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Protein-coding gene in the species Homo sapiens
of transcription 4 (STAT4) is a transcription factor belonging to the STAT protein family, composed of STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6
STAT4
Autoimmune disease in which the immune system attacks healthy tissue
et al. (April 2009). "Population differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in
Lupus
Type of autoimmune arthritis
pro-inflammatory cytokines, including TNFα. Possible gene polymorphism: STAT4, PTPN2, PSORS1C1 and TRAF3IP2 genes had been correlated with response to
Rheumatoid_arthritis
Biological signaling pathway h
groups to) proteins. There are seven STAT proteins: STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B and STAT6. STAT proteins contain many different domains
JAK-STAT_signaling_pathway
Autoimmune disease
polymorphisms located at six independent loci were also detected; IRF5, STAT4, BLK, IL12A, TNIP1, and CXCR5. This also suggested the activation of the
Sjögren's_disease
Type of immune cell
IgG B cells, and IFN-γ CD4 T cells. The key Th1 transcription factors are STAT4 and T-bet. IFN-γ secreted by CD4 T cells can activate macrophages to phagocytose
Helper_T_cell
Protein-coding gene in the species Homo sapiens
IL-12 signaling through the IL12 receptor leads to the phosphorylation of STAT4 and continued Th1 differentiation. The IL12Rβ2 subunit plays an important
Interleukin 12 receptor, beta 2 subunit
Interleukin_12_receptor,_beta_2_subunit
Interleukin
important in activating critical transcription factor proteins such as STAT4 that are implicated in IL-12 signaling in T cells and NK cells. This pathway
Interleukin_12
Form of localized cell signaling
and craniosynostosis syndromes Stat3 Lethal Tissue specific phenotypes Stat4 Viable defective IL-12-driven Th1 differentiation, increased susceptibility
Paracrine_signaling
The following is a partial list of the "D" codes for Medical Subject Headings (MeSH), as defined by the United States National Library of Medicine (NLM)
List of MeSH codes (D12.776.930)
List_of_MeSH_codes_(D12.776.930)
Mammalian protein found in humans
type 1 regulatory (Tr1) cells or Th17 cells from naïve T cells via STAT1, STAT4, and STAT5 phosphorylation. Several studies have shown that tumor-associated
CXCL9
Protein and coding gene in humans
BB, Niu P, Surowy CS, Faltynek CR (August 1999). "Direct interaction of STAT4 with the IL-12 receptor". Archives of Biochemistry and Biophysics. 368 (1):
Interleukin 12 receptor, beta 1 subunit
Interleukin_12_receptor,_beta_1_subunit
Family of intracellular transcription factors
mammalian STAT family members that have been identified: STAT1, STAT2, STAT3, STAT4, STAT5 (STAT5A and STAT5B), and STAT6. STAT1 homodimers are involved in
STAT_protein
Protein domain
SOCS2; SOCS3; SOCS4; SOCS5; SOCS6; SOCS7 SRC; SRMS STAT1; STAT2; STAT3; STAT4; STAT5A; STAT5B; STAT6 SUPT6H; SYK TEC; TENC1; TNS; TNS1; TNS3; TNS4; TXK
SH2_domain
Protein-coding gene in the species Homo sapiens
to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling
IL12A
Heterodimeric cytokine acting as mediator of inflammation
and Tyrosine kinase 2 transduce the signal and phosphorylate STAT3 and STAT4. STATs dimerise and activate transcription of target genes in nucleus. STAT3
Interleukin_23
ENSG00000168610 STAT Known motif – In vivo/Misc source [887] HTTCCYRKMA STAT4 ENSG00000138378 STAT Known motif – In vivo/Misc source [888] BDHTTCTBGKAAD
List of human transcription factors
List_of_human_transcription_factors
Biologist
Vol. 80, 2007, pp. 867-875 doi:10.1086/516736 with E.F. Remmers et al.: STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. In:
Lars_Klareskog
Protein-coding gene in the species Homo sapiens
be induced via 2 independent signalling pathways, IFNg-STAT1 and IL-12-STAT4 pathways. Both need to cooperate to reach stable Th1 phenotype. Th1 phenotype
TBX21
Protein-coding gene in Homo sapiens
R, et al. (August 1999). "Urokinase induces activation and formation of Stat4 and Stat1-Stat2 complexes in human vascular smooth muscle cells". The Journal
STAT2
Gene regulation in autoimmune diseases
identification of STAT4 as a key transcription factor responsible for influencing the regulation of many target genes involved in DLE. STAT4 is a very important
Epigenetics of autoimmune disorders
Epigenetics_of_autoimmune_disorders
modulates gene expression. Additionally, transcription factors, including STAT4 and RUNX family transcription factors play a role in the introduction of
Trained_immunity
Medical condition
Lau YL (April 2009). "Population differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in
Childhood-onset systemic lupus erythematosus
Childhood-onset_systemic_lupus_erythematosus
Transcription factor and coding gene in humans
Gulba DC (August 1999). "Urokinase induces activation and formation of Stat4 and Stat1-Stat2 complexes in human vascular smooth muscle cells". The Journal
STAT1
Protein involved in immune suppression
a STAT1/STAT4 complex is activated in T cells expressing CD4. Homodimer signaling, on the other hand, occurs through activation of only STAT4 by IL-12Rβ2
Interleukin_35
Protein-coding gene in humans
component of FIP1L1-PDGFRA is required for the fusion protein to activate STAT4 and protein kinase B. The age-adjusted incidence of hypereosinophilic syndrome/chronic
FIP1L1
Group of cytokine proteins
this signalization are IL-17A, IL-4 and IL-6. IL-18 with IL-12, which is a STAT4 activator, have similar effects on Th1 cells by up-regulating expression
Interleukin-1_family
Heterodimeric receptor
IFNAR2 recruit STAT proteins (classically STAT1, STAT2, or STAT3, although STAT4, STAT5, and STAT6 may play a role in certain cell types) via their SH2 domains
Interferon-alpha/beta receptor
Interferon-alpha/beta_receptor
P42224 15952 STAT2 HGNC:11363; P52630 15953 STAT3 HGNC:11364; P40763 15954 STAT4 HGNC:11365; Q14765 15955 STAT5A HGNC:11366; P42229 15956 STAT5B HGNC:11367;
List of human protein-coding genes 8
List_of_human_protein-coding_genes_8
Animal model of brain inflammation
inducing MS type II demyelination (pattern II) Deficiency of TBX21 or STAT4 provides resistance against EAE, while interferon-γ-, interferon-γ-receptor-
Experimental autoimmune encephalomyelitis
Experimental_autoimmune_encephalomyelitis
Medical condition
signalling cascade formed by TYK and JAK2 kinases, eventually leading to STAT4 phosphorylation and nuclear translocation. The final response to IL12 stimulation
Mendelian susceptibility to mycobacterial disease
Mendelian_susceptibility_to_mycobacterial_disease
Somatic hypermutation Specific granule Specol STAT protein STAT1 STAT2 STAT3 STAT4 STAT5 STAT6 Stem cell educator Stimulator of interferon genes Stromal cell-derived
Index_of_immunology_articles
Protein-coding gene in the species Homo sapiens
Zisoulis DG, Stritesky GL, Yu Q, O'Malley JT, et al. (April 2007). "Stat3 and Stat4 direct development of IL-17-secreting Th cells". Journal of Immunology.
Interleukin-17A
Protein-coding gene in the species Homo sapiens
(Sep 2000). "Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity". Blood. 96 (5): 1844–52
MAP2K6
Mammalian gene encoding V-ATPase enzyme
lymphocyte proliferation, SHP-1 recruitment, decrease in phosphorylation of STAT4, TCR-ζ chain and ZAP70 as well as inhibition of FasL expression. HLA-DRα2
TCIRG1
024.421.300 – stat3 transcription factor MeSH D12.776.476.024.421.400 – stat4 transcription factor MeSH D12.776.476.024.421.500 – stat5 transcription
List of MeSH codes (D12.776.476)
List_of_MeSH_codes_(D12.776.476)
057.186.300 – stat3 transcription factor MeSH D12.776.157.057.186.400 – stat4 transcription factor MeSH D12.776.157.057.186.500 – stat5 transcription
List of MeSH codes (D12.776.157)
List_of_MeSH_codes_(D12.776.157)
024.342.300 – stat3 transcription factor MeSH D12.644.360.024.342.400 – stat4 transcription factor MeSH D12.644.360.024.342.500 – stat5 transcription
List_of_MeSH_codes_(D12.644)
STAT4
STAT4
STAT4
STAT4
Boy/Male
Australian, Danish, Dutch, Swedish
Well-advised Ruler
Girl/Female
Indian
Beautiful
Female
English
English elaborated form of Latin Charis, CHARISSA means "grace."
Boy/Male
American, Australian, British, Christian, English, French, German, Latin, Scottish, Teutonic
Northerner; Nurse; Caretaker; Man of the North
Girl/Female
Bengali, Hindu, Indian, Marathi, Punjabi, Sikh
Love
Boy/Male
Sikh
Boy/Male
Hindu, Indian, Marathi
Part of Love; Made from Love
Girl/Female
African, American, British, Czechoslovakian, Danish, English, Finnish, German, Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Sanskrit, Swedish, Tamil, Telugu
High Priestess of Mecca; Goat; Not Born; Love of Vishnu; One who is Self Existent
Biblical
brother of goodness
Girl/Female
Hindu, Indian, Traditional
Garland of the Moon
STAT4
STAT4
STAT4
STAT4
STAT4