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Protein complex for polypeptide membrane transport
The translocon (also called a translocator or translocation channel) is a general term for a protein channel in biological membranes that functions to
Translocon
Protein domain
The TIC and TOC complexes are translocons located in the chloroplast of a eukaryotic cell, that is, protein complexes that facilitate the transfer of
TIC/TOC_complex
Protein spanning across a biological membrane
normally folded co-translationally within the large transmembrane translocon. The translocon channel provides a highly heterogeneous environment for the nascent
Transmembrane_protein
Protein family
protein complex found in all domains of life. As the core component of the translocon, it transports proteins to the endoplasmic reticulum in eukaryotes and
Sec61
Plant organelle that conducts photosynthesis
complex, or translocon on the outer chloroplast membrane, and the TIC translocon, or translocon on the inner chloroplast membrane translocon. Chloroplast
Chloroplast
DNA located in cellular organelles called chloroplasts
is the most abundant of these. The TIC translocon, or translocon on the inner chloroplast membrane translocon is another protein complex that imports
Plastid_DNA
Cell organelle that processes proteins
binding site of the ribosome on the rough endoplasmic reticulum is the translocon. However, the ribosomes are not a stable part of this organelle's structure
Endoplasmic_reticulum
PorKN and GldKN which associate with the outer membrane Soc and SprA translocon Other subunits include GldO, GldJ, β-barrel, and plug proteins. PorL,
Type_IX_secretion_system
Short peptide present at N-terminal of newly synthesized proteins
sequence is inserted into the translocon. Ribosomes are then physically docked onto the cytoplasmic face of the translocon and protein synthesis resumes
Signal_peptide
Protein-coding gene in the species Homo sapiens
Translocon-associated protein subunit beta also known as TRAP-beta is a protein that in humans is encoded by the SSR2 gene. The signal sequence receptor
SSR2
Physiology & Biophysics researcher, academic
protein-bilayer interactions, experimentally determined hydrophobicity scales, translocon-assisted folding of membrane proteins, structure of fluid lipid bilayers
Stephen_H._White
Class of enzymes
step in the N-linked glycosylation pathway. OST is a component of the translocon in the endoplasmic reticulum (ER) membrane. A lipid-linked core-oligosaccharide
Oligosaccharyltransferase
Protein family
pathway and of a protein-secreting ATPase complex, also known as a SecYEG translocon. Homologs of the SecYEG complex are found in eukaryotes and in archaea
SecY_protein
Study of plant life
"Crystal Structure of Pea Toc34, a Novel GTPase of the Chloroplast Protein Translocon". Nature Structural Biology. 9 (2): 95–100. doi:10.1038/nsb744. PMID 11753431
Botany
American structural biologist
University of Utah (PhD) Known for Atomic structures of the ribosome, translocon Scientific career Fields Structural biology Membrane proteins Institutions
Bil_Clemons
American biochemist and cell biologist
Berkeley, Deshaies discovered Sec61, which comprises the heart of the translocon that mediates insertion of secretory and membrane proteins into the endoplasmic
Raymond_J._Deshaies
Protein-RNA complex
ribosome-nascent chain complex) to the protein-conducting channel, also known as the translocon, in the endoplasmic reticulum (ER) membrane. This occurs via the interaction
Signal_recognition_particle
Protein-coding gene in the species Homo sapiens
Translocon-associated protein subunit alpha is a protein that in humans is encoded by the SSR1 gene. The signal sequence receptor (SSR) is a glycosylated
SSR1
Protein-coding gene in the species Homo sapiens
Translocon-associated protein subunit delta is a protein that in humans is encoded by the SSR4 gene. SSR4, also called TRAPD, is assumed to be involved
SSR4
When it arrives at the ER, the signal sequence is transferred to the translocon, a protein-conducting channel in the membrane that allows the newly synthesized
Secretory_protein
the polypeptide, it is cleaved off after entering the ER-lumen (via a translocon) by a signal peptidase, and subsequently degraded. As an example, the
Topogenic_sequence
RNA family
ribosome, allowing translation to continue and the protein to enter the translocon. The protein transverses the membrane co-translationally (during translation)
Signal recognition particle RNA
Signal_recognition_particle_RNA
Mammalian protein found in Homo sapiens
PMID 17081983. S2CID 7827573. Liao HJ, Carpenter G (2007). "Role of the Sec61 Translocon in EGF Receptor Trafficking to the Nucleus and Gene Expression". Mol.
SEC61B
Swiss biochemist
of translocon function and how proteins are sorted in the cell and transported to their designated organelles. Spiess discovered that the translocon, in
Martin_Spiess
Sex chromosome present in both sexes in the XY and X0 sex-determination systems
paraplegia 16 (complicated, X-linked recessive) SSR4: encoding protein Translocon-associated protein subunit delta TAF7L: encoding protein TATA-box binding
X_chromosome
American biochemist
"Coassembly of SecYEG and SecA Fully Restores the Properties of the Native Translocon". Journal of Bacteriology. 201 (1). doi:10.1128/JB.00493-18. PMC 6287467
Linda_Randall
American biochemist (1934–2021)
each experiment. It was found that OT binds the ribosome, and the Sec61 translocon complex binds the ribosome as well to form a complex to glycosylate N-linked
William_J._Lennarz
Proteins that are part of, or interact with, biological membranes
until it binds to a SRP-receptor on the surface of the lipid bilayer. Translocons are channels in the membrane which allow proteins to be moved across
Membrane_protein
Protein complexes present on the cell membranes of bacteria for secretion of substances
state and delivers it to translocon-bound SecA. Then the pre-protein is secreted to the periplasm through the SecYEG translocon. Whereas in the SRP pathway
Bacterial_secretion_system
Phosphoglyceride attached to proteins
The protein is co-translationally inserted in the ER membrane via a translocon and is attached to the ER membrane by its hydrophobic C terminus; the
Glycosylphosphatidylinositol
SEC61A1, HSEC61, SEC61, SEC61A, Sec61 alpha 1, Sec61 translocon alpha 1 subunit, HNFJ4, SEC61 translocon subunit alpha 1, ADTKD5 External IDs OMIM: 609213;
Sec61_alpha_1
American professor of biology
ribosomal subunit is required for ribosome-associated quality control and translocon recycling at the ER, resolving a 50-year-old cell biological mystery.
Ron_Kopito
Protein family
LcrV protein, also regulates the secretion of YopD through the type III translocon, and itself acts as a protective "V" antigen for Yersinia pestis, the
LcrV
Topics referred to by the same term
station code TOC protocol, an instant message communications protocol Translocon at the outer membrane of chloroplast, in beta barrel Total organic carbon
TOC
Cell organelle
to a translocon and bound with guanosine triphosphate (GTP). This guanosine triphosphate is phosphorylated for energy and opens the translocon allowing
Membrane_bound_polyribosome
Gene which maintains basic cellular functions
nexin 19 SNX25 Sorting nexin 25 SSR1 Translocon-associated protein TRAPA. Protein translocation in ER SSR2 Translocon-associated protein TRAPB. Protein translocation
Housekeeping_gene
Protein-coding gene in the species Homo sapiens
activity did not co-fractionate with RRBP1 but rather with Sec61 (i.e. the translocon). RRBP1 can enhance the association of certain mRNAs to the endoplasmic
RRBP1
Outer membrane protein
synthesized in the cytoplasm and then exported into the periplasm by Sec translocon machinery. Then they are escorted to the inner surface of the outer membrane
Bam_A
Cellular stress response
occurs as soon as the protein sequence passes into the ER through the translocon, where it is glycosylated with a sugar molecule that forms the key ligand
Unfolded_protein_response
Viral proteins that modify cellular membranes
ribosome complex with the partially-translated protein is transferred to the translocon, and translation resumes as normal. The signal sequence is cleaved in
Viroporin
Group of transport proteins
a large soluble domain for binding transit peptides and other stromal translocon components. The C-terminal half of Tic110 possesses a rod-shaped helix-repeat
Tic110_family
Controlled release of substances by cells or tissues
proteins are translocated across the cytoplasmic membrane by the SecYEG translocon, one of two translocation systems, which requires the presence of an N-terminal
Secretion
Protein structure
complexes, the best characterised of which is Toc75 of the TOC complex (Translocon at the outer envelope membrane of chloroplasts). Lipocalins are typically
Beta_barrel
Class of enzymes
disease Bacterial secretion system Membrane transport Protein targeting Translocon "EC class 7". ExplorEnz - The Enzyme Database. Retrieved 24 October 2019
Translocase
American molecular biologist
"Cotranslational integration and initial sorting at the endoplasmic reticulum translocon of proteins destined for the inner nuclear membrane". Proceedings of the
Max_D._Summers
Classification of membrane proteins including ion channels
Arsenite-Antimonite efflux family 3.A.5 General secretory pathway (Sec) translocon (preprotein translocase SecY) 3.A.6 The Type III (Virulence-related) Secretory
Transporter Classification Database
Transporter_Classification_Database
Protein-coding gene in the species Homo sapiens
across the mitochondrial inner membrane: role of the TIM23 and TIM22 translocons". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1592
TIMM13
German-American cell biologist (born 1947)
of the endoplasmic reticulum by the Sec61 complex (also known as the translocon), how misfolded secretory proteins are degraded by endoplasmic reticulum
Tom_Rapoport
Protein export pathway
the Tat complex. At least two TatC molecules co-exist within each Tat translocon. Not all bacteria carry the tatABC genes in their genome; however, of
Twin-arginine translocation pathway
Twin-arginine_translocation_pathway
Mammalian protein found in humans
bicarbonate transmembrane transporter activity chaperone binding Sec61 translocon complex binding isomerase activity Cellular component cytoplasm recycling
Cystic fibrosis transmembrane conductance regulator
Cystic_fibrosis_transmembrane_conductance_regulator
Chemical compound
necrotizing agent, it was discovered to be a potent inhibitor of the Sec61 translocon. By blocking this gateway, mycolactone prevents cells from translocating
Mycolactone
Protein-coding gene in the species Homo sapiens
TRIM25 and molecular chaperone 14-3-3e to form a complex termed "translocon". The translocon travels to the mitochondria where it binds to the CARD region
Mitochondrial antiviral-signaling protein
Mitochondrial_antiviral-signaling_protein
Protein family
found as a fused single protein. Apoprotein transport occurs via the Sec translocon as well. Fungal, vertebrate and invertebrate mitochondria produce cytochrome
Cytochrome_c_family
Membrane enclosed compartments in chloroplasts and cyanobacteria
targeting peptide (shown in blue). Proteins are imported through the translocon of the outer and inner membrane (Toc and Tic) complexes. After entering
Thylakoid
Type of peptide chain
reticulum. Both the SecYEG and Sec61 channels are commonly referred to as the translocon, and transit through this channel is known as translocation. While secreted
Target_peptide
Protein-coding gene in the species Homo sapiens
that in humans is encoded by the TRAM2 gene. TRAM2 is a component of the translocon, a gated macromolecular channel that controls the posttranslational processing
TRAM2
Protein-coding gene in humans
peptide (amino acids 22-907) inserts its transmembrane domain into the translocon membrane prior to packaging towards the plasma membrane. LGR5 is highly
LGR5
Bacteria-produced protein complex and disease agent
degradation (ERAD) pathway to translocate into the cytosol through the Sec61 translocon. Unlike typical ERAD substrates, CTA1 evades ubiquitination due to its
Cholera_toxin
Proteins assisting in protein folding
translocation-competent (generally unfolded) state and guides them to the translocon. New functions for chaperones continue to be discovered, such as bacterial
Chaperone_(protein)
Australian scientist (born 1966)
health. In 2009, Crabb and his research team identified the export protein translocon in malaria. This discovery was published in Nature and solved the mystery
Brendan_Crabb
Protein-coding gene in the species Homo sapiens
Bordallo J, Sommer T, Wolf DH (Aug 1997). "Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation". Nature. 388
Binding immunoglobulin protein
Binding_immunoglobulin_protein
Biological mechanism for routing proteins
membrane in prokaryotes. There, the nascent protein is inserted into the translocon, a membrane-bound protein conducting channel composed of the Sec61 translocation
Protein_targeting
Type of protein
polypeptide, and (ii) it directs this polypeptide to the membrane and SecYEG translocon. Once folded, the precursor can no longer enter the translocation pathway
Maltose-binding_protein
RNA family
Endoplasmic Reticulum (ER), allowing the peptide to pass through the translocon into the ER lumen, where proteins are processed for secretion or trafficking
Small_nucleolar_RNA_SNORA73
Protein-coding gene in humans
"Climp-63-mediated binding of microtubules to the ER affects the lateral mobility of translocon complexes". Journal of Cell Science. 120 (13): 2248–58. doi:10.1242/jcs
CKAP4
Topics referred to by the same term
Protein translocase may refer to: Translocon complexes SecY and Sec61 Translocase of the inner membrane Translocase of the outer membrane See also Sorting
Protein_translocase
into a polypeptide, the polypeptide is simultaneously inserted via the translocon pore into the ER). The ER provides an environment that helps nascent polypeptides
TRAPP_complex
Protein family
regulates the targeting of SRP-ribosome-nascent polypeptide complexes to the translocon. SR-alpha binds to the SRP54 subunit of the SRP complex. The SR-beta subunit
Signal recognition particle receptor
Signal_recognition_particle_receptor
Membrane-spanning protein domain
translocation channel, positioning the ribosome exit tunnel proximal to the translocon central pore and minimizing exposure of the TMD to cytosol. Insertases
Transmembrane_domain
Large molecular machine for synthesizing proteins from messenger RNA
(May 2006). "Signal recognition particle receptor exposes the ribosomal translocon binding site". Science. 312 (5774): 745–747. Bibcode:2006Sci...312..745H
Eukaryotic_ribosome
Mammalian protein found in Homo sapiens
SEC61G Identifiers Aliases SEC61G, SSS1, Sec61 translocon gamma subunit, SEC61 translocon subunit gamma External IDs OMIM: 609215; MGI: 1202066; HomoloGene:
SEC61G
Bacterial system for secreting proteins
cannot exit the cell. GspD is transported into the periplasm via the Sec translocon and is then inserted into the outer membrane. This insertion is not spontaneous
Type_II_secretion_system
Bacterial virulence factor
translocators, are secreted first and produce a pore or a channel (a translocon) in the host cell membrane, through which other effectors may enter. Mutated
Type_III_secretion_system
French microbiologist
"Pore-forming activity of the Pseudomonas aeruginosa type III secretion system translocon alters the host epigenome". Nature Microbiology. 3 (3): 378–386. doi:10
Alain_Filloux
Protein involved in retrotranslocation of specific misfolded proteins and in ER stress
stress-induced pre-emptive quality control involving association of the translocon, Derlin-1, and HRD1". Scientific Reports. 8 (1): 7317. Bibcode:2018NatSR
Derlin-1
Index of articles on biophysics
channel Transient receptor potential channel-interacting protein database Translocon Transmembrane channels Treadmilling Turgor pressure Twin-arginine translocation
Index_of_biophysics_articles
enzyme class is ATP phosphohydrolase (protein-secreting). SecY protein Translocon Saier MH, Tam R, Reizer A, Reizer J (1994). "Two novel families of bacterial
Protein-secreting_ATPase
with a subset of membrane proteins after their integration at the sec61 translocon". The Journal of Biological Chemistry. 280 (6): 4195–206. doi:10.1074/jbc
Ribophorin
Protein
association with the class III phosphatylinositol 3 kinase VPS34-containing translocon machinery to form the MITA-Vps34 translocation complex; this linkage is
SNX8
Protein-coding gene in the species Homo sapiens
and stimulated its interaction with Sec63, a DnaJ family member and a translocon component. Disruption of the interaction between Sls1p and Kar2p significantly
SIL1
Israeli biologist
Michaelis S & Schuldiner M (2016). The Protease Ste24 Clears Clogged Translocons. Cell. 164, 103–114. Yofe I, Weill U, Meurer M, Chuartzman S, Zalckvar
Maya_Schuldiner
Protein-coding gene in the species Homo sapiens
working with Hsp70, assist polypeptide movement through the mitochondrial translocon. The HPD tripeptide motif of the J domain interacts with key regions of
DNAJC28
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