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Psychoactive substance found in plants in the family Apocynaceae
Ibogaine is a psychoactive indole alkaloid derived from plants such as Tabernanthe iboga, characterized by hallucinogenic and oneirogenic effects. Ibogaine
Ibogaine
Principal psychoactive metabolite of the oneirogen ibogaine
metabolite of the oneirogen ibogaine. It may be involved in the potential antiaddictive effects of ibogaine and ibogaine-containing plant extracts, such
Noribogaine
Species of plant
10 meters tall and contains psychoactive indole alkaloids, especially ibogaine, concentrated in its root bark, which produces strong neurological effects
Tabernanthe_iboga
Drug that produces a dream-like state of consciousness
oneirogen, oneirophrenic, or oneiric, was introduced to refer specifically to ibogaine- and harmaline-type hallucinogens by William Turner and Claudio Naranjo
Oneirogen
This is an overview of the legality of ibogaine by country. Ibogaine is not included on the UN International Narcotics Control Board's Green List, or
Legal status of ibogaine by country
Legal_status_of_ibogaine_by_country
Class of drugs
agonists like muscimol and gaboxadol Oneirogens (unknown mechanism) like ibogaine and harmaline Others like hallucinogenic bolete mushroom Leo Hollister
Hallucinogen
Chemical compound
deficits induced by ibogaine in these rats. However, this phenomenon involves high doses of ibogaine and has not been observed with ibogaine in primates or
Harmaline
2024 documentary film
a treatment unapproved for use in the U.S. involving the psychedelics ibogaine and 5-MeO-DMT. Marcus and a number of other veterans, at first skeptical
In_Waves_and_War
Dogbane and oleander family of flowering plants
alkaloid ibogaine, which is a psychedelic drug which may help with drug addiction, but which has significant adverse effects, with ibogaine being both
Apocynaceae
Chemical compound
zolunicant (INNTooltip International Nonproprietary Name), is a derivative of ibogaine invented in 1996 by the research team around the pharmacologist Stanley
18-Methoxycoronaridine
Drug class
approved and used in the treatment of pruritis as well. Noribogaine and ibogaine (via metabolism into noribogaine) act as potent atypical KOR agonists with
Κ-Opioid_receptor_agonist
Class of chemical compounds
An ibogalog, or simplified ibogaine analogue, also known as a substituted 1,2,3,4,5,6-hexahydroazepino[4,5-b]indole (or simply substituted hexahydroazepinoindole)
Ibogalog
Serotonergic psychedelic
and psychoplastogen of the ibogalog group related to the iboga alkaloid ibogaine but with a simplified chemical structure. Ibogainalog acts as a non-selective
Ibogainalog
Drug that increases wakefulness
oneirogens ibogaine and noribogaine have been found to promote wakefulness in rodents. Relatedly, low doses of Tabernanthe spp. extracts containing ibogaine have
Wakefulness-promoting_agent
Alkaloid found in Tabernanthe iboga
alkaloid found in Tabernanthe iboga along with the related chemical compounds ibogaine, ibogamine, and other minor alkaloids. It is a relatively smaller component
Ibogaline
Pharmaceutical compound
of ibogaine. It is a derivative of ibogaine lacking the tetrahydroazepine ring but with the isoquinuclidine ring retained. Similarly to ibogaine and
5-MeO-IsoqT
British philosopher
and now runs an ibogaine-assisted retreat centre - Tabula Rasa Retreat - in Portugal. He is also executive director of the Global Ibogaine Therapy Alliance
Jeremy_Weate
Pharmaceutical compound
mescaline. On the other hand, they have been said to be similar to those of ibogaine. 6-Methoxyharmalan shows modest affinity for the serotonin 5-HT2A receptor
6-Methoxyharmalan
Anti-convulsant, anti-addictive CNS stimulant alkaloid
related to how addiction affects the brain has used this chemical. Like ibogaine, it has seems to have similar pharmacology. It has effects on KOR, NMDAR
Ibogamine
Species of plant
occurring psychoactive compounds. Ibogaine is used in pain management and to treat opiate addiction. In low dosages, ibogaine is a stimulant and aphrodisiac
Tabernaemontana_undulata
Chemical compound
5-b]indole), is a parent compound of the iboga-type alkaloids such as ibogaine as well as of their simplified ibogalog analogues like ibogainalog. Chemical
Azepino(4,5-b)indole
Group of alkaloids related to Tabernanthe iboga
iboga-type alkaloids include ibogamine, ibogaine, tabernanthine, and other substituted ibogamines . Ibogaine is a hallucinogen and is referred to as an
Iboga-type_alkaloid
American computer scientist (born 1973)
psychedelic pharmaceutical companies like Soneira Bio, which is developing ibogaine (SON-001) for potential medical use. In 2002, Brin, along with Larry Page
Sergey_Brin
American scientific researcher
2010) was an American scientific researcher who pioneered the use of ibogaine as an approach in Western medicine in the treatment of substance addictions
Howard_Lotsof
Informal term for a drug that binds to many different molecular targets or receptors
drugs" include tramadol, chlorpromazine, olanzapine, dextromethorphan, ibogaine, and ethanol, all of which bind to multiple receptors or influence multiple
Dirty_drug
Pharmaceutical compound
been disclosed. However, it is known to be an "oxa-iboga" derivative. Oxa-ibogaine analogues have notably been patented and studied by Dalibor Sames and colleagues
GM-3009
Chemical compound
psychedelics like mescaline but similar to those of ibogaine. Along these lines, β-carbolines and ibogaine fully substitute for each other in rodent drug discrimination
Substituted_β-carboline
Pharmaceutical compound
EQL-101 is a non-hallucinogenic ibogaine analogue which is under development for the treatment of substance use disorders such as opioid use disorder.
EQL-101
Chemical compound
(under the now obsolete synonym Ervatamia coronaria) it was named. Like ibogaine, (R)-coronaridine and (S)-coronaridine can decrease intake of cocaine and
Coronaridine
New religious movement based in Slovenia
psychoactive plant Tabernanthe iboga and its psychoactive chemical constituent ibogaine. The founder of Sacrament of Transition is Marko Resinovic. The organization
Sacrament_of_Transition
Species of tree
semi-synthesis of ibogaine. Voacamidine and voacamine cleavage can be used to increase voacangine yield. While small amounts of ibogaine are found in Voacanga
Voacanga_africana
American social and political activist
known for his efforts to legalize marijuana and to promote the benefits of ibogaine as an addiction treatment. He is a founder and long-term activist in the
Dana_Beal
American actor and journalist
student director Peter Sellars. Cantor wrote for The Village Voice about ibogaine as a cure for heroin addiction, and had taken an interest in the cult surrounding
Max_Cantor
Pharmaceutical compound
unlike those of serotonergic psychedelics like LSD but similar to those of ibogaine. Along with harmaline and tetrahydroharmine, harmine is one of the psychoactive
Harmine
Chemical compound
(ME-18-MC) is a second generation synthetic derivative of ibogaine developed by the research team led by the pharmacologist Stanley D. Glick
2-Methoxyethyl-18-methoxycoronaridinate
2-Methoxyethyl-18-methoxycoronaridinate
American politician (born 1950)
treating military veterans with ibogaine, co-founded a non-profit organization that is focused on advancing ibogaine therapy in the United States, and
Rick_Perry
Chemical compound
alkaloid which commonly serves as a precursor for the semi-synthesis of ibogaine. Under UV-A and UV-B light its crystals fluoresce blue-green, and it is
Voacangine
Chemical compound
(−)-18-Methylaminocoronaridine (18-MAC) is a second generation synthetic derivative of ibogaine developed by the research team led by the pharmacologist Stanley D. Glick
18-Methylaminocoronaridine
Psychotic disorder featuring hallucinations
sleep deprivation, sensory deprivation, or drugs (such as the oneirogens ibogaine and harmaline). Oneirophrenia is often confused with an acute case of schizophrenia
Oneirophrenia
Sciences (merged with Beckley Psytech) – DMT (VLS-01), (R)-MDMA (EMP-01), ibogaine (IBX-210, DMX-1002), EGX-121, inidascamine (RL-007), EGX-A, EGX-B, arketamine
List of psychedelic pharmaceutical companies
List_of_psychedelic_pharmaceutical_companies
American pharmacologist
license, to permit her to research the addiction-stopping capabilities of ibogaine (an oneirogen that occurs in some plants). A lack of funding and other
Deborah_Mash
CIA program involving illegal experimentation on human test subjects (1953–1972)
Hashish Hash oil Synthetic cannabinoids JWH-018 APICA APINACA Spice Others Ibogaine Tabernanthe iboga Muscimol Amanita muscaria Oneirogens Calea zacatechichi
MKUltra
(non-hallucinogenic non-cardiotoxic ibogaine derivative) – substance use disorders – Equulus Therapeutics GM-3009 (ibogaine analogue(s); GMX-3009) – various
List of investigational hallucinogens and entactogens
List_of_investigational_hallucinogens_and_entactogens
Medical condition
eliminate the cardiotoxicity of traditional ibogaine, with clinical Phase 1 trials commencing in 2026. Ibogaine is illegal in the U.S. but is unregulated
Opioid_use_disorder
American writer, hacker and activist (born 1969)
Patrick K. Kroupa. Mondo 2000. Heroin Times: Ibogaine Series (2000–2003), Patrick K. Kroupa. Heroin Times. Ibogaine: Treatment Outcomes and Observations (2003)
Patrick_K._Kroupa
Pharmaceutical compound
and monoamine oxidase A (MAO-A). In contrast to iboga alkaloids like ibogaine and noribogaine, tabernanthalog showed negligible interactions with opioid
Tabernanthalog
Class of alkaloids
common medicine in India around 1000 BC. Various African tribes used the ibogaine-rich roots of the perennial rainforest shrub Iboga as a traditional medicine
Indole_alkaloid
Musical artist
skin abscesses and an infection. He was being treated for addiction with ibogaine, a psychoactive compound with anti-addictive properties that is illegal
Jason_Sears
Chemical compound
iboga-type alkaloids such as ibogaine and ibogamine. It is the 4-desethyl analogue of ibogamine and features the ibogaine ring system with no other substitutions
Desethylibogamine
American documentary television series
Story". IMDB. January 11, 2021. Retrieved January 28, 2022. "Synthetic Ibogaine: Natural Tramadol". IMDB. January 25, 2021. Retrieved January 28, 2022
Hamilton's_Pharmacopeia
others. Although not technically a serotonergic psychedelic, the oneirogen ibogaine, a constituent of Tabernanthe iboga and a compound structurally related
Legal status of psychedelic drugs in the United States
Legal_status_of_psychedelic_drugs_in_the_United_States
Genus of plants
versions of the psychedelic drink ayahuasca; the genus is known to contain ibogaine (e.g. in bëcchëte, T. undulata), conolidine (present in minor concentration
Tabernaemontana
Events regarding psychedelic drugs
related to psychedelics, but not other types of hallucinogens like ketamine, ibogaine, or cannabis. Spanish colonialists broadly ban the use of various hallucinogens
Timeline of psychedelic legalization and decriminalization
Timeline_of_psychedelic_legalization_and_decriminalization
Use of psychedelic drugs as treatment
LSD, psilocybin and psilocin (mushrooms), ayahuasca, DMT, 5-MeO-DMT, ibogaine and MDMA. As of 2021, psychedelic drugs are controlled substances in most
Psychedelic_therapy
Psychedelic medicine biotech company
18-MC, a non-hallucinogenic molecule based on the psychoactive alkaloid ibogaine. In June 2019, it acquired the 18-MC drug development program, previously
Definium_Therapeutics
Species of plant
dregamine, ibogamine, tabersonine, voacangine, voacamine and voacristine. Ibogaine may occur in multiple Tabernaemontana species. 'Flore Pleno' variety Crape
Tabernaemontana_divaricata
Class of anesthetics
inhibit NMDA/Gly-induced currents possibly by ifenprodil-like mechanism. Ibogaine: a naturally occurring alkaloid found in plants of the family Apocynaceae
NMDA_receptor_antagonist
List of plant species with reported psychoactive properties
Humanities. 20: 333–351. S2CID 37305695. "Erowid Online Books: "TIHKAL" – #25 IBOGAINE". Erowid.org. Retrieved 14 January 2015. Krengel F, Herrera Santoyo J,
List_of_psychoactive_plants
including ibogaine, noribogaine, harmine, tetrahydroharmine, and 6-MeO-THH are all not controlled substances. However, Health Canada has added ibogaine to its
Legal status of psychedelic drugs in Canada
Legal_status_of_psychedelic_drugs_in_Canada
Atypical opioid analgesic
Diprenorphine ECG EGC Epicatechin Eptazocine Gemazocine Ginsenoside R Hyperoside Ibogaine JDTic Levallorphan Lobeline LY-255582 LY-2196044 Methocinnamox Methylnaltrexone
7-Hydroxymitragynine
American neuroscientist (1982–2025)
Exploring Treatment Solutions (VETS) partnered with Williams to study ibogaine in those with traumatic brain injury and said in a statement that "his
Nolan_R._Williams
Protein-coding gene in the species Homo sapiens, named for ketazocine
Ibogaine, atypical KOR agonist with G-protein-biased signaling and complex pharmacodynamics involving multiple neurotransmitter systems. Ibogaine's primary
Κ-opioid_receptor
Class of naturally occurring chemical compounds
and many indole alkaloids (such as psilocybin, dimethyltryptamine and ibogaine) have hallucinogenic effect. Morphine and codeine are strong narcotic pain
Alkaloid
Opioid receptor antagonist
Diprenorphine ECG EGC Epicatechin Eptazocine Gemazocine Ginsenoside R Hyperoside Ibogaine JDTic Levallorphan Lobeline LY-255582 LY-2196044 Methocinnamox Methylnaltrexone
Naloxone
Chemical compound
(Ki = 0.15 μM) and NMDA receptor (Ki = 10.5 μM) antagonist. Compared to ibogaine, it binds weakly to σ1 and σ2 receptors. Coronaridine Ibogamine Voacangine
Tabernanthine
Atypical opioid drug
Diprenorphine ECG EGC Epicatechin Eptazocine Gemazocine Ginsenoside R Hyperoside Ibogaine JDTic Levallorphan Lobeline LY-255582 LY-2196044 Methocinnamox Methylnaltrexone
SR-17018
World's Fair held in Paris, France
237. Lotsof, H.S. (1995). "Ibogaine in the Treatment of Chemical Dependence Disorders: Clinical Perspectives". The Ibogaine Dossier. MAPS Bulletin. pp
Exposition_Universelle_(1867)
Psychoactive Substances Act 2016 in the context of basic or clinical research. Ibogaine was not included in the list of controlled drugs under the Misuse of Drugs
Legal status of psychedelic drugs in the United Kingdom
Legal_status_of_psychedelic_drugs_in_the_United_Kingdom
American football player (born 1980)
Mexico to undergo treatment with ibogaine, a psychoactive compound derived from the West African iboga plant. Ibogaine is classified as a Schedule I substance
Robert_Gallery
Class of indoles
some more complex compounds, for example cyclized tryptamines like LSD, ibogaine, harmaline, mitragynine and yohimbine. A thorough investigation of dozens
Substituted_tryptamine
Movement to decriminalize psilocybin in the United States
the possession of entheogenic plants, including psilocybin mushrooms and ibogaine. In February 2021, after continuous outreach by Decriminalize Nature Massachusetts
Psilocybin decriminalization in the United States
Psilocybin_decriminalization_in_the_United_States
Species of plant
Diprenorphine ECG EGC Epicatechin Eptazocine Gemazocine Ginsenoside R Hyperoside Ibogaine JDTic Levallorphan Lobeline LY-255582 LY-2196044 Methocinnamox Methylnaltrexone
Mitragyna_speciosa
Dried latex of the opium poppy containing narcotic compounds
including pharmacologically based treatments with naltrexone, methadone, or ibogaine. In 2021, the International Agency for Research on Cancer concluded that
Opium
Drug that blocks hallucinogen effects
Hashish Hash oil Synthetic cannabinoids JWH-018 APICA APINACA Spice Others Ibogaine Tabernanthe iboga Muscimol Amanita muscaria Oneirogens Calea zacatechichi
Trip_killer
Tramadol, Synthetic Ibogaine (about naturally occurring tramadol in Africa, recreational use of tramadol in Africa, entheogenic use of ibogaine in Africa, and
Bibliography of Hamilton Morris
Bibliography_of_Hamilton_Morris
American businessman and fashion industry entrepreneur
the Clear Sky Recovery clinic, which specializes in therapy utilising ibogaine, a medication with psychedelic properties. However, he was reported to
Matthew_Mellon
US pharmaceutical company
candidates of Atai Life Sciences prior to its merger into AtaiBeckley included ibogaine (IBX-210, DMX-1002), EGX-121 (a non-tryptamine new chemical entity), psilocin
AtaiBeckley
Drugs that promote rapid and sustained neuroplasticity
depression. 5-MeO-DMT is being studied for depression and eating disorders. Ibogaine and noribogaine are being studied for addiction. JRT, a nonhallucinogenic
Psychoplastogen
American football player (born 1996)
nearly drove him to retirement. He traveled to Mexico to be treated with ibogaine and 5-MeO-DMT, as the use of these psychedelic substances is banned in
Braden Smith (American football)
Braden_Smith_(American_football)
Anglo-American actor
substance abuse rehabilitation: Evaluating treatments with LSD, Peyote, Ibogaine and Ayahuasca". Current Drug Abuse Reviews. 7 (2): 101–16. doi:10
Peter_Youngblood_Hills
Chemical compound
used in semi-synthesis of ibogaine. Compared to voacangine, it has an extra O-atom. When it is degraded, iboxygaine and ibogaine are formed. Voacristine
Voacristine
1997 book by Alexander Shulgin and Ann Shulgin
β-carbolines or harmala alkaloids like harmaline, the iboga alkaloid ibogaine, and lysergamides like LSD. Whereas PiHKAL had 179 entries on phenethylamines
TiHKAL
Neurological disorder related to persistent cocaine use
December 2016). "Ibogaine treatment Clinic". Avante Institute. Retrieved 7 May 2021. Group, Clear Sky (1 August 2018). "Is Ibogaine Illegal in the United
Cocaine_dependence
Music genre and scene
Microdosing Smart shop Trip sitter Drugs 25I-NBOMe 2C-B Ayahuasca Cannabis DMT Ibogaine Ketamine LSD Mescaline Peyote Psilocybin mushrooms San Pedro cactus List
Post-noise
Microdosing Smart shop Trip sitter Drugs 25I-NBOMe 2C-B Ayahuasca Cannabis DMT Ibogaine Ketamine LSD Mescaline Peyote Psilocybin mushrooms San Pedro cactus List
List_of_psychedelic_chemists
Deadly nightshade, a flowering plant
Peganum harmala, Banisteriopsis caapi) Iboga alkaloids/azepinoindoles (e.g., ibogaine, noribogaine) (found in Tabernanthe iboga) Cannabinoids (CB1 agonists)
Atropa_bella-donna
Investigational substance-related disorder drugs
Igalmi; KalmPen) – α2-adrenergic receptor agonist – opioid-related disorders Ibogaine (DMX-1002; IBX-210) – various actions/unknown mechanism of action and
List of investigational substance-related disorder drugs
List_of_investigational_substance-related_disorder_drugs
9th episode of the 3rd season of Homeland
Brody's heroin withdrawals will take too long, Dar Adal endorses the use of ibogaine, a drug which speeds up the withdrawal process but also induces severe
One_Last_Thing_(Homeland)
specifically addressing the possession or use of ayahuasca. Legal status of ibogaine by country Legal status of psilocybin mushrooms Legal status of psychoactive
Legal status of ayahuasca by country
Legal_status_of_ayahuasca_by_country
American harm reductionist
his drug use, Mugianis traveled to the Netherlands for ibogaine treatment. During his ibogaine-induced hallucinations, he saw his Greek ancestors, his
Dimitri_Mobengo_Mugianis
Spiritual discipline of West Africa
African traditional religions Religion in Gabon Beti-Pahuin peoples Winti Ibogaine Bonhomme, Julien; De Ruyter, Magali; Moussavou, Guy-Max (2012). "Blurring
Bwiti
Pain medication
Diprenorphine ECG EGC Epicatechin Eptazocine Gemazocine Ginsenoside R Hyperoside Ibogaine JDTic Levallorphan Lobeline LY-255582 LY-2196044 Methocinnamox Methylnaltrexone
Oxycodone/paracetamol
Grayanotoxin (also found in Rhododendron pollen and mad honey) Iboga: ibogaine, noribogaine, ibogamine, voacangine, 18-methoxycoronaridine Ephedra: ephedrine
List of psychoactive plants, fungi, and animals
List_of_psychoactive_plants,_fungi,_and_animals
Opioid analgesic
antagonism. NMDA antagonists such as dextromethorphan, ketamine, tiletamine and ibogaine are being studied for their role in decreasing the development of tolerance
Methadone
Chemical compound
Diprenorphine ECG EGC Epicatechin Eptazocine Gemazocine Ginsenoside R Hyperoside Ibogaine JDTic Levallorphan Lobeline LY-255582 LY-2196044 Methocinnamox Methylnaltrexone
7-Acetoxymitragynine
United States drug-regulating law
can. Ibogaine, a naturally occurring psychoactive substance found in plants in the family Apocynaceae. Some countries in North America use ibogaine as an
Controlled_Substances_Act
Class of drug
mechanism as tolerance. While there are anecdotal claims of benefit with ibogaine, data to support its use in substance dependence is poor. Critically ill
Opioid
Chemical compound
Diprenorphine ECG EGC Epicatechin Eptazocine Gemazocine Ginsenoside R Hyperoside Ibogaine JDTic Levallorphan Lobeline LY-255582 LY-2196044 Methocinnamox Methylnaltrexone
Acetylpropionylmorphine
Psychoactive component of cannabis
Hashish Hash oil Synthetic cannabinoids JWH-018 APICA APINACA Spice Others Ibogaine Tabernanthe iboga Muscimol Amanita muscaria Oneirogens Calea zacatechichi
Tetrahydrocannabinol
Recreational drug beverage
Hashish Hash oil Synthetic cannabinoids JWH-018 APICA APINACA Spice Others Ibogaine Tabernanthe iboga Muscimol Amanita muscaria Oneirogens Calea zacatechichi
Lean_(drug)
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