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Protein found in humans
Ku80 is a protein that, in humans, is encoded by the XRCC5 gene. Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand break
Ku80
Protein domain
other). Eukaryotic Ku is a heterodimer of two polypeptides, Ku70 (XRCC6) and Ku80 (XRCC5), so named because the molecular weight of the human Ku proteins is
Ku_(protein)
Class of animals with milk-producing glands
DNA double-strand breaks as well as the level of the DNA repair protein Ku80. In a study of the cells from sixteen mammalian species, genes employed in
Mammal
Class of enzymes
non-homologous end joining DNA repair pathway, including DNA-PKcs, Ku70/Ku80 and DNA ligase IV assembled with topo IIβ and PARP-1. This assemblage was
Topoisomerase
Pathway that repairs double-strand breaks in DNA
during mammalian NHEJ. Eukaryotic Ku is a heterodimer consisting of Ku70 and Ku80, and forms a complex with DNA-PKcs, which is present in mammals but absent
Non-homologous_end_joining
Protein found in humans
Ku70 is a heterodimeric protein made up of Ku70 and Ku80, which together form Ku. In humans, is encoded by the XRCC6 gene. Ku70 plays a critical role in
Ku70
Hypothesis that aging is caused by accumulated DNA damage
particular, mutant mice defective in Ku70, or Ku80, or double mutant mice deficient in both Ku70 and Ku80 exhibit early aging. The mean lifespans of the
DNA_damage_theory_of_aging
Any type of epithelial lung cancer other than small-cell lung carcinoma
recombinational repair BRCA1 30% homologous recombinational repair XRCC5 (Ku80) 20% nonhomologous end joining FEN1 100% hypomethylated (increased expression)
Non-small-cell_lung_cancer
Faculty of mind to store and retrieve data
the non-homologous end joining (NHEJ) DNA repair pathway (DNA-PKcs, KU70, KU80, and DNA LIGASE IV) (see Figure). These enzymes repair the double-strand
Memory
Protein-coding gene in the species Homo sapiens
(XRCC6) and Ku80 (XRCC5)]. ETS1 interaction with DNA-PK phosphorylates ETS1. Such phosphorylation of ETS1 alters its target gene repertoire. The Ku80 portion
ETS1
Cellular mechanism
the recruitment of essential repair factors, including RAD51, KU70, and KU80, to double-strand breaks. Such chromatin-based mechanisms illustrate how
DNA_repair
Medical condition
Hoeijmakers JH, Vijg J, van Steeg H, Hasty P (2014). "The progeroid phenotype of Ku80 deficiency is dominant over DNA-PKCS deficiency". PLOS ONE. 9 (4) e93568
DNA repair-deficiency disorder
DNA_repair-deficiency_disorder
Mechanism of DNA repair in cells
initiated instead of NHEJ. In contrast, the presence of a Ku complex (Ku70 and Ku80) indicates that NHEJ has been initiated instead of HDR. HDR and NHEJ repair
Homology_directed_repair
Catalytic subunit of the enzyme telomerase
Telomerase reverse transcriptase has been shown to interact with: HSP90AA1, Ku70, Ku80, MCRS1, Nucleolin, PINX1, and YWHAQ. PAWR telomerase reverse transcriptase
Telomerase reverse transcriptase
Telomerase_reverse_transcriptase
Method of recording sound
translate adequately to a hi-fi speaker system. In 1972, Neumann released the KU80 binaural head, which would eventually lead to the KU100 binaural head, which
Binaural_recording
Protein found in humans
interact with: ATM, C1D, and CDC5L, CHEK1, CHUK, CIB1, DCLRE1C, ILF2, ILF3, Ku80, NCOA6, P53, RPA2, and WRN. AZD7648, M3814 (peposertib), M9831 (VX-984) and
DNA-PKcs
Protein-coding gene in the species Homo sapiens
is a dimeric protein complex, a heterodimer of two polypeptides, Ku70 and Ku80. Ku protein forms a ring structure. An early step in non-homologous end joining
RNF8
Enzyme and coding gene in humans
present. Tyrosine kinase 2 has been shown to interact with FYN, PTPN6, IFNAR1, Ku80 and GNB2L1. Tyrosine kinase inhibitor GRCh38: Ensembl release 89: ENSG00000105397
Tyrosine_kinase_2
Protein found in humans
with the aid of Cernunnos-XLF. DNA-PKcs and hXRCC4 are anchored to Ku70 / Ku80 heterodimer, which are bound to the DNA ends. Since hXRCC4 is the key protein
DNA_repair_protein_XRCC4
Protein-coding gene in the species Homo sapiens
PMC 528930. PMID 15489336. Sibani S, Price GB, Zannis-Hadjopoulos M (2005). "Ku80 binds to human replication origins prior to the assembly of the ORC complex"
ORC6
Cytogenetic technique
(NHEJ) protein repairs double-stranded DNA breaks and relies on the Ku70/Ku80 heterodimer to function. Disrupting these proteins causes telomeric shortening
Q-FISH
Protein-coding gene in the species Homo sapiens
PMID 15232106. S2CID 20936301. Sibani S, Price GB, Zannis-Hadjopoulos M (May 2005). "Ku80 binds to human replication origins prior to the assembly of the ORC complex"
ORC4
Protein-coding gene in the species Homo sapiens
double-strand breaks. The first step in this pathway depends on the Ku70/Ku80 heterodimer that forms a highly stable ring structure encircling DNA ends
APPBP1
Biological process of yeast
Ruan C, Workman JL, Simpson RT (October 2005). "The DNA repair protein yKu80 regulates the function of recombination enhancer during yeast mating type
Mating_of_yeast
Protein-coding gene in the species Homo sapiens
strand breaks. In Co-Immunoprecipitation experiments, MRI-2 bound to Ku70 and Ku80, two subunits of Ku, which play a major role in the NHEJ pathway. MRI-3 GRCh38:
CYREN_(protein)
Protein-coding gene in the species Homo sapiens
in neural stem cells. GCN5L2 has been shown to interact with: DDB1, Ku70, Ku80, TADA2L, TAF9, and Transcription initiation protein SPT3 homolog. GRCh38:
KAT2A
Gene which maintains basic cellular functions
considered a transcription factor MCM3AP possibly a primase XRCC5 NM_021141 Ku80 XRCC6 NM_001469 Homo sapiens thyroid autoantigen: Single-stranded DNA-dependent
Housekeeping_gene
Segment of nucleic acid that affects the expression of associated genes
the non-homologous end joining (NHEJ) DNA repair pathway (DNA-PKcs, KU70, KU80 and DNA LIGASE IV) (see figure). These enzymes repair the double-strand breaks
Regulatory_sequence
Mammalian protein found in Homo sapiens
structure-specific endonuclease 1 GADD45A GADD45G HDAC1 HUS1 ING1 KCTD13 KIAA0101 Ku70 Ku80 MCL1 MSH3 MSH6 MUTYH P21 POLD2 POLD3 POLDIP2 POLH POLL RFC1 RFC2 RFC3 RFC4
Proliferating cell nuclear antigen
Proliferating_cell_nuclear_antigen
Short length polypeptides
strand breaks. In Co-Immunoprecipitation experiments, MRI-2 bound to Ku70 and Ku80, two subunits of Ku, which play a major role in the NHEJ pathway. The 24
Micropeptide
the non-homologous end joining (NHEJ) DNA repair pathway (DNA-PKcs, KU70, KU80 and DNA LIGASE IV) (see Figure). These enzymes repair the double-strand breaks
TOP2B
Protein found in the human body
double-strand breaks. The first step in this pathway depends on the Ku70/Ku80 heterodimer that forms a highly stable ring structure encircling DNA ends
NEDD8
Author and cancer biologist
"Cellular senescence and organismal ageing in the absence of p21 CIP1/WAF1 in ku80-/-mice". The EMBO Journal. 10 (1): 71–78. doi:10.1038/embor.2008.220. PMC 2613205
Stuart_A._Aaronson
Protein-coding gene in the species Homo sapiens
receptor, Glyceraldehyde 3-phosphate dehydrogenase, Host cell factor C1, Ku80, MNAT1 NPAT, Nuclear receptor co-repressor 2, POU2AF1, RELA, Retinoid X receptor
POU2F1
Sporadic biological phenomenon at the molecular scale
to facilitate the occurrence of the indicated events. In NHEJ, the Ku70/Ku80 heterodimer and DNA-dependent protein kinase (DNA-PK) for bringing DNA fragments
Nuclear mitochondrial DNA segment
Nuclear_mitochondrial_DNA_segment
Protein-coding gene in the species Homo sapiens
showed that DDB2, in association with XRCC5 and XRCC6 (otherwise known as Ku80 and Ku70, which make up the Ku heterodimer), has transcriptional activities
DDB2
British scientist
S.; Jackson, S. P. (1996). "Identification of a Saccharomyces cerevisiae Ku80 homologue: Roles in DNA double strand break rejoining and in telomeric maintenance"
Simon_Boulton
Heritable characteristics affecting learning
the non-homologous end joining (NHEJ) DNA repair pathway (DNA-PKcs, KU70, KU80 and DNA LIGASE IV) (see Figure). These enzymes repair the double-strand breaks
Epigenetics in learning and memory
Epigenetics_in_learning_and_memory
KP32 — May 24, 2001 Kitt Peak Spacewatch · 1.1 km MPC · JPL 640447 2001 KU80 — May 31, 2001 Palomar NEAT · 2.4 km MPC · JPL 640448 2001 KV80 — April
List of minor planets: 640001–641000
List_of_minor_planets:_640001–641000
Jeggo PA, Jasin M (August 1996). "Chromosomal double-strand break repair in Ku80-deficient cells". PNAS. 93 (17): 8929–33. Bibcode:1996PNAS...93.8929L. doi:10
List of homing endonuclease cutting sites
List_of_homing_endonuclease_cutting_sites
Protein-coding gene in the species Homo sapiens
is encoded by the TERF2IP gene. TERF2IP has been shown to interact with Ku80, Rad50 and TERF2. Upon interaction, TERF2IP/TERF2 complex has been shown
TERF2IP
Group of proteins
FANC proteins also interacts with Ku70. FANC proteins also interacts with Ku80. FANC proteins also interacts with FAN1. FANC proteins also interacts with
FANC_proteins
Protein-coding gene in the species Homo sapiens
Estrogen receptor alpha, Estrogen receptor beta, HBXIP, HIST2H3C, HSF1, Ku70, Ku80, Liver X receptor beta, MLL3, RBBP5, Retinoblastoma protein, Retinoic acid
NCOA6
Protein-coding gene in the species Homo sapiens
PMID 15232106. S2CID 20936301. Sibani S, Price GB, Zannis-Hadjopoulos M (May 2005). "Ku80 binds to human replication origins prior to the assembly of the ORC complex"
ORC3
Enzyme found in humans
ATP-dependent helicase has been shown to interact with: BLM DNA-PKcs, FEN1, Ku70, Ku80, P53, PCNA, TERF2, WRNIP1, RNF4, and PIAS4. VVD-214 GRCh38: Ensembl release
Werner_syndrome_helicase
KU80
KU80
KU80
KU80
Boy/Male
Indian
Fisherman
Boy/Male
Scandinavian
Hebrew John 'Jehovah has been gracious; has shown favor.
Male
Welsh
Perhaps a masculine form of Welsh unisex Eilian, ELYAN means "second, a moment in time."Â In Arthurian legend, this is the name of a Knight of the Round Table. He was the illegitimate son of Sir Bors, and cousin to Lancelot. He is noted for helping to rescue Guinevere after her affair with Lancelot was exposed. He joined Lancelot in his exile. Also spelled Helyan.
Girl/Female
French German Greek
Angel.
Boy/Male
American, Australian, Chinese, French, German, Latin, Portuguese, Spanish
Dark-skinned; Moorish
Girl/Female
British, English
Princess of Sea
Male
Italian
Italian name ADALFIERI means "noble oath."
Girl/Female
Hindu
A small creeper
Girl/Female
Muslim
Pleasant
Male
Italian
Italian, Portuguese and Spanish form of Latin Eusebius, EUSEBIO means "pious."
KU80
KU80
KU80
KU80
KU80