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Chemical compound
U-69,593 is a drug which acts as a potent and selective κ1-opioid receptor agonist. In animal studies it has been shown to produce antinociception, anti-inflammation
U-69,593
Atypical opioid drug
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
SR-17018
Pharmaceutical compound
substituted for salvinorin A and the synthetic κ-opioid receptor agonist U-69593, and was active at doses as low as 0.005 mg/kg. Human bioassays found the
Salvinorin B ethoxymethyl ether
Salvinorin_B_ethoxymethyl_ether
Chemical compound
Xorphanol Arylacetamides: Enadoline LPK-26 Niravoline Spiradoline U-50488 U-69593 Others: HZ-2 Tifluadom GABAA agonists Isoxazoles: Gaboxadol (THIP)
Salvinorin_A
Species of fungus
hallucinogen". The Guardian. Retrieved 17 July 2026. Ruzanski W (8 April 2026). "U mycologists lead research on mushrooms that cause hallucinations of 'whimsical
Lanmaoa_asiatica
Chemical compound
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
MGM-15
Opioid analgesic
U-47700, also known as U4, pink heroin, pinky, and pink, is an opioid analgesic drug developed by a team at Upjohn in the 1970s which has around 7.5 times
U-47700
Opioid medication
opioid drugs recreationally. The U.S. Department of Health and Human Services estimates that about 11 million people in the U.S. consume oxycodone in a non-medical
Oxycodone
Class of drug
2023. Retrieved 2 November 2023. Stromgaard K, Krogsgaard-Larsen P, Madsen U (2009). Textbook of Drug Design and Discovery, Fourth Edition. CRC Press.
Opioid
Pharmaceutical compound
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
MGM-16
Opioid analgesic compound
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
Mitragynine_pseudoindoxyl
Species of plant
States. The U.S. Drug Enforcement Administration (DEA) stated in 2013 that there is no legitimate medical use for kratom, and in 2019, the U.S. Food and
Mitragyna_speciosa
Combination pain relief drug
opioid in the pharmaceutical industry. In-drug evidence was submitted to U.S. federal state and local forensic laboratories as reported by the Drug Enforcement
Hydrocodone/paracetamol
Psychoactive component of cannabis
Archived from the original on 19 June 2008. Aizpurua-Olaizola O, Soydaner U, Öztürk E, Schibano D, Simsir Y, Navarro P, et al. (February 2016). "Evolution
Tetrahydrocannabinol
Chemical compound
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
Semax
Opioid receptor antagonist
the original on 2 January 2015. Retrieved 2 January 2015. McDonald R, Lorch U, Woodward J, Bosse B, Dooner H, Mundin G, et al. (March 2018). "Pharmacokinetics
Naloxone
Chemical compound
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
Selank
Spice from Myristica fragrans
Xorphanol Arylacetamides: Enadoline LPK-26 Niravoline Spiradoline U-50488 U-69593 Others: HZ-2 Tifluadom GABAA agonists Isoxazoles: Gaboxadol (THIP)
Nutmeg
Atypical opioid analgesic
Takes Steps to Restrict 7-OH Opioid Products Threatening American Consumers". U.S. Food and Drug Administration (FDA). July 29, 2025. Retrieved August 18
7-Hydroxymitragynine
Impure form of heroin
tar heroin distribution has steadily risen in recent years, while that of U.S. East Coast powder varieties has dropped; heroin production in Colombia
Black_tar_heroin
Traditional patent medicine
disclosure of ingredients and limitation of narcotic content were instituted. The U.S. Harrison Narcotics Tax Act of 1914 restricted the manufacture and distribution
Paregoric
Opioid medication used for pain relief
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
Hydromorphone
Species of plant
divinorum is legal in some countries, including the U.S. at the federal level; however over half of U.S. states have passed laws criminalizing it. Its native
Salvia_divinorum
Chemical compound
Xorphanol Arylacetamides: Enadoline LPK-26 Niravoline Spiradoline U-50488 U-69593 Others: HZ-2 Tifluadom GABAA agonists Isoxazoles: Gaboxadol (THIP)
Adrenochrome
Substance derived from opium
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
Opiate
Recreational drug beverage
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
Lean_(drug)
Chemical compound
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
Isotonitazepyne
Deadly nightshade, a flowering plant
everything about the plant". Plantura. Retrieved 2024-12-07. Lindequist, U. (1992). "Atropa". Haegers Handbuch der pharmazeutischen Praxis (in German)
Atropa_bella-donna
Semi-synthetic opioid
Koninkrijksrelaties (in Dutch). Retrieved 2022-03-30. "Etorphine". PubChem. U.S. National Library of Medicine. CID 26721. Retrieved 2022-03-30. "List of
Etorphine
Opioid analgesic
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
Oxymorphazone
Compound medication
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
Codeine/paracetamol
Species of flowering plant in the poppy family
Suffolk, U.K.: C & M Floristics. ISBN 978-1-5272-2630-2. Clapham A, Tutin T, Warburg E (1981). Excursion flora of the British Isles (3 ed.). Cambridge, U.K.:
Papaver_somniferum
Medication used to treat ADHD
PMID 32044373. S2CID 211053123. Termine C, Selvini C, Rossi G, Balottin U (2013). "Emerging Treatment Strategies in Tourette Syndrome". Emerging treatment
Atomoxetine
Opioid medication
2023. Retrieved 26 January 2023. Lamy FR, Daniulaityte R, Barratt MJ, Lokala U, Sheth A, Carlson RG (June 2020). "Listed for sale: Analyzing data on fentanyl
Fentanyl
Peptide hormone and neuropeptide
administration modified the basal secretion of AVP and OT. Jørgensen H, Riis M, Knigge U, Kjaer A, Warberg J (March 2003). "Serotonin receptors involved in vasopressin
Oxytocin
Opioid analgesic compound
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
Mitragynine
Medication
September 2022.[page needed] Minozzi S, Amato L, Vecchi S, Davoli M, Kirchmayer U, Verster A (April 2011). Minozzi S (ed.). "Oral naltrexone maintenance treatment
Naltrexone
Centrally active opioid drug used for the treatment of diarrhea
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
Diphenoxylate
Zoroastrian sacred plant and drink
Xorphanol Arylacetamides: Enadoline LPK-26 Niravoline Spiradoline U-50488 U-69593 Others: HZ-2 Tifluadom GABAA agonists Isoxazoles: Gaboxadol (THIP)
Haoma
Dissociative hallucinogenic drug, mostly used recreationally
1111/bph.13222. PMC 4556466. PMID 26075331. Javitt DC, Zukin SR, Heresco-Levy U, Umbricht D (September 2012). "Has an angel shown the way? Etiological and
Phencyclidine
Synthetic opioid analgesic
1097/00004728-198503000-00001. PMID 2982931. S2CID 30414509. Uddayasankar U, Lee C, Oleschuk C, Eschun G, Ariano RE (June 2018). "The Pharmacokinetics
Carfentanil
Semi-synthetic opioid, morphine analogue
team working for Knoll in 1920. Desomorphine was later synthesised in the U.S. in 1932 and patented on 13 November 1934. In Russia, desomorphine was declared
Desomorphine
Opioid used to treat pain and opioid use disorder
PMID 35020693. S2CID 245925947. Hämmig R, Kemter A, Strasser J, von Bardeleben U, Gugger B, Walter M, et al. (20 July 2016). "Use of microdoses for induction
Buprenorphine
Species of flowering plant in the nightshade family
PMID 14635887. S2CID 43040585. De-la-Cruz, I. M.; Hallab, A.; Olivares-Pinto, U.; Tapia-López, R.; Velázquez-Márquez, S.; Piñero, D.; Oyama, K.; Usadel, B
Datura_stramonium
Psychoactive substance found in plants in the family Apocynaceae
ibogaine. Neither μ-opioid receptor agonists nor κ-opioid receptor agonists like U-50,488 substitute for ibogaine. In addition, the opioid antagonist naloxone
Ibogaine
Opiate alkaloid constituent of opium
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
Thebaine
Chemical compound
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
RAM-378
Preparation of opiates
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
Pantopon
Chemical compound
(R)-α-Aminobenzenepropanoic acid S Deprenon "Promeco", D-Phenylalanine, Sabiden U Antidepressant Unlisted Drugs. Unlisted Drugs Committee of the Pharmaceutical
D-Phenylalanine
Opioid analgesic
were confiscated by the U.S. Department of Commerce Intelligence, investigated by a Technical Industrial Committee of the U.S. Department of State and
Methadone
Chemical compound (analgesic drug)
March 2024. AH-7921 Etonitazepyne Isotonitazene MT-45 Piperidylthiambutene U-47700 Riksdagsförvaltningen. "Förordning (1992:1554) om kontroll av narkotika
Metonitazene
Mixture of carbon dioxide and oxygen
Xorphanol Arylacetamides: Enadoline LPK-26 Niravoline Spiradoline U-50488 U-69593 Others: HZ-2 Tifluadom GABAA agonists Isoxazoles: Gaboxadol (THIP)
Carbogen
Pain medication of the opiate family
ClinCalc. Retrieved 19 August 2025. "First Generic Drug Approvals 2023". U.S. Food and Drug Administration (FDA). FDA. 30 May 2023. Archived from the
Morphine
Chemical compound
doi:10.3389/fmed.2016.00044. PMC 5064048. PMID 27790616. Dinnendahl V, Fricke U, eds. (1982). Arzneistoff-Profile (in German). Eschborn, Germany: Govi Pharmazeutischer
Racecadotril
Combination drug
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
Oxycodone/aspirin
Chemical compound
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
N-Desethylisotonitazene
Phytocannabinoid discovered in 1940
1038/npp.2017.209. PMC 5719112. PMID 28875990. Aizpurua-Olaizola O, Soydaner U, Öztürk E, Schibano D, Simsir Y, Navarro P, et al. (February 2016). "Evolution
Cannabidiol
Drug
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
Opioid_modulator
Purported inhalant drug
site Erowid reported, "the jenkem stories that have been circulating in the U.S. media are almost certainly the strange result of a hoax." Jenkem use was
Jenkem
Chemical compound
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
Dynorphin_A
Pharmaceutical compound
receptor, being around 10x more potent than the reference kappa agonist U-69593, and is also an agonist at the nociceptin receptor with only slightly lower
SR-14136
Opiate and prodrug of morphine used to treat pain
Controlled Substance Schedules. Archived 21 November 2020 at the Wayback Machine U.S. DEPARTMENT OF JUSTICE, DRUG ENFORCEMENT ADMINISTRATION: Diversion Control
Codeine
Off-label, experimental use of the drug
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
Low-dose_naltrexone
Opioid analgesic
1978 and remains as the only opioid analgesic of this type (marketed in the U.S.) not controlled under the Controlled Substances Act (CSA). When the Controlled
Nalbuphine
Genus of poisonous, potentially psychoactive plants
Williamsburg Yorktown Daily. 22 October 2021. Retrieved 21 March 2025. Preissel, U.; Preissel, H.-G. (2002). Brugmansia and Datura: Angel's Trumpets and Thorn
Datura
Opioid analgesic
Xorphanol Arylacetamides: Enadoline LPK-26 Niravoline Spiradoline U-50488 U-69593 Others: HZ-2 Tifluadom GABAA agonists Isoxazoles: Gaboxadol (THIP)
Butorphanol
Chemical compound
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
Chloroxymorphamine
Chemical compound
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
Casomorphin
Fringe autism causation theory
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
Opioid_excess_theory
Chemical compound
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
SR-14968
Opioid analgesic and recreational drug
doi:10.1007/s11524-007-9198-y. PMC 2219559. PMID 17562183. Haasen C, Verthein U, Degkwitz P, Berger J, Krausz M, Naber D (July 2007). "Heroin-assisted treatment
Heroin
Opioid medication
Xorphanol Arylacetamides: Enadoline LPK-26 Niravoline Spiradoline U-50488 U-69593 Others: HZ-2 Tifluadom GABAA agonists Isoxazoles: Gaboxadol (THIP)
Levallorphan
Chemical compound
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
RB-64
Opioid analgesic drug used in research
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
BW373U86
Opioid drug used in pain relief
that paracetamol is the primary agent responsible for the ototoxicity. The U.S. Food and Drug Administration (FDA) assigns the drug to pregnancy category
Hydrocodone
Chemical compound
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
7-Acetoxymitragynine
Species of mushroom
Mexican species similar to A. caesarea of Europe. Poison control centres in the U.S. and Canada have become aware that amarill (Spanish for 'yellow') is a common
Amanita_muscaria
Chemical compound
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
Naloxazone
Opioid analgesic of benzenoid class
(oral route)". Mayo Clinic. Retrieved 2025-04-05. Nossaman VE, Ramadhyani U, Kadowitz PJ, Nossaman BD (December 2010). "Advances in perioperative pain
Tapentadol
Medication
original on 3 April 2022. Retrieved 13 May 2022. Orsolini L, Salvi V, Volpe U (June 2022). "Craving and addictive potential of esketamine as side effects
Esketamine
Pentapeptide
doi:10.1155/2017/1546125. PMC 5525068. PMID 28781901. Enkephalins at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Nosek, Thomas
Enkephalin
Opioid analgesic drug
"Conversion Factors for Controlled Substances". Drug Enforcement Administration. U.S. Department of Justice. Archived from the original on 2016-03-02. Retrieved
Dextromoramide
Group of stereoisomers
Xorphanol Arylacetamides: Enadoline LPK-26 Niravoline Spiradoline U-50488 U-69593 Others: HZ-2 Tifluadom GABAA agonists Isoxazoles: Gaboxadol (THIP)
Bremazocine
Medieval medical concoction
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
Theriac
Chemical compound
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
Akuammine
Species of plant
(2): 163–9. doi:10.1016/j.phrs.2012.04.003. PMID 22525682. Dinh LD, Simmen U, Bueter KB, et al. (2001). "Interaction of various Piper methysticum cultivars
Kava
Pair of enantiomers
Xorphanol Arylacetamides: Enadoline LPK-26 Niravoline Spiradoline U-50488 U-69593 Others: HZ-2 Tifluadom GABAA agonists Isoxazoles: Gaboxadol (THIP)
Tifluadom
Opioid analgesic and cough suppressant drug
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
Benzylmorphine
Synthetic opioid analgesic
Portal. U.S. National Library of Medicine. Archived from the original on June 28, 2019. "Remifentanil Hydrochloride". Drug Information Portal. U.S. National
Remifentanil
Herbal tea made out of poppy straw or poppy seeds
Urges FDA, DEA to Crack Down on Sale of Contaminated Poppy Seeds: At Least 12 U.S. Deaths Are Associated with ‘Tea’ Made with Poppy Seeds or Pods, 3 April
Poppy_tea
Opioid analgesic
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
Phenaridine
Semi-synthetic opioid
2174/138920010791636211. PMID 20540693. "Myovant Sciences and Pfizer Receive U.S. FDA Approval of Myfembree, a Once-Daily Treatment for the Management of
Dihydrocodeine
Chemical compound
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
14-Methoxymetopon
Slang for non-prescription opioids
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
Homebake_(slang)
Chemical compound
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
Acetylpropionylmorphine
Group of opioid peptides
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
Gluten_exorphin
Opioid analgesic
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
Parafluorofentanyl
Synthetic opioid analgesic drug
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
Sufentanil
Opioid analgesic drug
amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54494A U-69593 Xorphanol Antagonists 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI
Piminodine
Chemical compound
U-50488 is a drug which acts as a highly selective κ-opioid agonist, but without any μ-opioid antagonist effects. It has analgesic, diuretic and antitussive
U-50488
U 69593
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