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Type of membrane transport proteins
Cotransporters are a subcategory of membrane transport proteins (transporters) that couple the favorable movement of one molecule with its concentration
Cotransporter
Mammalian protein found in Homo sapiens
Sodium/glucose cotransporter 1 (SGLT1) also known as solute carrier family 5 member 1 is a protein in vertebrates that is encoded by the SLC5A1 gene which
Sodium/glucose cotransporter 1
Sodium/glucose_cotransporter_1
Protein found in humans
The sodium/glucose cotransporter 2 (SGLT2) is a protein, which facilitates glucose transport and is regulated by sodium ions. In humans it is encoded
Sodium/glucose cotransporter 2
Sodium/glucose_cotransporter_2
Group of transport proteins
Sodium-dependent glucose cotransporters (or sodium-glucose linked transporter, SGLT) are a family of glucose transporter found in the intestinal mucosa
Sodium-glucose transport proteins
Sodium-glucose_transport_proteins
Type of protein
The sodium/phosphate cotransporter is a member of the phosphate:Na+ symporter (PNaS) family within the TOG Superfamily of transport proteins as specified
Sodium/phosphate cotransporter
Sodium/phosphate_cotransporter
Group of transport proteins
The Na–K–Cl cotransporter (NKCC) is a transport protein that aids in the secondary active transport of sodium, potassium, and chloride into cells. In
Na–K–Cl_cotransporter
Class of medication
therefore lower blood sugar. They act by inhibiting sodium/glucose cotransporter 2 (SGLT2). SGLT2 inhibitors are used in the treatment of type 2 diabetes
SGLT2_inhibitor
Protein-coding gene in the species Homo sapiens
(also known as Na+-Cl− cotransporter, NCC or NCCT, or as the thiazide-sensitive Na+-Cl− cotransporter or TSC) is a cotransporter in the kidney which has
Sodium-chloride_symporter
Protein found in humans
Sodium/bile acid cotransporter also known as the Na+-taurocholate cotransporting polypeptide (NTCP) or liver bile acid transporter (LBAT) is a protein
Sodium/bile acid cotransporter
Sodium/bile_acid_cotransporter
Protein-coding gene in the species Homo sapiens
Sodium/myo-inositol cotransporter is a protein that in humans is encoded by the SLC5A3 gene. Expression of the myo-inositol transport protein is regulated
Sodium/myo-inositol cotransporter
Sodium/myo-inositol_cotransporter
Protein found in humans
transporter member 5 is also known by the names: KCC2 (potassium chloride cotransporter 2) for its ionic substrates, and SLC12A5 for its genetic origin from
Chloride potassium symporter 5
Chloride_potassium_symporter_5
Protein-coding gene in the species Homo sapiens
Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family. Solute carrier family GRCh38:
Vesicular glutamate transporter 1
Vesicular_glutamate_transporter_1
Protein-coding gene in the species Homo sapiens
Sodium-dependent phosphate transport protein 2A, also known as Na+-Pi cotransporter 2a (NaPi-2a), is a protein in humans that is encoded by the SLC34A1
Sodium-dependent phosphate transport protein 2A
Sodium-dependent_phosphate_transport_protein_2A
Protein-coding gene in the species Homo sapiens
Electrogenic sodium bicarbonate cotransporter 1, sodium bicarbonate cotransporter is a membrane transport protein that in humans is encoded by the SLC4A4
Electrogenic sodium bicarbonate cotransporter 1
Electrogenic_sodium_bicarbonate_cotransporter_1
Genetic kidney disorder
gene. The SLC12A3 gene encodes the thiazide-sensitive sodium-chloride cotransporter (also known as NCC, NCCT, or TSC), which can be found in the distal
Gitelman_syndrome
Protein-coding gene in the species Homo sapiens
Sodium bicarbonate cotransporter 3 is a protein which in humans is encoded by the SLC4A7 gene. Solute carrier family GRCh38: Ensembl release 89: ENSG00000033867
Sodium bicarbonate cotransporter 3
Sodium_bicarbonate_cotransporter_3
The cation-chloride cotransporter (CCC) family (TC# 2.A.30) is part of the APC superfamily of secondary carriers. Members of the CCC family are found
Cation-chloride_cotransporter
Diabetes medication
indicates that the addition of dapagliflozin and other sodium‑glucose cotransporter 2 (SGLT2) inhibitors to standard heart failure therapy can reduce the
Dapagliflozin
Chronic focal seizure disorder
In the field of neurology, temporal lobe epilepsy is an enduring brain disorder that causes unprovoked seizures from the temporal lobe. Temporal lobe epilepsy
Temporal_lobe_epilepsy
Protein-coding gene in the species Homo sapiens
cation-Cl− cotransporters (CCCs) such as the sodium chloride cotransporter (NCC), basolateral Na-K-Cl symporter (NKCC1), and potassium chloride cotransporter (KCC1)
WNK1
Family of monosaccharide transport proteins
range of molecules and ions into virtually every cell type. Cotransport Cotransporter GLUT1 deficiency syndrome GLUT2 deficiency syndrome Maier A, Völker
Glucose_transporter
Protein-coding gene in the species Homo sapiens
Ileal sodium/bile acid cotransporter, also known as apical sodium–bile acid transporter (ASBT) and ileal bile acid transporter (IBAT), is a bile acid:sodium
Ileal sodium/bile acid cotransporter
Ileal_sodium/bile_acid_cotransporter
Pharmaceutical drug
the gliflozin class, inhibits the transporter protein sodium/glucose cotransporter 2 (SGLT2) which leads to a reduction in blood glucose levels. In a 26-week
Henagliflozin
Protein family
following proteins: Mammalian sodium/sulphate cotransporter. Mammalian renal sodium/dicarboxylate cotransporter, which transports succinate and citrate. Mammalian
Sodium_sulfate_symporter
Type of membrane transport protein
activities of Na+/K+ ATPase and NKCC cotransporter, respectively. Hence, their net driving force acting on the K/Cl cotransporter favours the exit of both K+ and
Chloride_potassium_symporter
Medical condition
The SLC5A1 gene provides instructions for producing a sodium/glucose cotransporter protein called SGLT1. This protein is found mainly in the intestinal
Glucose-galactose malabsorption
Glucose-galactose_malabsorption
Physiological process in the kidney
sodium ions into the proximal convoluted tubule walls via the SGLT2 cotransporter. Some (typically smaller) amino acids are also transported in this way
Renal_glucose_reabsorption
Chemical compound
"Dose-dependent glucosuria of DWP16001, a novel selective sodium–glucose cotransporter-2 inhibitor, in healthy subjects". British Journal of Clinical Pharmacology
Enavogliflozin
Protein-coding gene in the species Homo sapiens
member 9 (SLC12A9), also known as cation-chloride cotransporter 6 (CCC6) or cation-chloride cotransporter-interacting protein 1 (CIP1), is a protein that
SLC12A9
Protein-coding gene in the species Homo sapiens
The low affinity sodium-glucose cotransporter also known as the sodium/glucose cotransporter 3 (SGLT3) or solute carrier family 5 member 4 (SLC5A4) is
SLC5A4
Protein-coding gene in the species Homo sapiens
Sialin, also known as H(+)/nitrate cotransporter and H(+)/sialic acid cotransporter, is a protein which in humans is encoded by the SLC17A5 gene. A deficiency
Sialin
Mammalian protein found in Homo sapiens
The sodium/iodide cotransporter, also known as the sodium/iodide symporter (NIS), is a protein that in humans is encoded by the SLC5A5 gene. It is a transmembrane
Sodium/iodide_cotransporter
Protein-coding gene in the species Homo sapiens
bicarbonate cotransporter 4 is a protein that in humans is encoded by the SLC4A5 gene. This gene encodes a member of the sodium bicarbonate cotransporter (NBC)
Electrogenic sodium bicarbonate cotransporter 4
Electrogenic_sodium_bicarbonate_cotransporter_4
Protein-coding gene in the species Homo sapiens
carrier family 12 member 8 (SLC12A8), also known as cation-chloride cotransporter 9 (CCC9), is a protein that in humans is encoded by the SLC12A8 gene
SLC12A8
Diabetes medication
PMID 18996802. Nair S, Wilding JP (January 2010). "Sodium glucose cotransporter 2 inhibitors as a new treatment for diabetes mellitus". The Journal
Empagliflozin
Protein-coding gene in the species Homo sapiens
Ghishan FK (March 2001). "Regulation of the human sodium-phosphate cotransporter NaP(i)-IIb gene promoter by epidermal growth factor". American Journal
Sodium-dependent phosphate transport protein 2B
Sodium-dependent_phosphate_transport_protein_2B
Protein-coding gene in the species Homo sapiens
gene is correlated closely with SLC34A1, an analogue sodium phosphate cotransporter protein. Symptoms include renal phosphate wasting in addition to increase
Sodium-dependent phosphate transport protein 2C
Sodium-dependent_phosphate_transport_protein_2C
Protein family
transporters that have been cloned to date (the anion exchangers and Na+/HCO−3 cotransporters) reveals that they are homologous. This is not entirely unexpected,
Anion_exchanger_family
Protein-coding gene in the species Homo sapiens
the SLC12A6 gene. This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular
SLC12A6
approved 2011 Withdrawn 2015 Bulevirtide Hepatitis D/B Sodium/bile acid cotransporter inactivator 2020 (EU) Cidofovir AIDS Viral DNA Polymerase inhibitor
List_of_antiviral_drugs
Medication
medication used for the treatment of cats. Velagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor. It is taken by mouth. Velagliflozin is indicated
Velagliflozin
Membrane protein involved in transportation
coupling the transport of two molecules, they are commonly referred to as cotransporters. Unlike channel proteins which only transport substances through membranes
Membrane_transport_protein
First section of the small intestine
Luzza, Francesco; Sesti, Giorgio (2017-11-01). "Duodenal Sodium/Glucose Cotransporter 1 Expression Under Fasting Conditions Is Associated With Postload Hyperglycemia"
Duodenum
Protein-coding gene in humans
(sodium-dependent citrate transporter), member 5 also known as the Na+/citrate cotransporter or mIndy is a protein that in humans is encoded by the SLC13A5 gene
SLC13A5
Protein-coding gene in the species Homo sapiens
characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters". J. Biol. Chem. 277 (25): 22966–73. doi:10.1074/jbc.M200374200. PMID 11959859
Proton-coupled amino acid transporter 2
Proton-coupled_amino_acid_transporter_2
Feature of kidney anatomy
surface (lumen side), cells of the DCT have a thiazide-sensitive Na-Cl cotransporter and are permeable to Ca, via the TRPV5 channel. On the basolateral surface
Distal_convoluted_tubule
Cellular molecule transport mechanism against the concentration gradient
One category of cotransporters that is especially prominent in research regarding diabetes treatment is sodium-glucose cotransporters. These transporters
Active_transport
Protein-coding gene in the species Homo sapiens
Sodium/bile acid cotransporter 7 is a protein which in humans is encoded by the SLC10A7 gene. SLC10A7+protein,+human at the U.S. National Library of Medicine
Sodium/bile acid cotransporter 7
Sodium/bile_acid_cotransporter_7
Family of membrane transport proteins
cation-Cl cotransporter (SLC12A1, SLC12A2, SLC12A3, SLC12A4, SLC12A5, SLC12A6, SLC12A7, SLC12A8, SLC12A9) Na+-sulfate/carboxylate cotransporter (SLC13A1
Solute_carrier_family
Class of transmembrane transporter protein
opposite directions across a phospholipid membrane. It is a type of cotransporter, which means that uses the energetically favorable movement of one molecule
Antiporter
Protein found in humans
functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family". J. Biol. Chem. 271 (27):
Chloride potassium symporter 4
Chloride_potassium_symporter_4
Concept used in cardiovascular research
Cannon CP, Perkovic V, Jardine MJ, Neal B (2020). "Sodium-Glucose Cotransporter 2 Inhibition for the Prevention of Cardiovascular Events in Patients
Major adverse cardiovascular events
Major_adverse_cardiovascular_events
Type of intestinal cell
crosses the apical membrane of the enterocyte using the sodium-glucose cotransporter. It moves through the cytosol (cytoplasm) and exits the enterocyte via
Enterocyte
Protein family
cation-Cl cotransporter SLC12A1 SLC12A2 SLC12A3 SLC12A4 SLC12A5 SLC12A6 SLC12A7 SLC12A8 SLC12A9 (13): human Na+-sulfate/carboxylate cotransporter SLC13A1
Importin
Class of membrane transport proteins
across the cell membrane at the same time, and is, therefore, a type of cotransporter. The transporter is called a symporter, because the molecules will travel
Symporter
Anatomical structure of the kidney
creating urinary casts. The thick ascending limb symporter: Na-K-Cl cotransporter. Descending limb of loop of Henle This article incorporates text in
Ascending limb of loop of Henle
Ascending_limb_of_loop_of_Henle
Antiporter membrane protein that removes calcium from cells
cation-Cl cotransporter SLC12A1 SLC12A2 SLC12A3 SLC12A4 SLC12A5 SLC12A6 SLC12A7 SLC12A8 SLC12A9 (13): human Na+-sulfate/carboxylate cotransporter SLC13A1
Sodium-calcium_exchanger
Mammalian protein found in Homo sapiens
and in the intestines in a proton dependent way, hence acting like a cotransporter. SLC15A1is localized to the brush border membrane of the intestinal
Peptide_transporter_1
Chemical compound
Tetraiodothyroacetic acid (Tetrac) Transporter (blockers) NISTooltip Sodium/iodide cotransporter Inhibitors: Cyanogenic glycosides Perchlorates (e.g., potassium perchlorate)
Liotrix
Chemical compound
breastfeeding is not recommended. Canagliflozin is a sodium-glucose cotransporter-2 (SGLT2) inhibitor. It works by increasing the amount of glucose lost
Canagliflozin
Medical condition
Atsuda K, Shimada A (September 2021). "On-label use of sodium–glucose cotransporter 2 inhibitors might increase the risk of diabetic ketoacidosis in patients
Diabetic_ketoacidosis
Medical condition
is caused by mutations of SLC5A2, which codes for the sodium-glucose cotransporter 2. Additionally, SGLT2 inhibitor medications produce glycosuria as their
Renal_glycosuria
Class of organic compounds
Tetraiodothyroacetic acid (Tetrac) Transporter (blockers) NISTooltip Sodium/iodide cotransporter Inhibitors: Cyanogenic glycosides Perchlorates (e.g., potassium perchlorate)
Thioamide
Antiviral medication
virus infection. Bulevirtide binds and inactivates the sodium/bile acid cotransporter, blocking both hepatitis B and hepatitis D viruses from entering hepatocytes
Bulevirtide
Protein-coding gene in the species Homo sapiens
that in humans is encoded by the SLC4A8 gene. Solute carrier family cotransporter SLC4A8 has been shown to interact with Sodium-hydrogen antiporter 3
Electroneutral sodium bicarbonate exchanger 1
Electroneutral_sodium_bicarbonate_exchanger_1
Chemical compound
2014, and in Russia on May 22, 2019. Ipragliflozin is a Sodium/glucose cotransporter 2 (SGLT2) inhibitor (gliflozin). These membrane proteins are on the
Ipragliflozin
Drug discovery
treatment of type 2 diabetes (T2D). They act by inhibiting sodium/glucose cotransporter 2 (SGLT-2), and are therefore also called SGLT-2 inhibitors. The efficacy
Discovery and development of gliflozins
Discovery_and_development_of_gliflozins
When dysfunction of the kidneys or heart induces dysfunction in the other
of ARNIs in cardiorenal syndrome are still evolving. Sodium-glucose cotransporter 2 (SGLT2) inhibitors are medications commonly used in regimens for treating
Cardiorenal_syndrome
Membrane transport protein
Na-monocarboxylate cotransporter 3Na-dicarboxylate cotransporter 3Na-tricarboxylate cotransporter H-monocarboxylate cotransporter organic anion-dicarboxylate
Carboxylate_transporter
Chemical compound
Tetraiodothyroacetic acid (Tetrac) Transporter (blockers) NISTooltip Sodium/iodide cotransporter Inhibitors: Cyanogenic glycosides Perchlorates (e.g., potassium perchlorate)
Resmetirom
Organic compound derived from maleic acid
functional expression of the K–Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family". Journal of Biological
N-Ethylmaleimide
Chemical compound
of death due to heart failure. It is an inhibitor of sodium-glucose cotransporter 1 and 2 (SGLT1/SGLT2 inhibitor). It is taken by mouth. The most common
Sotagliflozin
Antidiabetic medication
glycemic control in adults with type 2 diabetes. It is a sodium-glucose cotransporter 2 (SGLT2) inhibitor that is taken by mouth. The most common side effects
Bexagliflozin
Medical condition
mutations directly or indirectly involving the Na-K-2Cl cotransporter are key. The Na-K-2Cl cotransporter is involved in electroneutral transport of one sodium
Bartter_syndrome
Thyroid gland prepared for medical use
Tetraiodothyroacetic acid (Tetrac) Transporter (blockers) NISTooltip Sodium/iodide cotransporter Inhibitors: Cyanogenic glycosides Perchlorates (e.g., potassium perchlorate)
Desiccated_thyroid_extract
Medical condition
as their primary mechanism of action, by inhibiting sodium/glucose cotransporter 2 in the kidneys and thereby interfering with renal glucose reabsorption
Glycosuria
Protein-coding gene in the species Homo sapiens
PMID 7826357. Li H, Xie Z (1997). "Molecular cloning of two rat Na+/Pi cotransporters: evidence for differential tissue expression of transcripts". Cell.
Sodium-dependent phosphate transport protein 1
Sodium-dependent_phosphate_transport_protein_1
Chemical compound
Tetraiodothyroacetic acid (Tetrac) Transporter (blockers) NISTooltip Sodium/iodide cotransporter Inhibitors: Cyanogenic glycosides Perchlorates (e.g., potassium perchlorate)
VK2809
Chronic loss of kidney function
of filtered glucose, there is an up-regulation in the sodium-glucose cotransporter 2 (SGLT2) in the proximal tubules, which cotransports sodium and glucose
Diabetic_nephropathy
Protein-coding gene in the species Homo sapiens
humans is encoded by the SLC13A3 gene. Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into
SLC13A3
Tetraiodothyroacetic acid (Tetrac) Transporter (blockers) NISTooltip Sodium/iodide cotransporter Inhibitors: Cyanogenic glycosides Perchlorates (e.g., potassium perchlorate)
Thyromimetic
Enzyme blocker and diabetes treatment drug
Meeran K (April 2018). "Association Between Use of Sodium-Glucose Cotransporter 2 Inhibitors, Glucagon-like Peptide 1 Agonists, and Dipeptidyl Peptidase
Dipeptidyl peptidase-4 inhibitor
Dipeptidyl_peptidase-4_inhibitor
Part of the stomach
across the basolateral membrane of epithelial cells by the Na+/HCO3- cotransporter, and trafficked across the apical membrane by the Cl-HCO3 exchanger
Gastric_mucosal_barrier
Medication used for hyperthyroidism
Tetraiodothyroacetic acid (Tetrac) Transporter (blockers) NISTooltip Sodium/iodide cotransporter Inhibitors: Cyanogenic glycosides Perchlorates (e.g., potassium perchlorate)
Carbimazole
Protein-coding gene in the species Homo sapiens
intracellular oxalate for luminal chloride in parallel with the sodium–sulfate cotransporter, resulting in net sodium chloride readsorption. Under this model, a
Sulfate_transporter
Two drugs combined to treat diabetes
PMC 4770010. PMID 26966383. Schwartz SS, Katz A (2016). "Sodium-glucose cotransporter-2 inhibitor combination therapy to optimize glycemic control and tolerability
Dapagliflozin/metformin
Protein-coding gene in mammals
cation-Cl cotransporter SLC12A1 SLC12A2 SLC12A3 SLC12A4 SLC12A5 SLC12A6 SLC12A7 SLC12A8 SLC12A9 (13): human Na+-sulfate/carboxylate cotransporter SLC13A1
Prestin
Ion, and compounds containing the ion
Tetraiodothyroacetic acid (Tetrac) Transporter (blockers) NISTooltip Sodium/iodide cotransporter Inhibitors: Cyanogenic glycosides Perchlorates (e.g., potassium perchlorate)
Perchlorate
Protein family
SLC4A5 SLC4A6 SLC4A7 SLC4A8 SLC4A9 SLC4A10 SLC4A11 (5): Sodium glucose cotransporter SLC5A1 SLC5A2 SLC5A3 SLC5A4 SLC5A5 SLC5A6 SLC5A7 SLC5A8 SLC5A9 SLC5A10
Sodium–hydrogen_antiporter
Clear, colorless bodily fluid found in the brain and spinal cord
microglobulin, arginine vasopressin and nitric oxide into CSF. A Na-K-Cl cotransporter and Na/K ATPase found on the surface of the choroid endothelium, appears
Cerebrospinal_fluid
Organ for excreting excess salt
of the cell. Ions are moved into the epithelial cells by a Na-K-Cl cotransporter, also in the basolateral membrane. Increases in sodium opens the sodium-potassium
Salt_gland
Protein-coding gene in the species Homo sapiens
that in humans is encoded by the SLC12A7 gene. Solute carrier family cotransporter ENSG00000113504 GRCh38: Ensembl release 89: ENSG00000276482, ENSG00000113504
SLC12A7
Medical condition
(June 4, 2019). "Fournier Gangrene Associated With Sodium–Glucose Cotransporter-2 Inhibitors: A Review of Spontaneous Postmarketing Cases". Ann Intern
Fournier_gangrene
Diuretic medication
31 million prescriptions. Hydrochlorothiazide inhibits the sodium-chloride cotransporter in the distal convoluted tubules, which normally reabsorb 5–10% of sodium
Hydrochlorothiazide
Protein-coding gene in the species Homo sapiens
Gene: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter)". Online Mendelian Inheritance in Man (OMIM): 605583 Ruel J, Emery
Vesicular glutamate transporter 3
Vesicular_glutamate_transporter_3
Chemical compound
Tetraiodothyroacetic acid (Tetrac) Transporter (blockers) NISTooltip Sodium/iodide cotransporter Inhibitors: Cyanogenic glycosides Perchlorates (e.g., potassium perchlorate)
2-Thiouracil
Transmembrane protein that moves ions across a biological membrane
SLC4A5 SLC4A6 SLC4A7 SLC4A8 SLC4A9 SLC4A10 SLC4A11 (5): Sodium glucose cotransporter SLC5A1 SLC5A2 SLC5A3 SLC5A4 SLC5A5 SLC5A6 SLC5A7 SLC5A8 SLC5A9 SLC5A10
Ion_transporter
Enzyme expressed mainly in the thyroid gland
Tetraiodothyroacetic acid (Tetrac) Transporter (blockers) NISTooltip Sodium/iodide cotransporter Inhibitors: Cyanogenic glycosides Perchlorates (e.g., potassium perchlorate)
Thyroid_peroxidase
Part of kidney tissue
reabsorbed from the urine by secondary active transport by a Na–K–Cl cotransporter (NKCC2). The electrical and concentration gradient drives more reabsorption
Loop_of_Henle
Organosulfur compounds with an >NC(=S)N< structure
Tetraiodothyroacetic acid (Tetrac) Transporter (blockers) NISTooltip Sodium/iodide cotransporter Inhibitors: Cyanogenic glycosides Perchlorates (e.g., potassium perchlorate)
Thioureas
COTRANSPORTER
COTRANSPORTER
COTRANSPORTER
COTRANSPORTER
Boy/Male
Muslim
The unbeatable, Sky
Girl/Female
Hindu
Smile, Smiling
Boy/Male
Hindu
The Sun
Boy/Male
Muslim/Islamic
Desire
Boy/Male
Welsh
August.
Boy/Male
Hindu
Precious
Boy/Male
Indian, Marathi, Tamil
Cheerful; Happy; Optimistic; Lord Murugan
Boy/Male
Indian
Boy/Male
Tamil
Shriman | à®·à¯à®°à¯€à®®à®¾à®¨Â
A respectable person, Beautiful Man
Girl/Female
Tamil
New
COTRANSPORTER
COTRANSPORTER
COTRANSPORTER
COTRANSPORTER
COTRANSPORTER