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Class of enzymes which split thiol esters into an acid and alcohol
biochemistry, thioesterases are enzymes which belong to the esterase family. Esterases, in turn, are one type of the several hydrolases known. Thioesterases exhibit
Thioesterase
Enzymes that cleave off lipid modifications on proteins
Acyl-protein thioesterases are enzymes that cleave off lipid modifications on proteins, located on the sulfur atom of cysteine residues linked via a thioester
Acyl-protein_thioesterase
Protein-coding gene in humans
Acyl-CoA thioesterase 9 is a protein that is encoded by the human ACOT9 gene. It is a member of the acyl-CoA thioesterase superfamily, which is a group
Acyl-CoA_thioesterase_9
Class of enzymes
Palmitoyl protein hydrolase/thioesterases is an enzyme (EC 3.1.2.22) that removes thioester-linked fatty acyl groups such as palmitate from modified cysteine
Palmitoyl(protein)_hydrolase
Protein-coding gene in the species Homo sapiens
Acyl-CoA thioesterase 1 is a protein that in humans is encoded by the ACOT1 gene. The ACOT1 gene is located on the 14th chromosome, with its specific localization
ACOT1
The enzyme fluoroacetyl-CoA thioesterase (EC 3.1.2.29; systematic name fluoroacetyl-CoA hydrolase) catalyses the following reaction: fluoroacetyl-CoA +
Fluoroacetyl-CoA_thioesterase
Chemical compound
synthesis of 9-HN (Figure 5). MmpB contains a KS, KR, DH, 3 ACPs, and a thioesterase (TE) domain. It does not contain an enoyl reductase (ER) domain, which
Mupirocin
Protein-coding gene in the species Homo sapiens
Acyl-coenzyme A thioesterase 4 is an enzyme that in humans is encoded by the ACOT4 gene. The protein encoded by the ACOT4 gene is part of a family of Acyl-CoA
ACOT4
Class of enzymes
of an acyl carrier protein (ACP), and is released by the action of a thioesterase (TE) upon reaching a carbon chain length of 16 (palmitic acid). There
Fatty_acid_synthase
Chemical compound
formation by naphthoate synthase (MenB/NS). Thiolytic release of CoA by a thioesterase (MenH). Attachment of phytol chain to the naphthoate ring (MenA/ABC4)
Phytomenadione
Protein-coding gene in the species Homo sapiens
Acyl-coenzyme A thioesterase 8 is an enzyme that in humans is encoded by the ACOT8 gene. The protein encoded by this gene is a peroxisomal thioesterase that appears
ACOT8
Topics referred to by the same term
Palmitoyl protein thioesterase, enzymes that remove thioester-linked fatty acyl groups PPT1, a member of the palmitoyl protein thioesterase family PPT2, a
PPT
Chemical compound
PMSF is inactive against these serine enzymes like palmitoyl-protein thioesterase. Alternative sulfonyl fluoride reagents like p-APMSF and HDSF, have altered
PMSF
Protein-coding gene in the species Homo sapiens
Palmitoyl-protein thioesterase 1 (PPT-1), also known as palmitoyl-protein hydrolase 1, is an enzyme that in humans is encoded by the PPT1 gene. PPT-1 a
PPT1
InterPro Family
thioesterase. Direct analysis confirmed that MenH is unable to hydrolyze DHNA-CoA. In 2009, it was proposed that a dedicated hotdog fold thioesterase
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate_synthase
Medical condition
results in a deficient form of a lysosomal enzyme called palmitoyl protein thioesterase 1 (PPT1). The wild-type PPT1 is a 306-amino acid polypeptide that is
Neuronal ceroid lipofuscinosis
Neuronal_ceroid_lipofuscinosis
Chemical compound
Hydroxybutyric acid Ketogenesis This reaction is catalyzed by an unknown thioesterase enzyme. Offermanns S, Colletti SL, Lovenberg TW, Semple G, Wise A, IJzerman
Β-Hydroxybutyric_acid
Chemical compound
can be synthesized from MC-CoA via enoyl-CoA hydratase and an unknown thioesterase enzyme, which convert MC-CoA into HMB-CoA and HMB-CoA into HMB respectively
Leucine
Chemical compound
(I) a nonaketide, which then undergoes release from LovB through the thioesterase encoded by LovG. Dihydromonacolin L, (J), then undergoes oxidation and
Lovastatin
Protein-coding gene in the species Homo sapiens
Ubiquitin thioesterase otulin is a protein in humans that is encoded by the OTULIN gene. GRCh38: Ensembl release 89: ENSG00000154124 – Ensembl, May 2017
OTULIN
Protein-coding gene in the species Homo sapiens
Acyl-coenzyme A thioesterase 12 or StAR-related lipid transfer protein 15 (STARD15) is an enzyme that in humans is encoded by the ACOT12 gene. The protein
ACOT12
Protein-coding gene in the species Homo sapiens
Acyl-CoA thioesterase 13 is a protein that in humans is encoded by the ACOT13 gene. This gene encodes a member of the thioesterase superfamily. In humans
ACOT13
Protein-coding gene in the species Homo sapiens
Acyl-coenzyme A thioesterase 11 also known as StAR-related lipid transfer protein 14 (STARD14) is an enzyme that in humans is encoded by the ACOT11 gene
ACOT11
Protein domain
such as: 4-hydroxybenzoyl-CoA thioesterases FabA-like dehydratases YbgC-like acyl-CoA thioesterases TesB-like thioesterases MaoC dehydratase-like enzymes
HotDog_domain
Attachment of a palmitoyl group (fatty acid) to a protein
mammalian cells is catalyzed by acyl-protein thioesterases (APTs) in the cytosol and palmitoyl protein thioesterases in lysosomes. Because palmitoylation is
Palmitoylation
Antibiotic
(E), and a condensation domain (C). Cyclization is accomplished by a thioesterase. The first step is to have a loading domain, 6-methylheptanoic acid,
Colistin
consisting of an acyl carrier protein and an acyltransferase. The terminal Thioesterase acts solely to terminate DEBS polyketide synthesis and cyclize the macrolide
Erythronolide_synthase
Drug designed to treat obesity
elimination is through the feces. Orlistat was also found to inhibit the thioesterase domain of fatty acid synthase (FAS), an enzyme involved in the proliferation
Orlistat
Topics referred to by the same term
transmission, a weather satellite system Anterior pelvic tilt Acyl-protein thioesterase, an enzyme family that cleaves cysteine thioesters Advanced Passenger
Apt
Chemical compound
(T) domain, which houses the growing peptide chain. Additionally, a thioesterase (TE) domain is used by the final module to cleave and cyclize the final
Cereulide
Class of enzymes
The enzyme 4-hydroxybenzoyl-CoA thioesterase (EC 3.1.2.23) catalyzes the reaction 4-hydroxybenzoyl-CoA + H2O ⇌ {\displaystyle \rightleftharpoons } 4-hydroxybenzoate
4-hydroxybenzoyl-CoA thioesterase
4-hydroxybenzoyl-CoA_thioesterase
Protein-coding gene in the species Homo sapiens
Acyl-CoA thioesterase 2, also known as ACOT2, is an enzyme which in humans is encoded by the ACOT2 gene. Acyl-CoA thioesterases, such as ACOT2, are a group
ACOT2
Fatty acid (CH3–(CH2)6–COOH)
referred to as octanoyl-mtACP. In the absence of a mitochondrial acyl-mtACP thioesterase—none has been identified in any animal species—octanoic acid remains
Caprylic_acid
Protein-coding gene in the species Homo sapiens
Lysosomal thioesterase PPT2 (PPT-2), also known as S-thioesterase G14, is an enzyme that in humans is encoded by the PPT2 gene. This gene encodes a member
PPT2
Fatal childhood genetic condition
caused by different mutations. Elevated levels of palmitoyl-protein thioesterase is involved in CLN1. Acid protease is involved in CLN2. Cathepsin D is
Batten_disease
Antibiotic
mechanisms. Finally, a cyclization event occurs, which is catalyzed by a thioesterase enzyme, and subsequent release of the lipopeptide is granted. [citation
Daptomycin
Antifungal medication
polyketide syntheses modules (nysB, nysC, nysI, nysJ, and nysK) and two thioesterase modules (nysK and nysE). It is evident that the biosynthesis of the macrolide
Nystatin
Protein-coding gene in the species Homo sapiens
to acyl-protein thioesterases, and, therefore, it has been suggested that LYPLAL1 might be the third human acyl-protein thioesterase. However, the major
LYPLAL1
butyrylcholinesterase Small molecule thioesterases, including fatty acid synthase and the acyl-CoA thioesterases Some phospholipases, including phospholipase
Serine_hydrolase
Antibiotic medication
stereochemistry to another, and a thioesterase domain (TE) is used as a catalyst for cyclization and releases of the molecule via a thioesterase scission.[citation needed]
Vancomycin
palmitoyl thioesterase, palmitoyl coenzyme A hydrolase, palmitoyl-CoA deacylase, palmityl thioesterase, palmityl-CoA deacylase, fatty acyl thioesterase I, and
Palmitoyl-CoA_hydrolase
Protein-coding gene in the species Homo sapiens
Acyl-CoA thioesterase 6 is a protein that in humans is encoded by the ACOT6 gene. The protein, also known as C14orf42, is an enzyme with thioesterase activity
ACOT6
Manipulation of an organism's genome
genetically engineered to modify its oil content with a gene encoding a "12:0 thioesterase" (TE) enzyme from the California bay plant (Umbellularia californica)
Genetic_engineering
Protein family
of the SOBER1 family are considered closely related to acyl-protein thioesterases, judged by their protein structure. However, a change in their amino
SOBER1
Class of enzymes which split esters into an acid and alcohol via hydrolysis
(EC 3.1.1.11), clarifies fruit juices EC 3.1.2: Thiolester hydrolases Thioesterase Ubiquitin carboxy-terminal hydrolase L1 EC 3.1.3: Phosphoric monoester
Esterase
Species of bacteria
they metabolize faster and more. By disrupting an acyl-coenzyme A (CoA) thioesterase gene, Sabirova and colleagues were able to mutate the organism to hyper-produce
Alcanivorax_borkumensis
(ambiguous), choloyl-coenzyme A thioesterase, chenodeoxycholoyl-coenzyme A thioesterase, and peroxisomal acyl-CoA thioesterase 2. Hunt MC, Solaas K, Kase BF
Choloyl-CoA_hydrolase
Organic compound of the form R–B(OH)2
derivatives constitute a class of inhibitors for human acyl-protein thioesterase 1 and 2, which are cancer drug targets within the Ras cycle. In 1860
Boronic_acid
Chemical compound or substance produced by a living organism, found in nature
acyl-CoA synthase; AT: acyltransferase; ER: enoyl reductase; HD: hydroxyacyl dehydratase; KR: ketoacyl reductase; KS: ketoacyl synthase; TE: thioesterase.
Natural_product
Chemical compound
synthetase), containing the domain architecture adenylation-thiolation-thioesterase (A-T-TE). 4-HPP is produced from a deamination via an aminotransferase
Atromentin
Protein-coding gene in the species Homo sapiens
Acyl-protein thioesterase 1 is an enzyme that in humans is encoded by the LYPLA1 gene. Lysophospholipases are enzymes that act on biological membranes
LYPLA1
Chemical compound
NRPs domain. YbtT thioesterase may serve some editing function to remove abnormal molecules from the enzyme complex, and a thioesterase domain of HMWP1
Yersiniabactin
Polyketide
form the larger lactone ring is the final step of the process by the thioesterase domain. Anthracimycin was first noted for its potent activity against
Anthracimycin
Biochemical process in which fatty acids are derived from acetyl-CoA and NADPH
(ACP) reductase, 3-hydroxyacyl-ACP dehydratase, enoyl-ACP reductase, and thioesterase. These different enzymes are covalently linked within the FAS complex
Fatty_acid_synthesis
decarboxylase domain, an acyltransferase, and acyl carrier protein. The terminal Thioesterase terminates tylactone synthesis by cyclizing the macrolide ring. After
Tylactone_synthase
Chemical compound
hydroxylated with cytochrome P450 enzymes, peuH and peuG, and the terminal thioesterase domain in Module 7 catalyzes the product release and macrocycle formation
Peucemycin
Chemical compound
mode of action avoids resistance. It works by inhibiting fatty acid thioesterase, disrupting cell membranes. It was introduced in 1989. As of 2025, approval
Cynmethylin
Chemical compound
CoA, mMCoA= methyl malonyl CoA, AT= acyl transferase, ACP= acyl carrier protein, KS= ketosynthase, KR=ketoreductase, DH= dehydratase, TE=thioesterase
Conipyridoin_E
Chemical compound
fourth to sixth amino acids; CepC adds the last amino acid and includes a thioesterase domain to release the heptapeptide from the NRPS complex. The growing
Chloroeremomycin
Human enzyme involved in inflammation
"Vitamin D inhibits COX-2 expression and inflammatory response by targeting thioesterase superfamily member 4". The Journal of Biological Chemistry. 289 (17):
Cyclooxygenase-2
Chemical compound
can be found in Pseudomonas species. The enzyme 4-hydroxybenzoyl-CoA thioesterase utilizes 4-hydroxybenzoyl-CoA and H2O to produce 4-hydroxybenzoate and
4-Hydroxybenzoic_acid
Medical condition
out of the cell. The PPT1 gene codes for the enzyme palmotoyl-protein thioesterase-1. This enzyme is responsible for removing the fatty-acid side chains
Kufs_disease
Lipid-binding protein domain
the other domains, such as the RhoGAP domain, the homeodomain and the thioesterase domain. The crystal structure of START domain of human MLN64 shows an
StAR-related_transfer_domain
Membrane protein
transmembrane signaling. The palmitoyl group can be removed by palmitoyl thioesterases. It is believed that this reverse palmitoylation may regulate the interaction
Lipid-anchored_protein
Antibiotic
using malonyl-CoA, methylmalonyl-CoA, and ethylmalonyl-CoA. The final thioesterase domain hydrolyzes the polyketide to form the 18-membered tiacumicinone
Fidaxomicin
Chemical compound
can be synthesized from MC-CoA via enoyl-CoA hydratase and an unknown thioesterase enzyme, which convert MC-CoA into HMB-CoA and HMB-CoA into HMB respectively
Β-Hydroxy β-methylbutyric acid
Β-Hydroxy_β-methylbutyric_acid
Chemical compound
dimerization or cyclization of two polyketide monomers takes place within the thioesterase (TE) domain located in module 10, leading to the synthesis of disorazol
Disorazol
GTP-binding proteins functioning on cell-cycle regulation
vesicles of the secretory pathway. Depalmitoylation by acyl-protein thioesterases eventually releases the proteins from the membrane, allowing them to
Ras_GTPase
Species of bacterium
achieved by a phospholipase and three enzymes of the esterase-lipase-thioesterase family. Beta-oxidation of fatty acids is performed by a long-chain fatty
Flavobacterium_psychrophilum
acyl-thioester hydrolase, medium-chain hydrolase, and myristoyl-CoA thioesterase. It employs one cofactor, ADP. At least one compound, NADH is known to
ADP-dependent medium-chain-acyl-CoA hydrolase
ADP-dependent_medium-chain-acyl-CoA_hydrolase
Chemical compound
After the ten elongation modules, the active site serine residue of thioesterase (TE) acts as a nucleophile by attacking the ketone directly bound to
Pladienolide_B
Chemical compound
polyketide synthase (PKS) with three elongation modules and a lactonizing thioesterase domain. Genome mining of Streptomyces sp. BYK identified a scopranone
Prescopranone
Herbicide classification system
dihydroorotate dehydrogenase Tetflupyrolimet T Q 30 Inhibits fatty acid thioesterase Cynmethylin Benzyl-ether - - 31 Inhibits serine-threonine protein phosphatase
HRAC_classification
Chemical compound
NRPS LbnF completes the biosynthesis by coupling L-alanine before the thioesterase (TE) domain conducts a head-to-tail cyclization to produce the final
Lyngbyastatins
Chemical compound
lactone-forming ring closure reaction is catalyzed by two C-terminal thioesterase domains of Txo2, forming a lactone. Txo1 and Txo2 are together composed
Teixobactin
Thiamine analogue
present in the intestinal mucosa, and is then hydrolyzed to thiamine by thioesterases in the liver. Benfotiamine is more bioavailable than thiamine salts
Benfotiamine
Natural organic compounds derived from a [C(O)–CH2] chain
scaffold biosynthesis can also vary. It is sometimes accompanied by a thioesterase that releases the polyketide via hydrating the thioester linkage (as
Polyketide
Protein-coding gene in humans
ubiquitin-protein transferase activity protein binding identical protein binding thioesterase binding enzyme binding protein phosphatase binding protein kinase binding
TRAF2
InterPro Family
acyl coenzyme A thioesterase, acyl-CoA thioesterase, acyl coenzyme A hydrolase, thioesterase B, thioesterase II, and acyl-CoA thioesterase. As of late 2007
Acyl-CoA_hydrolase
officinale): identification of curcuminoid synthase and hydroxycinnamoyl-CoA thioesterases". Phytochemistry. 67 (18): 2017–29. Bibcode:2006PChem..67.2017R. doi:10
Curcumin_synthase
Chemical compound
MC-CoA, and HMG-CoA in humans. This reaction is catalyzed by an unknown thioesterase enzyme. Wilson JM, Fitschen PJ, Campbell B, Wilson GJ, Zanchi N, Taylor
Β-Hydroxy_β-methylbutyryl-CoA
Group of coenzymes that metabolize fatty acids
chain acyl-CoA synthase are 4-11 carbon fatty acids. The enzyme acyl-CoA thioesterase takes of the acyl-CoA to form a free fatty acid and coenzyme A. The second
Acyl-CoA
Drugs to treat parasitic worms and insect pests
respectively. The initial aglycon is subsequently released from the thioesterase domain of AVES 4 by formation of an intramolecular cyclic ester. The
Avermectin
Membrane proteins that adhere temporarily to membranes with which they are associated
transglycosidases), or proteins (signal peptidase and palmitoyl protein thioesterases). Lipases can also digest lipids that form micelles or nonpolar droplets
Peripheral_membrane_protein
Intracellular phospholipid binding protein
PCTP stimulates the acyl-CoA thioesterase activity of thioesterase superfamily member 2 (Them2)/acyl-CoA thioesterase 13 (ACOT13) and the activity of
Phosphatidylcholine transfer protein
Phosphatidylcholine_transfer_protein
Chemical compound
containing condensation (C), adenylation (A), and thiolation (T) domains and thioesterase domain (TE) at the end. C domain forms a peptide bond between two amino
Gramicidin_S
Chemical compound
L-proline is acylated to the acyl carrier protein domain of Bmp1 (ACP-thioesterase (TE) di-domain protein) by the proline adenyl transferase Bmp4 (A). The
Pentabromopseudilin
Space within the inner membrane of the mitochondrion
than being released as free fatty acids, as no mitochondrial acyl-mtACP thioesterase has been identified. As a result, mtFAS generates acyl-mtACP species
Mitochondrial_matrix
Group of antibiotics
peptide-bond formation and condensation reactions. The final steps involve a thioesterase domain at the C-terminal of the last module to cyclize the molecule and
Polymyxin
Protein-coding gene in the species Homo sapiens
alpha2-adrenergic receptor activity protein heterodimerization activity thioesterase binding heterotrimeric G-protein binding protein kinase binding Cellular
Alpha-2A_adrenergic_receptor
Chemical compound
module of MLSA. The C-terminal domains of both MLSA2 and MLSB includes a thioesterase (TE) that was thought to catalyze the formation of the mycolactone core
Mycolactone
Chemical compound
bacillibactin. Acronyms used: A (adenylated), ICL (isochorismate lyase), PCP (peptidyl carrier protein), C (condensation domain), Te (terminal thioesterase)
Bacillibactin
Chemical compound
peptide-polyketide carbon backbone intermediate is then cyclized by the thioesterase domain (TE) to yield intermediate 1. Methylmalonyl-CoA then condenses
Leinamycin
Protein-coding gene in the species Homo sapiens
Ubiquitin thioesterase OTUB1 also known as otubain-1 is an enzyme that in humans is encoded by the OTUB1 gene. Alternative splicing results in multiple
OTUB1
Protein-coding gene in the species Homo sapiens
protein N-terminus binding GTP binding protein binding GTPase activity thioesterase binding Cellular component cytoplasm recycling endosome endosome Golgi
ARF6
Chemical compound
3-hydroxyanthranilic acid, an N-methyltransferase tailoring enzyme, and a type II thioesterase. Commercially, A23187 is available as free acid, Ca2+ salt, and 4-brominated
A23187
Enzyme
acyl-acyl carrier protein hydrolase, oleoyl-ACP thioesterase, and oleoyl-acyl carrier protein thioesterase. It participates in fatty acid biosynthesis. As
Oleoyl-(acyl-carrier-protein) hydrolase
Oleoyl-(acyl-carrier-protein)_hydrolase
Protein family
this process is carried out by another enzyme called palmitoyl protein thioesterase (see figure). The availability of SNAP-25 in the SNARE complex is also
SNARE_protein
Chemical compound
molecule is attached by the pchF NRPS and the molecule gets released by the thioesterase domain (TE) of pchF, and converted to the final product pyochelin by
Pyonitrin
Subgroup of the streptogramin antibiotics family
N-methyltransferase domain (MT). The domain responsible for the termination is the thioesterase domain (TE) located in the final module. The general amino acid composition
Streptogramin_B
THIOESTERASE
THIOESTERASE
THIOESTERASE
THIOESTERASE
Girl/Female
Assamese, Bengali, Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Sanskrit, Sindhi, Tamil, Telugu
Celestial Apsara
Girl/Female
Biblical
Confirmation, or revenge, of the people.
Boy/Male
Hindu, Indian, Punjabi, Sikh
Brave Lion
Girl/Female
Gujarati, Hindu, Indian, Kannada
Genuine Courage
Girl/Female
Persian American English Greek
Child of light. Famous Bearer: Margaret Thatcher, former Prime Minister of the United Kingdom.
Boy/Male
Arabic
Star
Surname or Lastname
Dutch and German
Dutch and German : from a Germanic personal name, Halidher, composed of the elements halið ‘hero’ + hari, heri ‘army’, or from another personal name, Hildher, composed of the elements hild ‘strife’, ‘battle’ + the same second element.Dutch and North German : topographic name for someone living on a slope, from Middle Dutch helldinge ‘slanting surface’. Compare Halder.English : from an agent derivative of Old English healdan ‘to hold’, hence a name denoting an occupier or tenant. Compare Holder.English : variant of Hilder.English : possibly a variant of Elder, with the addition of an inorganic initial H-.
Boy/Male
Arabic, Muslim
Profit; Interest
Boy/Male
Gujarati, Hindu, Indian
Lord Shiva
Girl/Female
Hindu
Brilliant, Glittering
THIOESTERASE
THIOESTERASE
THIOESTERASE
THIOESTERASE
THIOESTERASE