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USP14

Pharmaceutical compound

selective inhibitor of the ubiquitin-specific processing protease enzyme USP14. It is of interest in anti-cancer and antiviral research and also as a potential

IU1

USP14

Protein-coding gene in the species Homo sapiens

Ubiquitin-specific protease 14 is an enzyme that in humans is encoded by the USP14 gene. This gene encodes a member of the ubiquitin-specific processing (UBP)

USP14

Proteasome

Protein complexes which degrade ubiquitin-tagged proteins by proteolysis

Ubp6/USP14 and UCH37. Rpn11 is the essential DUB responsible for the en block removal of the ubiquitin signal from the substrate, while Ubp6/USP14 and

Proteasome

CXCR4

Protein

CD20 expression.[citation needed] CXCR4 has been shown to interact with USP14. CXCR4 antagonist HIV tropism Entry inhibitor Discovery and development

CXCR4

Deubiquitinating enzyme

Protein family

USP4, USP5, USP6, USP7, USP8, USP9X, USP9Y, USP10, USP11, USP12, USP13, USP14, USP15, USP16, USP17, USP17L2, USP17L3, USP17L4, USP17L5, USP17L7, USP17L8

Deubiquitinating enzyme

Deubiquitinating_enzyme

Ubiquitin B

Protein-coding gene in the species Homo sapiens

Solution structure of the human Mms2-Ubiquitin complex 2ayo: Structure of USP14 bound to ubquitin aldehyde 2bgf: NMR STRUCTURE OF LYS48-LINKED DI-UBIQUITIN

Ubiquitin B

Ubiquitin_B

List of human protein-coding genes 8

P51784 17971 USP12 HGNC:20485; O75317 17972 USP13 HGNC:12611; Q92995 17973 USP14 HGNC:12612; P54578 17974 USP15 HGNC:12613; Q9Y4E8 17975 USP16 HGNC:12614;

List of human protein-coding genes 8

List_of_human_protein-coding_genes_8

Ubiquitin C

Mammalian protein found in humans

Solution structure of the human Mms2-Ubiquitin complex 2ayo: Structure of USP14 bound to ubquitin aldehyde 2bgf: NMR STRUCTURE OF LYS48-LINKED DI-UBIQUITIN

Ubiquitin C

Ubiquitin_C

Ubiquitin A-52 residue ribosomal protein fusion product 1

Human protein

Solution structure of the human Mms2-Ubiquitin complex 2ayo: Structure of USP14 bound to ubquitin aldehyde 2bgf: NMR STRUCTURE OF LYS48-LINKED DI-UBIQUITIN

Ubiquitin A-52 residue ribosomal protein fusion product 1

Ubiquitin_A-52_residue_ribosomal_protein_fusion_product_1

Housekeeping gene

Gene which maintains basic cellular functions

NM_130466 UBE3C NM_014671 UBE4A NM_004788 UBE4B NM_006048 USP10 NM_005153 USP14 NM_005151 USP16 NM_006447 USP19 NM_006677 USP22 NM_015276 USP25 NM_013396

Housekeeping gene

Housekeeping_gene

40S ribosomal protein S27a

Protein-coding gene in the species Homo sapiens

Solution structure of the human Mms2-Ubiquitin complex 2ayo: Structure of USP14 bound to ubquitin aldehyde 2bgf: NMR STRUCTURE OF LYS48-LINKED DI-UBIQUITIN

40S ribosomal protein S27a

40S_ribosomal_protein_S27a

TRIM14

Mammalian protein found in Homo sapiens

is suppressed. Induction of TRIM14 by type I IFN leads to activation of USP14 which then cleaves the polyubiquitin chain from cGAS and type I IFN signalling

TRIM14