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Class of membrane transport proteins
A symporter is an integral membrane protein that is involved in the transport of two (or more) different molecules across the cell membrane in the same
Symporter
Mammalian protein found in Homo sapiens
The sodium/iodide cotransporter, also known as the sodium/iodide symporter (NIS), is a protein that in humans is encoded by the SLC5A5 gene. It is a transmembrane
Sodium/iodide_cotransporter
Cellular molecule transport mechanism against the concentration gradient
membrane while another is cotransported in the opposite direction. In a symporter, two substrates are transported in the same direction across the membrane
Active_transport
Protein-coding gene in the species Homo sapiens
The sodium-chloride symporter (also known as Na+-Cl− cotransporter, NCC or NCCT, or as the thiazide-sensitive Na+-Cl− cotransporter or TSC) is a cotransporter
Sodium-chloride_symporter
Use of sodium by organisms
the symporter, which is in its outward facing conformation. Once sodium is bound, glucose can bind from the extracellular space, causing the symporter to
Sodium_in_biology
Type of membrane transport protein
The chloride potassium symporter is a membrane transport protein of the solute carrier family 12 that is present in the S3-segment of the renal proximal
Chloride_potassium_symporter
Chemical compound
of the nephron in the kidney, where they inhibit the sodium-chloride symporter. In the kidney, blood is filtered into the lumen, or open space, of the
Metolazone
Group of transport proteins
Members of the Solute:Sodium Symporter (SSS) Family (TC# 2.A.21) catalyze solute:Na+ symport. The SSS family is within the APC Superfamily. The solutes
Sodium-solute_symporter
Family of transport proteins
The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family is part of the major facilitator superfamily and catalyzes uptake of sugars (mostly,
Glycoside-pentoside-hexuronide:cation symporter family
Glycoside-pentoside-hexuronide:cation_symporter_family
Group of transport proteins
Because they move each solute in the same direction, they are considered symporters. They maintain electroneutrality by moving two positively charged solutes
Na–K–Cl_cotransporter
Group of transport proteins
well-studied members of this family. Both SGLT1 and SGLT2 function as symporters, utilizing the energy from the sodium gradient created by the Na+/K+ ATPase
Sodium-glucose transport proteins
Sodium-glucose_transport_proteins
Family of transport proteins
The Malonate:Na+ Symporter (MSS) Family (TC# 2.A.70) is a group of transport proteins belonging to the CPA superfamily. These proteins are composites
Malonate:Sodium_symporter
Type of protein
The sodium/phosphate cotransporter is a member of the phosphate:Na+ symporter (PNaS) family within the TOG Superfamily of transport proteins as specified
Sodium/phosphate cotransporter
Sodium/phosphate_cotransporter
Type of membrane transport proteins
cotransport (secondary active transport) and include antiporters and symporters. In general, cotransporters consist of two out of the three classes of
Cotransporter
Protein family
variety of molecules with the concomitant uptake of sodium ions (sodium symporters) can be grouped, on the basis of sequence and functional similarities
Sodium:dicarboxylate symporter
Sodium:dicarboxylate_symporter
Protein family
Divalent anion:Na+ symporters were found in bacteria, archaea, plant chloroplasts and animals. They vary in size from 432 amino acyl residues (M. jannaschii)
Divalent anion–sodium symporter
Divalent_anion–sodium_symporter
Substance that promotes the production of urine
hydrochlorothiazide act on the distal convoluted tubule and inhibit the sodium-chloride symporter leading to a retention of water in the urine, as water normally follows
Diuretic
The branched chain amino acid:cation symporter (LIVCS) family (TC# 2.A.26) is a member of the APC superfamily. Characterized members of this family transport
Branched chain amino acid–cation symporter
Branched_chain_amino_acid–cation_symporter
Protein family
The gluconate:H+ symporter (GntP) family (TC# 2.A.8) is a family of transport proteins belonging to the ion transporter (IT) superfamily. Members of the
Gluconate-proton_symporter
Family of transport proteins
The benzoate:H symporter (BenE) family (TC# 2.A.46) is a member of the APC Superfamily. The BenE family contains only two functionally characterized and
Benzoate:H_symporter
Type of neurotransmitter transporter
A neurotransmitter sodium symporter (NSS) (TC# 2.A.22) is a type of neurotransmitter transporter that catalyzes the uptake of a variety of neurotransmitters
Neurotransmitter sodium symporter
Neurotransmitter_sodium_symporter
Mucous membrane layer of the stomach
with the general epithelial lining of the stomach. The sodium-iodide symporter (NIS) is expressed in all the surface mucous cells (at the basolateral
Gastric_mucosa
Protein spanning across a biological membrane
acid:cation symporter (proton glutamate symporter) Monovalent cation/proton antiporter (Sodium/proton antiporter 1 NhaA) Neurotransmitter sodium symporter Ammonia
Transmembrane_protein
Thyroid hormone
the bloodstream by thyroid follicular cells through the sodium/iodide symporter (NIS) located in the basolateral membrane. Once inside the cell, iodide
Thyroxine
Antibodies targeted against the thyroid
on their effect on the TSH receptor. Anti-sodium/iodide (Anti–Na+/I−) symporter antibodies are a more recent discovery and their clinical relevance is
Antithyroid_autoantibodies
Measles virus encoding the human thyroidal sodium iodide symporter or MV-NIS is an attenuated oncolytic Edmonston (Ed) strain of measles virus. MV-NIS
Measles virus encoding the human thyroidal sodium iodide symporter
Measles_virus_encoding_the_human_thyroidal_sodium_iodide_symporter
Reabsorption of filtered sodium ions within the kidneys
reabsorbed in the thick ascending limb of loop of Henle, by Na-K-2Cl symporter and Na-H antiporter. It goes against its chemical driving force, but the
Renal_sodium_reabsorption
Hormone-producing cell in the thyroid gland
at the basolateral membrane of follicular cells by the sodium-iodide symporter. At the apical membrane iodide is secreted into the colloid by the chloride/iodide
Thyroid_follicular_cell
Membrane transport proteins
Dicarboxylate/Amino Acid:Cation (Na+ or H+) Symporter (DAACS) Family TC# 2.A.26 - Branched Chain Amino Acid:Cation Symporter (LIVCS) Family TC# 2.A.42 - Hydroxy/Aromatic
Amino_acid_transporter
Protein family
Sodium sulfate symporters are integral membrane proteins that mediate the intake of a wide variety of molecules with the concomitant uptake of sodium ions
Sodium_sulfate_symporter
Hormones produced by the thyroid gland
produce active T4. The steps in this process are as follows: The Na+/I− symporter transports two sodium ions across the basement membrane of the follicular
Thyroid_hormones
Mammalian protein found in humans
reducing serotonin reuptake. It is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has
Serotonin_transporter
Part of kidney tissue
ions are readily reabsorbed. As ions leave the lumen via the Na–K–Cl symporter and the Na–H antiporter, the concentration becomes more and more hypotonic
Loop_of_Henle
Family of glycoprotein hormones in vertebrata
hormone synthesis: (1) Up-regulating the activity of the sodium-iodide symporter (NIS) on the basolateral membrane of thyroid follicular cells, thereby
Thyroid-stimulating_hormone
Mexican physician, molecular biochemistry
physiology, molecular endocrinology, and cancer. She cloned the sodium/iodide symporter (NIS), a breakthrough in thyroid pathophysiology with ramifications for
Nancy_Carrasco
Transportation of substances via membrane
lipoproteins across the endoplasmic reticulum membrane. An example of a symporter mediated transport protein is SGLT1, a sodium/glucose co-transporter protein
Mediated_transport
Thiazide-like diuretic drug
reabsorption of sodium and chloride primarily through inhibition of the Na+/Cl− symporter in the apical membrane of distal convoluted tubule cells in the kidney
Chlortalidone
Protein found in humans
member 5 (aka: KCC2 and SLC12A5) is a neuron-specific chloride potassium symporter responsible for establishing the chloride ion gradient in neurons through
Chloride potassium symporter 5
Chloride_potassium_symporter_5
Family of transport proteins
The Nucleobase cation symporter-2 (NCS2) family, also called the Nucleobase ascorbate transporter (NAT) family, consists of over 1000 sequenced proteins
Nucleobase_cation_symporter-2
Effect of iodine on the thyroid
below a critical threshold secondary to down-regulation of sodium-iodide symporter (NIS) on the basolateral membrane of the thyroid follicular cell. The
Wolff–Chaikoff_effect
Protein-coding gene in the species Homo sapiens
or MFSD2A) -- also known as sodium-dependent lysophosphatidylcholine symporter 1 -- is a protein that in humans is encoded by the MFSD2A gene. MFSD2A
MFSD2
Endocrine gland in the neck
(I−), which is taken up into the follicular cells by a sodium-iodide symporter. This is an ion channel on the cell membrane which in the same action
Thyroid
Protein family
(Putative Amino Acid Permease), LIVCS (Branched Chain Amino Acid:Cation Symporter), NRAMP (Natural Resistance-Associated Macrophage Protein), CstA (Carbon
APC_superfamily
Protein family
The Nucleobase:Cation Symporter-1 (NCS1) Family (TC# 2.A.39) consists of over 1000 currently sequenced proteins derived from Gram-negative and Gram-positive
Nucleobase_cation_symporter-1
Protein family
This family of proteins are found both in prokaryotes and eukaryotes. In mammals, they are transmembrane proteins with functions in the liver and in the
Bile_acid:sodium_symporter
Enzyme expressed mainly in the thyroid gland
entering the thyroid follicle (or thyroid follicular cell) via a Na+/I− symporter (NIS) on the basolateral side, iodide is shuttled across the apical membrane
Thyroid_peroxidase
Chemical compound
Vivien; Badger, Murray; Ort, Donald R. (2017-03-28). "Bile Acid Sodium Symporter BASS6 Can Transport Glycolate and Is Involved in Photorespiratory Metabolism
Glycolic_acid
Topics referred to by the same term
(NET) Nucleobase ascorbate transporter (NAT) family, or Nucleobase cation symporter-2 (NCS2) family Sodium ammonium tartrate tetrahydrate, the material crystallized
Nat
Diuretics that act along the loop of Henle in the kidneys
transporter 1 (OAT-1), OAT-2, and ABCC4. Loop diuretics act on the Na+-K+-2Cl− symporter (NKCC2) located on the luminal membrane of cells along the thick ascending
Loop_diuretic
Protein-coding gene in the species Homo sapiens
(ASBT) and ileal bile acid transporter (IBAT), is a bile acid:sodium symporter protein that in humans is encoded by the SLC10A2 gene. ASBT/IBAT is most
Ileal sodium/bile acid cotransporter
Ileal_sodium/bile_acid_cotransporter
Anatomical structure of the kidney
but is responsible for creating urinary casts. The thick ascending limb symporter: Na-K-Cl cotransporter. Descending limb of loop of Henle This article
Ascending limb of loop of Henle
Ascending_limb_of_loop_of_Henle
Protein-coding gene in the species Homo sapiens
protein is involved in the active cellular uptake of carnitine. It acts a symporter, moving sodium ions and other organic cations across the membrane along
SLC22A5
Medical condition
mutations Defect neonatal Bartter's syndrome type 1 SLC12A1 (NKCC2) Na-K-2Cl symporter neonatal Bartter's syndrome type 2 ROMK/KCNJ1 thick ascending limb K+
Bartter_syndrome
Chemical compound
v t e Symporter inhibitors Na+-Cl− Thiazides: Bendroflumethiazide Chlorothiazide Cyclopenthiazide Cyclothiazide Hydrochlorothiazide Hydroflumethiazide
Polythiazide
Classification of membrane proteins including ion channels
Solute:Sodium Symporter Family 2.A.22 The Neurotransmitter:Sodium Symporter Family 2.A.23 The Dicarboxylate/Amino Acid:Cation (Na+ or H+) Symporter (DAACS)
Transporter Classification Database
Transporter_Classification_Database
Topics referred to by the same term
sulfide (chemical symbol NiS) N-Iodosuccinimide, a reagent Sodium-iodide symporter, a protein Network Information Service, directory service protocol Network
NIS
Membrane protein
major facilitator superfamily. Lactose permease can be classified as a symporter, which uses the proton gradient towards the cell to transport β-galactosides
Lactose_permease
Protein-coding gene in the species Homo sapiens
Pseudoephedrine Tyramine Neurotransmitter transporter Sodium:neurotransmitter symporter Solute carrier family Norepinephrine Monoamine transporter Orthostatic
Norepinephrine_transporter
Membrane protein involved in transportation
transport commonly uses types of carrier proteins, typically symporters and antiporters. Symporter proteins couple the transport of one molecule down its concentration
Membrane_transport_protein
Study of the physiology of the kidney
isosmotic) reabsorption (25%, thick ascending, Na-K-2Cl symporter) reabsorption (5%, sodium-chloride symporter) reabsorption (5%, principal cells), stimulated
Renal_physiology
Class of chemical compounds
blood through two indirect mechanisms: inhibition of sodium-chloride symporter at distal convoluted tubule of a nephron and stimulation of aldosterone
Thiazide
Type of virus
expressing an inhibitor of angiogenesis. Addition of the sodium-iodide symporter (NIS) gene to the viral genome causes infected tumour cells to express
Oncolytic_virus
Pharmaceutical compound
Agonists): Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters". Journal of Medicinal Chemistry. 60 (7): 3109–3123. doi:10.1021/acs.jmedchem
MRS7292
Family of transport proteins
The Citrate-Mg2+:H+ (CitM) / Citrate-Ca2+:H+ (CitH) Symporter (CitMHS) Family (TC# 2.A.11) is a family of transport proteins belonging to the Ion transporter
CitMHS_family
Topics referred to by the same term
non-segmented RNA virus Measles virus encoding the human thyroidal sodium iodide symporter, an attenuated strain Measles hemagglutinin, a hemagglutinin produced
Measles_(disambiguation)
Chemical compound
inhibits the sodium-chloride symporter. Clopamide selectively binds at the chloride binding site of the sodium-chloride symporter in the PCT cells on the luminal
Clopamide
Transmembrane protein that moves ions across a biological membrane
different types of transporters including pumps, uniporters, antiporters, and symporters. Active transporters or ion pumps are transporters that convert energy
Ion_transporter
Ion channel enzyme pump found in the membrane of all animal cells
Na+-K+ pump, whereas, on the reabsorbing (lumenal) side, the Na+-glucose symporter uses the created Na+ gradient as a source of energy to import both Na+
Sodium–potassium_pump
Overview of and topical guide to biochemistry
channel – proton pump – electron transport – ion gradient – antiporter – symporter – quinone – riboflavin Biomolecule (list) Biomolecular engineering Biomolecular
Outline_of_biochemistry
Protein found in humans
Potassium-chloride transporter, member 4 is a chloride potassium symporter protein. It is encoded by the gene SLC12A4. Solute carrier family GRCh38: Ensembl
Chloride potassium symporter 4
Chloride_potassium_symporter_4
Topics referred to by the same term
events and mechanisms relating to perception phenomena Sodium-chloride symporter, abbreviated as NCC National Certification Corporation, a nursing specialty
NCC
Loop diuretic medication
glutamate receptor modulators Glutamate metabolism/transport modulators v t e Symporter inhibitors Na+-Cl− Thiazides: Bendroflumethiazide Chlorothiazide Cyclopenthiazide
Furosemide
Chemical element with atomic number 53 (I)
In the cells of those tissues, iodine enters directly by sodium-iodide symporter (NIS). The action of iodine in mammal tissues is related to fetal and
Iodine
Protein-coding gene in the species Homo sapiens
such as the sodium chloride cotransporter (NCC), basolateral Na-K-Cl symporter (NKCC1), and potassium chloride cotransporter (KCC1) located within the
WNK1
Protein-coding gene in the species Homo sapiens
reference expression data BioGPS n/a Gene ontology Molecular function symporter activity L-glutamate transmembrane transporter activity neurotransmitter
Solute carrier family 17 (vesicular glutamate transporter), member 6
Solute_carrier_family_17_(vesicular_glutamate_transporter),_member_6
Biological process
transported against the concentration gradient by a dependent glucose symporter which provides a driving force to other glucose molecules in the cells
Facilitated_diffusion
Investigational pervasive developmental disorder drugs
phosphoric diester hydrolase inhibitor and sodium–potassium–chloride symporter inhibitor Sulforafan alfadex (sulforaphane alfadex; sulforafan α-cyclodextrin;
List of investigational autism and pervasive developmental disorder drugs
List_of_investigational_autism_and_pervasive_developmental_disorder_drugs
Feature of kidney anatomy
gradient for Na to be absorbed from the apical surface via the Na/Cl symporter, and for Ca to be reclaimed into the blood by the Na/Ca basolateral antiporter
Distal_convoluted_tubule
Family of transport proteins
Members of the Alanine or Glycine:Cation Symporter (AGCS) Family (TC# 2.A.25) transport alanine and/or glycine in symport with Na+ and or H+. Known proteins
AGCS_family
Antihypertensive diuretic drug
v t e Symporter inhibitors Na+-Cl− Thiazides: Bendroflumethiazide Chlorothiazide Cyclopenthiazide Cyclothiazide Hydrochlorothiazide Hydroflumethiazide
Bendroflumethiazide
Protein-coding gene in the species Homo sapiens
617301), also known as GlyT1 encephalopathy. Sodium:neurotransmitter symporter Solute carrier family GRCh38: Ensembl release 89: ENSG00000196517 – Ensembl
Sodium- and chloride-dependent glycine transporter 1
Sodium-_and_chloride-dependent_glycine_transporter_1
French physician
radioiodine retention and regression of liver cancer after Sodium Iodide Symporter gene transfer in Wistar rats. Cancer Research. 2004. Nov 1;64 (21): 8045
Christian_Bréchot
Investigational tinnitus drugs
NMDA receptor antagonist [3] AM-102 (AM102) – sodium–potassium–chloride symporter inhibitor [4] AUT-00063 – shaw potassium channel modulator [5] Disufenton/acetylcysteine
List of investigational tinnitus drugs
List_of_investigational_tinnitus_drugs
Diuretic medication
glutamate receptor modulators Glutamate metabolism/transport modulators v t e Symporter inhibitors Na+-Cl− Thiazides: Bendroflumethiazide Chlorothiazide Cyclopenthiazide
Hydrochlorothiazide
Protein
neurotransmitter:sodium symporter activity symporter activity amino acid transmembrane transporter activity taurine:sodium symporter activity Cellular component
Sodium- and chloride-dependent taurine transporter
Sodium-_and_chloride-dependent_taurine_transporter
Family of monosaccharide transport proteins
SLC5A12 (6): Sodium- and chloride- dependent sodium:neurotransmitter symporters SLC6A1 SLC6A2 SLC6A3 SLC6A4 SLC6A5 SLC6A6 SLC6A7 SLC6A8 SLC6A9 SLC6A10
Glucose_transporter
Protein-coding gene in the species Homo sapiens
SLC5A12 (6): Sodium- and chloride- dependent sodium:neurotransmitter symporters SLC6A1 SLC6A2 SLC6A3 SLC6A4 SLC6A5 SLC6A6 SLC6A7 SLC6A8 SLC6A9 SLC6A10
Sodium-hydrogen exchange regulatory cofactor 2
Sodium-hydrogen_exchange_regulatory_cofactor_2
Class of polyunsaturated fatty acids
2019. Retrieved 12 April 2014. "Sodium-dependent lysophosphatidylcholine symporter 1". UniProt. Archived from the original on 22 April 2019. Retrieved 2
Omega−3_fatty_acid
Cell membrane transport protein
transporter activity organic acid:sodium symporter activity lactate transmembrane transporter activity symporter activity transmembrane transporter activity
Sodium-coupled monocarboxylate transporter 2
Sodium-coupled_monocarboxylate_transporter_2
Protein found in humans
reference expression data Gene ontology Molecular function amino acid binding symporter activity glutamate binding L-glutamate transmembrane transporter activity
Excitatory amino acid transporter 1
Excitatory_amino_acid_transporter_1
Topics referred to by the same term
Territories, designated by the FATF "Na-Cl co-transporter", or sodium-chloride symporter National Center for Competency Testing, an American certification organization
NCCT
Gene found in fruit flies
subject to controversy. Both Indy proteins belong to the sodium sulfate symporter Pfam family. Its name originates from a well-known comic line in Monty
Indy_(gene)
Protein found in humans
Zinc transporter ZIP8 is a cation/bicarbonate symporter protein which in humans is encoded by the SLC39A8 gene. This transmembrane protein is responsible
Zinc_transporter_ZIP8
Mammalian protein found in Homo sapiens
including reward, and DAT facilitates regulation of that signal. DAT is a symporter that moves dopamine across the cell membrane by coupling the movement
Dopamine_transporter
Mammalian protein found in Homo sapiens
SLC5A12 (6): Sodium- and chloride- dependent sodium:neurotransmitter symporters SLC6A1 SLC6A2 SLC6A3 SLC6A4 SLC6A5 SLC6A6 SLC6A7 SLC6A8 SLC6A9 SLC6A10
Carnitine-acylcarnitine translocase
Carnitine-acylcarnitine_translocase
Protein-coding gene in the species Homo sapiens
cause cerebral creatine deficiency syndrome 1. Sodium:neurotransmitter symporter Solute carrier family GRCh38: Ensembl release 89: ENSG00000130821 – Ensembl
Sodium- and chloride-dependent creatine transporter 1
Sodium-_and_chloride-dependent_creatine_transporter_1
Topics referred to by the same term
to: Neuronal calcium sensor Neuronal calcium sensor-1 Nucleobase Cation Symporter 1 National Comorbidity Survey This disambiguation page lists articles
NCS1
(7) organic solute transporters (OST); TC# 2.A.82), (8) phosphate:Na+ symporters (PNaS); TC# 2.A.58) and (9) lysosomal cystine transporters (LCT); TC#
TOG_superfamily
hematopoietic cells, plant cells, and insect cells. Compare adherent culture. symporter Any of a class of transmembrane transporter proteins which facilitate
Glossary of cellular and molecular biology (M–Z)
Glossary_of_cellular_and_molecular_biology_(M–Z)
Protein family
SLC5A12 (6): Sodium- and chloride- dependent sodium:neurotransmitter symporters SLC6A1 SLC6A2 SLC6A3 SLC6A4 SLC6A5 SLC6A6 SLC6A7 SLC6A8 SLC6A9 SLC6A10
Ammonia_transporter
SYMPORTER
SYMPORTER
SYMPORTER
SYMPORTER
Boy/Male
Hindu
Lion
Female
Irish
Irish form of Hebrew Rachel, RÃICHÉAL means "ewe."
Boy/Male
American, Anglo, British, English, German, Norse
Ruler of All; Rule with Mercy; Ruler
Boy/Male
Tamil
Yudishan | யà¯à®‚தீஷந
Boy/Male
Bengali, Celebrity, Gujarati, Hindu, Indian, Malayalam, Marathi, Punjabi, Sanskrit, Sikh, Tamil, Traditional
Perceptive; Consciousness; Life; Excellent Intelligence
Girl/Female
Hebrew
Poetic.
Girl/Female
Hebrew
Cut stone.
Boy/Male
Indian, Jain
Obliged
Boy/Male
Bengali, Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi
Universal Soul
Girl/Female
Latin
Defender of man.
SYMPORTER
SYMPORTER
SYMPORTER
SYMPORTER
SYMPORTER