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Search references for IRF8. Phrases containing IRF8
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Protein-coding gene in the species Homo sapiens
factor 8 (IRF8) also known as interferon consensus sequence-binding protein (ICSBP), is a protein that in humans is encoded by the IRF8 gene. IRF8 is a transcription
IRF8
Protein family
DCs, whereas IRF8 is essential for CD8α + DCs. In addition to IRF4 and IRF8, IRF1 and IRF2 are also involved in DC subset development. IRF8 has also been
Interferon_regulatory_factors
Chemical compound
suggest that fluorine might react with iridium hexafluoride at 39 GPa to form IrF8. It is able to oxidize elemental chlorine to the blue-colored salt Cl 4IrF
Iridium_hexafluoride
Protein-coding gene in the species Homo sapiens
IRF4 and IRF8 work in concert to achieve DC differentiation. IRF4 expression is responsible for inducing development of CD4+ DCs, while IRF8 expression
IRF4
Cancer originating in lymph nodes
IRF8: Governing the virtues of B Lymphocytes". Frontiers in Biology. 9 (4): 269–282. doi:10.1007/s11515-014-1318-y. PMC 4261187. PMID 25506356. "IRF8
Follicular_lymphoma
Study of association of allergies with genes
R. (2009). Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nature genetics
GWAS_in_allergy
Formation of blood cellular components
cell development), and Gfi1 (promotes Th2 development and inhibits Th1) or IRF8 (basophils and mast cells). Significantly, certain factors elicit different
Haematopoiesis
Compound with 8 fluorine atoms
octafluororhenate(VII) ([ReF8]−), octafluoroiodate(VII) ([IF8]−), octafluoroiridate(VII) ([IrF8]−), and octafluoroxenate(VI) ([XeF8]2−) anions. Weinstock, Bernard; Malm
Octafluoride
Japanese American geneticist
for her contributions to immunogenetics and epigenetics in isolating the IRF8 transcription factor that aids humans in fighting off disease and for identifying
Keiko_Ozato
Group of immune cells in the bone marrow
marrow and in tumors. STAT3 also promotes development of MDSCs, whereas IRF8 could counteract MDSC-inducing signals. MDSCs migrate as immature cells from
Myeloid-derived suppressor cell
Myeloid-derived_suppressor_cell
State of being insusceptible or resistant to a noxious agent or process
MCTS1, RORC, TBX21, TYK2, CYBB, JAK1, IFNGR1, IFNGR2, STAT1, USP18, IRF1, IRF8, NEMO, SPPL2A). Antiserum Antivenin Cell-mediated immunity Herd immunity
Immunity_(medicine)
Type of tissue in the spleen
regulate the development and survival of RPMs, these factors being: Spi-C, IRF8/4, heme oxygenase-1 and M-CSF. RPM's are capable of inducing the differentiation
Red_pulp
Transcription factor for converting Naive T cells to TFH
mutated proteins). Mutations to the transcription factors for BCL6, MEF2B and IRF8, are common in direct transcriptional changes that cause DLBCL. Additionally
BCL6
Enzyme that creates mutations in DNA
AID expression. AID is induced by transcription factors TCF3 (E47), HoxC4, Irf8 and Pax5, and inhibited by PRDM1 (Blimp1) and Id2. At the post-transcriptional
Activation-induced cytidine deaminase
Activation-induced_cytidine_deaminase
American immunologist and geneticist
Theofilopoulos, Argyrios N. (February 19, 2013). "Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of
Bruce_Beutler
gain-of-function mutation STAT2 deficiency IRF7 deficiency CD16 deficiency IRF8 deficiency IFNAR2 deficiency TLR pathway deficiencies IRAK4 deficiency IRAK1
List of primary immunodeficiencies
List_of_primary_immunodeficiencies
ENSG00000185507 IRF Known motif – High-throughput in vitro [432] CGAAAVYGAAANY IRF8 ENSG00000140968 IRF Known motif – High-throughput in vitro [433] CGAAACYGAAACY
List of human transcription factors
List_of_human_transcription_factors
Membrane receptor protein found in humans
(April 2011). "The genetic association of variants in CD6, TNFRSF1A and IRF8 to multiple sclerosis: a multicenter case-control study". PLOS ONE. 6 (4)
Tumor necrosis factor receptor 1
Tumor_necrosis_factor_receptor_1
Medical condition
stimulates immune responses in T-cells, a set of non-B-cell lymphocytes; 2) IRF8 (10-50% of cases) which encodes the interferon regulatory factor 8 protein
Pediatric-type follicular lymphoma
Pediatric-type_follicular_lymphoma
American chemical biologist
(2025-08-03). "Covalent Degraders of Immune Regulatory Transcription Factors IRF8 and IRF5". bioRxiv 10.1101/2025.08.03.668300. Spradlin, Jessica N.; Hu, Xirui;
Daniel_Nomura
Protein-coding gene in the species Homo sapiens
directly and indirectly represses anti-osteoclastogenesis genes such as Bcl6, IRF8, and MafB, helping monocytes differentiate into osteoclasts. In mice, insufficient
PRDM1
Human protein
JR (2009). "Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci". Nat. Genet.
CD6
Protein-coding gene in the species Homo sapiens
activity. IRF1 has been shown to interact with: CHIP GAGE HSP70 / HSP90 IRF8 KPNA2 MYD88 PCAF STAT1 TAT VEGFR2 REDD2 IRF2 Interferon regulatory factors
IRF1
Protein-coding gene in the species Homo sapiens
cDC1s lineage specification via maintaining Interferon regulatory factor 8 (IRF8) expression. The DC-SCRIPT deficient cDC1s had impaired capacity to capture
ZNF366
Protein-coding gene in the species Homo sapiens
super-enhancer-associated genes, including the cell identity genes CEBPA and IRF8. Cyclin-dependent kinase 8 has been shown to interact with: CCNC CREB binding
Cyclin-dependent_kinase_8
HGNC:6120; Q13568 7781 IRF6 HGNC:6121; O14896 7782 IRF7 HGNC:6122; Q92985 7783 IRF8 HGNC:5358; Q02556 7784 IRF9 HGNC:6131; Q00978 7785 IRGC HGNC:28835; Q6NXR0
List of human protein-coding genes 4
List_of_human_protein-coding_genes_4
Indian immunologist
K. Subbarao; Geiger, Rechel; Zhu, Qifan; Neale, Geoffrey (3 May 2018). "IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation". Cell
Thirumala-Devi_Kanneganti
Protein-coding gene in humans
subunit of the COP9 signalosome. COPS2 has been shown to interact with: DAX1, IRF8, NIF3L1, and THRA. GRCh38: Ensembl release 89: ENSG00000166200 – Ensembl
COPS2
American gastroenterologist (1952–2013)
Chen; Liu, Jianguo; Ning, Huan; Shin, Min Sun (2011). "Transcription factor IRF8 directs a silencing programme for TH17 cell differentiation". Nature Communications
Lloyd_Mayer
IRF8
IRF8
IRF8
IRF8
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Helper; Pillow
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Sharp; Small and Ancient
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Safe. Trustworthy.
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Of the sea and winds.
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Nickname for Michael. 'Who is like God?'.
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Woman, Kind, Goddess Laxmi
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IRF8
IRF8
IRF8
IRF8
IRF8