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Chemical compound
JQ1 is a thienotriazolodiazepine and a potent inhibitor of the BET family of bromodomain proteins which include BRD2, BRD3, BRD4, and the testis-specific
JQ1
Chemical compound
GABAA receptor positive allosteric modulators include: Apafant Israpafant JQ1 Catabay, A.; Taniguchi, M.; Jinno, K.; Pesek, J. J.; Williamsen, E. (1 March
Thienotriazolodiazepine
21491 1998 JL1 — May 1, 1998 Haleakala NEAT NYS 3.0 km MPC · JPL 21492 1998 JQ1 — May 1, 1998 Haleakala NEAT · 2.9 km MPC · JPL 21493 1998 JA2 — May 1,
List of minor planets: 21001–22000
List_of_minor_planets:_21001–22000
May 3, 1994 San Marcello L. Tesi, G. Cattani · 11 km MPC · JPL 16684 1994 JQ1 — May 11, 1994 La Palma M. J. Irwin, A. Żytkow cubewano (cold) 155 km MPC ·
List of minor planets: 16001–17000
List_of_minor_planets:_16001–17000
Compounds that inhibit histone deacetylases
with the pan-HDAC inhibitor LBH589 (panobinostat) and the BET bromodomain JQ1 compound. Trichostatin A (TSA) and others are being investigated as anti-inflammatory
Histone_deacetylase_inhibitor
Cubewano
official cubewanos are 15760 Albion, (15807) 1994 GV9, and (16684) 1994 JQ1. "JPL Small-Body Database Browser: 19255 (1994 VK8)" (2000-11-27 last obs)
(19255)_1994_VK8
Comprehensive list of objects beyond Neptune
albedo: 0.079; BRmag: 1.26; taxonomy: BR-IR catalog · MPC · JPL (16684) 1994 JQ1 1994 950 Irwin, M. J., Zytkow, A. 155 cubewano (cold) 43.9 0.05 4 41.9 45
List of trans-Neptunian objects
List_of_trans-Neptunian_objects
Kuiper belt object, not controlled by an orbital resonance with Neptune
145452 Ritona (145453) 2005 RR43 148780 Altjira (15807) 1994 GV9 (16684) 1994 JQ1 174567 Varda (19255) 1994 VK8 19521 Chaos (202421) 2005 UQ513 (24835) 1995
Classical_Kuiper_belt_object
Polish astrophysicist
(8361) 1990 JN1 1 May 1990 list 15810 Arawn 12 May 1994 list (16684) 1994 JQ1 11 May 1994 list (48443) 1990 HY5 29 April 1990 list (58165) 1990 HQ5 29
Anna_N._Żytkow
Airline code for a journey between multiple points
2024-03-11. "Jetstar (JQ)#1 ✈ FlightAware". FlightAware. Retrieved 2024-03-19. "JQ1 schedule. (Jetstar Airways flight: Melbourne -> Honolulu)". info.flightmapper
Flight_number
Technique for mapping interactions between molecules and their protein targets
locations of Bio-JQ1 throughout the genome, as determined using Chem-seq, are almost identical to the ChIP-seq derived locations of the JQ1’s known target
Chem-seq
Removal of an animal's reproductive organ
cells, preventing maturation. Male mice – injection of a solution of the JQ1 molecule to bind to a pocket of BRDT necessary for chromatin remodeling,
Neutering
Chemical compound
hormone-free contraceptive solutions. Adjudin CDD-2807 Dimethandrolone undecanoate JQ1 TDI-11861 Skiffington S (13 December 2023). "YourChoice Therapeutics begins
YCT529
Researchers at RWTH Aachen University discovered that four senolytic compounds – JQ1, RG7112, nutlin-3a, and AMG232 – can decrease epigenetic age in in vitro
Timeline_of_aging_research
Chemical compound
motility, and it has been investigated as a potential male contraceptive drug. JQ1 TDI-11861 YCT529 Holdaway J, Georg GI (May 2024). "An emerging target for
CDD-2807
Cancer originating in precursors to muscle cells
demonstrated that FP-RMS subtypes were especially sensitive to inhibitors (such as JQ1) of a super enhancer bound protein BRD4. Embryonal RMS usually presents with
Rhabdomyosarcoma
Family of regulator genes
Shilatifard A, Roy AL (2014). "Regulation of MYC expression and differential JQ1 sensitivity in cancer cells". PLOS ONE. 9 (1) e87003. Bibcode:2014PLoSO.
Myc
Pregnancy prevention methods used by men
contraceptive products are in preclinical development: BRDT inhibitors such as JQ1 have been shown to produce reversible sterility in male mice by blocking
Male_contraceptive
— May 3, 2002 Desert Eagle W. K. Y. Yeung · 2.5 km MPC · JPL 48291 2002 JQ1 — May 4, 2002 Desert Eagle W. K. Y. Yeung fast 1.9 km MPC · JPL 48292 2002
List of minor planets: 48001–49000
List_of_minor_planets:_48001–49000
Hong Kong-born Canadian astronomer (born 1960)
2001 HY31 28 April 2001 list (48290) 2002 JH 3 May 2002 list (48291) 2002 JQ1 4 May 2002 list (48297) 2002 LJ24 9 June 2002 list 50412 Ewen 26 February
William_Kwong_Yu_Yeung
Antoniazzi May 1, 1997 Bologna San Vittore · 3.1 km MPC · JPL 42594 1997 JQ1 — May 1, 1997 Caussols ODAS · 5.3 km MPC · JPL 42595 1997 PL — August 1
List of minor planets: 42001–43000
List_of_minor_planets:_42001–43000
— April 29, 2003 Socorro LINEAR NYS · fast 2.6 km MPC · JPL 128008 2003 JQ1 — May 1, 2003 Socorro LINEAR EOS 4.7 km MPC · JPL 128009 2003 JP6 — May 1
List of minor planets: 128001–129000
List_of_minor_planets:_128001–129000
Drug class
inducers of Apolipoprotein A-I by both GSK and Resverlogix. In 2010, the use of JQ1, a tert-butyl synthetic precursor of OTX-015, was published having activity
BET_inhibitor
4140 1.15 0.20 n.a. Vestian S 1.96 15.90 LCDB · List 484. (48291) 2002 JQ1 4140 1.15 0.09 n.a. MBA (inner) S 2.06 15.80 LCDB · List 485. (634465) 2011
List of fast rotators (minor planets)
List_of_fast_rotators_(minor_planets)
Region of a genome which regulates expression of genes related to cell identity
super-enhancers are enriched in the target of the JQ1 small molecule, BRD4, so treatment with JQ1 causes exceptional losses in expression for super-enhancer—associated
Super-enhancer
Protein-coding gene in humans
histone hyperacetylation in elongating spermatids. BET inhibitors such as JQ1 block the region of BRDT responsible for chromatin binding, and cause a reversible
BRDT
Tool in chemical genetics
bromodomain-specific functions of members of the BET family, small-molecule inhibitors JQ1 and I-BET were developed, but they lacked inter- and intra-BET (between BDs
Bump_and_hole
Chemical compound
Ingenol-3-Angelate, PEP005, Targeted NF-kB Signaling in Combination with JQ1 Induced p-TEFb Activation". PLOS Pathogens. 11 (7) e1005066. doi:10.1371/journal
Ingenol_mebutate
2017-05-02). "IAU Minor Planet Center". "JPL Small-Body Database Browser: (2017 JQ1)" (last observation: 2017-05-03). "IAU Minor Planet Center". "JPL Small-Body
List of asteroid close approaches to Earth in 2017
List_of_asteroid_close_approaches_to_Earth_in_2017
February 17, 2015 Haleakala Pan-STARRS 1 EOS 1.6 km MPC · JPL 574324 2010 JQ1 — May 4, 2010 Nogales M. Schwartz, P. R. Holvorcem · 1.1 km MPC · JPL 574325
List of minor planets: 574001–575000
List_of_minor_planets:_574001–575000
and clinical settings: BET Inhibitors BET bromodomain inhibitors, such as JQ1, block the function of BRD4, reducing the transcription of oncogenes like
Transcriptional addiction in cancer
Transcriptional_addiction_in_cancer
Chemical compound
combined treatment with AI-10-49 and the BET-family bromodomain inhibitor JQ1, revealed a strong synergy in inv(16) AML cells and a significant delay in
AI-10-49
British astronomer
1990 JN1 1 May 1990 list[A] 15810 Arawn 12 May 1994 list[A] (16684) 1994 JQ1 11 May 1994 list[A] (19299) 1996 SZ4 16 September 1996 list[B][C] (48443)
Mike_Irwin
Chemical compound
potentially lead to the development of future male contraceptive drugs. CDD-2807 JQ1 YCT529 Rossetti T, Ferreira J, Ghanem L, Buck H, Steegborn C, Myers RW, et al
TDI-11861
JG1 to JG100 Issued only on GEORGIA.gov base. JQ Augusta State University JQ1 to JQ2 Manufacture began by February 4, 2008, but no issued plates yet observed
Non-passenger and optional vehicle registration plates of Georgia
Non-passenger_and_optional_vehicle_registration_plates_of_Georgia
Numbered minor planet with uncertain position and orbit
1995 DA2 (15875) 1996 TP66 (15883) 1997 CR29 (16636) 1993 QP (16684) 1994 JQ1 (19255) 1994 VK8 (19299) 1996 SZ4 (19308) 1996 TO66 (19521) Chaos (20108)
Critical-list_minor_planet
Nonprofit consortium of bioscience researchers to openly share protein structure data
that have generated clinical interest in their targets include PFI-1 and JQ1 for the BET family, UNC0642 for G9a/GLP, UNC1999 for EZH2/H1, LLY-283 and
Structural Genomics Consortium
Structural_Genomics_Consortium
Jakkaraj, S.; Georg, G. I. Scalable synthesis of the BET bromodomain inhibitor JQ1. Tetrahedron Lett. 2015, 56, 3454–3457. Coulup, S. K.; Huang, D. S.; Wong
Gunda_Georg
study focused on the incidence of opening data on a pharmaceutical compound, JQ1: 105 patents have been filed in the following years, in comparison with less
Economics_of_open_science
104888 2000 JL1 — May 1, 2000 Socorro LINEAR · 5.4 km MPC · JPL 104889 2000 JQ1 — May 1, 2000 Socorro LINEAR · 2.9 km MPC · JPL 104890 2000 JT1 — May 1
List of minor planets: 104001–105000
List_of_minor_planets:_104001–105000
American cardiologist
images, FamilySearch (https://www.familysearch.org/ark:/61903/3:1:S3HT-69P9-JQ1?view=index : May 8, 2025), image 183 of 428; Minnesota. Census Bureau. "As
Fredrick_Arthur_Willius
Molecular biologist
important for leukemia, leading to a series of clinical trials with a new drug, JQ1. By studying cancer epigenetics, Vakoc has also identified a new subtype
Christopher_Vakoc
Provisional Named after Date Site Discoverer(s) Category Diam. 329901 2005 JQ1 — May 3, 2005 Kitt Peak Spacewatch · 1.2 km MPC · JPL 329902 2005 JS47 —
List of minor planets: 329001–330000
List_of_minor_planets:_329001–330000
2012 HT2 — February 19, 2009 Catalina CSS H 620 m MPC · JPL 436769 2012 JQ1 — March 28, 2012 Kitt Peak Spacewatch · 440 m MPC · JPL 436770 2012 JV3
List of minor planets: 436001–437000
List_of_minor_planets:_436001–437000
Private Montessori school in Sandy Springs, Georgia, United States
Montessori School". www.springmont.com. Atlanta Journal and Constitution. Page JQ1. March 31, 2005. "Admission - Springmont - Atlanta's First Montessori School"
Springmont
HH103 — April 18, 2009 Kitt Peak Spacewatch · 1.8 km MPC · JPL 359311 2009 JQ1 — February 16, 2004 Kitt Peak Spacewatch · 1.8 km MPC · JPL 359312 2009
List of minor planets: 359001–360000
List_of_minor_planets:_359001–360000
HA8 — April 21, 2001 Socorro LINEAR AMO +1km 1.6 km MPC · JPL 322776 2001 JQ1 — May 14, 2001 Kitt Peak Spacewatch · 3.6 km MPC · JPL 322777 2001 KL43
List of minor planets: 322001–323000
List_of_minor_planets:_322001–323000
2011 Mount Lemmon Mount Lemmon Survey EUN 1.1 km MPC · JPL 729631 2011 JQ1 — March 28, 2011 Mount Lemmon Mount Lemmon Survey EUP 3.2 km MPC · JPL 729632
List of minor planets: 729001–730000
List_of_minor_planets:_729001–730000
Chemical compound
to have anti-nephrotoxic properties, and to mobilize calcium transport. JQ1 Hirota N, Yasuda D, Hashidate T, Yamamoto T, Yamaguchi S, Nagamune T, et al
Israpafant
HG115 — April 22, 2007 Kitt Peak Spacewatch THM 1.6 km MPC · JPL 794811 2007 JQ1 — March 15, 2007 Mount Lemmon Mount Lemmon Survey · 1.7 km MPC · JPL 794812
List of minor planets: 794001–795000
List_of_minor_planets:_794001–795000
494689 2004 JR — May 9, 2004 Socorro LINEAR APO 600 m MPC · JPL 494690 2004 JQ1 — May 11, 2004 Socorro LINEAR APO · PHA 340 m MPC · JPL 494691 2004 MB2 —
List of minor planets: 494001–495000
List_of_minor_planets:_494001–495000
1990s astronomical survey
23 September 1998 list (40233) 1998 UH2 20 October 1998 list (42594) 1997 JQ1 1 May 1997 list (42611) 1998 EU1 2 March 1998 list (42666) 1998 HU6 22 April
OCA–DLR_Asteroid_Survey
September 20, 2007 Kitt Peak Spacewatch · 2.4 km MPC · JPL 496742 2016 JQ1 — March 13, 2010 Catalina CSS · 3.7 km MPC · JPL 496743 2016 JJ9 — December
List of minor planets: 496001–497000
List_of_minor_planets:_496001–497000
Brazilian amateur astronomer and mathematician
VH361[2] 6 December 2013 (573652) 2009 MR10[2] 13 December 2012 (574324) 2010 JQ1[2] 4 May 2010 (574378) 2010 JA211[2] 17 December 2012 (574397) 2010 LD16[2]
Paulo_R._Holvorcem
JQ1
JQ1
JQ1
JQ1
Boy/Male
Indian, Tamil
Chola King; Best Warrior
Girl/Female
Tamil
Name of a Raga
Boy/Male
Celtic
Son of the wolf.
Boy/Male
Gujarati, Hindu, Indian
Lord Shiva
Boy/Male
Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Tamil
Giant; Huge; Massive; Great
Boy/Male
Hindu
Rich Man
Boy/Male
Tamil
Lord Krishna
Girl/Female
British, Christian, English
Boar Battle
Boy/Male
Indian, Sanskrit
Living Creature
Boy/Male
Arabic, Muslim
One who Entrusts his Affairs to the Management of Another
JQ1
JQ1
JQ1
JQ1
JQ1