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Proposed cause of autoimmunity
Molecular mimicry is the theoretical possibility that sequence similarities between foreign and self-peptides are enough to result in the cross-activation
Molecular_mimicry
Deceptive mimicry of a harmless species by a predator
camouflage. Treated separately is molecular mimicry, which shares some similarity; for instance a virus may mimic the molecular properties of its host, allowing
Aggressive_mimicry
Disorders of adaptive immune system
more speculatively, as a contributor to rheumatoid arthritis through molecular mimicry. Reviews caution, however, that an actual causal role for HERVs in
Autoimmune_disease
Evolutionary strategy
evolutionary biology, mimicry is the evolved resemblance of an organism to something else, often another organism of a different species. Mimicry may evolve between
Mimicry
Group of autoantibodies
that promote a residual autoimmune response – this is the theory of molecular mimicry. Staphylococcal and streptococcal superantigens have been characterized
Anti-neutrophil cytoplasmic antibody
Anti-neutrophil_cytoplasmic_antibody
Post-streptococcal inflammatory disease
of RHD is not fully understood, though it has been observed to use molecular mimicry via group A streptococci carbohydrates and genetic predisposition
Rheumatic_fever
Biological mimicry using chemicals
Chemical mimicry (or molecular mimicry) is a type of biological mimicry involving the use of chemicals to dupe an operator. A chemical mimic dupes an operator
Chemical_mimicry
Bluffing imitation of a species with strong defenses
Batesian mimicry is a form of mimicry wherein a harmless species has evolved to imitate the warning signals of a harmful species in order to benefit from
Batesian_mimicry
Infectious disease caused by Borrelia bacteria, spread by ticks
disease. The production of this reaction might be due to a form of molecular mimicry, where Borrelia avoids being killed by the immune system by resembling
Lyme_disease
Class of molecules found in the outer membrane of Gram-negative bacteria
responsible for the ability of some bacterial strains to display molecular mimicry and antigenic diversity, aiding in the evasion of host immune defenses
Lipopolysaccharide
Autoimmune disease affecting the peripheral nervous system
Molecular mimicry may be particularly relevant to the tolerance breakdown linked to autoimmune neuropathies. The process known as "molecular mimicry"
Chronic inflammatory demyelinating polyneuropathy
Chronic_inflammatory_demyelinating_polyneuropathy
Autoimmune disease resulting in uncontrollable jerking motions
infection leads to autoantibodies being produced against host tissues (molecular mimicry) causing a variety of streptococcal related diseases including Sydenham's
Sydenham's_chorea
Disease that damages the myelin sheaths around nerves
immune system to mistakenly attack the body's own nervous system. This molecular mimicry offers a possible explanation for how EBV could help trigger MS. MS
Multiple_sclerosis
Species of horsehair worm
similar to proteins known from other insects, suggesting an instance of molecular mimicry. A similar parasitic worm is Paragordius tricuspidatus. "Spinochordodes
Spinochordodes_tellinii
Removal of autoreactive B and T cells before they become immunocompetent
lymphocytes. Complete clonal deletion can lead to opportunities for molecular mimicry, which has adverse effects for the host. Therefore, incomplete clonal
Clonal_deletion
Autoantibody that binds to contents of the cell nucleus
is not fully understood, but apoptosis (programmed cell death) and molecular mimicry may play a role. The Ro and La antigens are expressed on the surface
Antinuclear_antibody
Protein found on the surface of Candida albicans
Hwp1 (Hyphal wall protein 1) is a protein (glycoprotein) located on the surface of an opportunistic diploid fungus called Candida albicans. This "hyphal"
Hwp1
Mutually beneficial mimicry of strongly defended species
Müllerian mimicry is a type of biological mimicry in which two or more well-defended species, often foul-tasting and sharing common predators, converge
Müllerian_mimicry
Form of mimicry in plants
hypersensitivity, Gilbertian mimicry at a molecular level. The name was coined by the French biologist Georges Pasteur as a phrase for the rare mimicry system. He named
Gilbertian_mimicry
Immune response against an organism's own healthy cells
self-tolerance without necessarily requiring loss of T cell self-tolerance. Molecular mimicry – An exogenous antigen may share structural similarities with certain
Autoimmunity
Chronic neurological sleep disorder
demonstrated that T-cells stimulated by Pandemrix were cross-reactive by molecular mimicry with part of the hypocretin peptide, the loss of which is associated
Narcolepsy
Species of bacterium
presence of these residues on A. muciniphila LOS may thus mediate host molecular mimicry, inhibiting potential pro-inflammatory responses. The lipid A moiety
Akkermansia_muciniphila
Autoimmune disease
of these antibodies after an infection probably is the result of molecular mimicry, where the immune system is reacting to microbial substances, but
Guillain–Barré_syndrome
Group of anti-nuclear antibodies
antibodies can also be produced through infection via a mechanism known as molecular mimicry. Upon exposure to pneumococcal polysaccharides, cross reactive antibodies
Anti-dsDNA_antibodies
Type of antigen
HLA-B27/self-peptide pair. HLA-B27 can bind peptides at the cell surface. The molecular mimicry hypothesis is similar, although it suggests that cross-reactivity
HLA-B27
Hypothesis in pediatric medicine
antibodies attack the brain and cause neuropsychiatric conditions. The molecular mimicry hypothesis is a proposed mechanism for PANDAS: this hypothesis is
PANDAS
Infectious disease
cause an autoimmune response in the body through what has been termed molecular mimicry. In these cases, the antibodies which the person's immune system developed
Scarlet_fever
Autoimmune disease
molecules, or degraded self-structures may initiate autoimmunity via molecular mimicry. This may increase the chances of developing Sjögren's disease. Epstein–Barr
Sjögren's_disease
Autoimmune disease
can lead to disease development, including immune upregulation and molecular mimicry. Other Other environmental factors include selenium deficiency, other
Hashimoto's_thyroiditis
Animal reliance on other individuals to raise its young
usually using egg mimicry, with eggs that resemble the host's. The strategy involves a form of aggressive mimicry called Kirbyan mimicry. The evolutionary
Brood_parasitism
Medical condition affting the eyes
to molecular mimicry, in which foreign antigens and self antigens have a similar sequence, eliciting an autoimmune response. In nPAIR, the molecular mimicry
Autoimmune_retinopathy
Species of butterfly
pattern evolution and the origins of mimicry among North American admiral butterflies (Nymphalide: Limenitis)". Molecular Phylogenetics and Evolution. 39 (3):
Viceroy_(butterfly)
HPV Vaccination program in Japan
Medicine, Kindai University conducted a computational analysis of the “molecular mimicry hypothesis,” which has been cited as a basis for claims that HPV vaccination
HPV_vaccination_in_Japan
Strategy where one sex mimics the opposite sex
Sexual mimicry occurs when one sex mimics the opposite sex in its behavior, appearance, or chemical signalling. It is more commonly seen within invertebrate
Sexual_mimicry
Protein
proliferation in mice. The presence of the F-box domain is an example of molecular mimicry of eukaryotic F-box by which Legionella exploits the proteasomal degradation
AnkB_F-Box
Vertebrate natural glucocorticoid hormone
1002/cncr.31943. PMC 6467795. PMID 30768779. Wheatland R (May 2004). "Molecular mimicry of ACTH in SARS – implications for corticosteroid treatment and prophylaxis"
Cortisol
Inflammation of a nerve or generally any part of the nervous system
commonly an upper respiratory infection or gastroenteritis, due to molecular mimicry between peripheral nerve and microbial antigens. AIDP, which represents
Neuritis
Study of how viruses cause diseases
which occurs via different proposed mechanisms: molecular mimicry and bystander mechanism. Molecular mimicry refers to an overlap in structural similarity
Viral_pathogenesis
Species of insect
species of one katydid, it was found that this was accomplished by the molecular mimicry of host proteins, which were linked to neurotransmitter release. In
Caedicia_simplex
Informal grouping of viruses
a mere 13% of disease-free brain tissues possessed the virus. The molecular mimicry hypothesis, in which T cells confuse an HHV-6 viral protein with myelin
Human_herpesvirus_6
Butterflies of family Papilionidae
Bettina; ffrench-Constant, Richard H. (May 2000). "The molecular basis of melanism and mimicry in a swallowtail butterfly". Current Biology. 10 (10):
Swallowtail_butterfly
Medical condition
triggering an inflammatory response. Alternatively, by means of molecular mimicry, which involves the host's immune system reacting to these antigens
Enteropathic_arthropathy
Flu vaccine
demonstrated that T-cells stimulated by Pandemrix were cross-reactive by molecular mimicry with part of the hypocretin peptide, the loss of which is associated
Pandemrix
Lack of red blood cells due to vitamin B12 deficiency
infection may cause gastric autoimmunity by a mechanism known as molecular mimicry. Antibodies produced by the immune system can be cross-reactive and
Pernicious_anemia
Evolutionary strategy
Pouyannian mimicry Pouyannian mimicry is a form of mimicry in plants that deceives an insect into attempting to copulate with a flower. The flower mimics
Pouyannian_mimicry
Type of hormone
ISSN 2230-8210. PMC 3079864. PMID 21584161. Wheatland R (2004). "Molecular mimicry of ACTH in SARS - implications for corticosteroid treatment and prophylaxis"
Stress_hormone
Inflammatory demyelinating disease
as a possible pathophysiologic mechanism. Other reports point to molecular mimicry between MOG and some viruses as a possible etiology. Demyelinating
MOG_antibody_disease
Parasitic creature
response and neural function. Other sources suggest a possible origin in molecular mimicry. Mermithid nematodes infect arthropods, residing in their haemocoel
Behavior-altering_parasite
Accumulation of collagen in the skin and internal organs
association. It may also be caused by an immune reaction to a virus (molecular mimicry) or by toxins. The Juvenile Scleroderma Network is an organization
Systemic_scleroderma
Species of horsehair worm
the Wnt family that are similar to insect proteins, which suggests molecular mimicry as a possible source for behavioral manipulation. Should the cricket
Paragordius_tricuspidatus
Chemical compound
R, Binda C, Tortorici M, McCammon JA, Mattevi A (February 2011). "Molecular mimicry and ligand recognition in binding and catalysis by the histone demethylase
Bomedemstat
Species of bacterium
blood. Research conducted at King's College, London has implicated molecular mimicry between HLA-B27 and two Klebsiella surface molecules as the cause
Klebsiella_pneumoniae
Red rash due to infection with parvovirus B19
due to being immunocompromised. This happens due to processes like molecular mimicry, cell death, and enzyme activation. While relatively rare, those who
Fifth_disease
Mechanism used in cells
of the ribosomal RNA to which the protein binds, in an example of molecular mimicry. Zengel JM, Lindahl L (1994). "Diverse mechanisms for regulating ribosomal
Ribosomal_protein_leader
Species of bacterium
antibodies. Campylobacter infections often precede GBS, indicating that molecular mimicry between the bacteria and host nervous tissues may be the underlying
Campylobacter_jejuni
Archaic theory of chronic disease
inflammation, and probably, among other immunologic mechanisms, by molecular mimicry resulting in antigenic crossreaction with host biomolecules, while
Focal_infection_theory
Parasitic flatworm
The appearance and behaviour of the sporocysts is a case of aggressive mimicry, where the parasite vaguely resembles the food of the host, thereby gaining
Leucochloridium_paradoxum
Impaired flow of bile from the liver to the small intestine
possess a similar PDC-E2 as humans which could trigger autoimmunity via molecular mimicry. Chronic cholestasis is a feature in primary sclerosing cholangitis
Cholestasis
Blood disorder in which antibodies target red blood cells
immuno-allergic mechanism, drug-independent autoantibodies due to molecular mimicry, or nonspecific stimulation of the immune system. AIHA cannot be attributed
Autoimmune_hemolytic_anemia
Disease in the valves of the heart
Cellular and Molecular Immunology (10th ed.). Elsevier. p. 371. ISBN 978-0-323-75748-5. Cunningham, Madeleine W. (2019). "Molecular Mimicry, Autoimmunity
Valvular_heart_disease
American microbiologist
Era of the Microbiome: Persistent Pathogens, Autoantibodies, and Molecular Mimicry". Discovery Medicine. 25 (140): 299–308. PMID 30021103. Proal, Amy
Amy_Proal
Family of wasps
have eight phenotypically distinct and geographically limited Müllerian mimicry rings (Desert, Eastern, Madrean, Texan, Red-headed Timulla, Black-headed
Velvet_ant
Species having two or more distinct forms
in many organisms. Other examples are mimetic forms of butterflies (see mimicry), and human hemoglobin and blood types. According to the theory of evolution
Polymorphism_(biology)
Vasculogenic mimicry (VM) is a strategy used by tumors to ensure sufficient blood supply is brought to its cells through establishing new tumor vascularization
Vasculogenic_mimicry
Group of transport proteins
transport a neurotoxicant, the methylmercury-L-cysteine complex, by molecular mimicry. Hip1 of S. cerevisiae (TC #2.A.3.1.5) has been implicated in heavy
APC_Family
Species of butterfly
females, which are often given as an example of Batesian mimicry in insects. This female-limited mimicry was first described in 1869 by Roland Trimen. Males
Papilio_dardanus
Species of snake
due to mimicry. Whether this is classical Batesian mimicry, classical Müllerian mimicry, a modified form of Müllerian mimicry, or no mimicry at all,
Erythrolamprus_aesculapii
Immune response by adaptive immune system
(akin to secondary immune response). Moreover, many organisms exhibit molecular mimicry, which involves showing those antigens on their surface that are antigenically
Polyclonal_B_cell_response
Protein that in humans is encoded by the IL33 gene
S2CID 42558099. Roussel L, Erard M, Cayrol C, Girard JP (October 2008). "Molecular mimicry between IL-33 and KSHV for attachment to chromatin through the H2A-H2B
Interleukin_33
Class of pharmaceutical drugs
Wilkins. pp. 368–376. Nancy, Joy; University of Canterbury (2019). Molecular mimicry of anti-migraine drugs with neurotransmitters, dopamine (DA) & serotonin
Triptan
Clusters of receptor proteins
endogenous ligands is a molecular mechanism for the missing-self hypothesis of NK activation. A number of examples of molecular mimicry by pathogens, emulating
Paired_receptors
He and his group originated several important concepts, including molecular mimicry, disease associated with immune complexes, and the idea that persistent
Michael_Oldstone
Biological process
Pseudocopulation in Pouyannian mimicry Pseudocopulation is a behavior similar to copulation that serves a reproductive function for one or both participants
Pseudocopulation
Bacterium-produced toxin
Lewis, Amanda L (2023). "Gardnerella Vaginolysin Potentiates Glycan Molecular Mimicry by Neisseria gonorrhoeae". The Journal of Infectious Diseases. 228
Vaginolysin
Hunziker IP, Kwappenberg KM, Reichen J, Melief CJ, Cerny A (1999). "Molecular mimicry of human cytochrome P450 by hepatitis C virus at the level of cytotoxic
Liver kidney microsomal type 1 antibody
Liver_kidney_microsomal_type_1_antibody
Australian immunologist (born 1936)
Ebringer is the pioneer researcher behind autoimmune disease and "molecular mimicry," and was head of the Middlesex AS (Ankylosing Spondylitis) Clinic
Alan_Ebringer
Species of butterfly
cosmopolitan genus Limenitis. It has been studied for its evolution of mimicry, and for the several stable hybrid wing patterns within this nominal species;
Limenitis_arthemis
Protein family
predisposition to MS to the MBP gene, though a majority have not. A "molecular mimicry" hypothesis of multiple sclerosis has been suggested, in which T cells
Myelin_basic_protein
American rheumatologist
joints of rheumatoid arthritis patients. These studies demonstrated molecular mimicry between these microbial and human proteins, and in some cases, Prevotella
Allen_Steere
Hardened insect forewing
A Greek–English Lexicon at the Perseus Project. Tihelka, Erik et al. "Mimicry in Cretaceous Bugs." iScience vol. 23,7 (2020): 101280. doi:10.1016/j.isci
Elytron
Use of mimicry as an anti-predator adaptation in animals with backbones
In evolutionary biology, mimicry in vertebrates is mimicry by a vertebrate of some model (an animal, not necessarily a vertebrate), deceiving some other
Mimicry_in_vertebrates
Order of arachnids
of glandular emissions of two other quinone-producing species. Mimicry (Müllerian mimicry) occurring between Brazilian harvestmen that resemble others could
Opiliones
Family of beetles
suggestions that they and some species of chrysomelids form Müllerian mimicry rings particularly to defend them from birds. Despite their chemical defenses
Coccinellidae
Directional movement of a cell away from a substance
5115. hdl:11577/156399. PMID 16210615. Howard, J; et al. (1998). "Molecular mimicry of the inflammation modulatory proteins (IMPs) of poxviruses: evasion
Chemorepulsion
Basal body Base Base analogue Base pair Base pairs Base sequence Batesian mimicry Bayesian analysis Bead theory Behavioral genetics Behavioural genetics
Index_of_genetics_articles
MIMIC (immunology) Mimotope Minor histocompatibility antigen Mitogen Molecular mimicry Monoclonal antibody Monoclonal antibody therapy Monokine Mononuclear
Index_of_immunology_articles
cell injury, epithelial adherence, cellular invasion, inflammation, molecular mimicry and resistance to immunologic clearance. The group focuses on the
Victor_Nizet
Human disease
Hellström C, Kammer P, Biström M, Ayoglu B, et al. (August 2019). "Molecular mimicry between Anoctamin 2 and Epstein-Barr virus nuclear antigen 1 associates
Inflammatory demyelinating diseases of the central nervous system
Inflammatory_demyelinating_diseases_of_the_central_nervous_system
Ecological interaction between taxa
types of mimicry are Batesian and Müllerian, the first involving one-sided exploitation, the second providing mutual benefit. Batesian mimicry is an exploitative
Symbiosis
Genus of insect
protective Müllerian mimicry. Harmless insects such as hoverflies often derive protection from resembling bumblebees, in Batesian mimicry, and may be confused
Bumblebee
Genus of bivalves
Some species, notably Lampsilis ovata (pocketbook mussel) use aggressive mimicry to lure large predatory fish by using their mantle as a lure, ejecting
Lampsilis
Genus of snakes
due to mimicry. Whether this is classical Batesian mimicry, classical Müllerian mimicry, a modified form of Müllerian mimicry, or no mimicry at all,
Erythrolamprus
Family of birds
out of the nest. Parasitic cuckoos that show the highest levels of egg mimicry are those whose hosts exhibit high levels of egg rejection behaviour. Some
Cuckoo
General appearance of an animal
signal their sexual status to other members of the same species; and in mimicry, taking advantage of the warning coloration of another species. Some animals
Animal_coloration
Clade of insects
in many harmless insects that mimic bees or wasps, a form of Batesian mimicry. The largest species of bee is thought to be Wallace's giant bee Megachile
Bee
Genus of birds
The song of the lyrebird is a mixture of elements of its own song and mimicry of other species. Lyrebirds render with great fidelity the individual songs
Lyrebird
Study of genetics in natural populations
of such traits include flowering time, drought tolerance, polymorphism, mimicry, and avoidance of attacks by predators. Research usually involves a mixture
Ecological_genetics
Emission of light by a living organism
of bioluminescence by animals include counterillumination camouflage, mimicry of other animals, for example to lure prey, and signaling to other individuals
Bioluminescence
Parasitologist
Disease in Aboriginal Australians Provides Support for Pathogenic Molecular Mimicry". The Journal of Infectious Diseases. 216 (11): 1460–1470. doi:10
Jenefer_Blackwell
Indian immunologist and structural biologist
of immunology involving structural biology of immune recognition, molecular mimicry and allergy. Salunke has been awarded Shanti Swarup Bhatnagar Prize
Dinakar_Mashnu_Salunke
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