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Protein family
Deubiquitinating enzymes (DUBs), also known as deubiquitinating peptidases, deubiquitinating isopeptidases, deubiquitinases, ubiquitin proteases, ubiquitin
Deubiquitinating_enzyme
Ubiquitin-AMC is a fluorogenic substrate for a wide range of deubiquitinating enzymes (DUBs), including ubiquitin C-terminal hydrolases (UCHs) and ubiquitin
Ub-AMC
Protein-coding gene in the species Homo sapiens
protein 20 and VHL protein-interacting deubiquitinating enzyme 2 (VDU2), is a cysteine protease deubiquitinating enzyme (DUB). The catalytic site of USP20
USP20
Regulatory protein found in most eukaryotic tissues
protein. These effects can all modulate the transcription of genes. Deubiquitinating enzymes (deubiquitinases; DUBs) oppose the role of ubiquitylation by removing
Ubiquitin
Protein complexes which degrade ubiquitin-tagged proteins by proteolysis
horseshoe-like structure enclosing the Rpn8/Rpn11 heterodimer. Rpn11, the deubiquitinating enzyme, is placed at the mouth of the AAA-ATPase hexamer, ideally positioned
Proteasome
Enzyme
(EC 3.4.19.12), also known as deubiquitinating enzyme 27, ubiquitin thioesterase 27 and USP27X, is a deubiquitinating enzyme which is mainly characterized
USP27X
Pharmaceutical compound
Cheng C, et al. (November 2017). "An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons". The Journal
IU1
Protein-coding gene in humans
screen conducted to identify interacting partners of 75 human deubiquitinating enzymes (DUBs) has revealed several novel binding partners of USP7. Loss-of-function
USP7
Protein-coding gene in the species Homo sapiens
proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the nucleoli and deubiquitinate nucleophosmin and
USP36
Protein-coding gene in the species Homo sapiens
L1 (EC 3.1.2.15, ubiquitin C-terminal hydrolase, UCH-L1) is a deubiquitinating enzyme. UCH-L1 is a member of a gene family whose products hydrolyze small
Ubiquitin carboxy-terminal hydrolase L1
Ubiquitin_carboxy-terminal_hydrolase_L1
Protein-coding gene in the species Homo sapiens
specific proteases family (USPs) which is a sub-family of the Deubiquitinating enzymes (DUBs).USPs are multiple domain proteases and belong to the C19
USP11
Protein-coding gene in the species Homo sapiens
associated protein-1 (ubiquitin carboxy-terminal hydrolase) is a deubiquitinating enzyme that in humans is encoded by the BAP1 gene. BAP1 encodes an 80
BAP1
Protein-coding gene in the species Homo sapiens
ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the
USP1
Protein-coding gene in the species Homo sapiens
UBR1 Deubiquitinating enzyme: Ataxin 3 USP6 CYLD ATG3 BIRC6 UFC1 Ubiquitin-like proteins (UBL) SUMO protein (SUMOylation) E1 SUMO-activating enzyme SAE1
DNAJB4
Class of enzymes
Ubiquitin-activating enzymes, also known as E1 enzymes, catalyze the first step in the ubiquitination reaction, which (among other things) can target
Ubiquitin-activating_enzyme
Protein-coding gene in the species Homo sapiens
of nomenclature USP4 was known as UNP, and was one of the first deubiquitinating enzymes to be identified in mammals. In the mouse and human the USP4 protein
USP4
American biochemist (born 1965)
transition in mammalian cells. His lab identified the first centriolar deubiquitinating enzyme, USP33, whose expression regulates centrosome biogenesis via deubiquitination
Brian_David_Dynlacht
Protein-coding gene in the species Homo sapiens
carboxyl-terminal hydrolase 16 is an enzyme that in humans is encoded by the USP16 gene. This gene encodes a deubiquitinating enzyme that is phosphorylated at the
USP16
Mammalian protein found in Homo sapiens
2794 nucleotide base-pairs on the X-chromosome. The USP26 enzyme is a deubiquitinating enzyme that places a very significant role in the regulation of
USP26
Mammalian protein found in humans
Several deubiquitinating enzymes (DUBs) modulate p53 stability by removing ubiquitin chains. USP7, also known as HAUSP, can deubiquitinate both p53 and
P53
Topics referred to by the same term
doo-wop vocal group "Dub", a song by Yeat from 2 Alive (2022) Deubiquitinating enzyme Dysfunctional uterine bleeding DUB (cuneiform), an alphabetic sign
Dub
Mammalian protein found in humans
Messing EM, Wu G (February 2002). "Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein"
Von Hippel–Lindau tumor suppressor
Von_Hippel–Lindau_tumor_suppressor
Protein-coding gene in the species Homo sapiens
ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the
USP14
Protein-coding gene in the species Homo sapiens
the protein controlling critical functions). CYLD protein is a deubiquitinating enzyme, i.e. a protease that removes ubiquitin from certain proteins and
CYLD_(gene)
Type of enzymes
transcription. Ubiquitin ligases add these ubiquitin proteins while deubiquitinating enzymes (DUBs) remove these groups. Ubiquitination of the H2A core histone
Histone-modifying_enzymes
Protein family
Ubiquitin-conjugating enzymes, also known as E2 enzymes and more rarely as ubiquitin-carrier enzymes, perform the second step in the ubiquitination reaction
Ubiquitin-conjugating_enzyme
Protein in humans
ME, Bennett EJ, Gygi SP, Harper JW (2009). "Defining the Human Deubiquitinating Enzyme Interaction Landscape". Cell. 138 (2): 389–403. doi:10.1016/j.cell
Cereblon
Protein-coding gene in humans
variants. BRCC36, the protein product of the BRCC3 gene, is a deubiquitinating enzyme and a core component of the deubiquitin complex BRCA1-A. BRCA1
BRCC3
Protein-coding gene in the species Homo sapiens
members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family
USP48
Protein-coding gene in the species Homo sapiens
Buyon JP (September 2001). "Interaction between 52 kDa SSA/Ro and deubiquitinating enzyme UnpEL: a clue to function". The International Journal of Biochemistry
TRIM21
Protein-coding gene in the species Homo sapiens
carboxyl-terminal hydrolase 6 (USB6), also termed TRE17 and Tre-2, is a deubiquitinating enzyme that in humans is encoded by the hominid (i.e. found only in primates)
USP6
WJ, Wilkinson KD, Hill CP (July 1997). "Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 A resolution". The EMBO Journal. 16 (13):
Ubiquitinyl_hydrolase_1
Factors causing Parkinson's disease
gene is associated with lysosome storage and autophagy. GBA encodes the enzyme glucocerebrosidase (GCase), necessary for breaking down glucosylceramide
Causes_of_Parkinson's_disease
Protein-coding gene in the species Homo sapiens
phosphatidylinositol 3-kinase p85beta subunit and HUMORF8, a putative deubiquitinating enzyme". Oncogene. 16 (13): 1767–72. doi:10.1038/sj.onc.1201695. PMID 9582025
USP8
Proteins assisting in protein folding
UBR1 Deubiquitinating enzyme: Ataxin 3 USP6 CYLD ATG3 BIRC6 UFC1 Ubiquitin-like proteins (UBL) SUMO protein (SUMOylation) E1 SUMO-activating enzyme SAE1
Chaperone_(protein)
Protein-coding gene in the species Homo sapiens
PMID 25260751. Kato M, Miyazawa K, Kitamura N (December 2000). "A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein
Signal transducing adaptor molecule
Signal_transducing_adaptor_molecule
Protein-coding gene in the species Homo sapiens
1093/dnares/9.3.99. PMID 12168954. D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators". Crit. Rev. Biochem. Mol
USP15
Family of heat shock proteins
UBR1 Deubiquitinating enzyme: Ataxin 3 USP6 CYLD ATG3 BIRC6 UFC1 Ubiquitin-like proteins (UBL) SUMO protein (SUMOylation) E1 SUMO-activating enzyme SAE1
Hsp70
Protein-coding gene in the species Homo sapiens
in humans is encoded by the OTUD6B gene. OTUD6B is a functional deubiquitinating enzyme, a class of protease that specifically cleaves ubiquitin linkages
OTUD6B
Protein-coding gene in the species Homo sapiens
is encoded by the USP53 gene. Although USP53 is classified as a deubiquitinating enzyme based on sequence homology to other proteases from this group,
USP53
Short peptide present at N-terminal of newly synthesized proteins
UBR1 Deubiquitinating enzyme: Ataxin 3 USP6 CYLD ATG3 BIRC6 UFC1 Ubiquitin-like proteins (UBL) SUMO protein (SUMOylation) E1 SUMO-activating enzyme SAE1
Signal_peptide
Protein-coding gene in the species Homo sapiens
Ubiquitin-like modifier activating enzyme 1 (UBA1) is an enzyme which in humans is encoded by the UBA1 gene. UBA1 participates in ubiquitination and the
UBA1
Family of proteins
UBR1 Deubiquitinating enzyme: Ataxin 3 USP6 CYLD ATG3 BIRC6 UFC1 Ubiquitin-like proteins (UBL) SUMO protein (SUMOylation) E1 SUMO-activating enzyme SAE1
Heat_shock_protein
Neurodevelopmental disorder
2. The USP7 gene encodes for ubiquitin-specific protease 7, a deubiquitinating enzyme (DUB). DUBs are crucial for regulating protein stability, localization
Hao–Fountain_syndrome
Protein
ubiquitin ligase) is a protein that recruits an E2 ubiquitin-conjugating enzyme that has been loaded with ubiquitin, recognizes a protein substrate, and
Ubiquitin_ligase
Medical condition
ubiquitin carboxyl-terminal hydrolase 6a, that has uncontrolled deubiquitinating enzyme activity. This may result in the inappropriate stimulation of multiple
Nodular_fasciitis
Protein-coding gene in the species Homo sapiens
UBR1 Deubiquitinating enzyme: Ataxin 3 USP6 CYLD ATG3 BIRC6 UFC1 Ubiquitin-like proteins (UBL) SUMO protein (SUMOylation) E1 SUMO-activating enzyme SAE1
HSPA8
Protein-coding gene in the species Homo sapiens
Maillard M, Song L, Cohen RE, Dijke PT, Chantry A (Dec 2005). "The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling".
Ubiquitin carboxyl-terminal hydrolase L5
Ubiquitin_carboxyl-terminal_hydrolase_L5
Proteins with backbone entangled in a knot
preventing it from being pulled into the proteasome. Because it is a deubiquitinating enzyme, it is often found in proximity of proteins soon to be degraded
Knotted_protein
Medical condition
gene, CYLD lysine 63 deubiquitinase protein (CYLD protein), is a deubiquitinating enzyme, i.e. a protease that removes ubiquitin from certain proteins and
CYLD_cutaneous_syndrome
Aggregation of misfolded proteins in cells
when there is a protein. Ataxin-3 is the protein that, in the deubiquitinating enzyme function, forms SCA type-1 and 2 DRPLA intranuclear inclusions
Aggresome
Protein-coding gene in the species Homo sapiens
The protein encoded by this gene is a zinc finger protein and a deubiquitinating enzyme, and has been shown to inhibit NF-kappa B activation as well as
TNFAIP3
Protein found in humans
Yamamoto T, Kanai-Azuma M, Wood SA, Kaibuchi K (Dec 1999). "The deubiquitinating enzyme Fam interacts with and stabilizes beta-catenin". Genes to Cells
Afadin
Type of peptide chain
UBR1 Deubiquitinating enzyme: Ataxin 3 USP6 CYLD ATG3 BIRC6 UFC1 Ubiquitin-like proteins (UBL) SUMO protein (SUMOylation) E1 SUMO-activating enzyme SAE1
Target_peptide
Protein found in humans
conjugating enzymes. The activating E1 enzyme (UBE1L) charges ISG15 by forming a high-energy thiolester intermediate and transfers it to the UBE2E2 E2 enzyme. UBE2E2
ISG15
Biological mechanism for routing proteins
through the meshwork until it reaches the nucleus. Once inside, a GTPase enzyme called Ran, which can exist in two different forms (one bound to GTP and
Protein_targeting
Protein-coding gene in the species Homo sapiens
531–4. PMID 15182641. Berruti G, Martegani E (January 2005). "The deubiquitinating enzyme mUBPy interacts with the sperm-specific molecular chaperone MSJ-1:
DNAJB6
Class of enzymes
Galectin-9-TAK1 system and ubiquitination responses at controlled by deubiquitinating enzymes such as USP9X leading to AMPK activation in response to lysosomal
AMP-activated_protein_kinase
Genus of amphibians
M, Zacchigna L, Adorno M, et al. (January 2009). "FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination"
Xenopus
Protein-coding gene in the species Homo sapiens
iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation". J. Clin. Invest. 112 (2):
USP33
Protein-coding gene in the species Homo sapiens
begun to suggest a regulatory correlation between HSP60 and the glycolytic enzyme, 6-phosphofructokinase-1. Although not much information is available, cytoplasmic
GroEL
Protein-coding gene in the species Homo sapiens
polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes". Proceedings of the National Academy of Sciences of the United
HDAC6
Family of heat shock proteins
2008-06-28 at the Wayback Machine The Chaperonin Home Page The Protein Data Bank Enzyme Database on HSP60 Archived 2021-04-18 at the Wayback Machine HSP60 on Pub
Chaperonin
Swiss researcher and academic
Kessler, B. M. (2010). Post-translational modification of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to Yersinia
Benedikt_Kessler
Protein-coding gene in the species Homo sapiens
FRAGMENT OF HUMAN UBIQUITIN 1nbf: Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde 1ogw: SYNTHETIC
Ubiquitin_B
Post-translational modification
sites and only a few are extensively modified, the most heavily modified enzyme being carbamoyl‑phosphate synthetase 1 (CPS1) of the urea cycle with 31
Lysine_malonylation
InterPro Family
UBR1 Deubiquitinating enzyme: Ataxin 3 USP6 CYLD ATG3 BIRC6 UFC1 Ubiquitin-like proteins (UBL) SUMO protein (SUMOylation) E1 SUMO-activating enzyme SAE1
Hsp33
Protein-coding gene in the species Homo sapiens
UBR1 Deubiquitinating enzyme: Ataxin 3 USP6 CYLD ATG3 BIRC6 UFC1 Ubiquitin-like proteins (UBL) SUMO protein (SUMOylation) E1 SUMO-activating enzyme SAE1
DNAJB2
accumulate DNA damage. These cells also over-express a histone deubiquitinating enzyme, Usp16, which regulates the DNA damage response. These dysfunctions
Mouse_models_of_Down_syndrome
Human gene
UBR1 Deubiquitinating enzyme: Ataxin 3 USP6 CYLD ATG3 BIRC6 UFC1 Ubiquitin-like proteins (UBL) SUMO protein (SUMOylation) E1 SUMO-activating enzyme SAE1
HSPA12A
Protein-coding gene in humans
UBR1 Deubiquitinating enzyme: Ataxin 3 USP6 CYLD ATG3 BIRC6 UFC1 Ubiquitin-like proteins (UBL) SUMO protein (SUMOylation) E1 SUMO-activating enzyme SAE1
Mdm2
Stage in embryonic development
Ectodermin (Ecto, TIF1-γ, TRIM33); later, it was found that the deubiquitinating enzyme, FAM/USP9x, is able to overcome the effects of ubiquitination made
Ectoderm_specification
Mammalian protein found in humans
Yamamoto T, Kanai-Azuma M, Wood SA, Kaibuchi K (December 1999). "The deubiquitinating enzyme Fam interacts with and stabilizes beta-catenin". Genes to Cells
Catenin_beta-1
Post-translational modifications involving the protein NEDD8
lysine residue of a target protein, which is catalyzed by a cascade of enzymes including UBA3, NAE1, UBE2M or UBE2F, and NEDD8 E3 ligases. Neddylation
Neddylation
Protein-coding gene in the species Homo sapiens
deubiquitinase 1 is a protein that in humans is encoded by the OTUD1 gene. Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin
OTUD1
Chemical changes in proteins following their translation from mRNA
such as phosphate. Phosphorylation is highly effective for controlling the enzyme activity and is the most common change after translation. Many eukaryotic
Post-translational modification
Post-translational_modification
Albumin found in human blood
Bennett EJ, Gygi SP, Harper JW (July 2009). "Defining the human deubiquitinating enzyme interaction landscape". Cell. 138 (2): 389–403. doi:10.1016/j.cell
Human_serum_albumin
Protein-coding gene in humans
UBR1 Deubiquitinating enzyme: Ataxin 3 USP6 CYLD ATG3 BIRC6 UFC1 Ubiquitin-like proteins (UBL) SUMO protein (SUMOylation) E1 SUMO-activating enzyme SAE1
SMN2
Human gene and enzyme
SC, Larsen CN, Cook WJ, et al. (1997). "Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 A resolution". EMBO J. 16 (13): 3787–96.
UCHL3
Mammalian protein found in humans
Beyaert R, Blundell TL, Kilshaw PJ (June 2003). "A novel type of deubiquitinating enzyme". The Journal of Biological Chemistry. 278 (25): 23180–6. doi:10
Ubiquitin_C
Protein-coding gene in the species Homo sapiens
Ubiquitin-conjugating enzyme E2 G2 is a protein that in humans is encoded by the UBE2G2 gene. The modification of proteins with ubiquitin is an important
UBE2G2
Change of a linear protein chain to a 3D structure
Fersht A (1999). Structure and Mechanism in Protein Science: A Guide to Enzyme Catalysis and Protein Folding. Macmillan. ISBN 978-0-7167-3268-6. "Protein
Protein_folding
Addition of a succinyl group to a lysine group of a protein
acetylation, it has been suggested that succinyl-CoA is the cofactor of enzyme-mediated lysine succinylation. Xie, Z.; Dai, J.; Dai, L.; Tan, M.; Cheng
Succinylation
Enzyme found in humans
(Rpn13, Rpn10) and the deubiquitinating enzyme Uch37, can be ubiquitinated in situ by proteasome-associating ubiquitination enzymes. Ubiquitination of proteasome
PSMC6
American cancer researcher (born 1956)
colleagues have identified and cloned a family of cytokine-inducible deubiquitinating enzymes that regulate hematopoietic cell growth by controlling the ubiquitin-mediated
Alan_D'Andrea
Protein in animal cells
UBR1 Deubiquitinating enzyme: Ataxin 3 USP6 CYLD ATG3 BIRC6 UFC1 Ubiquitin-like proteins (UBL) SUMO protein (SUMOylation) E1 SUMO-activating enzyme SAE1
Survival_of_motor_neuron
Cellular process
active sites. Ubiquitin is cleaved before terminal digestion by deubiquitinating enzymes. This third step is very closely associated with the second one
Endoplasmic-reticulum-associated protein degradation
Endoplasmic-reticulum-associated_protein_degradation
Protein-coding gene in the species Homo sapiens
UBR1 Deubiquitinating enzyme: Ataxin 3 USP6 CYLD ATG3 BIRC6 UFC1 Ubiquitin-like proteins (UBL) SUMO protein (SUMOylation) E1 SUMO-activating enzyme SAE1
Ataxin_3
Protein-coding gene in humans
encodes the protein Ubiquitin-conjugating enzyme E2 R1. This protein is a member of the ubiquitin-conjugating enzyme family, which catalyzes the covalent attachment
CDC34
Protein-coding gene in the species Homo sapiens
Ubiquitin-conjugating enzyme E2 B is a protein that in humans is encoded by the UBE2B gene. The modification of proteins with ubiquitin is an important
UBE2B
Protein-coding gene in the species Homo sapiens
UBR1 Deubiquitinating enzyme: Ataxin 3 USP6 CYLD ATG3 BIRC6 UFC1 Ubiquitin-like proteins (UBL) SUMO protein (SUMOylation) E1 SUMO-activating enzyme SAE1
TRAP1
Medical condition
LINKED syndrome is mutations in the OTUD5 gene, which encodes a deubiquitinating enzyme essential for regulating protein stability during embryogenesis
LINKED_syndrome
Protein-coding gene in the species Homo sapiens
Schoen SR, Messing EM, Wu G (Feb 2002). "Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein"
ELOC
Protein-coding gene in the species Homo sapiens
Ubiquitin-conjugating enzyme E2 variant 2 is a protein that in humans is encoded by the UBE2V2 gene. Ubiquitin-conjugating enzyme E2 variant proteins constitute
UBE2V2
Protein-coding gene in humans
"hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37". The EMBO Journal. 25 (24): 5742–53. doi:10.1038/sj.emboj
ADRM1
Family of proteins which attach to other proteins to modify them
E1 enzyme (SUMO Activating Enzyme (SAE)) which is a heterodimer (subunits SAE1 and SAE2). It is then passed to an E2, which is a conjugating enzyme (Ubc9)
SUMO_protein
Protein-coding gene in the species Homo sapiens
glycoproteins such as LAMP1, LAMP2, SCRAB2, TMEM192, etc., repulsion of deubiquitinating enzyme USP9X, increased K63 ubiquitination of TAK1 (MAP3K7) kinase, which
Galectin-9
Hydrophobic scaffold protein
protein appears to function as a docking site for ubiquitin-conjugating enzymes (E2s). Other proteins contain a cullin-homology domain, such as CUL9, also
Cullin
Human gene
Bennett EJ, Gygi SP, Harper JW (July 2009). "Defining the human deubiquitinating enzyme interaction landscape". Cell. 138 (2): 389–403. doi:10.1016/j.cell
PBDC1
Protein-coding gene in the species Homo sapiens
(2004). "Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8". Mol. Cell. Biol. 24 (17): 7748–57. doi:10.1128/MCB.24.17
BIRC6
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