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Field of study in cancer research
Cancer epigenetics is the study of epigenetic modifications to the DNA of cancer cells that do not involve a change in the nucleotide sequence, but instead
Cancer_epigenetics
Cancer of the colon or rectum
Diederich M (March 2012). "Epigenetics Offer New Horizons for Colorectal Cancer Prevention". Current Colorectal Cancer Reports. 8 (1): 66–81. doi:10
Colorectal_cancer
Research into causes and treatment of cancer
gene in cancer progression may vary tremendously, depending on the stage and type of cancer involved. Cancer epigenetics is the study of epigenetic modifications
Cancer_research
Study of DNA modifications that do not change its sequence
in epigenetics implies features that are "on top of" or "in addition to" the traditional DNA-sequence-based mechanism of inheritance. Epigenetics usually
Epigenetics
PMC 3174267. PMID 21941615. Staff. "Cancer Epigenetics and Biology Programme". pebc.cat. Retrieved 8 May 2011. Epigenetics Editorial Board Wade, Nicholas (5
Manel_Esteller
American epigenetics academic
evidence for a role of epigenetics in cancer and helped establish the role of epigenetic mechanisms in human disease beyond cancer. In 1994, Feinberg returned
Andrew_Paul_Feinberg
PMID 23539594. Wang YP, Lei QY (2018). "Metabolic recoding of epigenetics in cancer". Cancer Commun (Lond). 38 (1): 1–8. doi:10.1186/s40880-018-0302-3. PMC 5993135
DNA_methylation_in_cancer
Non-coding RNA in the species Homo sapiens
"A lincRNA connected to cell mortality and epigenetically-silenced in most common human cancers". Epigenetics. 10 (11): 1074–1083. doi:10.1080/15592294
MORT_(long_non-coding_RNA)
Aspect of cancer
likely central to progression to cancer. Eukaryotic transcription Gene expression Transcriptional regulation Cancer epigenetics Saxonov S, Berg P, Brutlag DL
Regulation of transcription in cancer
Regulation_of_transcription_in_cancer
Formation of cancer
a cancer, whereby normal cells are transformed into cancer cells. The process is characterized by changes at the cellular, genetic, and epigenetic levels
Carcinogenesis
Group of diseases involving cell growth
Diederich M (March 2012). "Epigenetics Offer New Horizons for Colorectal Cancer Prevention". Current Colorectal Cancer Reports. 8 (1): 66–81. doi:10
Cancer
US non-profit organisation
and Betty Van Andel in 1996. The institute's research focuses on cancer epigenetics and Parkinson's disease. Its educational efforts support teacher development
Van_Andel_Institute
Epigenetic transmission without DNA primary structure alteration
development must be considered as 'epigenetic.' Holliday R (2006). "Epigenetics: a historical overview". Epigenetics. 1 (2): 76–80. doi:10.4161/epi.1.2
Transgenerational epigenetic inheritance
Transgenerational_epigenetic_inheritance
Computational epigenetics uses statistical methods and mathematical modelling in epigenetic research. Due to the recent explosion of epigenome datasets
Computational_epigenetics
American geneticist
pharmacology. Szyf's main research interests lie with epigenetics, including behavioral epigenetics as well as cancer research. Szyf received his Ph.D. from the
Moshe_Szyf
Phenomenon
that is important for the regulation of gene expression in cancer cells, as an epigenetic control aberration responsible for gene inactivation. Hypermethylation
CpG_island_hypermethylation
American oncologist
Hopkins University School of Medicine. His research focus is epigenetics in the development of cancer, and he was one of the first researchers in this field
Stephen_B._Baylin
Alternative or complementary treatments for cancer that have not demonstrated efficacy
understand how mutations in the epigenetic machinery of cells will alter histone acetylation patterns to create cancer epigenetics. DNA damage appears to be
Alternative_cancer_treatments
Argentine-born physician and biomedical researcher
biomedical researcher specialising in haematological malignancies and cancer epigenetics. Since 2025, he is the Director of the Josep Carreras Leukaemia Research
Ari_Melnick
Tumor or other abnormal growth of tissue
surrounding colon cancers (extending to at about 10 cm on each side of a cancer) were shown by Facista et al. to frequently have epigenetic defects in 2 or
Neoplasm
Proportion of individuals that express the trait associated with an allele
for constitutive BRCA1 promoter methylation, childhood cancer and secondary cancer". Epigenetics. 7 (1): 47–54. doi:10.4161/epi.7.1.18814. ISSN 1559-2294
Penetrance
Study of how diet changes gene expression
bioactive food components on epigenetic events. Some of the earliest studies done in the field of nutritional epigenetics were performed in rodent models
Nutritional_epigenetics
Use of epigenome-influencing techniques to treat medical conditions
potentially treating diseases by targeting epigenetic mechanisms such as DNA methylation and histone modifications. Epigenetics is the study of changes in gene expression
Epigenetic_therapy
Hospital in Houston, Texas, U.S.
Areas of study include biochemistry and cell biology, cancer biology, genetics and epigenetics, immunology, medical physics, microbiology and infectious
MD_Anderson_Cancer_Center
Peer-reviewed scientific journal
articles, reviews, and commentaries related to cancer biology, molecular oncology, cancer genetics, epigenetics, signal transduction, and targeted therapy
Molecular_Cancer
Type of endocrine gland cancer
Pancreatic cancer is any cancer with a primary location in the pancreas, a glandular organ lying behind the stomach. It arises when cells in the pancreas
Pancreatic_cancer
Biochemical test for age
incorporating classical aging theories and epigenetics. Steve Horvath and Kenneth Raj extended this theory, proposing an epigenetic clock theory of aging with the
Epigenetic_clock
Spreading of a disease inside a body
PMC 3592916. PMID 23520493. Lujambio A, Esteller M (February 2009). "How epigenetics can explain human metastasis: a new role for microRNAs". Cell Cycle.
Metastasis
Any type of epithelial lung cancer other than small-cell lung carcinoma
Non-small-cell lung cancer (NSCLC), or non-small-cell lung carcinoma, is a type of epithelial lung cancer other than small-cell lung cancer (SCLC). Non-small-cell
Non-small-cell_lung_cancer
Uterine cancer that is located in tissues lining the uterus
Endometrial cancer is a cancer that arises from the endometrium (the lining of the uterus or womb). It is the result of the abnormal growth of cells that
Endometrial_cancer
Mainstream medical research into cancer treatment
"Medicine's New Epicenter? Epigenetics: New field of epigenetics may hold the secret to flipping cancer's "off" switch". CURE (Cancer Updates, Research and
Experimental_cancer_treatment
RNA family
several cancers including: Bladder cancer Breast cancer Melanoma Ovarian cancer Pancreatic cancer Prostate cancer Stomach cancer Lung cancer Colorectal
Mir-200
American physician
Medical School, and director of the Center for Functional Cancer Epigenetics in the Dana–Farber Cancer Institute. Brown was elected to the National Academy
Myles_A._Brown
Cancer arises in the head or neck region
Head and neck cancer is a general term encompassing multiple cancers that can develop in the head and neck region. These include cancers of the mouth,
Head_and_neck_cancer
Type of modification to a cell's epigenome
tumor-suppressor gene activation in cancer treatment respectively. Epigenetic priming refers to a latent epigenetic state triggered by stimuli, such as
Epigenetic_priming
Yang, Kwang-Mo; Yi, Joo Mi (2013-07-18). "Epigenetics Meets Radiation Biology as a New Approach in Cancer Treatment". International Journal of Molecular
Biological effects of radiation on the epigenome
Biological_effects_of_radiation_on_the_epigenome
Cellular mechanism
lung cancer". Molecular Cancer. 3 (4): 14. doi:10.1186/1476-4598-3-14. PMC 419366. PMID 15125777. Baylin SB, Ohm JE (February 2006). "Epigenetic gene
DNA_repair
High frequency of mutations within the genome of a cellular lineage
expression were likely due to epigenetic overexpression of the microRNA, miR-155, which down-regulates MLH1. In cancer epigenetics (see section Frequencies
Genome_instability
Medical intervention
Cancer treatments are a wide range of treatments available for the many different types of cancer, with each cancer type needing its own specific treatment
Cancer_treatment
Indian-American physician, writer b. 1970
Hutchinson Cancer Research Center, opined that, "Mukherjee seemed not to realize that transcription factors occupy the top of the hierarchy of epigenetic information
Siddhartha_Mukherjee
German biologist (born 1942)
Jaenisch has focused on creating genetically modified mice to study cancer, epigenetic reprogramming and neurological diseases. Jaenisch's first breakthrough
Rudolf_Jaenisch
Biological processes
of stomach cancers, 74% of thyroid cancers, 40–90% of colorectal cancers, and 50% of brain cancers.[citation needed] Similarly, epigenetic downregulation
Downregulation and upregulation
Downregulation_and_upregulation
Protein-coding gene in the species Homo sapiens
Cancer Research. 60 (1): 121–128. PMID 10646863. Gu L, Fu Y, Li X (2024). "Roles of post-translational modifications of UHRF1 in cancer". Epigenetics
UHRF1
Sub-field of genomics
more frequently than gene mutation in many types of cancer (see Cancer epigenetics). Thus, epigenetic repression often plays a more important role than
Oncogenomics
Process whereby cells acquire the properties of cancer
in cancers is altered epigenetic regulation of transcription. In cancers, loss of gene expression occurs about 10 times more frequently by epigenetic transcription
Malignant_transformation
Form of dynamic modification
role in cancer. Epigenetic instability caused by deregulation in chromatin remodeling is studied in several cancers, including breast cancer, colorectal
Chromatin_remodeling
Cancer of plasma cells
myeloma (MM), also known as plasma cell myeloma and simply myeloma, is a cancer of plasma cells, a type of white blood cell that normally produces antibodies
Multiple_myeloma
Field of study
evidence shows that epigenetics also plays an important role in determining the safety and efficacy of drug treatment in patients. Epigenetics is a bridge that
Pharmacoepigenetics
Mammalian protein found in Homo sapiens
its promoter region in various cancers (see table of such genes in Cancer epigenetics). The promoter methylation of ATM causes reduced protein or mRNA expression
ATM_serine/threonine_kinase
RNA family
head and neck. miR-137 is epigenetically silenced in colorectal adenomatous tissues to the same extent as in colorectal cancer tissues, suggesting that
MiR-137
Type of throat cancer; most common to occur in the nasopharynx
Nasopharyngeal carcinoma (NPC), or nasopharynx cancer, is the most common cancer originating in the nasopharynx, most commonly in the postero-lateral
Nasopharyngeal_carcinoma
Australian biomedical researcher
Susan J. Clark is an Australian biomedical researcher in epigenetics of development and cancer. She was elected a Fellow of the Australian Academy of Science
Susan_J._Clark
Field of study
Epigenetics of physical exercise is the study of epigenetic modifications to the cell genome resulting from physical exercise. Environmental factors,
Epigenetics of physical exercise
Epigenetics_of_physical_exercise
Form of metabolism in tumors
Understanding the relationship between metabolism and epigenetics in cancer cells may open new avenues for anti-cancer strategies. The Warburg effect has served as
Warburg_effect_(oncology)
DNA repair process
Arnoletti JP (Jan 2009). "Epigenetic downregulation of the DNA repair gene MED1/MBD4 in colorectal and ovarian cancer". Cancer Biology & Therapy. 8 (1):
Base_excision_repair
Taking measures to decrease cancer incidence
alter gene regulation through epigenetic modifications. A systematic review on epigenetics, microbiota, and breast cancer revealed that factors like maternal
Cancer_prevention
Medical condition
Liver cancer, also known as hepatic cancer, primary hepatic cancer, or primary hepatic malignancy, is cancer that starts in the liver. Liver cancer can
Liver_cancer
Indian-American academic scientist
advisor for leading global cancer conferences. His participation underscores his pioneering contributions to cancer epigenetics, molecular oncology, and
Rajvir_Dahiya
Australian biomedical institute in Sydney
Director and Laboratory Head Professor Susan Clark – Head of the Cancer Epigenetics Laboratory Associate Professor Jodie Ingles – Director of the Genomics
Garvan Institute of Medical Research
Garvan_Institute_of_Medical_Research
Professor at Johns Hopkins University
on cancer epigenetics and on new strategies for prostate cancer and prevention. He serves on the boards of the V Foundation, the Break Through Cancer Foundation
William_G._Nelson
Mammalian protein found in humans
Balgkouranidou I, Liloglou T, Lianidou ES (February 2013). "Lung cancer epigenetics: emerging biomarkers". Biomarkers in Medicine. 7 (1): 49–58. doi:10
P16
Tumor of the glial cells of the brain or spine
can then, by a process of natural selection, lead to progression to cancer. Epigenetic repression of DNA repair genes is often found in progression to sporadic
Glioma
Protein-coding gene in the species Homo sapiens
Le Bourhis X, Angrand PO (2015). "Diverse involvement of EZH2 in cancer epigenetics". Am J Transl Res. 7 (2): 175–93. PMC 4399085. PMID 25901190. Chang
XRCC2
Viruses that can cause cancer
An oncovirus or oncogenic virus is a virus that can cause cancer. This term originated from studies of acutely transforming retroviruses in the 1950–60s
Oncovirus
Small roll of tobacco made to be smoked
smoking has many negative health effects. These include diseases such as cancer, chronic obstructive pulmonary disease (COPD), heart disease, birth defects
Cigarette
Cancer cells with features of normal cells
Cancer stem cells (CSCs) are cancer cells (found within tumors or hematological cancers) that possess characteristics associated with normal stem cells
Cancer_stem_cell
Form of cancer
malignancy. This alteration process is referred to as epigenetics (Patino et al. 2008). Epigenetics is the term used to refer to stable changes in DNA that
Epigenetics_and_melanoma
Independence movement in Europe
Economics at UPF. Manel Esteller, Catalan scientist, director of the Cancer Epigenetics and Biology Program of the Bellvitge Institute for Biomedical Research
Catalan_independence_movement
Cancer caused by ionizing radiation exposure
Exposure to ionizing radiation is known to increase the future incidence of cancer, particularly leukemia. The mechanism by which this occurs is well understood
Radiation-induced_cancer
Use of DNA methylation patterns to predict phenotypes
Epigenetics refers to heritable changes in gene expression that are not changes in the underlying DNA sequence... DNA methylation is a key epigenetic
Epiphenotyping
Medical classification system
Breast cancer classification divides breast cancer into categories according to different schemes criteria and serving a different purpose. The major
Breast_cancer_classification
Influence the environment on gene expression
Environmental epigenetics is a branch of epigenetics that studies the effects of external environmental factors on the gene expression of a developing
Environmental_epigenetics
Accumulation of mutations
Diederich M (March 2012). "Epigenetics Offer New Horizons for Colorectal Cancer Prevention". Current Colorectal Cancer Reports. 8 (1): 66–81. doi:10
Somatic_evolution_in_cancer
Pathogens as a cause of cancer
cancers from infectious causes at 16.1%. Viral infections are risk factors for cervical cancer, 80% of liver cancers, and 15–20% of the other cancers
Infectious_causes_of_cancer
Overview article
through epigenetic mechanisms that are highly dynamic in regulating the chromatin structure as well as specific gene transcription programs. Epigenetics has
Epigenetics in stem-cell differentiation
Epigenetics_in_stem-cell_differentiation
Neoplasm in the brain
A brain tumor (sometimes referred to as brain cancer) occurs when a group of cells within the brain grow out of control, creating a mass. There are two
Brain_tumor
Relationship between cancer and the consumption of alcohol
Alcohol and cancer have a complex relationship. Alcohol causes cancers of the oesophagus, liver, breast, colon, oral cavity, rectum, pharynx, and larynx
Alcohol_and_cancer
Cancer-research organization
Oxford Branch – University of Oxford, United Kingdom (focus: cancer plasticity and epigenetics) Previously, the Institute also operated branches in London
Ludwig_Cancer_Research
Molecular biologist
trials with a new drug, JQ1. By studying cancer epigenetics, Vakoc has also identified a new subtype of lung cancer and has discovered how gene expression
Christopher_Vakoc
Field of study
Epigenetics of anxiety and stress–related disorders is the field studying the relationship between epigenetic modifications of genes and anxiety and stress-related
Epigenetics of anxiety and stress–related disorders
Epigenetics_of_anxiety_and_stress–related_disorders
Region of often-methylated DNA with a cytosine followed by a guanine
Schnekenburger M, Diederich M (2012). "Epigenetics Offer New Horizons for Colorectal Cancer Prevention". Curr Colorectal Cancer Rep. 8 (1): 66–81. doi:10.1007/s11888-011-0116-z
CpG_site
British molecular biologist
of The Epigenetics Revolution and Junk DNA: A Journey Through the Dark Matter of the Genome which explore advances in the field of epigenetics and their
Nessa_Carey
German physician and molecular biologist
is a senior investigator and head of the epigenetics section at the Frederick National Laboratory for Cancer Research. Kathrin Muegge obtained a M.D.
Kathrin_Muegge
Medical diagnostic method
Prostate cancer screening is the screening process used to detect undiagnosed prostate cancer in men without signs or symptoms. When abnormal prostate
Prostate_cancer_screening
Virus of the herpes family
likelihood of developing EBV-related cancer. EBV-related cancers are unique in that they are frequent in making epigenetic changes but are less likely to mutate
Epstein–Barr_virus
Protein-coding gene in the species Homo sapiens
cancer (NSCLC) tumours. RAD23B appears to be one of 26 DNA repair genes that are epigenetically repressed in various cancers (see Cancer epigenetics)
RAD23B
Chromatin remodeling complex
Complex: A Frequently Mutated Chromatin Remodeling Complex in Cancer". Epigenetics in Oncology. Cancer Treatment and Research. Vol. 190. pp. 211–244. doi:10
Mammalian SWI/SNF (BAF) complex
Mammalian_SWI/SNF_(BAF)_complex
Italian American epigeneticist and clinical endocrinologist
Professor of Environmental Epigenetics from 2010 to 2016. Baccarelli's research has pioneered the field of public health epigenetics, which explores how environmental
Andrea_Baccarelli
Protein-coding gene in the species Homo sapiens
Le Bourhis X, Angrand PO (2015). "Diverse involvement of EZH2 in cancer epigenetics". American Journal of Translational Research. 7 (2): 175–93. PMC 4399085
RAD51C
Project to catalogue genetic mutations responsible for cancer
The Cancer Genome Atlas (TCGA) is a project to catalogue the genomic alterations responsible for cancer using genome sequencing and bioinformatics. The
The_Cancer_Genome_Atlas
Protein-coding gene in the species Homo sapiens
C, Dammann RH (November 2009). "Frequent epigenetic inactivation of RASSF10 in thyroid cancer". Epigenetics. 4 (8): 571–6. doi:10.4161/epi.4.8.10056.
Ras association domain family member 10
Ras_association_domain_family_member_10
Chemical compound
may be greater for cancer cells than for normal cells if the cancer cells are already deficient in DNA repair due to prior epigenetic silencing of DNA repair
Pevonedistat
factors and mechanisms that control this process and epigenetics is one way this is accomplished. Epigenetics refers to persistent changes in expression patterns
Epigenetics of human herpesvirus latency
Epigenetics_of_human_herpesvirus_latency
Professor of Biostatistics and Computational Biology at Dana-Farber and Harvard
translational cancer research. Her group developed widely used approaches and frameworks that have advanced our understanding of transcriptional and epigenetic gene
Xiaole_Shirley_Liu
Transformation of large areas of cells into cancerous forms
initial step in field cancerization is associated with various molecular lesions such as acquired genetic mutations and epigenetic changes, occurring over
Field_cancerization
Protein found in humans
26 different DNA repair proteins that are epigenetically repressed in various cancers (see Cancer epigenetics). Ku80 has been shown to interact with: DNA-PKcs
Ku80
Academic journal
Epigenetics & Chromatin is a peer-reviewed open access scientific journal published by BioMed Central that covers the biology of epigenetics and chromatin
Epigenetics_&_Chromatin
Surgeon
Johns Hopkins Hospital, Baltimore, USA. Ahuja researches in the field of epigenetics and is a passionate advocate of clinician scientist. She also served
Nita_Ahuja
Cancer of the myeloid line of blood cells
on Cancer. 1846 (2): 326–341. doi:10.1016/j.bbcan.2014.05.004. PMID 24880135. Sharma S, Kelly TK, Jones PA (January 2010). "Epigenetics in cancer". Carcinogenesis
Acute_myeloid_leukemia
PMID 21747404. Dawson, Mark A.; Kouzarides, Tony (2012-07-06). "Cancer Epigenetics: From Mechanism to Therapy". Cell. 150 (1): 12–27. Bibcode:2012Cell
Epigenome-wide association study
Epigenome-wide_association_study
CANCER EPIGENETICS
CANCER EPIGENETICS
Surname or Lastname
English
English : occupational name for a maker or seller of cans, from an agent derivative of Old English canne ‘can’.Respelling of Kanner.
Surname or Lastname
Scottish
Scottish : habitational name from any of the various places called Calder, Caldor, or Cawdor. Calder in Thurso is recorded in the early 13th century in the form Kalfadal and was named with Old Norse kalfr ‘calf’ + dalr ‘valley’. The others are probably the same as in 2 below.English : habitational name from Calder in Cumbria, named from the river on which it stands. This is probably a British name, from Welsh caled ‘hard’, ‘violent’ + dwfr ‘water’, ‘stream’.
Male
English
English occupational surname transferred to forename use, CARVER means "carver" of wood or stone.
Male
English
English form of Spanish Gaspar, CASPER means "treasure bearer." Early Christians assigned names to the three Magi ("wise men from the east") who visited the baby Jesus. They are mentioned but not named in the bible; Casper is one of them, the other two are Balthasar and Melchior. Also spelled Jasper and Kasper.
Male
Hindi/Indian
Variant spelling of Hindi Chandra, CHANDER means "moon."
Surname or Lastname
English
English : occupational name for a dancer or acrobat, from an agent derivative of Middle English, Old French dance ‘dance’ (see Dance).Translation of German Dänzer or Danser (see Danzer).
Surname or Lastname
English
English : variant spelling of Canter.German and Jewish (Ashkenazic) : variant spelling of Kantor.French (Picardy) : learned form of chantre ‘singer’. Compare Canter 1.
Surname or Lastname
English
English : from an agent derivative of Anglo-Norman French cant ‘song’, applied as an occupational name for a singer in a chantry or a nickname for someone who had a good voice or who sang a lot.Americanized spelling of Kanter or Kantor.
Male
English
Variant spelling of English Clancy, CLANCEY means "red warrior."
Boy/Male
Latin
Prisoner.
Boy/Male
American, British, Christian, English, Indian, Jamaican
Sculptor; One who Carves Wood; Wood Carver; Carver of Wood or Stone
Surname or Lastname
English (Midlands)
English (Midlands) : metonymic occupational name for a standard bearer, from Anglo-Norman French banere ‘flag’, ‘ensign’ (see Bannerman).German : occupational name for a standard bearer, Middle High German banier, Middle Low German banner, from French bannière ‘flag’, ‘standard’.
Male
English
English occupational surname transferred to forename use, CARTER means "carter," someone who uses a cart.
Surname or Lastname
English
English : from Middle English gander, Old English gand(r)a ‘gander’, ‘male goose’, hence a metonymic occupational name for a keeper of geese, or a nickname for someone supposedly resembling a gander in some way.English : variant of Ganter.North German : perhaps a habitational name from Gandern in Brandenburg.North German : nickname for a vain or self-important man from ganter ‘male goose’, ‘gander’.South German and Swiss German : habitational name from a place named with Middle High German gant ‘scree’ (Swiss gand), or topographic name for someone living by an area of scree.
Male
English
English unisex name derived from the vocabulary word, CHANCE means "chance."Â
Surname or Lastname
English
English : occupational name for a wool-carder or for a maker of carders, from an agent derivative of Middle English, Old French card(e) ‘carder’ (the implement). See also Carda.
Surname or Lastname
English
English : topographic name from Middle English hanger, hangre ‘wood on a steep hillside’, or habitational name from a place named with this word, as for example Hanger in Netley Marsh, Hampshire.
Male
English
Wood Carver
Boy/Male
American, Australian, British, Chinese, Christian, Danish, English, German, Indian
Transporter of Goods with a Cart; Cart Driver; Carter; Someone who Uses a Cart
Male
English
Variant spelling of English Connor, CONNER means "hound-lover."
CANCER EPIGENETICS
CANCER EPIGENETICS
CANCER EPIGENETICS
CANCER EPIGENETICS
CANCER EPIGENETICS
CANCER EPIGENETICS
CANCER EPIGENETICS