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Process in developmental biology
Transdifferentiation, also known as lineage reprogramming, is the process in which one mature somatic cell is transformed into another mature somatic cell
Transdifferentiation
Species of small, biologically immortal jellyfish
polyp colony. It does this through the cell development process of transdifferentiation, which alters the differentiated state of the cells and transforms
Turritopsis_dohrnii
Cellular process of loss of specialization
more closely with transdifferentiation, because metaplasia refers more to the idea of a phenotypic transition. Transdifferentiation refers to the conversion
Dedifferentiation
Transformation of cells from one type to another
hypotheses of origin in Barrett's esophagus. They include direct transdifferentiation of squamous cells to columnar cells, the stem cell changing from
Metaplasia
Japanese stem cell researcher (born 1962)
carry out transdifferentiation using combinations of transcription factors that induce cell fate switches. They found transdifferentiation within germ
Shinya_Yamanaka
Species of hydrozoan
umbrella and part of the animals digestive system. The ability of transdifferentiation, in which a non-stem cell can morph into a different type of cell
Turritopsis_nutricula
Biological process
transdifferentiate into new hair cells, resulting in hearing recovery. Direct transdifferentiation is when neighboring supporting cells convert into hair cells without
Inner_ear_regeneration
Animals of the phylum Porifera
Adamska, Maja; Tokina, Daria B.; Ereskovsky, Alexander V. (2015). "Transdifferentiation is a driving force of regeneration in Halisarca dujardini (Demospongiae
Sponge
Soft-bodied, aquatic invertebrates
"Reversing the life cycle: medusae transforming into polyps and cell transdifferentiation in Turritopsis nutricula (Cnidaria, Hydrozoa)". Biological Bulletin
Jellyfish
Type of gastric gland cell
process is known as transdifferentiation. The gene Mist1 has been shown to regulate mucus neck cell to chief cell transdifferentiation and plays a role in
Gastric_chief_cell
Last stage in an insect's metamorphosis
dictionary. Arenas-Mena, C. (27 February 2010). "Indirect Development, Transdifferentiation and the Macroregulatory Evolution of Metazoans". Philosophical Transactions
Imago
Primary cell of the nervous system
found a way to transform human skin cells into nerve cells using transdifferentiation, in which "cells are forced to adopt new identities". During neurogenesis
Neuron
State in which the rate of mortality from senescence is stable or decreasing
are small (5 millimeters (0.20 in)) species of jellyfish that use transdifferentiation to replenish cells after sexual reproduction. This cycle can repeat
Biological_immortality
Multipotent stem cell in the adult body
endoderm and mesoderm. This phenomenon is referred to as stem cell transdifferentiation or plasticity. It can be induced by modifying the growth medium when
Adult_stem_cell
Organisms that live in salt water
"Reversing the life cycle: medusae transforming into polyps and cell transdifferentiation in Turritopsis nutricula (Cnidaria, Hydrozoa)". Biological Bulletin
Marine_life
Blood vessel formation, when new vessels emerge from existing vessels
regulates angioblast differentiation ID1/ID3 Regulates endothelial transdifferentiation Class 3 semaphorins Modulates endothelial cell adhesion, migration
Angiogenesis
Juvenile form of distinct animals before metamorphosis
the free dictionary. Arenas-Mena, C. (2010) Indirect development, transdifferentiation and the macroregulatory evolution of metazoans. Philosophical Transactions
Larva
Ability of a cell to differentiate into other cell types
transcription factors can directly induce other defined somatic cell fates (transdifferentiation); researchers identified three neural-lineage-specific transcription
Cell_potency
Family of large biological molecules
mRNA for efficient and fast human iPS cell generation and direct transdifferentiation to myoblasts". Biochemical and Biophysical Research Communications
RNA
Concept of eternal life
transform itself back into a polyp using the cell conversion process of transdifferentiation. Turritopsis dohrnii repeats this cycle, meaning that it may have
Immortality
List of examples of in vivo transdifferentiation through transfection
A list of examples of in vivo transdifferentiation through transfection: mouse hepatocytes → B cells (Pdx1) exocrine cells → B cells (Pdx1, Ngn3, and v-maf
Examples of in vivo transdifferentiation by lineage-instructive approach
Examples_of_in_vivo_transdifferentiation_by_lineage-instructive_approach
Chemical compound
efficacy as a cardiac differentiation factor because it promotes the transdifferentiation of cardiac cells to skeletal myocytes. Azacitidine also has antiviral
Azacitidine
Marine phylum of animals often with radial symmetries
and remodelling of existing tissues to replace lost parts. Direct transdifferentiation of one type of tissue to another during tissue replacement is also
Echinoderm
Greek-American pathologist
acknowledged in a bibliometric analysis. Michalopoulos researched transdifferentiation of hepatocytes and biliary cells in liver repair. In a collaborative
George_Michalopoulos
Indian actress
Nirmala, Subramanian; Krishnakumar, Subramanian (2016). "In vitro transdifferentiation of human skin keratinocytes to corneal epithelial cells". Cytotherapy
Vidya_Pradeep
Deterioration of function with age
"Reversing the Life Cycle: Medusae Transforming into Polyps and Cell Transdifferentiation in Turritopsis nutricula (Cnidaria, Hydrozoa)". The Biological Bulletin
Senescence
Longest recorded life span
"Reversing the Life Cycle: Medusae Transforming into Polyps and Cell Transdifferentiation in Turritopsis nutricula (Cnidaria, Hydrozoa)". The Biological Bulletin
Maximum_life_span
Intravenous transference of blood products
donors to older recipients that is claimed to have health benefits Transdifferentiation AIDS "Blood Transfusion". National Heart, Lung, and Blood Institute
Blood_transfusion
Transformation of a stem cell to a more specialized cell
Wiley-Blackwell. ISBN 978-0-470-92351-1. Slack JM (May 2007). "Metaplasia and transdifferentiation: from pure biology to the clinic". Nature Reviews. Molecular Cell
Cellular_differentiation
Lymphatic-like vessel in the eye
LYVE1 and PDPN. It develops via a unique mechanism involving the transdifferentiation of venous endothelial cells in the eye into lymphatic-like endothelial
Schlemm's_canal
Resilient and smooth elastic tissue present in animals
(March 2017). "Evolutionary origin of endochondral ossification: the transdifferentiation hypothesis". Development Genes and Evolution. 227 (2): 121–127. doi:10
Cartilage
Protein-coding gene in the species Homo sapiens
involved in the Epithelial–mesenchymal transition and Neuroendocrine Transdifferentiation of Prostate Cancer cells in aggressive disease. Dysregulation of
Aurora_kinase_A
factor expression. In 1995 he pioneered this technique permitting the transdifferentiation of white blood cells into red blood cell precursors and vice versa
Thomas_Graf_(biologist)
Species of small South Pacific hydrozoan
earlier stage of its life cycle at will. These cells can then perform transdifferentiation and morph into other types of cells needed to fully create the polyp
Turritopsis_rubra
Lecturer and researcher (1925–2003)
conditions when grown isolated in culture; a rare example of the transdifferentiation of one differentiated cell type into another, and a phenomenon that
Ruth_Clayton
Fibroblasts → neural stem/progenitor cells (Oct4, Sox2, c-Myc, Klf4) Transdifferentiation Induced stem cells Pournasr, B.; Khaloughi, K.; Salekdeh, G. H.;
Examples of in vitro transdifferentiation by initial epigenetic activation phase approach
Examples_of_in_vitro_transdifferentiation_by_initial_epigenetic_activation_phase_approach
endothelial wall of the embryonic dorsal aorta, through an endothelial transdifferentiation process referred to as an 'endothelial-to-haematopoietic transition'
Aorta-gonad-mesonephros
Investigational anticancer drug
androgen receptor transcription factors Promotion of neuroendocrine transdifferentiation Mevrometostat demonstrates dose-dependent EZH2 inhibition, leading
Mevrometostat
Cell type with functions of both muscular and fibrous connective tissue
the other cell types as intermediates. Epithelial to mesenchymal transdifferentiation (EMT) of an epithelial cell. Perhaps the most studied pathway of
Myofibroblast
Protein
participates in the osteoblastic determination, differentiation, and transdifferentiation under p38 MAPK and JNK regulation. M-Ras is involved in TNF-alpha-stimulated
MRAS
Biological process of renewal, restoration, and tissue growth
use of adult somatic stem cells and the dedifferentiation and/or transdifferentiation of cells, and more than one mode can operate in different tissues
Regeneration_(biology)
Group of disorders
FDCS may derive from follicular lymphoma cells by the process of transdifferentiation. FDCS affects primarily young to middle-aged adults of both sexes
Epstein–Barr virus–associated lymphoproliferative diseases
Epstein–Barr_virus–associated_lymphoproliferative_diseases
people of Maquehue, Chile and in Singapore, Malaysia and Thailand "Transdifferentiation of Stem Cells – Page 1174245593 – Experimental Biology". Archived
A1_broth
Hormonal treatment for prostate cancer
activate epithelial–mesenchymal transition (EMT), neuroendocrine transdifferentiation (NEtD) and cancer stem cell-like gene programs. EMT has established
Androgen_deprivation_therapy
Method of creating a cloned embryo by replacing the egg nucleus with a body cell nucleus
Zhao, A.; Fu, X. (2017). "Small molecules for reprogramming and transdifferentiation". Cellular and Molecular Life Sciences. 74 (19): 3553–3575. doi:10
Somatic_cell_nuclear_transfer
Biological process in animal connective tissue
therapy-induced epithelial mesenchymal plasticity and neuroendocrine transdifferentiation in prostate cancer: an opportunity for intervention". Front Oncol
Epithelial–mesenchymal transition
Epithelial–mesenchymal_transition
Season of television series
cells from her and Sheldon to produce some primitive neurons through transdifferentiation. This inspires Sheldon to want to have a child with Amy, though she
The_Big_Bang_Theory_season_10
Protein found in humans
cellular response to hypoxia leukocyte migration signal transduction transdifferentiation negative regulation of neuron death cell-cell adhesion hemopoiesis
CD34
Type of liver cell
proliferation, contractility, and chemotaxis. This change is seen as a transdifferentiation whereby the cells lose their stellate shape and acquire that of myofibroblasts
Hepatic_stellate_cell
Paracrine soluble factors produced by stem cells
contrary to the historic hypothesis that stem cell migration and transdifferentiation is the primary mechanism of effect of stem cell injection therapies
Stem_cell_secretome
Surroundings of tumors including nearby cells and blood vessels
originate from neighboring non-cancerous stromal cells or undergo transdifferentiation from tumor cells. Stromal cells contribute to tumor initiation, progression
Tumor_microenvironment
Class of compounds
Fang P, et al. (May 2018). "Lysophospholipids induce innate immune transdifferentiation of endothelial cells, resulting in prolonged endothelial activation"
Lysophosphatidylcholine
Medical condition
hypersomatotropism, hypoprolactinemia, and pituitary enlargement with transdifferentiation". Domestic Animal Endocrinology. 35 (1): 98–111. doi:10.1016/j.domaniend
Hypothyroidism_in_dogs
Protein-coding gene in humans
Induced knockout of DMRT1 in adult male mice has been found to cause transdifferentiation of somatic cells in the testis to the equivalent cell types that
DMRT1
Persistence of a biological trait under uncertain conditions
leads to imperfect cell differentiation that is later corrected by transdifferentiation, migration or cell death of the misplaced cells. Additionally, the
Robustness_(evolution)
Marine animals without a vertebral column
"Reversing the life cycle: medusae transforming into polyps and cell transdifferentiation in Turritopsis nutricula (Cnidaria, Hydrozoa)". Biological Bulletin
Marine_invertebrates
Place where cartilage is replaced with bone
art of building bone: emerging role of chondrocyte-to-osteoblast transdifferentiation in endochondral ossification". Bone Research. 6: 19. doi:10.1038/s41413-018-0021-z
Ossification_center
Cell group in amphibian embryos
Xenopus blastula by researcher Osamu Nakamura. The new concept of transdifferentiation was proposed by T.S. Okada and G. Eguchi. These discoveries and many
Spemann–Mangold_organizer
Protein and coding gene in humans
"Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism". Molecular Biology of the Cell
Transforming_protein_RhoA
Kidney disease
their regenerative capabilities, the kidney can benefit from it by transdifferentiation into kidney cells. Moreover, they can give anti-inflammatory and
Kidney_ischemia
Genetically-modified hydrozoan
metazoan Hydra is maintained by both stem cell based mechanisms and transdifferentiation. Dev. Biol. 313: 13-24 Milde S, G Hemmrich, F Anton-Erxleben, K Khalturin
Transgenic_hydra
Mammalian protein found in Homo sapiens
development positive regulation of transcription by RNA polymerase II transdifferentiation endocrine pancreas development Sources:Amigo / QuickGO Orthologs
Neurogenin-3
Glucagon secreting cell
gamma‐aminobutyric acid (GABA) in pancreatic β‐cell regeneration through transdifferentiation of pancreatic α‐ to β‐cells". Cell Biology International. 44 (4)
Alpha_cell
Catalytic subunit of the enzyme telomerase
negative regulation of glial cell proliferation positive regulation of transdifferentiation cellular response to hypoxia positive regulation of vascular associated
Telomerase reverse transcriptase
Telomerase_reverse_transcriptase
PSK has been demonstrated to promote cellular proliferation and transdifferentiation. It has been demonstrated that PSK binds to a membrane bound LRR
Plant_peptide_hormone
Hepatic cell line model
express major properties of stem cells including high plasticity & transdifferentiation capacity. The HepaRG cells have been found to express major nuclear
HepaRG
Protein-coding gene in humans
osteoblast development embryonic cranial skeleton morphogenesis transdifferentiation paraxial mesoderm morphogenesis response to hypoxia positive regulation
SMAD3
Id in the regulation of TGF-beta-induced epithelial-mesenchymal transdifferentiation". Cell Death and Differentiation. 11 (10): 1092–101. doi:10.1038/sj
Inhibitor of DNA-binding protein
Inhibitor_of_DNA-binding_protein
Chemical compound
Fang P, et al. (May 2018). "Lysophospholipids induce innate immune transdifferentiation of endothelial cells, resulting in prolonged endothelial activation"
Lysophosphatidylinositol
Biogerontologist
generally considered a primary cause of cellular dedifferentiation and transdifferentiation, which degrade organismal function. While critical of SENS and other
Preston_Estep
Cytoplasmic enzyme involved in amino acid metabolism
concentration negative regulation of mitochondrial depolarization transdifferentiation cellular response to mechanical stimulus response to transition metal
GOT1
and the germline. Stem cell research includes differentiation and transdifferentiation in the hematopoietic system, somatic cell reprogramming, and tissue
Centre_for_Genomic_Regulation
Benign cartilage tumor on the ends of long bones
production of osteoid and collagen I, which could result from the transdifferentiation of chondrocytes towards osteoblasts. A variety of imaging studies
Chondroblastoma
Method of nerve regeneration
need to be done in order to standardize the yield with transdifferentiation. Transdifferentiation of multipotent stem cells is a potential means for obtaining
Nerve_guidance_conduit
Aspect of medical care
processes of neurogenesis, angiogenesis and synaptic plasticity. Transdifferentiation of MSCs into excitable neuron-like cells has been shown to be possible
Stroke_recovery
Protein
forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells". Gastroenterology. 132 (4): 1434–46. doi:10
Forkhead_box_protein_O1
Bioengineering methodology
the cell type of interest is formed. This method, also known as transdifferentiation or direct conversion, consists in overexpressing one or several factors
Directed_differentiation
A, Nguyen L, Malgrange B (April 2015). "Cochlear supporting cell transdifferentiation and integration into hair cell layers by inhibition of ephrin-B2
Hensen's_cell
Mammalian protein found in Homo sapiens
example is that ectopic expression of FOXA2 together with HNF4A drives transdifferentiation of fibroblasts to hepatocyte-like cells. Consistent with its role
FOXA2
Protein-coding gene in the species Homo sapiens
stimulus positive regulation of transcription by RNA polymerase II transdifferentiation aortic valve morphogenesis development of the heart animal organ
GATA4
Meijuan (2015-12-03). "Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung". Nature. 528 (7580): 127–131. Bibcode:2015Natur
3DISCO
Precursor cells of neurons and glia during embryonic development
tissues, the differentiation of pluripotent stem cells (PSC) and transdifferentiation from somatic cells. Induced NCSs can be reprogrammed from somatic
Neural_stem_cell
Protein involved in the pancreas and duodenum differentiation
DNA-templated stem cell differentiation response to glucocorticoid transdifferentiation response to fatty acid Sources:Amigo / QuickGO Orthologs Species
PDX1
American genetic researcher (1937–2021)
attention to muscle gene expression, myocyte differentiation, and transdifferentiation, including early forays into cardiac gene therapy. He was also a
Laurence_H._Kedes
specialized cell lineage to a different lineage. It is contrasted to transdifferentiation where a differentiated cell switches to another lineage without intermediate
Transdetermination
Protein-coding gene in the species Homo sapiens
development negative regulation of cell population proliferation transdifferentiation regulation of cell cycle process neuron differentiation Sources:Amigo
INSM1
Regrowth of eye lens tissue in animals
basal layer of the cornea in the eye . These cells do not undergo transdifferentiation as seen in Wolffian regeneration, as they were never differentiated
Lens_regeneration
Species of sponge
and metamorphosis in a haplosclerid demosponge: gastrulation and transdifferentiation of larval ciliated cells to choanocytes". Invertebrate Biology. 121
Amphimedon_queenslandica
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Boy/Male
African, Arabic, Indian, Muslim
Judge
Boy/Male
Gujarati, Hindu, Indian
Like a Feather
Biblical
that made the sun stand still
Boy/Male
Australian, Indian, Punjabi, Sikh
Supreme God
Girl/Female
Arabic, Muslim
The Empowerer; The Strengthener
Girl/Female
Gujarati, Hindu, Indian
In Remembrance of God; Meditation; Remembrance
Surname or Lastname
English
English : variant of Ufford with the addition of an inorganic H-.
Girl/Female
American, Australian, Greek, Latin
Girdle; Belt; A Girth
Girl/Female
Tamil
Krianshree | கà¯à®°à¯€à®‚à®·à¯à®°à¯€
Surname or Lastname
English (Wiltshire)
English (Wiltshire) : unexplained. Compare Racy, Racey, Rasey.
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