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High-efficacy agonist
In the field of pharmacology, a superagonist is a type of agonist that is capable of producing a maximal response greater than the endogenous agonist for
Superagonist
Chemical compound
Suprelorin among others, is an injectable gonadotropin releasing hormone superagonist (GnRH agonist) which is used in veterinary medicine for various indications
Deslorelin
Biotechnology company based in Rockville, Maryland, US
bovine high affinity glycoprotein hormone and related growth factor superagonist analogs for human infertility and animal superovulation, as well as targeted
Trophogen
Chemical which binds to and activates a biochemical receptor
antagonist. An example is the cannabinoid inverse agonist rimonabant. A superagonist is a term used by some to identify a compound that is capable of producing
Agonist
Half maximal inhibitory concentration
Excitatory Agonist Endogenous agonist Irreversible agonist Partial agonist Superagonist Physiological agonist Inhibitory Antagonist Competitive antagonist Irreversible
IC50
South African and American doctor (born 1952)
also known as N-803 and marketed as ANKTIVA), an interleukin-15 (IL-15) superagonist designed to stimulate proliferation and activation of natural killer
Patrick_Soon-Shiong
Medication
Gonzalgo ML, Agarwal PK, Bassett JC, et al. (January 2023). "IL-15 Superagonist NAI in BCG-Unresponsive Non-Muscle-Invasive Bladder Cancer". NEJM Evidence
Nogapendekin_alfa_inbakicept
Czech biotechnology company
and North America. The company has clinical programs which include a superagonist of the immuno-oncology target IL-15 and new generation of potent and
Sotio
Pharmaceutical compound
chimeric triple action NLRP3 inhibitor, Nrf2 inducer, and nitric oxide superagonist". Frontiers in Oncology. 13 1204143. doi:10.3389/fonc.2023.1204143. PMC 10258348
Nibrozetone
Field of study
Excitatory Agonist Endogenous agonist Irreversible agonist Partial agonist Superagonist Physiological agonist Inhibitory Antagonist Competitive antagonist Irreversible
Pharmacoepigenetics
Cytokine with structural similarity to Interleukin-2
decrease tumor growth mice. Currently there are two varieties of IL-15 superagonist available. One combines IL-15 and IL-15Rα-Fc (R&D Systems) in vitro to
Interleukin_15
Measure of organism response to stimulus
Excitatory Agonist Endogenous agonist Irreversible agonist Partial agonist Superagonist Physiological agonist Inhibitory Antagonist Competitive antagonist Irreversible
Dose–response_relationship
Integral of drug concentration in blood plasma over time
Excitatory Agonist Endogenous agonist Irreversible agonist Partial agonist Superagonist Physiological agonist Inhibitory Antagonist Competitive antagonist Irreversible
Area under the curve (pharmacokinetics)
Area_under_the_curve_(pharmacokinetics)
Dopamine agonist medication
(Emax, %) Action D2S 3.3 99 (130% beta-arrestin) Full agonist (Gi/o); superagonist (β-arrestin) D2L 3.9 99 (70% beta-arrestin) Full agonist (Gi/o); partial
Pramipexole
Biochemical analysis procedure
Excitatory Agonist Endogenous agonist Irreversible agonist Partial agonist Superagonist Physiological agonist Inhibitory Antagonist Competitive antagonist Irreversible
Ligand_binding_assay
Chemical compound
Efficacy (Emax [%]) Action D1 214–32,000 ? Agonist D2S 0.5–0.62 102 Superagonist D2L 0.95 75 Partial agonist D3 0.80–1.0 86 Full agonist D4 56 49 Partial
Cabergoline
Dopamine agonist medication
Efficacy (Emax [%]) Action D1 692 60% Partial agonist D2S 5.01 110% Superagonist D2L 14.8 84% Agonist D3 6.76 87% Agonist D4 372 43% Partial agonist D5
Bromocriptine
Benzodiazepine drug
and meclonazepam. SH-I-048A is described as a non subtype selective superagonist at the benzodiazepine site of GABAA receptors, with a binding affinity
SH-I-048A
Theoretical drug measure in pharmacology
Excitatory Agonist Endogenous agonist Irreversible agonist Partial agonist Superagonist Physiological agonist Inhibitory Antagonist Competitive antagonist Irreversible
Volume_of_distribution
Drug discovery by identifying protein targets
Excitatory Agonist Endogenous agonist Irreversible agonist Partial agonist Superagonist Physiological agonist Inhibitory Antagonist Competitive antagonist Irreversible
Reverse_pharmacology
Type of gender-affirming medical treatment
goserelin (Zoladex), and buserelin (Suprefact), are GnRH receptor superagonists, and work by producing profound desensitization of the GnRH receptor
Feminizing_hormone_therapy
Naturally occurring sedative and hallucinogen
of differing subunit compositions. However, it was found to act as a superagonist of extrasynaptic α4β3δ subunit-containing GABAA receptors (EmaxTooltip
Muscimol
Chemical compound
Halberstadt AL, Stucke AG, McCorvy JD (2023). "Mu-opioid receptor selective superagonists produce prolonged respiratory depression". iScience. 26 (7) 107121.
N-Desethylisotonitazene
Mammalian protein found in humans
TeGenero, and unexpectedly caused multiple organ failure in trials, is a superagonist of CD28. Unfortunately, it is often ignored that the same receptors also
CD28
Chemical compound
Halberstadt A, Stucke A, McCorvy J (July 2023). "Mu-opioid receptor selective superagonists produce prolonged respiratory depression". iScience. 26 (7) 107121.
Isotonitazene
Monoclonal antibody
ISBN 978-0-00-735074-2. Hünig T (September 2016). "The rise and fall of the CD28 superagonist TGN1412 and its return as TAB08: a personal account". The FEBS Journal
Theralizumab
Drug discovery by phenotypic screening
Excitatory Agonist Endogenous agonist Irreversible agonist Partial agonist Superagonist Physiological agonist Inhibitory Antagonist Competitive antagonist Irreversible
Classical_pharmacology
Regulators of the immune system
cells, prompts T cell expansion. CD28 was the target of the TGN1412 'superagonist' which caused severe inflammatory reactions in the first-in-man study
Immune_checkpoint
Excitatory Agonist Endogenous agonist Irreversible agonist Partial agonist Superagonist Physiological agonist Inhibitory Antagonist Competitive antagonist Irreversible
Pharmacomicrobiomics
Pharmaceutical compound
appears to act as a prodrug of DFNZ. The drug is a highly selective superagonist of the μ-opioid receptor (MOR), with an affinity (Ki) of 1.0 nM, an EC50Tooltip
N-Desethylfluornitrazene
Chemical compound
Buserelin is a GnRH agonist, or an agonist of the GnRH receptor. It is a superagonist of the GnRH receptor with potency for induction of luteinizing hormone
Buserelin
Measure of relative response to a drug
Ligand Description % Efficacy (E) Superagonist Efficacy higher than the endogenous agonist E > 100 Full agonist Efficacy equal to the endogenous agonist
Intrinsic_activity
Biochemical analysis procedure
Excitatory Agonist Endogenous agonist Irreversible agonist Partial agonist Superagonist Physiological agonist Inhibitory Antagonist Competitive antagonist Irreversible
Structural Dynamics Response Assay
Structural_Dynamics_Response_Assay
Chemical compound
(October 2010). "Novel pyridylmethylamines as highly selective 5-HT(1A) superagonists". Journal of Medicinal Chemistry. 53 (19): 7167–7179. doi:10.1021/jm100835q
Befiradol
Methods of cytokine delivery
Marco, A. (2022). Efficacy of PEGylated ciliary neurotrophic factor superagonist variant in diet-induced obesity mice. PLOS One, 17(3), e0265749. Fernandez-Botran
Cytokine_delivery_systems
SUPERAGONIST
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Girl/Female
Tamil
Victorious mind
Female
Norse
Old Norse name composed of the elements dagr "day" and rún "secret lore," hence "day-rune."
Male
Egyptian
, a mystical title of the deity Amen Ra.
Boy/Male
Arabic, Muslim
Apparent; Evident; One of the Attributes of Allah Almighty
Girl/Female
Biblical
Criminal, abominable.
Boy/Male
Muslim
One who remembers God
Male
German
German form of Arabic Ahmed, ACHMED means "praiseworthy."
Male
Spanish
Portuguese and Spanish form of Roman Latin Gratianus, GRACIANO means "pleasing, agreeable."
Girl/Female
Muslim/Islamic
Lament Scar; Mark
Girl/Female
Danish
Born to the conquering people.
SUPERAGONIST
SUPERAGONIST
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