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Accumulation of collagen in the skin and internal organs
Systemic scleroderma, or systemic sclerosis, is an autoimmune rheumatic disease characterised by excessive production and accumulation of collagen, called
Systemic_scleroderma
Group of autoimmune diseases resulting in abnormal growth of connective tissue
year develop the systemic form. The condition most often begins in middle age. Women are more often affected than men. Scleroderma symptoms were first
Scleroderma
Connective tissue disorder
spares the kidneys (a feature more common in the related condition systemic scleroderma). If the lungs are involved, it is usually in the form of pulmonary
CREST_syndrome
Form of scleroderma involving isolated patches of hardened skin
Morphea is a form of scleroderma that mainly involves isolated patches of hardened skin on the face, hands, and feet, or anywhere else on the body, usually
Morphea
Anti-topoisomerase antibody
diffuse systemic scleroderma (with a sensitivity of 28–70%), but is also seen in 10–18% of cases of the more limited form of systemic scleroderma called
Anti-Scl-70_antibodies
Small dilated blood vessels
radiation proctitis Chemotherapy Carcinoid syndrome Limited systemic sclerosis/scleroderma (a scleroderma sub-type) Chronic treatment with topical corticosteroids
Telangiectasia
Hardening of finger or toe skin into a claw-like shape
months or even years by Raynaud's phenomenon when it is part of systemic scleroderma.[citation needed] The term "sclerodactyly" comes from Greek skleros 'hard'
Sclerodactyly
Autoimmune disease in which the immune system attacks healthy tissue
Lupus, formally called systemic lupus erythematosus (SLE), is an autoimmune disease in which the body's immune system mistakenly attacks healthy tissue
Lupus
Autoantibody that binds to contents of the cell nucleus
diagnosis of some autoimmune disorders, including systemic lupus erythematosus, Sjögren syndrome, scleroderma, mixed connective tissue disease, polymyositis
Antinuclear_antibody
Stiffening of a tissue or anatomical feature
bile duct by scarring and repeated inflammation. Systemic sclerosis (progressive systemic scleroderma), a rare, chronic disease which affects the skin
Sclerosis_(medicine)
Medical condition
"window" to systemic microvascular dysfunction. Although its main application is within the connective tissue diseases such as systemic scleroderma and dermatomyositis
Microangiopathy
Category of diseases
Systemic lupus erythematosus - chronic, complex autoimmune inflammatory disorder that can affect every organ in the body. Scleroderma and systemic scleroderma
Connective_tissue_disease
Topics referred to by the same term
infection Systemic lupus erythematosus, a chronic autoimmune connective tissue disease that can affect any part of the body Systemic scleroderma, also known
Systemic
Autoimmune disease
attacks the body). People with scleromyositis have symptoms of both systemic scleroderma and either polymyositis or dermatomyositis, and is therefore considered
Scleromyositis
Medical disorders that destroy blood vessels by inflammation
Conference nomenclature. Primary systemic vasculitis is categorized by the size of the vessels mainly involved. Primary systemic vasculitis includes large-vessel
Vasculitis
Medical condition in which spasm of arteries causes episodes of reduced blood flow
Raynaud's has a number of associations: Connective tissue disorders: Scleroderma Systemic lupus erythematosus Rheumatoid arthritis Sjögren's disease Dermatomyositis
Raynaud_syndrome
Autoantibodies
autoantibody seen mainly in diffuse systemic scleroderma, but is also seen the more limited form of systemic scleroderma called CREST syndrome. However, CREST
Anti-topoisomerase_antibodies
Increased blood pressure in lung arteries
In systemic scleroderma, the incidence has been estimated to be 8 to 12% of all patients; in rheumatoid arthritis it is rare. However, in systemic lupus
Pulmonary_hypertension
Medical condition
also present in other autoimmune diseases such as systemic lupus erythematosus, polymyositis, scleroderma, etc. MCTD was characterized as an individual disease
Mixed connective tissue disease
Mixed_connective_tissue_disease
Medical condition
yellow-ish spots on the arms or legs. The syndrome, a special case of scleroderma, is named after the American physician, Telfer B. Reynolds, MD (1921–2004)
Reynolds_syndrome
Thai-French novelist (1932–2005)
couple. In 2001, Marayat suddenly fell ill. She was diagnosed with systemic scleroderma, a rare and incurable autoimmune disease, which had first given her
Emmanuelle_Arsan
Abnormally small mouth
seen as complication of facial burns. It can also be a feature of systemic scleroderma. Acquired microstomia is most often managed with surgical intervention
Microstomia
Medical condition
Relapsing polychondritis is a systemic disease characterized by repeated episodes of inflammation and in some cases deterioration of cartilage. The disease
Relapsing_polychondritis
Medical condition
and can be associated with subacute infective endocarditis, scleroderma, trichinosis, systemic lupus erythematosus (SLE), rheumatoid arthritis, psoriatic
Splinter_hemorrhage
Aspect of women's health
thyroiditis, Graves' disease), rheumatic diseases (systemic lupus erythematosus, rheumatoid arthritis, scleroderma, and Sjögren's disease), hepatobiliary diseases
Autoimmune_disease_in_women
Inflammation due to periodic blood vessel blockage
worse, or the EM is eventually a symptom of another disease such as systemic scleroderma.[citation needed] Some suffering with EM are prescribed ketamine
Erythromelalgia
Medical techniques to separate one or more components of blood
arthritis Refractory Immunoadsorption II Schizophrenia Plasmapheresis IV Systemic scleroderma Plasmapheresis III Photopheresis IV Sepsis with multi-organ failure
Apheresis
Immune response against an organism's own healthy cells
include celiac disease, diabetes mellitus type 1, Henoch–Schönlein purpura, systemic lupus erythematosus, Sjögren syndrome, eosinophilic granulomatosis with
Autoimmunity
arthritis Rheumatoid arthritis Ehlers-Danlos Syndrome Sarcoidosis Scleroderma Systemic lupus erythematosus Temporal arteritis Relapsing polychondritis Granulomatosis
List of systemic diseases with ocular manifestations
List_of_systemic_diseases_with_ocular_manifestations
Polish-American dermatologist
adhesion molecules in systemic sclerosis (scleroderma) and showed that activated peripheral blood mononuclear cells of scleroderma patients exhibit increased
Lidia_Rudnicka
Medical condition
syndrome. The presentation is similar to that of scleroderma or systemic sclerosis. However, unlike scleroderma, eosinophilic fasciitis affects the deeper fascial
Eosinophilic_fasciitis
Medication
especially on fingertips and less commonly the knuckles — in people with systemic scleroderma. Bosentan is contraindicated in people taking glyburide due to an
Bosentan
Chemical compound
development for the treatment of diffuse cutaneous systemic sclerosis, also known as scleroderma. It was dropped from further development in favour of
Metelimumab
British fashion designer
V&A Exhibition Wedding Dresses 1775–2014. Ian succumbed to Systemic Sclerosis (Scleroderma), an autoimmune disease on 18 October 2022. Rothstein, Ronald;
Ian_Stuart_(designer)
Region of a genome which regulates expression of genes related to cell identity
Alzheimer's disease, lupus, rheumatoid arthritis, multiple sclerosis, systemic scleroderma, primary biliary cirrhosis, Crohn's disease, Graves disease, vitiligo
Super-enhancer
Mammalian protein
collagen aminopropeptide levels in serum of patients with progressive systemic scleroderma". The Journal of Investigative Dermatology. 87 (6): 788–791. doi:10
Collagen,_type_III,_alpha_1
Skin disease
Papular Disseminated intravascular coagulation Vasculitis Indurated Scleroderma/morphea Granuloma annulare Lichen sclerosis et atrophicus Necrobiosis
Pityriasis_rosea
Chemical compound
Asengeprast (development code FT011) is an experimental scleroderma drug candidate. It is a small molecule inhibitor of the G-protein coupled receptor
Asengeprast
Medical condition
of African descent, and TTP secondary to autoimmune disorders such as systemic lupus erythematosus occurs more frequently in people of African descent
Thrombotic thrombocytopenic purpura
Thrombotic_thrombocytopenic_purpura
Melanin spots on skin
Papular Disseminated intravascular coagulation Vasculitis Indurated Scleroderma/morphea Granuloma annulare Lichen sclerosis et atrophicus Necrobiosis
Freckle
Medical condition where blood clots block small blood vessels
Gando S (1999). "Disseminated intravascular coagulation and sustained systemic inflammatory response syndrome predict organ dysfunctions after trauma:
Disseminated intravascular coagulation
Disseminated_intravascular_coagulation
Medical condition
Papular Disseminated intravascular coagulation Vasculitis Indurated Scleroderma/morphea Granuloma annulare Lichen sclerosis et atrophicus Necrobiosis
Keloid
Autoimmune diseases of the skin
unstable plaque psoriasis, particularly following the abrupt withdrawal of systemic glucocorticoids. This form of psoriasis can be fatal as the extreme inflammation
Psoriasis
Type of autoantibody
independently. This is in contrast to rheumatoid arthritis with systemic sclerosis (scleroderma) because anti-cardiolipin antibodies are present in both conditions
Anti-cardiolipin_antibodies
Formation of calcium deposits in soft tissue
Dermatomyositis Fahr's syndrome Hyperphosphatemia Primrose syndrome Scleroderma Wikimedia Commons has media related to Calcinosis. Le, Cuong; Bedocs
Calcinosis
Fungal infection
Papular Disseminated intravascular coagulation Vasculitis Indurated Scleroderma/morphea Granuloma annulare Lichen sclerosis et atrophicus Necrobiosis
Coccidioidomycosis
Long-term form of skin inflammation
needed if food allergies are suspected. More severe AD cases may need systemic medicines such as ciclosporin, methotrexate, dupilumab, or baricitinib
Atopic_dermatitis
Atrophoderma of Pasini and Pierini (dyschromic and atrophic variation of scleroderma, morphea plana atrophica, sclérodermie atrophique d'emblée) Calcinosis–Raynaud
List_of_skin_conditions
Auto-immune disease
autoimmune disease (such as systemic lupus erythematosus (SLE), scleroderma, mixed connective tissue disease, Sjögren syndrome, systemic sclerosis, polymyositis
Undifferentiated connective tissue disease
Undifferentiated_connective_tissue_disease
Benign tumor made of fat tissue
Papular Disseminated intravascular coagulation Vasculitis Indurated Scleroderma/morphea Granuloma annulare Lichen sclerosis et atrophicus Necrobiosis
Lipoma
asthma and white blood cell diseases Metelimumab mab human TGF-β1 systemic scleroderma Milatuzumab mab humanized CD74 multiple myeloma and other hematological
List of therapeutic monoclonal antibodies
List_of_therapeutic_monoclonal_antibodies
Group of diseases
inflammatory bowel disease, adult-onset Still's disease, scleroderma, juvenile idiopathic arthritis, and systemic lupus erythematosus (SLE). Symptoms of inflammatory
Inflammatory_arthritis
Human disease
One review found that the efficacy of permethrin is similar to that of systemic or topical ivermectin. A separate review found that although oral ivermectin
Scabies
Medical condition
Papular Disseminated intravascular coagulation Vasculitis Indurated Scleroderma/morphea Granuloma annulare Lichen sclerosis et atrophicus Necrobiosis
Pattern_hair_loss
Rough skin induced by UV exposure
number of actinic keratoses. For secondary prevention of actinic keratosis, systemic, low-dose acitretin was found to be safe, well tolerated and moderately
Actinic_keratosis
Loss of hair from areas on the body
in association with alopecia areata. Alopecia areata is thought to be a systemic autoimmune disorder in which the body attacks its own anagen hair follicles
Alopecia_areata
Localized collection of pus in body tissue
Papular Disseminated intravascular coagulation Vasculitis Indurated Scleroderma/morphea Granuloma annulare Lichen sclerosis et atrophicus Necrobiosis
Abscess
Skin condition characterized by pimples
Margolis DJ, James WD (February 2019). "Approaches to limit systemic antibiotic use in acne: Systemic alternatives, emerging topical therapies, dietary modification
Acne
Skin condition characterized by small bumps caused by overproduction of keratin
Pedis Manuum Faciei) Pityriasis rosea Secondary syphilis Mycosis fungoides Systemic lupus erythematosus Pityriasis rubra pilaris Parapsoriasis Ichthyosis Blistering
Keratosis_pilaris
Human viral disease
Papular Disseminated intravascular coagulation Vasculitis Indurated Scleroderma/morphea Granuloma annulare Lichen sclerosis et atrophicus Necrobiosis
Chickenpox
Filipino activist (1961–2020)
the Philippines' martial law, in 2016. Quimpo was diagnosed with systemic scleroderma, a painful autoimmune disease, in 2018, and died two years later
Susan_Quimpo
Form of breast imaging
in MRI contrast agents, resembles scleromyxedema and to some extent scleroderma. It may occur months after contrast has been injected. Patients with
Breast_MRI
Inflammation of skin surrounding a nail
Paronychia can occur with diabetes, drug-induced immunosuppression, or systemic diseases such as pemphigus. Paronychia aka "swollen nail" may be divided
Paronychia
Benign skin tumor originating in keratocytes
Papular Disseminated intravascular coagulation Vasculitis Indurated Scleroderma/morphea Granuloma annulare Lichen sclerosis et atrophicus Necrobiosis
Seborrheic_keratosis
Genital ulcer
Papular Disseminated intravascular coagulation Vasculitis Indurated Scleroderma/morphea Granuloma annulare Lichen sclerosis et atrophicus Necrobiosis
Chancre
Fungal infection of the lungs
disseminated disease are diverse and often present as a nondescript rash with systemic complaints. Diagnosis is best established by urine antigen testing, as
Histoplasmosis
Any medical condition that affects the integumentary system
Papular Disseminated intravascular coagulation Vasculitis Indurated Scleroderma/morphea Granuloma annulare Lichen sclerosis et atrophicus Necrobiosis
Skin_condition
Inflammation of fat tissue under the skin
Schwartz, R. A.; Nervi, S. J. (2007). "Erythema nodosum: A sign of systemic disease". American Family Physician. 75 (5): 695–700. PMID 17375516. Gilchrist
Erythema_nodosum
Thickened and hardened area of skin
Papular Disseminated intravascular coagulation Vasculitis Indurated Scleroderma/morphea Granuloma annulare Lichen sclerosis et atrophicus Necrobiosis
Callus
Mole or birthmark; visible, circumscribed, chronic skin lesion
Papular Disseminated intravascular coagulation Vasculitis Indurated Scleroderma/morphea Granuloma annulare Lichen sclerosis et atrophicus Necrobiosis
Nevus
Skin disease
versicolor in the event of widespread, severe, recalcitrant or recurrent cases. Systemic therapies include itraconazole (200 mg daily for seven days) and fluconazole
Tinea_versicolor
Chronic autoimmune disorder leading to blistering skin
such as bullous pemphigoid, linear IgA bullous dermatosis, and bullous systemic lupus erythematosus. The diagnosis may be confirmed by a simple blood test
Dermatitis_herpetiformis
Itchy skin rash due to clogged sweat glands
Papular Disseminated intravascular coagulation Vasculitis Indurated Scleroderma/morphea Granuloma annulare Lichen sclerosis et atrophicus Necrobiosis
Miliaria
Fluid found in the cavities of synovial joints
disease Trauma Rheumatic fever Chronic gout or pseudogout Scleroderma Polymyositis Systemic lupus erythematosus Erythema nodosum Neuropathic arthropathy
Synovial_fluid
Skin condition where patches lose pigment
thyroiditis, scleroderma, rheumatoid arthritis, type 1 diabetes mellitus, psoriasis, Addison's disease, pernicious anemia, alopecia areata, systemic lupus erythematosus
Vitiligo
Human disease (bacterial infection)
Papular Disseminated intravascular coagulation Vasculitis Indurated Scleroderma/morphea Granuloma annulare Lichen sclerosis et atrophicus Necrobiosis
Impetigo
Skin cancer originating in melanocytes
anti-PD-1 antibodies are more effective than anti-CTLA4 antibodies with less systemic toxicity. The five-year progression-free survival for immunotherapy with
Melanoma
Medical condition
Papular Disseminated intravascular coagulation Vasculitis Indurated Scleroderma/morphea Granuloma annulare Lichen sclerosis et atrophicus Necrobiosis
Ingrown_nail
Virus that causes digestive upset and sometimes heart damage
Papular Disseminated intravascular coagulation Vasculitis Indurated Scleroderma/morphea Granuloma annulare Lichen sclerosis et atrophicus Necrobiosis
Coxsackievirus
Fungal infection due to any type of Candida
frequently than in healthy individuals and have a higher potential of becoming systemic, causing a much more serious condition, a fungemia called candidemia. Symptoms
Candidiasis
Medical condition
Suzuki, Kimihiro (2002). "A variant of acrokeratoelastoidosis in systemic scleroderma: Report of 7 cases". Journal of the American Academy of Dermatology
Acrokeratoelastoidosis of Costa
Acrokeratoelastoidosis_of_Costa
Fungal infection
Papular Disseminated intravascular coagulation Vasculitis Indurated Scleroderma/morphea Granuloma annulare Lichen sclerosis et atrophicus Necrobiosis
Tinea_cruris
Medical condition with rash and bleeding risk
infection (HIV or HCV), malignancy (leukemia), autoimmune conditions (systemic lupus erythematosus or antiphospholipid syndrome), onyalai, and others
Immune thrombocytopenic purpura
Immune_thrombocytopenic_purpura
Small benign skin tumor
medical evidence. Cutaneous horn List of cutaneous neoplasms associated with systemic syndromes Molluscum contagiosum—A viral disease which is similar in appearance
Skin_tag
Excess connective tissue in healing
pneumoconiosis Retroperitoneal fibrosis (soft tissue of the retroperitoneum) Scleroderma/systemic sclerosis (skin, lungs) Some forms of adhesive capsulitis (shoulder)
Fibrosis
Skin infection caused by fungus
Papular Disseminated intravascular coagulation Vasculitis Indurated Scleroderma/morphea Granuloma annulare Lichen sclerosis et atrophicus Necrobiosis
Athlete's_foot
Skin disease characterized by red, raised, and itchy bumps
disease, type 1 diabetes, rheumatoid arthritis, Sjögren's syndrome or systemic lupus erythematosus. Hive-like rashes commonly accompany viral illnesses
Hives
Bacterial infection of the inner layers of the skin called the dermis
intervention, include purple bullae, skin sloughing, subcutaneous edema, and systemic toxicity. Misdiagnosis can occur in up to 30% of people with suspected
Cellulitis
Inflammation from allergen or irritant exposure
Papular Disseminated intravascular coagulation Vasculitis Indurated Scleroderma/morphea Granuloma annulare Lichen sclerosis et atrophicus Necrobiosis
Contact_dermatitis
Medical condition
fever, it has since been shown to occur also in SLE, Sjögren syndrome, scleroderma, dermatomyositis, psoriatic arthritis, vasculitis, ankylosing spondylitis
Jaccoud_arthropathy
Rash in several vector-borne diseases
Papular Disseminated intravascular coagulation Vasculitis Indurated Scleroderma/morphea Granuloma annulare Lichen sclerosis et atrophicus Necrobiosis
Erythema_migrans
Medical condition
Baibergenova, Akerke (2017-09-01). "Melasma: systematic review of the systemic treatments". International Journal of Dermatology. 56 (9): 902–908. doi:10
Melasma
Alleged condition of hair suddenly turning white
Pedis Manuum Faciei) Pityriasis rosea Secondary syphilis Mycosis fungoides Systemic lupus erythematosus Pityriasis rubra pilaris Parapsoriasis Ichthyosis Blistering
Canities_subita
Medical condition
syndrome Atypical hemolytic uremic syndrome Cancer Malignant hypertension Scleroderma renal crisis Malfunctioning cardiac valves (called the "Waring Blender
Microangiopathic hemolytic anemia
Microangiopathic_hemolytic_anemia
Human and animal disease of follicles
prescribed. Oral antibiotics may also be used. Some patients may benefit from systemic narrow-spectrum penicillinase-resistant penicillins (such as dicloxacillin
Folliculitis
Medical condition
disease. It has also been associated with autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, Lyme disease and Addison's disease
Granuloma_annulare
Viral infection of the skin
flaking/scaling (5%), erosion (2%), and weeping/exudate (2%)." Potential systemic absorption of imiquimod, with negative effects on white blood cell counts
Molluscum_contagiosum
Medical condition
better tolerated than itraconazole. For superficial white onychomycosis, systemic rather than topical antifungal therapy is advised. Topical agents include
Onychomycosis
Skin disease
have little effectiveness in the treatment of seborrhoeic dermatitis. Systemic therapy with oral antifungals including itraconazole, fluconazole, ketoconazole
Seborrhoeic_dermatitis
Abnormally rapid shedding of hair
Papular Disseminated intravascular coagulation Vasculitis Indurated Scleroderma/morphea Granuloma annulare Lichen sclerosis et atrophicus Necrobiosis
Telogen_effluvium
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