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CD28

  • CD28
  • Mammalian protein found in humans

    CD28 (cluster of differentiation 28) is a protein expressed on T cells that provides essential co-stimulatory signals required for T cell activation and

    CD28

    CD28

    CD28

  • Theralizumab
  • Monoclonal antibody

    Theralizumab (also known as TGN1412, CD28-SuperMAB, and TAB08) is an immunomodulatory drug developed by immunologist Thomas Hünig [de] of the University

    Theralizumab

    Theralizumab

  • CD28 family receptor
  • Group of regulatory cell surface receptors

    CD28 family receptors are a group of regulatory cell surface receptors expressed on immune cells. The CD28 family in turn is a subgroup of the immunoglobulin

    CD28 family receptor

    CD28 family receptor

    CD28_family_receptor

  • CD80
  • Mammalian protein found in humans

    works in tandem. Both CD80 and CD86 interact with costimulatory receptors CD28, CTLA-4 (CD152) and the p75 neurotrophin receptor. CD80 is a member of the

    CD80

    CD80

    CD80

  • Cytotoxic T-lymphocyte associated protein 4
  • Mammalian protein found in humans

    and avidity than CD28 thus enabling it to outcompete CD28 for its ligands. CTLA-4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory

    Cytotoxic T-lymphocyte associated protein 4

    Cytotoxic T-lymphocyte associated protein 4

    Cytotoxic_T-lymphocyte_associated_protein_4

  • CAR T cell
  • Genetically engineered T cell

    significant remissions. In the early 2000s, co-stimulatory domains such as CD28 or 4-1BB were added to first generation CAR's CD3ζ intracellular domain.

    CAR T cell

    CAR_T_cell

  • B7 (protein)
  • Integral membrane protein

    activated antigen-presenting cells (APC) that, when paired with either a CD28 or CD152 (CTLA-4) surface protein on a T cell, can produce a costimulatory

    B7 (protein)

    B7_(protein)

  • Ipilimumab
  • Pharmaceutical drug

    CTLA-4 in mice, its conservation in humans and similarities with CD28 were soon noticed. CD28 at that time was a recently identified "T cell costimulatory"

    Ipilimumab

    Ipilimumab

    Ipilimumab

  • Co-stimulation
  • Signal to activate immune cells

    receptor is genetically closely related to CD28 but cannot substitute for its function. Among many similarities with CD28, it also induces Akt activity through

    Co-stimulation

    Co-stimulation

  • T cell
  • White blood cells of the immune system

    simultaneous engagement of the T-cell receptor and a co-stimulatory molecule (like CD28, or ICOS) on the T cell by the major histocompatibility complex (MHCII) peptide

    T cell

    T cell

    T_cell

  • Antigen-presenting cell
  • Cell that displays antigen bound by MHC proteins on its surface

    for T cell activation, including CD40 and B7. The latter can interact with CD28 on the surface of a CD4+ T cell. The dendritic cell is then a fully mature

    Antigen-presenting cell

    Antigen-presenting cell

    Antigen-presenting_cell

  • Fc receptor
  • Surface protein important to the immune system

    successfully substitute the CD28 requirement during autoimmunity. In an autoimmune background CD4+ T cells bypass the requirement of CD28 cosignaling to become

    Fc receptor

    Fc receptor

    Fc_receptor

  • CD86
  • Mammalian protein found in humans

    molecule CD28 on the surface of all naïve T cells, and to the inhibitory receptor CTLA-4 (cytotoxic T-lymphocyte antigen-4, also known as CD152). CD28 and

    CD86

    CD86

    CD86

  • Programmed cell death protein 1
  • Mammalian protein found in humans

    I membrane protein of 288 amino acids. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. The protein's structure includes an extracellular

    Programmed cell death protein 1

    Programmed cell death protein 1

    Programmed_cell_death_protein_1

  • CD278
  • Protein found in humans

    the ICOS (Inducible T-cell COStimulator) gene. The protein belongs to the CD28 and CTLA-4 cell-surface receptor family. These are proteins expressed on

    CD278

    CD278

    CD278

  • Immune checkpoint
  • Regulators of the immune system

    Another two stimulatory checkpoint molecules belong to the B7-CD28 superfamily—CD28 itself and ICOS. CD27: This molecule supports antigen-specific expansion

    Immune checkpoint

    Immune checkpoint

    Immune_checkpoint

  • CD134
  • Protein-coding gene in humans

    receptors which is not constitutively expressed on resting naïve T cells, unlike CD28. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed

    CD134

    CD134

    CD134

  • BTLA
  • Protein-coding gene in the species Homo sapiens

    cluster of differentiation 272 or CD272) is a protein that belongs to the CD28 immunoglobulin superfamily (IgSF) which is encoded by the BTLA gene located

    BTLA

    BTLA

    BTLA

  • Superantigen
  • Antigen which strongly activates the immune system

    up to 20% of the body's T-cells. Furthermore, Anti-CD3 and Anti-CD28 antibodies (CD28-SuperMAB) have also shown to be highly potent superantigens (and

    Superantigen

    Superantigen

    Superantigen

  • Helper T cell
  • Type of immune cell

    interaction between CD28 on the CD4+ T cell and the proteins CD80 (B7.1) or CD86 (B7.2) on the professional APCs. Both CD80 and CD86 activate the CD28 receptor.

    Helper T cell

    Helper T cell

    Helper_T_cell

  • Reactive arthritis
  • Inflammatory arthritis triggered by infection elsewhere in the body

    Quest. Somoza, C.; Lanier, L.L. (February 1995). "T-cell costimulation via CD28-CD80/CD86 and CD40-CD40 ligand interactions". Research in Immunology. 146

    Reactive arthritis

    Reactive arthritis

    Reactive_arthritis

  • Compugen Ltd.
  • Israeli biotechnology company

    Evogene, established as an agriscience division in 1999. PVRIG is a novel B7/CD28-like immune checkpoint target candidate. In June 2016, Compugen announced

    Compugen Ltd.

    Compugen_Ltd.

  • Interleukin 2
  • Mammalian protein found in humans

    pathways: NFAT, NFkB and AP-1. In addition and after costimulation from CD28 the optimal activation of expression of IL-2 and these pathways is induced

    Interleukin 2

    Interleukin 2

    Interleukin_2

  • Carbohydrate
  • Organic compound that consists only of carbon, hydrogen, and oxygen

    Ma BY, Mikolajczak SA, Yoshida T, Yoshida R, Kelvin DJ, Ochi A (2004). "CD28 T cell costimulatory receptor function is negatively regulated by N-linked

    Carbohydrate

    Carbohydrate

    Carbohydrate

  • Acazicolcept
  • Pharmaceutical compound

    Acazicolcept (ALPN-101) is an experimental dual CD28/ICOS antagonist developed by AbbVie. It appears to be a peptide with 363 residues. Yang, Jing; Lickliter

    Acazicolcept

    Acazicolcept

  • Craig B. Thompson
  • American cell biologist and cancer researcher

    of CD28 in augmenting lymphoid effector function, proliferation, and survival. Thompson identified the evolutionary duplication of CD28 into CD28 and

    Craig B. Thompson

    Craig B. Thompson

    Craig_B._Thompson

  • VEL-101
  • formerly FR104, is an experimental monovalent, pegylated fab' antibody against CD28. It is developed for transplant rejection and autoimmune diseases. Ville

    VEL-101

    VEL-101

  • CNPY2
  • CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42

    CNPY2

    CNPY2

    CNPY2

  • ICOSLG
  • Protein-coding gene in the species Homo sapiens

    B7 family due to the significant homology with B7 family members. The B7/CD28 superfamily provides both positive and negative co-signals to immunocytes

    ICOSLG

    ICOSLG

    ICOSLG

  • Abatacept
  • Immunomodulating pharmaceutical drug

    the APC must present a B7 protein (CD80 or CD86) on its cell surface to a CD28 protein on the surface of the T cell. These two signals activate the T cell

    Abatacept

    Abatacept

  • Interleukin 10
  • Anti-inflammatory cytokine

    "A molecular basis for T cell suppression by IL-10: CD28-associated IL-10 receptor inhibits CD28 tyrosine phosphorylation and phosphatidylinositol 3-kinase

    Interleukin 10

    Interleukin 10

    Interleukin_10

  • List of minor planets: 364001–365000
  • 6, 2007 Mount Lemmon Mount Lemmon Survey  · 2.5 km MPC · JPL 364467 2007 CD28 — January 27, 2007 Kitt Peak Spacewatch  · 1.8 km MPC · JPL 364468 2007 CS28

    List of minor planets: 364001–365000

    List_of_minor_planets:_364001–365000

  • Immunosenescence
  • Immune system deterioration brought on by aging

    antigen-recognition repertoire of T-cell receptor (TcR) diversity down-regulation of CD28 costimulatory molecules cytotoxic activity of Natural Killer T cells (NKTs)

    Immunosenescence

    Immunosenescence

    Immunosenescence

  • Kinetic-segregation model of T cell activation
  • Model for the mechanism of T-cell receptor triggering

    receptors of the Non-catalytic tyrosine-phosphorylated receptors family such as CD28. On plasma membrane of a T cell there is the T-cell receptor (consists of

    Kinetic-segregation model of T cell activation

    Kinetic-segregation_model_of_T_cell_activation

  • Avery August
  • Belizean-born American scientist (born 1964)

    the molecular basis for T cell co-stimulation by the cell surface protein CD28. This work resulted in 9 publications (see references at PubMed). This work

    Avery August

    Avery August

    Avery_August

  • P-selectin glycoprotein ligand-1
  • Protein-coding gene in the species Homo sapiens

    CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42

    P-selectin glycoprotein ligand-1

    P-selectin glycoprotein ligand-1

    P-selectin_glycoprotein_ligand-1

  • Cytotoxic T cell
  • T cell that kills infected, damaged or cancerous cells

    coreceptor and the class I MHC molecule to stabilize this signal. Second Signal CD28 molecule on the T cell either CD80 or CD86 (also called B7-1 and B7-2) CD80

    Cytotoxic T cell

    Cytotoxic T cell

    Cytotoxic_T_cell

  • Michel Sadelain
  • American immunologist

    Latouche, JB; Tan, C; Cheung, NK; Sadelain, M (1998). "Antigen-dependent CD28 signaling selectively enhances survival and proliferation in genetically

    Michel Sadelain

    Michel Sadelain

    Michel_Sadelain

  • CD22
  • Lectin molecule

    CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42

    CD22

    CD22

    CD22

  • Rheumatoid arthritis
  • Type of autoimmune arthritis

    loci include genes affecting co-stimulatory immune pathways—for example CD28 and CD40, cytokine signaling, lymphocyte receptor activation threshold (e

    Rheumatoid arthritis

    Rheumatoid arthritis

    Rheumatoid_arthritis

  • CD20
  • Mammalian protein found in humans

    CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42

    CD20

    CD20

    CD20

  • Interleukin-4 receptor
  • Protein-coding gene in the species Homo sapiens

    CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42

    Interleukin-4 receptor

    Interleukin-4 receptor

    Interleukin-4_receptor

  • VE-cadherin
  • Protein-coding gene in the species Homo sapiens

    CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42

    VE-cadherin

    VE-cadherin

    VE-cadherin

  • Basigin
  • Mammalian protein found in Homo sapiens

    CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42

    Basigin

    Basigin

    Basigin

  • Immunological synapse
  • Interface between lymphocyte and target cell

    (central-SMAC) composed of the θ isoform of protein kinase C, CD2, CD4, CD8, CD28, Lck, and Fyn. p-SMAC (peripheral-SMAC) within which the lymphocyte function-associated

    Immunological synapse

    Immunological synapse

    Immunological_synapse

  • OX40 ligand
  • Protein family

    CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42

    OX40 ligand

    OX40_ligand

  • Single-chain variable fragment
  • Fragment

    recombinant antibody fragments derived from antibodies that block the CD80/CD86-CD28 costimulatory pathway". Protein Expression and Purification. 22 (1): 11–24

    Single-chain variable fragment

    Single-chain variable fragment

    Single-chain_variable_fragment

  • Stichodactyla toxin
  • Protein family

    memory T cells that are CD28+ are refractory to suppression by Kv1.3 blockers when they are co-stimulated by anti-CD3 and anti-CD28 antibodies, but are sensitive

    Stichodactyla toxin

    Stichodactyla toxin

    Stichodactyla_toxin

  • Hashimoto's thyroiditis
  • Autoimmune disease

    Greenberg DA, Barbesino G, Concepcion E, Davies TF (April 2001). "CTLA-4 and not CD28 is a susceptibility gene for thyroid autoantibody production". The Journal

    Hashimoto's thyroiditis

    Hashimoto's thyroiditis

    Hashimoto's_thyroiditis

  • P-glycoprotein
  • Protein found in humans

    CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42

    P-glycoprotein

    P-glycoprotein

    P-glycoprotein

  • Cereblon E3 ligase modulator
  • Class of immunomodulatory drugs

    with the co-stimulation of T-cells through the B7-CD28 complex by phosphorylating tyrosine on the CD28 receptor. In vitro data suggests this co-stimulation

    Cereblon E3 ligase modulator

    Cereblon E3 ligase modulator

    Cereblon_E3_ligase_modulator

  • Lymphocyte-activation gene 3
  • Protein-coding gene in the species Homo sapiens

    CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42

    Lymphocyte-activation gene 3

    Lymphocyte-activation gene 3

    Lymphocyte-activation_gene_3

  • CD8A
  • Protein-coding gene in humans

    CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42

    CD8A

    CD8A

    CD8A

  • Carl H. June
  • American immunologist and oncologist

    T-cell therapy for cancer. In the 1980s, his lab supported research for the CD28 molecule as the major control switch for T cells. A few years later, his

    Carl H. June

    Carl H. June

    Carl_H._June

  • Integrin alpha 5
  • Protein

    CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42

    Integrin alpha 5

    Integrin alpha 5

    Integrin_alpha_5

  • Endothelial protein C receptor
  • Protein-coding gene in the species Homo sapiens

    CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42

    Endothelial protein C receptor

    Endothelial protein C receptor

    Endothelial_protein_C_receptor

  • Non-catalytic tyrosine-phosphorylated receptor
  • Group of cell surface receptors expressed by leukocytes

    inhibits NTR triggering. Similar findings have been reported for Receptors, CD28 family receptors, Dectin-1. Phosphorylated tyrosine residues in cytoplasmic

    Non-catalytic tyrosine-phosphorylated receptor

    Non-catalytic_tyrosine-phosphorylated_receptor

  • Immunosuppressive drug
  • Drug that inhibits activity of immune system

    transduction pathways; Th1 and Th2 genomic fingerprints are defined by TCR and CD28-mediated signaling". BMC Immunology. 13 (1) 12. doi:10.1186/1471-2172-13-12

    Immunosuppressive drug

    Immunosuppressive drug

    Immunosuppressive_drug

  • P110δ
  • Protein-coding gene in the species Homo sapiens

    subsets. In T cells, the antigen receptor (TCR) and costimulatory receptors (CD28 and ICOS) are thought to be main receptors responsible for recruiting and

    P110δ

    P110δ

    P110δ

  • CD36
  • Mammalian protein found in humans

    CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42

    CD36

    CD36

    CD36

  • CD300A
  • Human gene

    CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42

    CD300A

    CD300A

    CD300A

  • Glycophorin C
  • Protein family

    CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42

    Glycophorin C

    Glycophorin_C

  • Autocrine signaling
  • Signaling within the same cell

    peptide:MHC complex on a professional antigen-presenting cell and by the B7:CD28 costimulatory signal. Upon activation, "low-affinity" IL-2 receptors are

    Autocrine signaling

    Autocrine signaling

    Autocrine_signaling

  • CD3G
  • Protein-coding gene in humans

    CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42

    CD3G

    CD3G

    CD3G

  • RHCE (gene)
  • Protein-coding gene in the species Homo sapiens

    CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42

    RHCE (gene)

    RHCE (gene)

    RHCE_(gene)

  • Memory T cell
  • Subset of T lymphocytes

    cells, TSCM cells are CD45RO−, CCR7+, CD45RA+, CD62L+ (L-selectin), CD27+, CD28+, and IL-7Rα+, but they also express large amounts of CD95, IL-2Rβ, CXCR3

    Memory T cell

    Memory_T_cell

  • Toll-like receptor 3
  • Protein found in humans

    CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42

    Toll-like receptor 3

    Toll-like receptor 3

    Toll-like_receptor_3

  • CD160
  • Protein found in humans

    mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial

    CD160

    CD160

    CD160

  • Cluster of differentiation
  • Classification in immunology

    CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42

    Cluster of differentiation

    Cluster_of_differentiation

  • Null cell
  • Lymphocytes without surface receptors

    Cytomegalovirus (CMV) has been shown to induce T-lymphocytes to stop expressing CD28 and other critical surface molecules. This alteration essentially converts

    Null cell

    Null cell

    Null_cell

  • MSR1
  • Protein-coding gene in the species Homo sapiens

    CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42

    MSR1

    MSR1

    MSR1

  • CLEC10A
  • Protein-coding gene in humans

    CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42

    CLEC10A

    CLEC10A

    CLEC10A

  • Cytokine-induced killer cell
  • cytokine-induced killer cells with chimeric antigen receptors: CD28 outperforms combined CD28-OX40 "super-stimulation"". Molecular Therapy. 21 (12): 2268–77

    Cytokine-induced killer cell

    Cytokine-induced_killer_cell

  • CD44
  • Cell-surface glycoprotein

    CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42

    CD44

    CD44

    CD44

  • T-cell receptor
  • Protein complex on the surface of T cells that recognizes antigens

    molecule. Signal 2 comes from co-stimulatory receptors on T cell such as CD28, triggered via ligands presented on the surface of other immune cells such

    T-cell receptor

    T-cell receptor

    T-cell_receptor

  • Long-lived plasma cell
  • White blood cell

    high-affinity antibodies. CD28: Signaling through the Vav/Grb2 motif can induce NF-κB signaling and expression of BLIMP-1. CD28 engagement with its ligands

    Long-lived plasma cell

    Long-lived_plasma_cell

  • Plasma cell leukemia
  • Medical condition

    multiple myeloma patients; and pPCL plasma cells more frequently express CD28 than do sPCL plasma cells. Thus, immunophenotyping supports that notion that

    Plasma cell leukemia

    Plasma cell leukemia

    Plasma_cell_leukemia

  • CD137
  • Protein found in humans

    antibody secretion. As a T cell co-stimulator, T cell receptor (TCR) and CD28 signaling causes expression of CD137 on T cell membranes. When CD137 then

    CD137

    CD137

    CD137

  • Centroblast
  • Enlarged B cell in the germinal center of lymphoid follicles

    in the lymphoid follicle and is produced by centroblasts interacting with CD28+ helper T cells. The production of the germinal center is important for the

    Centroblast

    Centroblast

    Centroblast

  • List of minor planets: 28001–29000
  • CQ27 — February 10, 1999 Socorro LINEAR EOS 6.6 km MPC · JPL 28279 1999 CD28 — February 10, 1999 Socorro LINEAR  · 15 km MPC · JPL 28280 1999 CG28 — February

    List of minor planets: 28001–29000

    List_of_minor_planets:_28001–29000

  • FCGR2B
  • Antibody fragment receptor in humoral immunity

    CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42

    FCGR2B

    FCGR2B

    FCGR2B

  • CTL-mediated cytotoxicity
  • Second, a costimulatory signal is transmitted by the interaction between CD28 and B7 of the precursor cell and the licensed antigen-presenting cell. Last

    CTL-mediated cytotoxicity

    CTL-mediated_cytotoxicity

  • Immunometabolism
  • receptor (TCR) and the costimulatory molecule cluster of differentiation 28 (CD28) engagement. However, it can also be activated by growth factors like IL-7

    Immunometabolism

    Immunometabolism

  • Outline of immunology
  • Overview of and topical guide to immunology

    Co-stimulatory molecules CD80 - Expressed by APCs CD86 - Expressed by APCs CD28 family receptors CD28 - Expressed by T Cells CD278 (ICOS) - Homodimer, expressed by

    Outline of immunology

    Outline_of_immunology

  • CARD11
  • Protein-coding gene in humans

    Wang D, Matsumoto R, You Y, Che T, Lin XY, Gaffen SL, Lin X (2004). "CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of

    CARD11

    CARD11

    CARD11

  • Tania Watts
  • Canadian Immunologist

    University of Toronto. Her group was among the first to provide evidence for CD28-independent co-stimulation. Watts held the Sanofi Pasteur Chair in Human

    Tania Watts

    Tania_Watts

  • Cadherin-2
  • Protein found in humans

    CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42

    Cadherin-2

    Cadherin-2

    Cadherin-2

  • Intraepithelial lymphocyte
  • Found in the epithelial layer of mucosal linings

    activation markers (CD44, CD69) and unlike natural TCR+IELs express CD2, CD5, CD28, LFA-1, and Thy1. Upon the entry into the intestinal epithelium, these cells

    Intraepithelial lymphocyte

    Intraepithelial lymphocyte

    Intraepithelial_lymphocyte

  • B-cell linker
  • Mammalian protein found in Homo sapiens

    PMID 16493428. S2CID 22368341. Rudd CE, Raab M (April 2003). "Independent CD28 signaling via VAV and SLP-76: a model for in trans costimulation". Immunological

    B-cell linker

    B-cell linker

    B-cell_linker

  • Necrotizing fasciitis
  • Infection that results in the death of the body's soft tissue

    IVIG use. AB103: Reltecimod, aka AB103, is a new drug that binds to the CD28 T-cell receptor and thus mitigates the effects of bacterial toxins. Studies

    Necrotizing fasciitis

    Necrotizing fasciitis

    Necrotizing_fasciitis

  • Glypican 1
  • Protein-coding gene in the species Homo sapiens

    Li D, Pan J, Ren H, Hoeltzel G, et al. (April 2023). "The IgG4 hinge with CD28 transmembrane domain improves VHH-based CAR T cells targeting a membrane-distal

    Glypican 1

    Glypican 1

    Glypican_1

  • Integrin alpha E
  • Protein-coding gene in the species Homo sapiens

    Tilburgs T, Scherjon SA, Roelen DL, Claas FH (February 2009). "Decidual CD8+CD28- T cells express CD103 but not perforin". Human Immunology. 70 (2): 96–100

    Integrin alpha E

    Integrin alpha E

    Integrin_alpha_E

  • Gamma-glutamyltransferase 1
  • Protein-coding gene in the species Homo sapiens

    CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42

    Gamma-glutamyltransferase 1

    Gamma-glutamyltransferase 1

    Gamma-glutamyltransferase_1

  • Complement receptor 2
  • Protein found in humans

    CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42

    Complement receptor 2

    Complement receptor 2

    Complement_receptor_2

  • Sialyl-Lewis X
  • Chemical compound

    CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42

    Sialyl-Lewis X

    Sialyl-Lewis X

    Sialyl-Lewis_X

  • GB 12052
  • Korean-language character set in China

    CDFB 췽 CDFD 츼 CE3C 츽 CE3D 칀 CE40 칄 CE44 칏 CE4F 4D5x/CDDx 칑 CE51 촤 CD24 촨 CD28 촹 CD39 춷 CDB7 쵀 CD40 췡 CDE1 췠 CDE0 칻 CE7B 캇 CE87 캍 CE8D 캰 CEB0 켝 CF1D 켣 CF23

    GB 12052

    GB_12052

  • Priming (immunology)
  • First contact antigen-specific T helper cell precursors have with an antigen

    includes a B7 ligand complex on antigen-presenting cells binding to the CD28 receptor on T cells); and cytokines that control differentiation into different

    Priming (immunology)

    Priming_(immunology)

  • B-cell activating factor
  • Mammalian protein found in Homo sapiens

    CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42

    B-cell activating factor

    B-cell activating factor

    B-cell_activating_factor

  • Single-domain antibody
  • Antibody fragment

    Li D, Pan J, Ren H, Hoeltzel G, et al. (April 2023). "The IgG4 hinge with CD28 transmembrane domain improves VHH-based CAR T cells targeting a membrane-distal

    Single-domain antibody

    Single-domain antibody

    Single-domain_antibody

  • Myricetin
  • Chemical compound

    T-lymphocyte stimulation in a mouse model by binding to anti-CD3 and anti-CD28 monoclonal antibodies immobilised on beads. The inhibitory effect of myricetin

    Myricetin

    Myricetin

    Myricetin

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Online names & meanings

  • Suprita
  • Girl/Female

    Hindu, Indian, Kannada, Malayalam, Marathi, Sindhi, Telugu

    Suprita

    Well Pleased

  • Jazzmyn
  • Girl/Female

    Arabic, Chinese, French

    Jazzmyn

    A Flower Name from the Older Form Jessamine

  • Ameyatma | அமேயத்மா
  • Boy/Male

    Tamil

    Ameyatma | அமேயத்மா

    Manifests in infinite varieties, Lord Vishnu

  • Katrina
  • Girl/Female

    English Finnish German Scandinavian Swedish American Greek

    Katrina

    Pure.

  • JENNY
  • Female

    English

    JENNY

    Pet form of English Jennifer, JENNY means "white and smooth."

  • Amarjeet
  • Boy/Male

    Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Punjabi, Sikh

    Amarjeet

    Victorious

  • Chulin
  • Girl/Female

    Hindu, Indian, Mexican, Russian

    Chulin

    Crisp; Calm; Reserved

  • Rikhap
  • Boy/Male

    Hindu, Indian

    Rikhap

    Success

  • Franzen
  • Boy/Male

    German, Latin

    Franzen

    Frenchman

  • Shriyanshi
  • Girl/Female

    Indian

    Shriyanshi

    Part of God

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Other words and meanings similar to

CD28

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