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Protein-coding gene in the species Homo sapiens
protein 1 is an E3 ubiquitin ligase that in humans is encoded by the Keap1 gene. Keap1 has four discrete protein domains. The N-terminal Broad complex, Tramtrack
KEAP1
Human protein and coding gene
like-ECH-associated protein 1 (KEAP1) and Cullin 3, which degrade NRF2 by ubiquitination. Cullin 3 ubiquitinates NRF2, while Keap1 is a substrate adaptor protein
NFE2L2
Chemical compound
parent and other cells as detailed elsewhere (see SUCNR1 and succinic acid). KEAP1 (i.e., Kelch-like ECH-associated protein 1) resides in the cytoplasm of
Itaconic_acid
Protein-coding gene in the species Homo sapiens
caloric restriction) induction of NQO1 is mediated solely through the Keap1/Nrf2/ARE. Keap1 acts as the sensor which loses its ability to target Nrf2 for degradation
NAD(P)H dehydrogenase (quinone 1)
NAD(P)H_dehydrogenase_(quinone_1)
(blue), ankyrin repeat domain of ANKRA2 (orange), kelch repeat domain of Keap1 (yellow) and HEAT repeat domain of a PP2A regulatory subunit R1a (magenta)
Protein_tandem_repeats
Medical condition
genes such as TP53 (mutated in 81% of cases), MLL2 (20%), CDKN2A (15%), KEAP1 (12%) and PTEN (8%). Recurrent loss-of-function mutations have been observed
Squamous-cell carcinoma of the lung
Squamous-cell_carcinoma_of_the_lung
Chicken bred for meat
stress-induced liver oxidative damage in broilers by activating the Nrf2-Keap1 signaling pathway". Ecotoxicology and Environmental Safety. 249 114411.
Broiler
Medical condition
has been described. Other genes involved affected by this mutation are Keap1, Nrf2 and HMOX1. The diagnosis is made either by testing of the fumarate
Hereditary leiomyomatosis and renal cell cancer syndrome
Hereditary_leiomyomatosis_and_renal_cell_cancer_syndrome
(blue), ankyrin repeat domain of ANKRA2 (orange), kelch repeat domain of Keap1 (yellow) and HEAT repeat domain of a PP2A regulatory subunit R1a (magenta)
Solenoid_protein_domain
Chinese herbal medicine
herbal formula Free and Easy Wanderer ameliorates oxidative stress through KEAP1-NRF2/HO-1 pathway". Scientific Reports. 7 (1): 11551. Bibcode:2017NatSR
Xiao_Yao_Wan
Chemical processes that make use of arsenic
normal conditions the Nrf2 is bound to Kelch-like ECH associated protein 1 (Keap1) in its inactive form. With the uptake of arsenic within cells and the subsequent
Arsenic_biochemistry
Protein-coding gene in humans
RhoBTB2. CUL3 has been shown to interact with: CAND1, Cyclin E1, DCUN1D1, KEAP1, and KLHL12. GRCh38: Ensembl release 89: ENSG00000036257 – Ensembl, May
CUL3
Protein family
KBTBD10; KBTBD11; KBTBD2; KBTBD3; KBTBD4; KBTBD5; KBTBD6; KBTBD7; KBTBD8; KEAP1; KIAA1900; KLHDC1; KLHDC2; KLHDC3; KLHDC4; KLHDC5; KLHDC6; KLHDC7A; KLHDC7B;
Kelch_protein
Human disease
inactivations of p53 and RB (~40%), or inactivation of TP53 and STK11 or KEAP1 (~40%). The World Health Organization classification of lung tumors recognizes
Large cell neuroendocrine carcinoma of the lung
Large_cell_neuroendocrine_carcinoma_of_the_lung
Cytoplasmic biomolecular condensates of proteins and RNA occurring in cells under stress
Antioxidant Response in Amyotrophic Lateral Sclerosis through Interactions with KEAP1". Molecular and Cellular Biology. 35 (14): 2385–2399. doi:10.1128/MCB.00087-15
Stress_granule
Compound that increases the activity of a protein
STRUCTURAL FEATURES THAT DETERMINE INDUCER POTENCY AND REACTIVITY WITH Keap1". The Journal of Biological Chemistry. 285 (44): 33747–33755. doi:10.1074/jbc
Enzyme_inducer
identified higher rates of KEAP1 gene mutations in papillary adenocarcinoma, highlighting its important role in the KEAP1–NRF2 pathway, which regulates
Papillary adenocarcinoma of the lung
Papillary_adenocarcinoma_of_the_lung
Class of proteins
malignancy. Certain cancers contain somatic mutations in NRF2(NFE2L2) or KEAP1 that cause constitutive activation of Nrf2 and promote cell proliferation
Small_Maf
Cellular molecules that help resolve inflammation
the sulfur residues in the KEAP1 component of the KEAP1-NFE2L2 protein complex in the cytosol of cells. This negates KEAP1's ability to bind NFE2L2; in
Specialized pro-resolving mediators
Specialized_pro-resolving_mediators
Lung cancer of glandular origin or characteristics
genes, including TP53 (mutated in 46% of cases), EGFR (27%), KRAS (32%), KEAP1, STK11 and NF1. EGFR and KRAS mutations tend to appear in a mutually exclusive
Adenocarcinoma_of_the_lung
Post-translational carbohydrate modification of proteins
stress leads to conformational changes in KEAP1 that repress degradation of NRF2. O-GlcNAc modification of KEAP1 at S104 is required for efficient ubiquitination
O-GlcNAc
Investigational Parkinson's disease drugs
actions [202] Research programme: KEAP1 inhibitors - Keapstone Therapeutics – Kelch-like ECH-associated protein 1 (KEAP1) inhibitors [203] Research programme:
List of investigational Parkinson's disease drugs
List_of_investigational_Parkinson's_disease_drugs
Prostaglandin subset
effect of this inhibition is to inhibit and/or refers inflammation. KEAP1: cytosolic KEAP1 serves to promote the degradation of Nrf2 by proteasomes thereby
Cyclopentenone_prostaglandins
Chemical compound
placebo-treated patients was similar. Bardoxolone methyl is an activator of the KEAP1-Nrf2 pathway in mice. Bardoxolone methyl also inhibits the pro-inflammatory
Bardoxolone_methyl
Protein-coding gene in humans
residues in length. Within cells, DPP3 plays a critical role in activating the Keap1-Nrf2 antioxidant pathway, which helps combat oxidative stress. Studies have
DPP3
Mammalian protein found in humans
(September 2008). "Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy". Proceedings of the National Academy
Ubiquitin_C
Short protein motif that forms a solenoid domain
IFT140, IFT172, IFT80, IQWD1, KATNB1, KIAA1336, KIF21A, KIF21B, KM-PA-2, KEAP1, LLGL1, LLGL2, LRBA, LRRK1, LRRK2, LRWD1, LYST, MAPKBP1, MED16, MORG1, NBEA
WD40_repeat
Gene of the species Homo sapiens
is intimately associated with the p62-KEAP1-NRF2 pathway, a significant oxidative stress regulator. Usually, KEAP1 binds NRF2 and targets it for degradation
TRIM16
Process of introducing a phosphate group on to a protein
phosphorylated, the binding affinity between protein complex p62 and the protein Keap1 is strengthened, which is linked to stress response. When serine 337 is
Protein_phosphorylation
HGNC:25840; Q8N371 8109 KDR HGNC:6307; P35968 8110 KDSR HGNC:4021; Q06136 8111 KEAP1 HGNC:23177; Q14145 8112 KEL HGNC:6308; P23276 8113 KERA HGNC:6309; O60938
List of human protein-coding genes 4
List_of_human_protein-coding_genes_4
of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival. J
Sulfiredoxin
stress-induced liver oxidative damage in broilers by activating the Nrf2-Keap1 signaling pathway". Ecotoxicology and Environmental Safety. 249 114411.
Effects of climate change on livestock
Effects_of_climate_change_on_livestock
Protein-coding gene in the species Homo sapiens
Wakabayashi N, Katoh Y, Ishii T, Igarashi K, Engel JD, Yamamoto M (Jan 1999). "Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2
GABPA
(1) 593 89 28 49 5 NP_009177.3 KLHL 3 (2) 555 90 28 49 3 NP_001244123.1 KEAP1 624 93 28 43 1 NP_036421.2 KLHL17 642 93 27 46 6 NP_938073.1 KLHL1 (1) 748
KLHL36
Protein-coding gene in the species Homo sapiens
the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum". The Biochemical
NFE2L1
Chemical compound
upregulated through the anti-oxidant response element (ARE) by forcing cytosolic KEAP1 to release NFE2L2 which then moves to the nucleus, binds ARE, and induces
15-Hydroxyeicosatetraenoic acid
15-Hydroxyeicosatetraenoic_acid
Precursor microRNA family
Zhang Y, Zhou Q (October 2011). "MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism". Breast Cancer Research and Treatment. 129 (3): 983–91
Mir-28 microRNA precursor family
Mir-28_microRNA_precursor_family
KEAP1
KEAP1
KEAP1
KEAP1
Boy/Male
Hindu, Indian, Punjabi, Sikh
One who is Happy and Delightful
Male
Spanish
Spanish name, possibly GAEL means "a Gael."Â
Boy/Male
Tamil
Dark
Boy/Male
Irish
Servant.
Boy/Male
American, Australian, British, Chinese, Danish, English, French, Hebrew
Hidden Spot; From the Hidden Place; Secret
Biblical
same as Mahaleleel
Boy/Male
English
Power and good fortune.
Boy/Male
Hindu
Happy
Girl/Female
Hindu
Girl/Female
Australian, Spanish
Diminutive Form of Juana; Derived from John
KEAP1
KEAP1
KEAP1
KEAP1
KEAP1