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Protein-coding gene in Homo sapiens
activator of transcription 2 is a protein that in humans is encoded by the STAT2 gene. It is a member of the STAT protein family. This protein is critical
STAT2
Biological signaling pathway h
(add phosphate groups to) proteins. There are seven STAT proteins: STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B and STAT6. STAT proteins contain many different
JAK-STAT_signaling_pathway
Hemorrhagic fever caused by ebolaviruses
its receptors on the neighbouring cell, the signalling proteins STAT1 and STAT2 are activated and move to the cell's nucleus. This triggers the expression
Ebola
Species of virus
degrade STAT2. In fact, after the cleavage of NS5 by the protease, an E3 ligase association with STAT2 occurs, and the E3 ligase targets STAT2 for the
Dengue_virus
Family of intracellular transcription factors
are seven mammalian STAT family members that have been identified: STAT1, STAT2, STAT3, STAT4, STAT5 (STAT5A and STAT5B), and STAT6. STAT1 homodimers are
STAT_protein
Protein-coding gene in the species Homo sapiens
in humans is encoded by the PIAS2 gene. Protein inhibitor of activated STAT2 has been shown to interact with: Androgen receptor, DNMT3A, PARK7, and UBE2I
Protein inhibitor of activated STAT2
Protein_inhibitor_of_activated_STAT2
Signaling proteins released by host cells in response to the presence of pathogens
phosphorylate both STAT1 and STAT2. As a result, an IFN-stimulated gene factor 3 (ISGF3) complex forms—this contains STAT1, STAT2 and a third transcription
Interferon
Genetic study of ancient Neanderthal DNA
affected by introgression, which may have aided migration, such as OAS1, STAT2, TLR6, TLR1, TLR10, and several related to immune response. Of the inherited
Neanderthal_genetics
Protein-coding gene in the species Homo sapiens
including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. IFNAR1 has been shown to interact with: PRMT1, STAT2, and Tyrosine kinase
IFNAR1
Liberal arts college in Mount Vernon, Iowa, US
Cornell College News Center. 2019-04-19. Retrieved 2020-06-24. "Stat2 Authors". www.stat2.org. Retrieved 2020-06-24. "Glenn Cunningham". USA Track & Field
Cornell_College
Protein-coding gene in the species Homo sapiens
kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have
IFNAR2
receptors as IFN-α and induces intracellular signalling through STAT1, STAT2, and Tyk2. This leads to the production of antiviral and immunomodulatory
Interferon_tau
Transcription factor and coding gene in humans
phosphorylate and activate the Jak kinases TYK2 and JAK1 and also STAT1 and STAT2. STAT molecules form dimers and bind to ISGF3G/IRF-9, which is Interferon
STAT1
American statistics educator
textbook Stat2: Building Models for a World of Data (W. H. Freeman, 2013). The second edition of this textbook was released under the title Stat2: Modeling
Ann_R._Cannon
Protein-coding gene in the species Homo sapiens
transcription factor belonging to the STAT protein family, composed of STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6. STAT proteins are key activators of
STAT4
ENSG00000115415 STAT Known motif – In vivo/Misc source [885] HTTCCYRGAAR STAT2 ENSG00000170581 STAT Known motif – In vivo/Misc source [886] TNRGTTTCDNTTYC
List of human transcription factors
List_of_human_transcription_factors
Protein-coding gene in the species Homo sapiens
the dissociation of the cytokine-receptor complex. This process requires STAT2 to traffic USP18 to the receptor These events terminate signaling and draw
USP18
deficiency RORc deficiency STAT1 deficiency, gain-of-function mutation STAT2 deficiency IRF7 deficiency CD16 deficiency IRF8 deficiency IFNAR2 deficiency
List of primary immunodeficiencies
List_of_primary_immunodeficiencies
Mammalian protein found in Homo sapiens
doi:10.1074/jbc.272.2.1032. PMID 8995399. Bluyssen HA, Levy DE (1997). "Stat2 is a transcriptional activator that requires sequence-specific contacts
Janus_kinase_1
Topics referred to by the same term
Vallarta (P113), a patrol boat of the Mexican Navy Papyrus 113, a biblical manuscript STAT2, signal transducer and activator of transcription 2 TCG Yarhisar (P-113)
P113
Protein-coding gene in the species Homo sapiens
activity suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity cell-cell adhesion protein localization vesicle-mediated transport
SCRIB
Complex interplay of factors
affected by introgression, which may have aided migration, such as OAS1, STAT2, TLR6, TLR1, TLR10, and several related to immune response. In addition
Causes_of_autism
Mammalian protein found in Homo sapiens
namely STAT1 and STAT2, members of the family Signal Transducer and Activator of Transcription (STAT protein); phosphorylated STAT1 and STAT2 bind IRF9 forming
IFNA2
Protein domain
SLA; SLA2 SOCS1; SOCS2; SOCS3; SOCS4; SOCS5; SOCS6; SOCS7 SRC; SRMS STAT1; STAT2; STAT3; STAT4; STAT5A; STAT5B; STAT6 SUPT6H; SYK TEC; TENC1; TNS; TNS1;
SH2_domain
Nuclear protein that binds to CREB
NF-κB p53 p73 Parp1 pCREB pCAF PCNA Pit1 RAR RXR SCRAP SMAD Src1 Srebp1c STAT1 STAT2 STAT3 Sumo T3R[22] TBP Tdg TFIIB TFIIE TFIIF Wrn Xpa Zta (BZLF1)
CREB-binding_protein
Protein-coding gene in the species Homo sapiens
gene, previously known as ISGF3G. IRF9 has been shown to interact with STAT2 and STAT1. ENSG00000285048 GRCh38: Ensembl release 89: ENSG00000213928,
IRF9
Form of speciation involving hybridization between two different species
study of genetic variation at the loci containing the immune genes OAS1 and STAT2 (Phd thesis). University of Arizona. Retrieved 6 December 2013. "Bear shot
Hybrid_speciation
British immunologist (born 1980)
immune system. In 2017, his team identified novel mutations in the gene STAT2 which lead to primary immunodeficiency. Liston also led a team that developed
Adrian_Liston
Protein-coding gene in humans
'Ser-708' seems also to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (gamma-activation factor) (STAT1:STAT1)
IKBKE
Process of introducing nucleic acids into eukaryotic cells
innate and adaptive immunity. Inhibiting only three proteins, interferon-β, STAT2, and EIF2AK2 is sufficient to rescue human fibroblasts from the cell death
Transfection
Protein-coding gene in the species Homo sapiens
and STAT2 are activated by these tyrosine kinases, and STAT1 and STAT2 mediate the antiviral and inflammatory effects of IFN-α/IFN-β. STAT1 and STAT2 form
Interferon_alpha-1
Transmembrane proteins
receptor activating signal transducer and activator of transcription (STAT)1, STAT2 and STAT3". The Biochemical Journal. 370 (Pt 2): 391–6. doi:10.1042/BJ20021935
Type_II_cytokine_receptor
Protein and coding gene in humans
(October 1999). "IFN-alpha activates Stat6 and leads to the formation of Stat2:Stat6 complexes in B cells". Journal of Immunology. 163 (7). Baltimore,
STAT6
Sendai virus, virus of rodents
Irie T, Sakaguchi T (December 2017). "Structural analysis of the STAT1:STAT2 heterodimer revealed the mechanism of Sendai virus C protein-mediated blockade
Murine_respirovirus
American biostatistician and statistics educator
Association of America in 2009. She is one of eight co-authors of the textbook STAT2: Building Models for a World of Data (Macmillan, 2013). In 2013, Legler
Julie_Legler
Protein-coding gene
and TYK2 (in combination with IFNAR1) upon receptor engagement. STAT1 and STAT2 dock at these phosphorylation sites, phosphorylate, dimerize, and attach
IFNK
Sharma, Sapna; Jansen, Sander; Weyenbergh, Johan Van; Ma, Ji (2020-04-24). "STAT2 signaling as double-edged sword restricting viral dissemination but driving
Johan_Neyts
Q9Y365 15950 STARD13 HGNC:19164; Q9Y3M8 15951 STAT1 HGNC:11362; P42224 15952 STAT2 HGNC:11363; P52630 15953 STAT3 HGNC:11364; P40763 15954 STAT4 HGNC:11365;
List of human protein-coding genes 8
List_of_human_protein-coding_genes_8
354.249.500 – stat1 transcription factor MeSH D12.776.930.354.249.750 – stat2 transcription factor MeSH D12.776.930.375.750.249 – sp1 transcription factor
List of MeSH codes (D12.776.930)
List_of_MeSH_codes_(D12.776.930)
Heterodimeric receptor
residues on IFNAR1 and IFNAR2 recruit STAT proteins (classically STAT1, STAT2, or STAT3, although STAT4, STAT5, and STAT6 may play a role in certain cell
Interferon-alpha/beta receptor
Interferon-alpha/beta_receptor
Protein-coding gene in the species Homo sapiens
Myc, NR3C1, P53, POLR2A, PHB, SIN3A, SMARCB1, SMARCC1, SMARCC2, SMARCE1, STAT2, and STK11. GRCh38: Ensembl release 89: ENSG00000127616 – Ensembl, May 2017
SMARCA4
Protein-coding gene in the species Homo sapiens
phosphorylation-deficient Stat1 is associated with impaired expression of Stat2, ICSBP/IRF8 and C/EBPepsilon". Scand. J. Immunol. 64 (3): 271–9. doi:10
IRF8
Most expressed structure in coronaviruses
signaling by suppressing phosphorylation and nuclear translocation of STAT1 and STAT2". Cell Discovery. 6 (1): 65. doi:10.1038/s41421-020-00208-3. PMC 7490572
Coronavirus nucleocapsid protein
Coronavirus_nucleocapsid_protein
atopic dermatitis, and inflammatory bowel disease. Furthermore, STAT1 and STAT2 are essential factors in the cellular antiviral and adaptive immune defenses
Protein inhibitor of activated STAT
Protein_inhibitor_of_activated_STAT
Protein-coding gene in humans
(Nov 2005). "Simian virus 5 V protein acts as an adaptor, linking DDB1 to STAT2, to facilitate the ubiquitination of STAT1". Journal of Virology. 79 (21):
CUL4A
Family of interleukins
Stat3, Stat5 IL-22 IL-22R IL-10RB Stat3, Stat1, Stat5 IL-22BP (antagonist) IL-26 IL-20RA IL-10RB Stat3, Stat1 IL-28A/28B/29 IL-28R IL-10RB Stat1, Stat2
IL-10_family
theory Somatic hypermutation Specific granule Specol STAT protein STAT1 STAT2 STAT3 STAT4 STAT5 STAT6 Stem cell educator Stimulator of interferon genes
Index_of_immunology_articles
Protein-coding gene in the species Homo sapiens
with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles
PTPN21
Overview article
J; Brownlee, W; Frost, C; Greenwood, J; et al. (March 2019). "TP1-11 MS-STAT2: a phase 3 trial of high dose simvastatin in secondary progressive multiple
Multiple sclerosis drug pipeline
Multiple_sclerosis_drug_pipeline
Protein-coding gene in humans
MED14 has been shown to interact with PPARGC1A, Estrogen receptor alpha, STAT2, Cyclin-dependent kinase 8, Glucocorticoid receptor and Hepatocyte nuclear
MED14
Protein-coding gene in the species Homo sapiens
or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL-2 and
N-myc-interactor
500.500 – stat1 transcription factor MeSH D12.644.360.024.301.500.750 – stat2 transcription factor MeSH D12.644.360.024.301.750 – interferon-stimulated
List_of_MeSH_codes_(D12.644)
500.500 – stat1 transcription factor MeSH D12.776.476.024.381.500.750 – stat2 transcription factor MeSH D12.776.476.024.381.750 – interferon-stimulated
List of MeSH codes (D12.776.476)
List_of_MeSH_codes_(D12.776.476)
500.500 – stat1 transcription factor MeSH D12.776.157.057.061.500.750 – stat2 transcription factor MeSH D12.776.157.057.061.750 – interferon-stimulated
List of MeSH codes (D12.776.157)
List_of_MeSH_codes_(D12.776.157)
STAT2
STAT2
STAT2
STAT2
Boy/Male
Biblical
Who is happy; or walks; or looks.
Boy/Male
Slavic
Wreath of glory.
Boy/Male
African, Hindu, Indian
God; People
Girl/Female
English
Abbreviation of Melinda.
Girl/Female
Tamil
Nireksha | நீரேகà¯à®·à®¾
Male
African
a promise kept.
Boy/Male
Hebrew
Descending.
Male
English
Lame
Male
Icelandic
Icelandic name derived from Old Norse hrafn, HRAFN means "raven."
Boy/Male
American, Australian, British, English, Shakespearean
From the Raven's Estate
STAT2
STAT2
STAT2
STAT2
STAT2