AI & ChatGPT searches , social queriess for NEDD8
Search references for NEDD8. Phrases containing NEDD8
See searches and references containing NEDD8!
Search references for NEDD8. Phrases containing NEDD8
See searches and references containing NEDD8!NEDD8
Protein found in the human body
NEDD8 is a protein that in humans is encoded by the NEDD8 gene. (in Saccharomyces cerevisiae this protein is known as Rub1) This ubiquitin-like (UBL)
NEDD8
Post-translational modifications involving the protein NEDD8
to the post-translational modification in which ubiquitin-like protein NEDD8 is covalently attached to the lysine residue of a target protein, which
Neddylation
Hydrophobic scaffold protein
in metazoans. The only identified Nedd8 substrates are cullins. Neddylation results in covalent conjugation of a Nedd8 moiety onto a conserved cullin lysine
Cullin
Chemical compound
(MLN4924) is a selective NEDD8 inhibitor. It is being investigated as a cancer treatment, e.g. for mantle cell lymphoma (MCL). NEDD8-activating enzyme (NAE)
Pevonedistat
Protein-coding gene in the species Homo sapiens
is encoded by the UBA1 gene. UBA1 participates in ubiquitination and the NEDD8 pathway for protein folding and degradation, among many other biological
UBA1
Protein-coding gene in the species Homo sapiens
NEDD8-activating enzyme E1 regulatory subunit is a protein that in humans is encoded by the NAE1 gene. The protein encoded by this gene binds to the beta-amyloid
APPBP1
Protein-coding gene in the species Homo sapiens
NEDD8-conjugating enzyme Ubc12 is a protein that in humans is encoded by the UBE2M gene. The modification of proteins with ubiquitin is an important cellular
UBE2M
Change of a linear protein chain to a 3D structure
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
Protein_folding
Family of small proteins
SENP1) reported around the same time by a variety of investigators in 1996, NEDD8 in 1997, and Apg12 in 1998. A systematic survey has since identified over
Ubiquitin-like_protein
Vertebrate receptor protein and transcription factor
also been shown to interact with the following: AIP ARNTL CCNT1 ESR1 NCOA1 NEDD8 NRIP1 RELA RELB RP GRCh38: Ensembl release 89: ENSG00000106546 – Ensembl
Aryl_hydrocarbon_receptor
Protein-coding gene in the species Homo sapiens
NEDD8-activating enzyme E1 catalytic subunit is a protein that in humans is encoded by the UBA3 gene. The modification of proteins with ubiquitin is an
UBE1C
Topics referred to by the same term
preparation Massage, the rubbing or kneading of the body's soft tissues NEDD8, a protein in Saccharomyces cerevisiae known as Rub1 Rubredoxin A (RubA)
Rub
Chemical changes in proteins following their translation from mRNA
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
Post-translational modification
Post-translational_modification
Protein-coding gene in the species Homo sapiens
NEDD8-conjugating enzyme UBE2F is a protein that in humans is encoded by the UBE2F gene. NEDD8 Neddylation GRCh38: Ensembl release 89: ENSG00000184182
Ubiquitin conjugating enzyme E2 F (putative)
Ubiquitin_conjugating_enzyme_E2_F_(putative)
Short peptide present at N-terminal of newly synthesized proteins
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
Signal_peptide
Human chromosome
titin TUBA4B: encoding protein Tubulin alpha 4b UBE2F: encoding protein NEDD8-conjugating enzyme UBE2F UBXD2: UBX domain-containing protein 4 UXS1: UDP-glucuronic
Chromosome_2
Addition of a succinyl group to a lysine group of a protein
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
Succinylation
Family of proteins
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
Heat_shock_protein
Protein-coding gene in the species Homo sapiens
DC, Hunt HW, Hammel M, Schulman BA (Sep 2008). "Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation"
RBX1
Protein-coding gene in humans
the complex is regulated by the attachment of the ubiquitin-like protein NEDD8 to a conserved Lys residue in the cullin-homology domain, the process called
CUL3
Regulatory protein found in most eukaryotic tissues
neuronal-precursor-cell-expressed developmentally downregulated protein-8 (NEDD8, also called Rub1 in S. cerevisiae), human leukocyte antigen F-associated
Ubiquitin
Protein-coding gene in the species Homo sapiens
NEDD8 ultimate buster 1 is a protein that in humans is encoded by the NUB1 gene. NUB1 interacts with and negatively regulates NEDD8 (MIM 603171), a ubiquitin-like
NUB1
American biochemist and cell biologist
regulating SCF and other CRL enzymes by removing the ubiquitin-like protein NEDD8 from their cullin subunit. In 2013, they showed that Cand1 has the unusual
Raymond_J._Deshaies
Protein-coding gene in humans
of CRL4B complexes. CUL4B is also modified by covalent attachment of a NEDD8 molecule at a highly conserved lysine residue in the C-terminal region.
CUL4B
Biological mechanism for routing proteins
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
Protein_targeting
Protein-coding gene in the species Homo sapiens
Sentrin-specific protease 8 is an enzyme that in humans is encoded by the SENP8 gene. NEDD8 (MIM 603171) is a ubiquitin-like protein that becomes conjugated to the
SENP8
EC 2.3.2.32: cullin-RING-type E3 NEDD8 transferase EC 2.3.2.33: RCR-type E3 ubiquitin transferase EC 2.3.2.34: E2 NEDD8-conjugating enzyme EC 2.3.2.35:
List_of_EC_numbers_(EC_2)
Protein family
role of DUBs is the cleavage of ubiquitin-like proteins such as SUMO and NEDD8. Some DUBs may have the ability to cleave isopeptide bonds between these
Deubiquitinating_enzyme
Protein-coding gene in the species Homo sapiens
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
Heat_shock_protein_47
American biochemist
proteins (UBLs), a class of proteins that are similar to ubiquitin, such as NEDD8. She has also extensively studied enzymes that for which ubiquitin and UBLs
Brenda_Schulman
induce T-cell responses. COP9 signalosome: Catalyses the hydrolysis of NEDD8 protein from the Cullin subunit of Cullin-RING ubiquitin ligases (CRL).
Signalosome
Proteins assisting in protein folding
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
Chaperone_(protein)
Protein
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
Ubiquitin_ligase
Protein in animal cells
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
Survival_of_motor_neuron
Family of heat shock proteins
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
Chaperonin
Topics referred to by the same term
acid excretion, the net amount of acid excreted in the urine per unit time NEDD8 activating enzyme North American English, a generalized variety of the English
NAE
Enzyme
for Type 2 diabetes and other diseases. CRAT is known to interact with NEDD8, PEX5, SUMO1. GRCm38: Ensembl release 89: ENSMUSG00000026853 – Ensembl,
Carnitine_O-acetyltransferase
Protein-coding gene in humans
core of CRL4 complexes. CUL4A is also modified by covalent attachment of a NEDD8 molecule at a highly conserved lysine residue in the C-terminal region.
CUL4A
Protein-coding gene in humans
"Covalent modification of all members of human cullin family proteins by NEDD8". Oncogene. 18 (48): 6829–34. doi:10.1038/sj.onc.1203093. PMID 10597293
CUL1
Protein in budding yeast
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
ATG8
Protein-coding gene in humans
Cullin-associated NEDD8-dissociated protein 1 is a protein that in humans is encoded by the CAND1 gene. CAND1 has been shown to interact with: CUL1, CUL2
CAND1
Protein-coding gene in the species Homo sapiens
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
UFM1
Protein family
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
Ubiquitin-conjugating_enzyme
Protein-coding gene in the species Homo sapiens
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
Heat shock protein 90kDa alpha (cytosolic), member A1
Heat_shock_protein_90kDa_alpha_(cytosolic),_member_A1
Family of proteins which attach to other proteins to modify them
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
SUMO_protein
Post-translational modification
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
Lysine_malonylation
Protein-coding gene in the species Homo sapiens
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
DNAJC1
Protein-coding gene in the species Homo sapiens
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
DNAJA3
Type of protein domain
Santonico, Elena (7 April 2020). "Old and New Concepts in Ubiquitin and NEDD8 Recognition". Biomolecules. 10 (4): 566. doi:10.3390/biom10040566. PMC 7226360
Ubiquitin-binding_domain
Protein-coding gene in humans
complex binding protein N-terminus binding ubiquitin protein ligase activity NEDD8 ligase activity disordered domain specific binding protein domain specific
Mdm2
protein complex with isopeptidase activity. It catalyses the hydrolysis of NEDD8 protein from the cullin subunit of Cullin-RING ubiquitin ligases (CRL).
COP9_signalosome
Protein-coding gene in the species Homo sapiens
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
UBE2V2
Protein family
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
URM1
6.2.1.63: L-arginine—[L-arginyl-carrier protein] ligase EC 6.2.1.64: E1 NEDD8-activating enzyme EC 6.2.1.65: salicylate—CoA ligase EC 6.2.1.66: glyine—[glycyl-carrier
List_of_EC_numbers_(EC_6)
Protein-coding gene in humans
reference expression data Gene ontology Molecular function protein binding NEDD8-specific protease activity Cellular component cytoplasm COP9 signalosome
COPS4
Family of heat shock proteins
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
Hsp70
Q8NHV4 10409 NEDD4 HGNC:7727; P46934 10410 NEDD4L HGNC:7728; Q96PU5 10411 NEDD8 HGNC:7732; Q15843 10412 NEDD9 HGNC:7733; Q14511 10413 NEFH HGNC:7737; P12036
List of human protein-coding genes 5
List_of_human_protein-coding_genes_5
Protein-coding gene in the species Homo sapiens
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
UBE2E1
Mammalian protein found in humans
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
Von Hippel–Lindau tumor suppressor
Von_Hippel–Lindau_tumor_suppressor
Human gene
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
HSPA12A
Protein-coding gene in the species Homo sapiens
Coggins MB, Pierce JW, Podust VN, Luo RS, Chau V, Palombella VJ (2000). "Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination
S-phase kinase-associated protein 1
S-phase_kinase-associated_protein_1
Type of peptide chain
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
Target_peptide
Protein-coding gene in humans
Gladysheva TB, Hottelet M, Parent LA, Coggins MB, et al. (April 2000). "Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination
CDC34
Protein-coding gene in humans
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
SMN1
American chemical biologist and protein engineer
Proximity Tagging of Small Molecule Protein Targets Using an Engineered NEDD8 Ligase". Journal of the American Chemical Society. 138 (40): 13123–13126
James_A._Wells
Class of enzymes
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
Ubiquitin-activating_enzyme
Protein-coding gene in the species Homo sapiens
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
HSPA8
Protein-coding gene in the species Homo sapiens
C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1". Mol. Cell. Biol. 20
RNF7
Protein found in humans
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
ISG15
Protein-coding gene in the species Homo sapiens
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
Binding immunoglobulin protein
Binding_immunoglobulin_protein
Protein-coding gene in Homo sapiens
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
Ubiquitin-protein_ligase_E3B
Protein-coding gene in humans
Hammel Michal, Schulman Brenda A (Sep 2008). "Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation"
CUL5
Protein-coding gene in the species Homo sapiens
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
DNAJC19
Protein-coding gene in the species Homo sapiens
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
TRAP1
Protein-coding gene in the species Homo sapiens
Caskey LS, Yeh ET, Kamitani T (Oct 1998). "Cleavage of the C-terminus of NEDD8 by UCH-L3". Biochemical and Biophysical Research Communications. 251 (3):
Ubiquitin carboxy-terminal hydrolase L1
Ubiquitin_carboxy-terminal_hydrolase_L1
Protein-coding gene in the species Homo sapiens
Hill CP (1999). "Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes". J. Biol. Chem. 273 (52):
UBE2K
Mammalian gene
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
CBL_(gene)
Protein-coding gene in the species Homo sapiens
ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8". Nature. 422 (6929): 330–4. Bibcode:2003Natur.422..330W. doi:10.1038/nature01456
UBA2
Hidenori; Yeh, Edward T. H; Kamitani, Tetsu (2003). "Regulation of the NEDD8 Conjugation System by a Splicing Variant, NUB1L". Journal of Biological
Fuzzy_complex
Protein-coding gene in the species Homo sapiens
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
HSP90B1
Protein-coding gene in the species Homo sapiens
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
Hsp27
Protein family
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
Prokaryotic ubiquitin-like protein
Prokaryotic_ubiquitin-like_protein
InterPro Family
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
Hsp33
Protein-coding gene in the species Homo sapiens
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
UBE2O
Heat shock proteins with a molecular mass around 90kDa
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
Hsp90
Protein-coding gene in the species Homo sapiens
MB, Pierce JW, Podust VN, Luo RS, Chau V, Palombella VJ (April 2000). "Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination
BTRC_(gene)
Protein-coding gene in the species Homo sapiens
thiol-dependent deubiquitinase peptidase activity cysteine-type peptidase activity NEDD8-specific protease activity ubiquitin binding protein binding hydrolase activity
OTUB2
Protein-coding gene in humans
PMC 108784. PMID 9447969. Wada H, Yeh ET, Kamitani T (1999). "Identification of NEDD8-conjugation site in human cullin-2". Biochem. Biophys. Res. Commun. 257
CUL2
Protein-coding gene in the species Homo sapiens
Y, Liu W, Naumovski L, Neve RL (2003). "ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation
TP53BP2
Protein-coding gene in the species Homo sapiens
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
GroEL
Protein found in humans
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
Clusterin
Protein-coding gene in the species Homo sapiens
of Ku80, allowing it to be released from the Ku protein ring, or else by NEDD8 promoted ubiquitination of Ku protein, causing its release from DNA. UV-induced
RNF8
Human gene and enzyme
humans is encoded by the UCHL3 gene. UCHL3 has been shown to interact with NEDD8 and the tauopathy and synucleinopathy associated mutated ubiquitin molecule
UCHL3
Protein-coding gene in the species Homo sapiens
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
HSPA4
Protein-coding gene in the species Homo sapiens
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
UBE2I
Protein-coding gene in the species Homo sapiens
data Gene ontology Molecular function cysteine-type peptidase activity NEDD8-specific protease activity thiol-dependent deubiquitinase peptidase activity
OTUB1
Protein-coding gene in the species Homo sapiens
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
ATG12
Protein-coding gene in the species Homo sapiens
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
HSPA4L
Protein-coding gene in humans
enzyme UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like
SMN2
English structural biologist
in the mechanisms of ubiquitination, solving the structure of the E1 for Nedd8. In London, Walden studied the specificity and regulation of E3 ubiquitin
Helen_Walden
NEDD8
NEDD8
NEDD8
NEDD8
Girl/Female
Czechoslovakian Slavic
Industrious.
Boy/Male
Hindu, Indian, Sanskrit
A Name of Lord Ganesh
Boy/Male
Biblical
His redemption; ox-yoke.
Girl/Female
American, Australian
Denni's Field
Boy/Male
Hindu, Indian, Marathi, Tamil, Telugu
Lord Murugan
Girl/Female
Hindu
Very special
Boy/Male
Gujarati, Hindu, Indian, Jain, Kannada, Malayalam, Marathi, Sanskrit, Telugu
Effect
Female
Babylonian
, the mother of the gods.
Surname or Lastname
English
English : variant spelling of Colston.
Surname or Lastname
English
English : habitational name from Stanborough in Devon, so named from Old English stÄn ‘stone’ + beorg ‘hill’, ‘tumulus’. There is a place called Stanbury in West Yorkshire near Haworth, but it does not seem to have given rise to the surname.
NEDD8
NEDD8
NEDD8
NEDD8
NEDD8