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Chemical compound
Bardoxolone methyl (also known as “RTA 402”, “CDDO-methyl ester”, CDDO-Me, and more formally methyl bardoxolonate) is an experimental and orally-bioavailable
Bardoxolone_methyl
U.S. healthcare company
anti-inflammatory compounds bardoxolone methyl and RTA 408 are the lead clinical development compounds in Reata’s portfolio. Bardoxolone methyl was one of the first
Reata_Pharmaceuticals
Protein-coding gene in the species Homo sapiens
target genes.[citation needed] The lead compound in this series, bardoxolone methyl (also known as CDDO-Me or RTA 402), was in late-stage clinical trials
KEAP1
Biochemistry; detoxification enzyme system
allyl isothiocyanate, phenethyl isothiocyanate, sulforaphane, and bardoxolone methyl, and MG scavengers including aminoguanidine, alagebrium, and benfotiamine
Glyoxalase_system
CDDO and second generation synthetic triterpenoid CDDO Methyl Ester, also known as bardoxolone methyl. Sporn's research also contributed to the development
Michael_B._Sporn
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BARDOXOLONE METHYL
n.
A hydrocarbon radical, CH2, not known in the free state, but regarded as an essential residue and component of certain derivatives of methane; as, methylene bromide, CH2Br2; -- formerly called also methene.
n.
See Methyl amine, under Methyl.
n.
A colorless oily liquid, C4H3S.CH3, analogous to, and resembling, toluene; -- called also methyl thiophene.
a.
Impregnated with, or containing, methyl alcohol or wood spirit; as, methylated spirits.
n.
A colorless volatile alkaline liquid, N.(CH3)3, obtained from herring brine, beet roots, etc., with a characteristic herringlike odor. It is regarded as a substituted ammonia containing three methyl groups.
n.
A hydrocarbon radical, CH3, not existing alone but regarded as an essential residue of methane, and appearing as a component part of many derivatives; as, methyl alcohol, methyl ether, methyl amine, etc.
a.
Pertaining to, or designating, a complex red dyestuff (called rosolic acid) which is analogous to rosaniline and aurin. It is produced by oxidizing a mixture of phenol and cresol, as a dark red amorphous mass, C20H16O3, which forms weak salts with bases, and stable ones with acids. Called also methyl aurin, and, formerly, corallin.
n.
A liquid hydrocarbon obtained together with furfuran (tetrol) by the distillation of pine wood; -- called also methyl tetrol, or methyl furfuran.
n.
A light, volatile liquid, H2C(OCH3)2, regarded as a complex ether, and having a pleasant ethereal odor. It is obtained by the partial oxidation of methyl alcohol. Called also formal.
n.
An alcoholate of methyl alcohol in which the hydroxyl hydrogen is replaced by a metal, after the analogy of a hydrate; as, sodium methylate, CH3ONa.
n.
Any one of a series of nitrogenous bases, resembling the amines and produced by the reduction of certain nitroso and diazo compounds; as, methyl hydrazine, phenyl hydrazine, etc. They are derivatives of hydrazine proper, H2N.NH2, which is a doubled amido group, recently (1887) isolated as a stable, colorless gas, with a peculiar, irritating odor. As a base it forms distinct salts. Called also diamide, amidogen, (or more properly diamidogen), etc.
a.
Of, pertaining to, or designating, any one of a series of acids regarded as acid ethereal salts of hyposulphurous acid; as, methyl sulphinic acid, CH3.SO.OH, a thick unstable liquid.
n.
A hydrocarbon, C6H5.CH3, of the aromatic series, homologous with benzene, and obtained as a light mobile colorless liquid, by distilling tolu balsam, coal tar, etc.; -- called also methyl benzene, phenyl methane, etc.
n.
A crystalline nitrogenous substance, formed in the decomposition of creatin (one of the constituents of muscle tissue). Chemically, it is methyl glycocoll.
a.
Pertaining to, derived from, or containing, methyl; specifically, designating methyl alcohol. See under Methyl.
v. t.
To impregnate or mix with methyl or methyl alcohol.
a.
Of, pertaining to, or designating, an acid, C4H7CO2H (called also methyl crotonic acid), homologous with crotonic acid, and obtained from croton oil (from Croton Tiglium) as a white crystalline substance.
a.
Containing substitutions or replacements; having been subjected to the process of substitution, or having some of its parts replaced; as, alcohol is a substituted water; methyl amine is a substituted ammonia.
n.
A constituent of human faeces formed in the small intestines as a product of the putrefaction of albuminous matter. It is also found in reduced indigo. Chemically it is methyl indol, C9H9N.