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Biological process
Citrullination or deimination is the conversion of the amino acid arginine in a protein into the amino acid citrulline. Citrulline is not one of the 20
Citrullination
Type of enzymes
modifications including O-GlcNAcylation, sumoylation, ADP-ribosylation, citrullination and proline isomerization. For a detailed example of histone modifications
Histone-modifying_enzymes
Autoantibodies
citrulline residues in proteins such as vimentin, by a process called citrullination. If their shapes are significantly altered, the proteins may be seen
Anti–citrullinated protein antibody
Anti–citrullinated_protein_antibody
Protein family around which DNA winds to form nucleosomes
in their globular domains. Such modifications include methylation, citrullination, acetylation, phosphorylation, SUMOylation, ubiquitination, and ADP-ribosylation
Histone
Chemical compound
deiminases, which convert arginine into citrulline in a process called citrullination or deimination with the help of calcium ions. Proteins that normally
Citrulline
symptoms often are lacking but when medical therapy is most effective. Citrullination is a modification of proteins where a nitrogen in the amino acid arginine
Mutated citrullinated vimentin
Mutated_citrullinated_vimentin
Protein family
protein, which include phosphorylation, methylation, deamidation, and citrullination. These forms differ by the presence or the absence of short (10 to 20
Myelin_basic_protein
Enzyme
of post translational modification called arginine de-imination or citrullination: protein L-arginine + H2O ⇌ {\displaystyle \rightleftharpoons } protein
Protein-arginine_deiminase
Species of bacterium
contains the enzyme peptidyl-arginine deiminase, which is involved in citrullination. Patients with rheumatoid arthritis have increased incidence of periodontal
Porphyromonas_gingivalis
Monoamine neurotransmitter
et al. (April 2025). "5-HT orchestrates histone serotonylation and citrullination to drive neutrophil extracellular traps and liver metastasis". The Journal
Serotonin
commonly methylation, acetylation, ubiquitination, phosphorylation, and citrullination. histone variant hnRNA See heterogeneous nuclear RNA. holocentric (of
Glossary of cellular and molecular biology (0–L)
Glossary_of_cellular_and_molecular_biology_(0–L)
Type of autoimmune arthritis
associated with periodontitis are implicated as mediators of protein citrullination in the gums of people with RA. Vitamin D deficiency is more common in
Rheumatoid_arthritis
Species of bacterium
disease rheumatoid arthritis due to its ability to stimulate protein citrullination, a post-translational protein modification targeted by autoantibodies
Aggregatibacter actinomycetemcomitans
Aggregatibacter_actinomycetemcomitans
Study of DNA modifications that do not change its sequence
methylation, ubiquitylation, phosphorylation, sumoylation, ribosylation and citrullination. Acetylation is the most highly studied of these modifications. For
Epigenetics
Amino acid
form citrulline, in a post-translational modification process called citrullination. This is important in fetal development, is part of the normal immune
Arginine
Addition of a sulfate group to a compound
Succinylation Sumoylation Ubiquitination Arginine ADP-ribosylation Citrullination Methylation Proline Hydroxylation Histidine Adenylylation Diphthamide
Sulfation
Chemical changes in proteins following their translation from mRNA
pupylation, the covalent linkage to the prokaryotic ubiquitin-like protein citrullination, or deimination, the conversion of arginine to citrulline deamidation
Post-translational modification
Post-translational_modification
Chinese-born Wisconsin professor
Spectrometry-Based Method for Simultaneous Qualitative and Quantitative Protein Citrullination Analysis of Complex Biological Samples (2020) US 20210181206 A1 Phillips
Lingjun_Li
Immune response against an organism's own healthy cells
incidence and severity of rheumatoid arthritis. This may relate to abnormal citrullination of proteins, since the effects of smoking correlate with the presence
Autoimmunity
Scientist researching clinical proteomics
Genomic and Precision Medicine Distinguished Achievement Award Role of citrullination in diagnosing diseases (2021) US 11,105,817 B2 Biomarkers of myocardial
Jennifer_Van_Eyk
Topics referred to by the same term
Citrullinated protein may refer to: Any protein having undergone citrullination The proteins (often cyclic ones) being the targets of anti-citrullinated
Citrullinated_protein
Post-translational histone modifications involving monoamines
Wang, Deng (2025-04-15). "5-HT orchestrates histone serotonylation and citrullination to drive neutrophil extracellular traps and liver metastasis". Journal
Histone_monoaminylation
Chemical compound
citrulline: development of a phenylglyoxal-based probe to visualize protein citrullination". J Am Chem Soc. 134 (41): 17015–8. doi:10.1021/ja308871v. PMC 3572846
Phenylglyoxal
Protein-coding gene in the species Homo sapiens
responsible for the conversion of arginine to citrulline residues (citrullination). This gene may play a role in granulocyte and macrophage development
PADI4
Post-translational modification involving the monoamine serotonin
Wang, Deng (2025-04-15). "5-HT orchestrates histone serotonylation and citrullination to drive neutrophil extracellular traps and liver metastasis". The Journal
Serotonylation
Proposed biochemical transcription of genetic information
(such as methylation, acetylation, ADP-ribosylation, ubiquitination, citrullination, SUMO-ylation and phosphorylation) to histone tails alter chromatin
Histone_code
Protein-coding gene in the species Homo sapiens
"Proteomics implicates peptidyl arginine deiminase 2 and optic nerve citrullination in glaucoma pathogenesis". Invest. Ophthalmol. Vis. Sci. 47 (6): 2508–14
PADI2
Networks of fibres which bind pathogens
reactive oxygen species (ROS) intermediaries. PAD4 is responsible for the citrullination of histones in the neutrophil, resulting in decondensation of chromatin
Neutrophil extracellular traps
Neutrophil_extracellular_traps
Pharmaceutical compound
Arginine Deiminases (PADs): Biochemistry and Chemical Biology of Protein Citrullination". Accounts of Chemical Research. 52 (3): 818–832. doi:10.1021/acs.accounts
GSK484
Gene regulation in autoimmune diseases
histone H3 citrullination contributes to demyelination, research demonstrates that inhibitors of the enzymes involved in this citrullination improve the
Epigenetics of autoimmune disorders
Epigenetics_of_autoimmune_disorders
Measurable indicator
Lüthke K, Rudolph PE, Fredenhagen G, et al. (2007). "Mutation and citrullination modifies vimentin to a novel autoantigen for rheumatoid arthritis".
Biomarker_(medicine)
Post-translational modifications involving monoamines
Wang, Deng (2025-04-15). "5-HT orchestrates histone serotonylation and citrullination to drive neutrophil extracellular traps and liver metastasis". The Journal
Monoaminylation
Protein-coding gene in the species Homo sapiens
protein and are not thoroughly characterised yet, such as acetylation, citrullination, S-glutathiolation, S-nitrosylation and carbonylation. Truncation mutations
Myosin binding protein C, cardiac
Myosin_binding_protein_C,_cardiac
Dutch medical scientist
1999. ISBN 90-6984-249-1. Vossenaar, E; Robinson, W (2005-10-01). "Citrullination and auto-immune disease: 8th Bertine Koperberg meeting". Annals of the
Leo_van_de_Putte
Knowledgebase of protein termini
It renders modifications of protein termini, such as acetylation and citrullination, easily accessible and searchable and provides the means to identify
TopFIND
Organisms that contribute to gum disease
gingivalis produces peptidylarginine deiminase (PAD), which induces citrullination of proteins Citrullinated proteins trigger the production of anti-citrullinated
Periodontal_pathogen
Biologist
(shared epitope) -restricted immune reactions to autoantigens modified by citrullination . In: Arthritis & Rheumatism , Volume 54, January 2006, pp. 38-46. doi:10
Lars_Klareskog
(methionine), hydroxylation (proline), deamidation (glutamine/asparagine), citrullination (arginine), phosphorylation (serine/threonine/tyrosine), N-terminus
Ancient_protein
Pathologic overview
some cortical gray matter region of MS patients than normal controls. Citrullination appears in SPMS. It seems that a defect of sphingolipid metabolism modifies
Pathology of multiple sclerosis
Pathology_of_multiple_sclerosis
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Girl/Female
Tamil
Night
Boy/Male
Hindu, Indian
Saint; Senior
Girl/Female
Australian, Christian, French, Latin
Flower; Form of Florence; Blooming
Boy/Male
German
Meets
Male
Danish
, kettle, cauldron.
Surname or Lastname
Southern Irish
Southern Irish : Anglicized form of Gaelic Ó CrÃodáin or Mac CrÃodáin ‘descendant (or ‘son’) of CrÃodán’, an Old Irish personal name of uncertain meaning (the ending is diminutive in form).English : habitational name from Creeton in Lincolnshire, so named with an unattested Old English personal name CrÇ£ta + Old English tÅ«n.
Girl/Female
Indian
Joy Love beauty (Wife of prophet Ibrahim)
Surname or Lastname
English
English : unexplained.
Girl/Female
Tamil
Goddess of destiny
Girl/Female
Hindu, Indian
Lustrous
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