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Search references for BRD4. Phrases containing BRD4
See searches and references containing BRD4!BRD4
Protein-coding gene in the species Homo sapiens
by the BRD4 gene. BRD4 is a member of the BET (bromodomain and extra terminal domain) family, which also includes BRD2, BRD3, and BRDT. BRD4, similar
BRD4
Drug class
bromodomains of Bromodomain and Extra-Terminal motif (BET) proteins BRD2, BRD3, BRD4, and BRDT, and prevent protein-protein interaction between BET proteins and
BET_inhibitor
Chemical compound
inhibitor of the BET family of bromodomain proteins which include BRD2, BRD3, BRD4, and the testis-specific protein BRDT in mammals. BET inhibitors structurally
JQ1
Medical condition
of NUTM1 in band 14 on the long (or "q") arm of chromosome 15 is fused to BRD4 or BRD3, which creates a chimeric gene that encodes the BRD-NUT fusion protein
NUT_carcinoma
DNA changes that regulate human traits
regulatory regions, BRD4 enhances activation of these DNA regions. BRD4 enhances this activation by recruiting P-TEFb; if either BRD4 or P-TEFb is not functional
Epigenetics of human development
Epigenetics_of_human_development
Protein complex regulating transcription in eukaryotes
P-TEFb associates with other factors including the bromodomain protein BRD4, and is found associated with a large complex of proteins called the super
P-TEFb
1,132-amino acid
particular cell type), immature-appearing cells containing a BRD4-NUTM1 fusion gene. BRD4 is the bromodomain-containing protein 4 gene. A fusion gene is
Nuclear protein in testis gene
Nuclear_protein_in_testis_gene
Region of a genome which regulates expression of genes related to cell identity
Acetylated NF-κB recruits a specific histone acetyltransferase enzyme, BRD4. BRD4 acetylates histone 3 at histone 3 lysine 122 (see Figure "Nucleosome at
Super-enhancer
Small molecule (PROTAC)
"Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4". ACS Chemical Biology. 10 (8): 1770–1777. doi:10.1021/acschembio.5b00216
Proteolysis_targeting_chimera
American cancer scientist
particularly the roles of BRD4 and super-enhancers in cancer. His studies published in Nucleic Acids Research and Cell Reports highlight how BRD4 cooperates with
Steven_A._Johnsen
Small nuclear RNA found in metazoans
either the HIV transactivator Tat or the bromodomain containing protein BRD4. This release leads to a conformational change in 7SK RNA and the ejection
7SK_RNA
Japanese American geneticist
factor that aids humans in fighting off disease and for identifying the BRD4 protein that regulates cellular and viral genes that can invoke epigenetic
Keiko_Ozato
Protein
(2015-06-18). "Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4". Chemistry & Biology. 22 (6): 755–763. doi:10.1016/j.chembiol.2015.05.009
Ubiquitin_ligase
Chemical compound
MK-8628) is an experimental small molecule inhibitor of BRD2, BRD3, and BRD4 under investigation for the treatment of cancer. It is in development by
Birabresib
Protein-coding gene in the species Homo sapiens
distinct isoforms have been described. RFC3 has been shown to interact with: BRD4, CHTF18, PCNA, RFC1, and RFC4. GRCh38: Ensembl release 89: ENSG00000133119
RFC3
American geneticist
studies of regulation in cancer cells. Kuroda's laboratory has shown that BRD4-NUT regulator leads to cancer via causing histone modification changes that
Mitzi_Kuroda
Artificial peptide attached to protein for marking purpose
BromoTag, a "bump-and-hole" mutated version of the second bromodomain of Brd4, Brd4-BD2 L387A, that can be highly selectively bound by tag-specific PROTAC
Protein_tag
German virologist (born 1964)
2018 Jan 2;215(1):51-62. doi:10.1084/jem.20161066 "The Short Isoform of BRD4 Promotes HIV-1 Latency by Engaging Repressive SWI/SNF Chromatin-Remodeling
Melanie_Ott
metabolism, and survival, making it a prime target for cancer therapies. BRD4 BRD4, a member of the BET (Bromodomain and Extra-Terminal) family of proteins
Transcriptional addiction in cancer
Transcriptional_addiction_in_cancer
Committee for human gene name standards
gene. A marked example is CAP which can refer to any of 6 different genes (BRD4 Archived 2013-10-27 at the Wayback Machine, CAP1 Archived 2013-11-02 at the
HUGO Gene Nomenclature Committee
HUGO_Gene_Nomenclature_Committee
Chemical compound
synaptotagmin function. LY294002 is also a BET inhibitor (e.g. of BRD2, BRD3, and BRD4). It has been shown that LY294002 administration has an additive effect on
LY294002
Protein domain
extraterminal domain) family. Members of this family include BRD2, BRD3, BRD4 and BRDT. However proteins such as ASH1L also contain a bromodomain. Dysfunction
Bromodomain
Protein in humans
(2015-06-18). "Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4". Chemistry & Biology. 22 (6): 755–763. doi:10.1016/j.chembiol.2015.05.009
Cereblon
Family of viruses
replication. E2 also utilizes a cellular protein known as Bromodomain-4 (Brd4) to tether the viral genome to cellular chromosomes. This tethering to the
Papillomaviridae
Control of DNA to RNA conversion in cells
cluster interacts with its own mediator multi-protein complex. The protein BRD4 complexes with each typical enhancer and stabilizes the super-enhancer structure
Transcriptional_regulation
Protein complexes which degrade ubiquitin-tagged proteins by proteolysis
both programmed cell death and for immunity. Molecular glues that target BRD4 for degradation, lead to 26S proteasome generated peptides that release Inhibitor
Proteasome
Family of regulator genes
can cooperate with the RAS gene. Expression of Myc is highly dependent on BRD4 function in some cancers. BET inhibitors have been used to successfully block
Myc
Chemical compound
terminal domain (BET) proteins, and in particular the BET family member BRD4. BET proteins, which contain two bromodomains, interact with acetylated lysines
Apabetalone
Topics referred to by the same term
document .BRD, a file type in the EAGLE design automation software BRD2, BRD3, BRD4 and BRDT, bromodomain families Business requirements document Bycatch reduction
BRD
Mechanism of transmission of gene expression programs through cell division
Notable transcription factors implicated in mitotic bookmarking include: BRD4 GATA1 HSP70 TFIID ESRRB Sarge, K. D.; Park-Sarge, O. K. (2005). "Gene bookmarking:
Bookmarking
Italian molecular and systems biologist
supply of purines, as well as the purine synthesis of a cell can influence BRD4 activity and thus play a role in the carcinogenesis process. Additionally
Giulio_Superti-Furga
Study of cell metabolism in the development of cancer
proteins appear to be involved in oncometabolism and targeting and uncoupling BRD4 actions in carcinogenic cells, as well as stopping pro-migratory signals
Oncometabolism
Pharmaceutical compound
Zhang C, Bolinger AA, Zhou J (October 2024). "An updated patent review of BRD4 degraders". Expert Opinion on Therapeutic Patents. 34 (10): 929–951. doi:10
Ezobresib
Protein-coding gene in the species Homo sapiens
similar to BRD2, does not have a long C-terminal domain as BET family proteins BRD4 and BRDT do. Like other BET protein family members, BRD3 associates with
Bromodomain-containing protein 3
Bromodomain-containing_protein_3
Protein-coding gene in humans
reorganization. As BET inhibitors also inhibit other BET proteins BRD2, BRD3, and BRD4, they are likely to have effects in people beyond temporary male sterility
BRDT
Mammalian protein found in Homo sapiens
VP, Tamura T, et al. (September 2002). "A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase"
Proliferating cell nuclear antigen
Proliferating_cell_nuclear_antigen
Cancer originating in precursors to muscle cells
sensitive to inhibitors (such as JQ1) of a super enhancer bound protein BRD4. Embryonal RMS usually presents with a loss of heterozygosity (LOH) in the
Rhabdomyosarcoma
Protein-coding gene in the species Homo sapiens
Bromodomain and Extra-Terminal motif (BET) protein family that also contains BRD3, BRD4, and BRDT in mammals Early descriptions demonstrated that BRD2 gene product
BRD2
Protein-coding gene in the species Homo sapiens
PMID 12477932. Farina A, Hattori M, Qin J, et al. (2004). "Bromodomain Protein Brd4 Binds to GTPase-Activating SPA-1, Modulating Its Activity and Subcellular
SIPA1
P25440 1654 BRD3 HGNC:1104; Q15059 1655 BRD3OS HGNC:24742; A0A1B0GUI7 1656 BRD4 HGNC:13575; O60885 1657 BRD7 HGNC:14310; Q9NPI1 1658 BRD8 HGNC:19874; Q9H0E9
List of human protein-coding genes 1
List_of_human_protein-coding_genes_1
Segment of nucleic acid that affects the expression of associated genes
to the enhancer to the promoter of their joint target gene. The protein BRD4 forms a complex with each typical enhancer in the super-enhancer and helps
Regulatory_sequence
Molecular biologist
cancer drug targets. In 2011, Vakoc discovered that the epigenetic protein BRD4 was particularly important for leukemia, leading to a series of clinical
Christopher_Vakoc
DNA sequence that binds activators to increase the likelihood of gene transcription
PMID 26119834. Zou Z, Huang B, Wu X, Zhang H, Qi J, Bradner J, et al. (May 2014). "Brd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated
Enhancer_(genetics)
Investigational oral small-molecule drug
clinical use. Pelabresib is a selective inhibitor of BET proteins (BRD2, BRD3, BRD4, BRDT), which regulate gene expression by binding to acetylated histones
Pelabresib
oncogene Myc, the Rett syndrome protein MECP2, and the BET bromodomain protein BRD4. In particular, the Myc protein amplifies transcription by binding to promoters
Transcriptional_amplification
Technique for mapping interactions between molecules and their protein targets
bromodomain inhibitor JQ1 to the BET bromodomain family members BRD2, BRD3 and BRD4 2) Map the genomic binding sites of AT7519, an inhibitor of the cyclin dependent
Chem-seq
Paired box gene 3
MYOG and MYCN as well as chromatin structural proteins, such as CHD4 and BRD4, to contribute to the formation of super enhancers in the vicinity of a subset
PAX3
Protein-coding gene in the species Homo sapiens
distinct isoforms have been reported. RFC5 has been shown to interact with: BRD4, CHTF18, PCNA, RFC2, and RFC4. GRCh38: Ensembl release 89: ENSG00000111445
RFC5
Nepalese-American scientist (born 1963)
38813771) His work on medulloblastoma also focuses on combination therapy of BRD4, PI3K, and Hedgehog inhibitors (PMID: 36599397) as anti-neoplastics and radiosensitizers
Ram_I._Mahato
Proteine
have a role in telomere stability. RFC1 has been shown to interact with: BRD4, HDAC1, PCNA, RELA and RFC3. Biallelic intronic repeat expansions (a series
RFC1
Chinese-American scientist
H, Evers BM, Zhou MM, Zhou BP (Feb 2014). "Disrupting the Interaction of BRD4 with Diacetylated Twist Suppresses Tumorigenesis in Basal-like Breast Cancer"
Ming-Ming_Zhou
Form of dynamic modification
Aksoy, Ozlem; Bolden, Jessica E.; Chen, Chi-Chao; Fennell, Myles (2016). "BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance". Cancer Discovery
Chromatin_remodeling
Italian British biochemist
"Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4". ACS Chemical Biology. 10 (8): 1770–1777. doi:10.1021/acschembio.5b00216
Alessio_Ciulli
Field of study in cancer research
normally activates genes). Some research has focused on blocking the action of BRD4 on acetylated histones, which has been shown to increase the expression of
Cancer_epigenetics
Protein-coding gene in humans
Other interactions include those with: BRD3 (remodels DNA nucleosomes), BRD4 (binds acetylated lysine residues in DNA-associated histone to regulate gene
GATA1
Protein-coding gene in the species Homo sapiens
distinct isoforms have been described. RFC2 has been shown to interact with BRD4, CHTF18, PCNA, RFC4 and RFC5. GRCh38: Ensembl release 89: ENSG00000049541
RFC2
Mammalian protein found in humans
"Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4". ACS Chemical Biology. 10 (8): 1770–1777. doi:10.1021/acschembio.5b00216
Von Hippel–Lindau tumor suppressor
Von_Hippel–Lindau_tumor_suppressor
American immunologist (born 1948)
regulate MHC class I transcription in vivo. Some of her studies have identified BRD4, as a kinase that regulates early transcription, linking mitosis and transcription
Dinah_Singer
Protein-coding gene in the species Homo sapiens
K, Zhou M, Jeong HS, Brady JN, Ozato K (2005). "The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase
Cyclin_T2
Protein-coding gene in the species Homo sapiens
esophageal squamous cell carcinoma. RFC4 has been shown to interact with: BRD4, CHTF18, PCNA, RFC2, RFC3, and RFC5. GRCh38: Ensembl release 89: ENSG00000163918
RFC4
Protein-coding gene in the species Homo sapiens
promoter methylation to cancer. (pg. 14) — Thus PARP/RelA and OGG1/RelA/BRD4 are two complementary targets for cancer, as they induce alternative mechanisms
RELA
Tool in chemical genetics
Tao, Min; Rusinova, Elena (February 2014). "Disrupting the Interaction of BRD4 with Diacetylated Twist Suppresses Tumorigenesis in Basal-like Breast Cancer"
Bump_and_hole
Spiliotopoulos, Dimitrios; Caflisch, Amedeo (2014-06-01). "Discovery of BRD4 bromodomain inhibitors by fragment-based high-throughput docking". Bioorganic
LeDock
Chemical compound
inhibitors include JQ1 (inhibits the interaction between acetylated histones and BRD4); 79-6 (inhibits BCL6 BTB domain dimerization); MI-463 and MI-503 (inhibit
AI-10-49
Medical condition
I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA (January 2003). "BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma". Cancer Research
Porocarcinoma
Interaction between Aire and p-TEFb is enabled by another partner molecule Brd4, which stabilizes this molecular complex. Altogether, Aire requires around
Promiscuous_gene_expression
Protein-coding gene in the species Homo sapiens
leukemia through effects on isoform usage of epigenetic regulators including BRD4". Nature Communications. 9 (1): 5378. Bibcode:2018NatCo...9.5378T. doi:10
SRPK1
Protein-coding gene in the species Homo sapiens
hits BRD4 as an off-target leading to false or inconclusive results. Consequently, ERK5 inhibitors with improved selectivity (void of the BRD4 off-target
MAPK7
Professor of Cancer Structural Biology
novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4. Myers SM, Miller DC, Molyneux L, Arasta M, Bawn RH, Blackburn TJ, Cook SJ
Jane_Endicott
Protein-coding gene in the species Homo sapiens
overlapping kinase (MOK) controls microglial inflammatory/type-I IFN responses via Brd4 and is involved in ALS". Proceedings of the National Academy of Sciences
RAGE_(gene)
structure of the extraterminal domain of the bromodomain-containing protein BRD4". Protein Science. 17 (12): 2174–2179. doi:10.1110/ps.037580.108. PMC 2590908
FAM199X
Protein-coding gene in the species Homo sapiens
PMID 15489334. Jang MK, Mochizuki K, Zhou M, et al. (2005). "The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase
MED17
BRD4
BRD4
BRD4
BRD4
Female
Greek
Variant spelling of Greek Desdemona, DISDEMONA means "ill-starred."Â
Boy/Male
American, Australian, British, English, Jamaican
My Own Meadow; At the Clearing; Hermitage Meadow
Boy/Male
Arabic, Indian, Muslim
Servant of God
Boy/Male
English
Lives at tbe bridge.
Boy/Male
Tamil
Boy/Male
Hebrew American Spanish
God is with us; god is among us.
Girl/Female
Indian, Sanskrit
Sharp
Girl/Female
Muslim
A flower
Boy/Male
Hindu, Indian, Marathi
Lord Krishna
Boy/Male
Muslim/Islamic
Name of a previous chief army guard
BRD4
BRD4
BRD4
BRD4
BRD4