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OTULIN

OTULIN

Protein-coding gene in the species Homo sapiens

Ubiquitin thioesterase otulin is a protein in humans that is encoded by the OTULIN gene. GRCh38: Ensembl release 89: ENSG00000154124 – Ensembl, May 2017

OTULIN

Vishva Dixit

Kenyan molecular biologist

out the complex molecular mechanisms that regulate activity of caspase-8, OTULIN, RIPK1, RIPK3 and other proteins that modulate inflammation, apoptosis and

Vishva Dixit

Vishva_Dixit

LUBAC

inflammasome. Antagonistic to LUBAC are deubiquitinases such as OTULIN or CYLD, of which OTULIN is the only deubiquitinase that removes M1-linked ubiquitin

LUBAC

Autoinflammatory diseases

Group of innate immune system disorders

NF-κB signaling. Also the hypomorphic mutations in deubiquitinase enzyme OTULIN (from OTU deubiquitinase with linear linkage specificity), results in elevated

Autoinflammatory diseases

Autoinflammatory_diseases

Tumor necrosis factor

Immune system messenger protein which induces inflammation

Complex I is negatively regulated by deubiquitinases such as A20, CYLD, and OTULIN, which destabilize complex I. Complex II is formed when RIPK1 and/or TRADD

Tumor necrosis factor

Tumor_necrosis_factor

Timeline of aging research

system. Scientists at the University of New Mexico reported that the enzyme OTULIN, known for regulating immune activity, plays a major role in producing Tau

Timeline of aging research

Timeline_of_aging_research

Spiradenoma

Medical condition

PMID 31101826. Lork M, Verhelst K, Beyaert R (July 2017). "CYLD, A20 and OTULIN deubiquitinases in NF-κB signaling and cell death: so similar, yet so different"

Spiradenoma

NGLY1

Protein-coding gene in the species Homo sapiens

Akutsu M, Olma MH, Gomes LC, Kawasaki M, Dikic I (May 2014). "Binding of OTULIN to the PUB domain of HOIP controls NF-κB signaling". Molecular Cell. 54

NGLY1

List of human protein-coding genes 6

Q8N6M0 11564 OTUD7A HGNC:20718; Q8TE49 11565 OTUD7B HGNC:16683; Q6GQQ9 11566 OTULIN HGNC:25118; Q96BN8 11567 OTULINL HGNC:25629; Q9NUU6 11568 OTX1 HGNC:8521;

List of human protein-coding genes 6

List_of_human_protein-coding_genes_6

CYLD cutaneous syndrome

Medical condition

PMID 32783365. Lork M, Verhelst K, Beyaert R (July 2017). "CYLD, A20 and OTULIN deubiquitinases in NF-κB signaling and cell death: so similar, yet so different"

CYLD cutaneous syndrome

CYLD_cutaneous_syndrome

Valosin-containing protein

Protein-coding gene in the species Homo sapiens

Akutsu M, Olma MH, Gomes LC, Kawasaki M, Dikic I (May 2014). "Binding of OTULIN to the PUB domain of HOIP controls NF-κB signaling". Molecular Cell. 54

Valosin-containing protein

Valosin-containing_protein

Cluster of Excellence Frankfurt Macromolecular Complexes

local NF-κB signalling platform and provided insights into the function of OTULIN in NF-κB activation during bacterial pathogenesis. Another example is the

Cluster of Excellence Frankfurt Macromolecular Complexes

Cluster_of_Excellence_Frankfurt_Macromolecular_Complexes