forming cross-links in newly formed bacterial cell wall. Peptidoglycan
Peptidoglycan
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