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Chemical compound
Cyclic ADP-ribose, frequently abbreviated as cADPR, is a cyclic adenine nucleotide (like cAMP) with two phosphate groups present on 5' OH of the adenosine
Cyclic_ADP-ribose
Chemical compound which is reduced and oxidized
reactions, as a donor of ADP-ribose moieties in ADP-ribosylation reactions, as a precursor of the second messenger molecule cyclic ADP-ribose, as well as acting
Nicotinamide adenine dinucleotide
Nicotinamide_adenine_dinucleotide
Protein found in humans
CD38 (cluster of differentiation 38), also known as cyclic ADP ribose hydrolase, is a glycoprotein found on the surface of many immune cells (white blood
CD38
Chemical compound
diphosphate ribose (ADPR) is an ester molecule formed into chains by the enzyme poly ADP ribose polymerase. ADPR is created from cyclic ADP-ribose (cADPR)
Adenosine_diphosphate_ribose
Addition of one or more ADP-ribose moieties to a protein
ADP-ribosylation is the addition of one or more ADP-ribose moieties to a protein. It is a reversible post-translational modification that is involved in
ADP-ribosylation
Group of simple sugar and carbohydrate compounds
first isolated and from which they prepared l-ribose. Like most sugars, ribose exists as a mixture of cyclic forms in equilibrium with its linear form, and
Ribose
Enzyme
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase (EC 3.2.2.6), which catalyzes the same reaction, this reaction does not proceed through a cyclic ADP-ribose
NAD+_glycohydrolase
Enzyme
In enzymology, a ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase (EC 3.2.2.6) is a bifunctional enzyme that catalyzes the chemical reaction NAD+ + H2O
ADP-ribosyl_cyclase
Enzyme
ADP-ribose diphosphatase (EC 3.6.1.13) is an enzyme that catalyzes a hydrolysis reaction in which water nucleophilically attacks ADP-ribose to produce
ADP-ribose_diphosphatase
Protein-coding gene in the species Homo sapiens
the ADP-ribosyl cyclase family of enzymes that catalyze the formation of nicotinamide and adenosine diphosphate ribose (ADPR) or cyclic ADP-ribose (cADPR)
BST1
Chemical compound
extracellular stimuli. Like its mechanistic cousins, IP3 and cyclic adenosine diphosphoribose (Cyclic ADP-ribose), NAADP binds to and opens Ca2+ channels on intracellular
Nicotinic acid adenine dinucleotide phosphate
Nicotinic_acid_adenine_dinucleotide_phosphate
Chemical element with atomic number 5 (B)
monophosphate (ADP) and S-adenosyl methionine (SAM-e), two compounds involved in important cellular functions. Furthermore, boron appears to inhibit cyclic ADP-ribose
Boron
Chemical compound
2019). "A Cell-Permeant Mimetic of NMN Activates SARM1 to Produce Cyclic ADP-Ribose and Induce Non-apoptotic Cell Death". iScience. 15: 452–466. Bibcode:2019iSci
Nicotinamide_mononucleotide
Biological process of axonal degeneration
SARM1 catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. SARM1 activation locally triggers a rapid collapse
Wallerian_degeneration
Chemical compound
carriers adenosine mono-, di-, and triphosphate, also known as AMP/ADP/ATP. Cyclic adenosine monophosphate (cAMP) is pervasive in signal transduction
Adenosine
Energy-carrying molecule in living cells
it consists of three components: a nitrogenous base (adenine), the sugar ribose, and the triphosphate. ATP consists of three parts: a sugar, an amine base
Adenosine_triphosphate
Charged chemical group of the form >CO–
intermediate. An example of this reaction can be seen in the cyclization cyclic ADP ribose, which is an important molecule for intracellular calcium signaling
Oxocarbenium
Class of intracellular transport proteins
muscle cells. In heart and pancreas cells, another second messenger (cyclic ADP-ribose) takes part in the receptor activation. The localized and time-limited
Ryanodine_receptor
Biological molecules constituting nucleic acids
case, the ribose sugar is linear rather than forming the ring seen in other nucleotides. Examples of non-nucleic acid nucleotides cAMP, a cyclic nucleotide
Nucleotide
Chemical compound
AMP/ADP protects AMPK from being inactivated by binding to the γ-subunit and maintaining the dephosphorylation state. AMP can also exist as a cyclic structure
Adenosine_monophosphate
Protein-coding gene in the species Homo sapiens
(December 2019). "Resolving the topological enigma in Ca2+ signaling by cyclic ADP-ribose and NAADP". The Journal of Biological Chemistry. 294 (52): 19831–19843
SARM1
glycotransferase EC 2.4.99.20: 2′-phospho-ADP-ribosyl cyclase/2′-phospho-cyclic-ADP-ribose transferase EC 2.4.99.21: dolichyl-phosphooligosaccharide-protein
List_of_EC_numbers_(EC_2)
British pharmacologist (born 1963)
myriad of cellular processes with precision. Galione established that cyclic ADP-ribose regulates calcium-induced calcium release and globalisation of calcium
Antony_Galione
Class of G protein-coupled receptors involved in chemotaxis
activation NAD+ molecules will enter the cytoplasm. NAD+ is converted into cyclic ADP ribose (cADPR), a second messenger which interacts with ryanodine receptors
Formyl_peptide_receptor
Protein-coding gene in the species Homo sapiens
Higashi T, Konishi Y, Mori Y, Tominaga M (2006). "TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion". The EMBO Journal
TRPM2
Nucleotide containing ribose as its pentose component
In biochemistry, a ribonucleotide is a nucleotide containing ribose as its pentose component. It is considered a molecular precursor of nucleic acids.
Ribonucleotide
List of medical subject headings and corresponding terminology
adenosine diphosphate ribose MeSH D13.695.667.138.124.070.125.040 – o-acetyl-adp-ribose MeSH D13.695.667.138.124.070.125.195 – cyclic adp-ribose MeSH D13.695.667
List_of_MeSH_codes_(D13)
Naturally produced monosaccharide
degradation of glycogen, sphingolipids, mucopolysaccharides, and poly (ADP-ribose) polymerases. Humans do not produce cellulases, chitinases, or trehalases
Glucose
adenosine diphosphate ribose MeSH D09.408.620.569.070.125.040 – o-acetyl-adp-ribose MeSH D09.408.620.569.070.125.195 – cyclic adp-ribose MeSH D09.408.620.569
List_of_MeSH_codes_(D09)
Protein-coding gene in humans
Takasawa S, Nata K, Tohgo A, Kato I, Ikehata F, et al. (February 1997). "Cyclic ADP-ribose binds to FK506-binding protein 12.6 to release Ca2+ from islet microsomes"
FKBP1B
Toxin from bacteria that destroys or disrupts cells
this A-subunit activity is called ADP-ribosylation in which the A-subunit catalyzes the addition of an ADP-ribose group onto specific residues on a protein
Exotoxin
carbon of a ribose sugar. Adenine bonded to deoxyribose is known as deoxyadenosine, which is the version used in DNA. adenosine diphosphate (ADP) A nucleoside
Glossary of cellular and molecular biology (0–L)
Glossary_of_cellular_and_molecular_biology_(0–L)
Class of enzyme
Cyclic GMP-AMP synthase (cGAS, cGAMP synthase), belonging to the nucleotidyltransferase family, is part of the cytosolic DNA sensor that activates a type-I
Cyclic_GMP-AMP_synthase
Heterocyclic aromatic organic compound
with deoxyribose moiety and ribonucleosides (guanosine, adenosine) with ribose moiety. These nucleosides with phosphoric acid form corresponding nucleotides
Purine
Metabolic disorder leading to muscle dysfunction
AMP contains ribose, a sugar molecule that is also used to make DNA, RNA, and some enzymes. Though the body can manufacture some ribose and obtain more
Adenosine monophosphate deaminase deficiency type 1
Adenosine_monophosphate_deaminase_deficiency_type_1
Acetylcholine Actin Actinomycin D Adenine Adenosine Adenosine diphosphate (ADP) Adenosine monophosphate (AMP) Adenosine triphosphate (ATP) Adenylate cyclase
List_of_biomolecules
Chemical compound
attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine can be phosphorylated to become guanosine monophosphate (GMP), cyclic guanosine
Guanosine
nucleosidase EC 3.2.2.5: NAD+ glycohydrolase EC 3.2.2.6: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase EC 3.2.2.7: adenosine nucleosidase EC 3.2.2.8:
List_of_EC_numbers_(EC_3)
Order of positive-sense, single-stranded RNA viruses
include papain-like proteases, ADP-ribose/poly(ADP-ribose)-binding or ADP-ribose 1''-phosphate phosphatase activities and cyclic nucleotide phosphodiesterase
Nidovirales
Chemical compound
their ribose sugar. GTP has the guanine nucleobase attached to the 1' carbon of the ribose and it has the triphosphate moiety attached to ribose's 5' carbon
Guanosine_triphosphate
Chemical compound
supplements. Guggulsterone was also found to have interactions with the viral ADP ribose phosphatase enzyme of SARS-CoV-2 and has been proposed as a potential
Guggulsterone
Chemical compound
nucleoside guanosine. GMP consists of the phosphate group, the pentose sugar ribose, and the nucleobase guanine; hence it is a ribonucleotide monophosphate
Guanosine_monophosphate
Aromatic compound (C4H4N2)
how pyrimidine nucleosides can be synthesized from small molecules and ribose, driven solely by wet-dry cycles. Purine nucleosides can be synthesized
Pyrimidine
Chemical compound of RNA
hydrogen bond acceptor and a hydrogen bond donor. In RNA, uracil binds with a ribose sugar to form the ribonucleoside uridine. When a phosphate attaches to uridine
Uracil
Bitter alkaloid of the cacao plant
purine alkaloid derived from xanthosine, a nucleoside. Cleavage of the ribose and N-methylation yields 7-methylxanthosine. 7-Methylxanthosine in turn
Theobromine
Adam's Curse Adaptation Adenine Adenosine Adenovirus Adenosine diphosphate (ADP) Ala Alagille syndrome Albino Alcoholism Alkylating agent Allele Allele frequency
Index_of_genetics_articles
Protein-coding gene in the species Homo sapiens
PMID 10713066. Song D, Sakamoto S, Taniguchi T (2002). "Inhibition of poly(ADP-ribose) polymerase activity by Bcl-2 in association with the ribosomal protein
40S_ribosomal_protein_S3a
Chemical compound
vidarabine (ara-ADP) also has an inhibitory effect. Other nucleoside analogs need to be triphosphorlated to give any antiviral effect, but ara-ADP inhibits the
Vidarabine
Anticoagulant drug
increases unassisted patency of synthetic arteriovenous hemodialysis grafts. Cyclic adenosine monophosphate impairs platelet aggregation and also causes arteriolar
Dipyridamole
Biological communication between cells involving purine nucleosides and their receptors
peripheral nervous system. Receptors for adenosine (called P1) and for ATP and ADP (called P2) were distinguished in 1978. Later, the P2 receptors were subdivided
Purinergic_signalling
- cyclic AMP receptor - cyclic AMP receptor protein - cyclic AMP-responsive DNA-binding protein - cyclic electron flow - cyclic nucleotide - cyclic peptide
Index of biochemistry articles
Index_of_biochemistry_articles
Chemical compound
Radix puerariae, potentiates endothelium-independent relaxation via the cyclic AMP pathway in porcine coronary artery". European Journal of Pharmacology
Puerarin
Chemical compound
Mechanistically, the authors proposed that PDE3 inhibition raises intracellular cyclic GMP in growth-plate chondrocytes — cilostazol-treated bones showed an approximately
Cilostazol
Monoterpenoid and alcohol that is the primary component of citronella oil
gives tetrahydrogeraniol. In acidic solutions, geraniol is converted to the cyclic terpene α-terpineol. Geraniol is classified as D2B (Toxic materials causing
Geraniol
Chemical compound
(2009). "Reactive oxygen species-dependent activation of Bax and Poly(ADP)-ribose) polymerase-1 is required for mitochondrial cell death induced by triterpenoid
Quinone_methide
American chemist
also affect other targets including the retinoid X receptor (RXR), poly [ADP-ribose] polymerase 1 (PARP-1), topoisomerase II, estrogen receptor, vascular
Mark_Cushman
Set of chemical reactions in organisms
of nucleotides. Each nucleotide is composed of a phosphate attached to a ribose or deoxyribose sugar group which is attached to a nitrogenous base. Nucleic
Metabolism
Human chromosome
zeta OTOL1: encoding glycoprotein Otolin PARP14 encoding protein Poly(ADP-ribose) polymerase family member 14 PCCB: propionyl Coenzyme A carboxylase, beta
Chromosome_3
NAD+) EC 6.5.1.7: DNA ligase (ATP, ADP or GTP) EC 6.5.1.8: 3′-phosphate/5′-hydroxy nucleic acid ligase EC 6.5.1.9: cyclic 2,3-diphosphoglycerate synthase
List_of_EC_numbers_(EC_6)
Situation where tumor cells have been deprived of oxygen
flow, thereby reducing tumor hypoxia. Niacinamide also inhibits poly(ADP-ribose) polymerases (PARP-1), enzymes involved in the rejoining of DNA strand
Tumor_hypoxia
Protein-coding gene in the species Homo sapiens
P2Y12 is a chemoreceptor for adenosine diphosphate (ADP) that belongs to the Gi class of a group of G protein-coupled (GPCR) purinergic receptors. This
P2Y12
Immunoglobulin superfamily
archaea can degrade NAD+ into the products nicotinamide and ADP-ribose (ADPR) (or cyclic-ADPR). Ig-like domain is the part of receptor which is located
Interleukin-1_receptor_family
Protein-coding gene in the species Homo sapiens
current amplitude. P2X7 receptors respond to BzATP more readily than ATP. ADP and AMP are weak agonists of P2X7 receptors, but a brief exposure to ATP
P2RX7
Carbocyclic sugar
Adenine Adenosine AMP ADP ATP Cytosine Cytidine CMP CDP CTP Guanine Guanosine GMP GDP GTP Hypoxanthine Inosine IMP IDP ITP Ribose Uracil Uridine UMP UDP
Inositol
Chemical compound
by blocking phosphodiesterase which increases tissue concentrations of cyclic adenosine monophosphate (cAMP) which in turn promotes catecholamine stimulation
Aminophylline
4: Succinate—CoA ligase (GDP-forming) EC 6.2.1.5: Succinate—CoA ligase (ADP-forming) EC 6.2.1.6: Glutarate—CoA ligase EC 6.2.1.7: Cholate—CoA ligase
List_of_enzymes
Toxic, waxy organic compound
timber tree from South East Asia. It is classified as a terpenoid and a cyclic ketone. It also occurs in some other related trees in the laurel family
Camphor
Alkaloid responsible for the pungency of black pepper
can be used as an insecticide and to deter animal pests. Piperidine – a cyclic six-membered amine that results from hydrolysis of piperine Piperic acid
Piperine
Protein-coding gene in the species Homo sapiens
receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation
P2RY1
Central nervous system stimulant
which allows it to bind and block its receptors. Caffeine also increases cyclic AMP levels through nonselective inhibition of phosphodiesterase, increases
Caffeine
Organic compound (H–CHO); simplest aldehyde
formaldehyde Monomeric formaldehyde (subject of this article) Trioxane is a stable cyclic trimer of formaldehyde. Paraformaldehyde is a common form of formaldehyde
Formaldehyde
Chemical compound
2–50 μM and does not inhibit PDE8 or PDE9. Essayan, DM (November 2001). "Cyclic Nucleotide Phosphodiesterases". The Journal of Allergy and Clinical Immunology
IBMX
Chemical compound
CD001733.pub3. PMC 7061323. PMID 23235582. Essayan DM (November 2001). "Cyclic nucleotide phosphodiesterases". The Journal of Allergy and Clinical Immunology
Pentoxifylline
containing five carbon atoms. The compounds ribose and deoxyribose are both pentose sugars, which, in the form of cyclic five-membered rings, serve as the central
Glossary of cellular and molecular biology (M–Z)
Glossary_of_cellular_and_molecular_biology_(M–Z)
Chemical compound
with the sulfur atom being part of a cyclic group, similar to the structure of phenolphthalein. However, this cyclic structure could not be confirmed by
Phenol_red
Protein-coding gene in humans
SGF29. Without the K491 monomethylation, cGAS binds to poly(ADP-ribosyl)ated poly(ADP-ribose) polymerase 1 and blocks homologous recombination repair. Research
RIOX1
Pungent chemical compound in chili peppers
Pregnenolone sulfate Progesterone Pyr3 Tolfenamic acid TRPM Activators ADP-ribose BCTC Calcium (intracellular) CIM-0216 Cold Coolact P Cooling Agent 10
Capsaicin
Class of enzymes
phosphorylase since ATP is a product of the catabolic pathway. Conversely, ADP would likely stimulate sucrose phosphorylase to increase levels of ATP. Further
Sucrose_phosphorylase
Chemical compound
prostacyclin-stimulated rise in the levels of platelet adenosine 3',5'-cyclic monophosphate (cAMP) was stimulated by myricetin. Myricetin's preclinical
Myricetin
Chemical compound
neuropharm.2012.11.029. PMC 3562388. PMID 23261866. Essayan DM (November 2001). "Cyclic nucleotide phosphodiesterases". The Journal of Allergy and Clinical Immunology
Paraxanthine
Chemical stimulant produced by some plants
biosynthetic pathway of nicotine involves a coupling reaction between the two cyclic structures that comprise nicotine. Metabolic studies show that the pyridine
Nicotine
Drug used to treat respiratory diseases
2165/00002018-199106060-00006. PMID 1793525. S2CID 21875026. Essayan DM (November 2001). "Cyclic nucleotide phosphodiesterases". The Journal of Allergy and Clinical Immunology
Theophylline
Active ingredient in fermented drinks
Adenine Adenosine AMP ADP ATP Cytosine Cytidine CMP CDP CTP Guanine Guanosine GMP GDP GTP Hypoxanthine Inosine IMP IDP ITP Ribose Uracil Uridine UMP UDP
Alcohol_(drug)
Protein-coding gene in the species Homo sapiens
various adenosine and uridine nucleotides. This receptor is activated by ADP. Two transcript variants encoding the same protein have been identified for
P2RY13
Chemical compound
behavioural alterations in rats induced by rolipram and other selective adenosine cyclic 3', 5'-monophosphate phosphodiesterase inhibitors". Psychopharmacology.
Cartazolate
Chemical compound
Pregnenolone sulfate Progesterone Pyr3 Tolfenamic acid TRPM Activators ADP-ribose BCTC Calcium (intracellular) CIM-0216 Cold Coolact P Cooling Agent 10
Umbellulone
Chemical compound
Synthesis of Sulphoxides". The Syntheses of Sulphones, Sulphoxides and Cyclic Sulphides. Wiley. pp. 109–254, See pp. 112–6. doi:10.1002/9780470666357
Hydrogen_peroxide
Post-translational modification
reaction: malonyl-lysine-protein + NAD+ → lysine-protein + O-malonyl-ADP-ribose + nicotinamide Proteomic profiling of mouse liver revealed that SIRT5
Lysine_malonylation
Psychoactive component of cannabis
in cannabinoid hyperemesis syndrome (CHS), a condition characterized by cyclic nausea, vomiting, and abdominal pain that may persist for months to years
Tetrahydrocannabinol
Protein
et al. (October 2003). "Human proliferating cell nuclear antigen, poly(ADP-ribose) polymerase-1, and p21waf1/cip1. A dynamic exchange of partners". Journal
P21
Protein and coding gene in humans
Pregnenolone sulfate Progesterone Pyr3 Tolfenamic acid TRPM Activators ADP-ribose BCTC Calcium (intracellular) CIM-0216 Cold Coolact P Cooling Agent 10
TRPA1
Protein-coding gene in the species Homo sapiens
nucleotides. This receptor is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. Four transcript variants encoding the same isoform
P2RY6
Biological system of neurotransmitters
concurrent stimulation of dopamine and CB1 receptors to an acute rise in cyclic adenosine monophosphate (cAMP) production, it is generally accepted that
Endocannabinoid_system
Toxin harmful to nervous tissue
V.; Dawson, T.; Snyder, S. (1994). "Nitric Oxide Activation of Poly(ADP-ribose) Synthetase in Neurotoxicity". Science. 263 (5147): 687–89. Bibcode:1994Sci
Neurotoxin
115.660.060 – adp-ribosyl cyclase MeSH D08.811.913.400.725.115.680 – pertussis toxin MeSH D08.811.913.400.725.115.690 – poly(adp-ribose) polymerases MeSH D08
List_of_MeSH_codes_(D08)
Protein-coding gene in the species Homo sapiens
recombination DNA repair and sensitivity to DNA damaging agents and poly(ADP-ribose) polymerase (PARP) inhibitors in human breast cancer cells". Oncotarget
Cyclin_A2
Chemical compound
acid, ethyl ester, hydrochloride (SQ 20009)--a potent new inhibitor of cyclic 3',5'-nucleotide phosphodiesterases". Biochemical Pharmacology. 21 (18):
Etazolate
Protein found in humans
is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase". Cell. 81 (5): 801–809. doi:10.1016/0092-8674(95)90541-3
Caspase_3
1.25: bacteriophage T4 restriction endoribonuclease RegB EC 4.7.1.1 α-D ribose 1-methylphosphonate 5-phosphate C-P-lyase * EC 4.8.1.1: L-piperazate synthase
List_of_EC_numbers_(EC_4)
Chemical compound
Pregnenolone sulfate Progesterone Pyr3 Tolfenamic acid TRPM Activators ADP-ribose BCTC Calcium (intracellular) CIM-0216 Cold Coolact P Cooling Agent 10
Dehydroepiandrosterone sulfate
Dehydroepiandrosterone_sulfate
CYCLIC ADP-RIBOSE
CYCLIC ADP-RIBOSE
CYCLIC ADP-RIBOSE
CYCLIC ADP-RIBOSE
CYCLIC ADP-RIBOSE
CYCLIC ADP-RIBOSE
CYCLIC ADP-RIBOSE
CYCLIC ADP-RIBOSE
CYCLIC ADP-RIBOSE