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Drug biological activity
Off-target activity is biological activity of a drug that is different from and not directed at that of its intended biological target. It most commonly
Off-target_activity
Type of unintended effects of genetic modification techniques
Off-target genome editing refers to nonspecific and unintended genetic modifications that can arise through the use of engineered nuclease technologies
Off-target_genome_editing
Gene editing method
engineered variants of the Cas9 nuclease that significantly reduce off-target activity have been developed. CRISPR-Cas9 genome editing techniques have many
CRISPR_gene_editing
Class of drugs
also reduce the activity of related proteins such as GDF11, activins, and bone morphogenetic proteins. While this off target activity can increase their
Myostatin_inhibitor
Molecule used to overcome antibiotic resistance in bacteria
In addition to its β-lactamase inhibition, clavulanic acid shows off-target activity in the nervous system by upregulating the glutamate transporter 1
Clavulanic_acid
Concept in pharmacology
In pharmacology, an antitarget (or off-target) is a receptor, enzyme, or other biological target that, when affected by a drug, causes undesirable side-effects
Antitarget
Artificial enzymes
theoretically yield less off-target activity. A comparison of a pair of 3-finger ZFNs and a pair of 4-finger ZFNs detected off-target cleavage in human cells
Zinc-finger_nuclease
Drug class
and TB-21007. Certain drugs show weak GABAA receptor NAM activity as an off-target activity that is responsible for undesirable side effects like anxiety
GABAA receptor negative allosteric modulator
GABAA_receptor_negative_allosteric_modulator
Medication class with multiple uses
antagonistic beta blocker in 1962. But pronethalol suffered from off-target activity and associated side effects and toxicity. As such, it did not enter
Beta_blocker
Medication drug
other important hormonal activity. Because of its antimineralocorticoid activity and lack of undesirable off-target activity, drospirenone is said to
Drospirenone
Dopamine agonist medication
sustained efficacy in a rat model of Parkinson's disease and limited off-target activity". Br J Pharmacol bph.70351. doi:10.1111/bph.70351. PMID 41578631
Pramipexole
Chemical compound
reaction with glutathione. B-elimination reaction follows, resulting in off-target activity and a loss of efficacy of the drugs. No general method exist for
Maleimide
Techniques used to study protein–small molecule interactions
high-affinity interactions with therapeutic targets, but they may also lead to undesirable off-target activity, and they may also be substrates of metabolic
Chemoproteomics
Medication used to treat diabetes
Turkey as Pional. Metformin is a pleiotropic drug, with extensive off-target activity beyond its antidiabetic effect. Much of this has been attributed
Metformin
American biotechnology company
requirements, advantageous off-target activity, and allele-specific editing capabilities, which could broaden the range of targetable diseases in the genome
Mammoth_Biosciences
Class of pharmaceutical drugs
possess off-target actions including progestogenic, antimineralocorticoid, and/or glucocorticoid activity in addition to their antiandrogen activity, and
Antiandrogen
genome in what constitutes dramatic off-target activity. It is therefore necessary for fusion constructs and targeting mechanisms to be optimized for reliable
Epigenome_editing
Science of drugs and medications and their effects
epigenetic reprogramming. Therefore, drugs should be screened for off-target activity by gene expression profiling, in addition to conventional ligand
Pharmacology
Type of genetic engineering
construction and testing of the proteins created for targeting each DNA sequence. Because off-target activity of an active nuclease would have potentially dangerous
Genome_editing
American supernatural horror franchise
the demon when the daughter, Leila, is targeted as she was born on the same date as Hunter from Paranormal Activity 2. Along with normal recorders, the family
Paranormal Activity (franchise)
Paranormal_Activity_(franchise)
Subdiscipline of medicine employing interaction of drugs with light for drug delivery
selective activation of the biomolecules helps prevent or minimize off-target activity and systemic side effects. Moreover, light being the regulatory element
Photopharmacology
Enzymes that cleave DNA in specific ways
range like CRISPR based genome editing[clarification needed]. The off-target activity of an active nuclease may lead to unwanted double-strand breaks and
Transcription activator-like effector nuclease
Transcription_activator-like_effector_nuclease
Human sexual practice
the sub's body to deliver a sharp, non-erotic, and possibly injurious off-target blow, such as to the hipbones or ribs. The longer the falls, the more
Impact_play
Form of advertising
advertising currently uses second-order proxies for targets, such as tracking online or mobile web activities of consumers, associating historical web page
Targeted_advertising
Pharmaceutical drug
unclear and several competing hypotheses exist. Mefloquine has known off-target activities. This includes affinity for the serotonin 5-HT2A receptor and to
Mefloquine
Technique in molecular biology
and phage-induced directed evolution of Cas9 to engineer reduced off-target activity". PLOS ONE. 15 (4) e0231716. Bibcode:2020PLoSO..1531716C. doi:10
Site-directed_mutagenesis
Dhekelia, and the West Bank. Additional alleged activity was reported in Azerbaijan, while maritime targets included vessels of the United States Navy and
List of attacks during the 2026 Iran war
List_of_attacks_during_the_2026_Iran_war
Small molecule (PROTAC)
PROTACs need only to bind their targets with high selectivity (rather than inhibit the target protein's enzymatic activity), efforts are underway to retool
Proteolysis_targeting_chimera
Potent human TAAR1 antagonist
stability, and a favorable preliminary profile of off-target activity (≥1–10 μM at 42 other targets). It is far more potent (893-fold) as an antagonist
RTI-7470-44
Information technology paradigm at certain aerodromes
involves the establishment of a target start approval time (TSAT), target off block time (TOBT) and target take off time (TTOT) for each flight. Airport
Airport Collaborative Decision Making
Airport_Collaborative_Decision_Making
Stage of drug discovery
synthesize lead compounds, new analogs with improved potency, reduced off-target activities, and physiochemical/metabolic properties suggestive of reasonable
Hit_to_lead
RNA molecule that specifies a target sequence
Gang (June 2014). "CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences". Nucleic Acids
Guide_RNA
The history of Target Corporation, an American general merchandise retailer, first began in 1902 by George Dayton. The company was originally named Goodfellow
History_of_Target_Corporation
Entactogen drug
B (2024). "Methylone is a rapid-acting neuroplastogen with less off-target activity than MDMA". Front Neurosci. 18 1353131. doi:10.3389/fnins.2024.1353131
Methylone
Uncrewed spacecraft used during NASA's Gemini program
The Agena Target Vehicle (/əˈdʒiːnə/; ATV), also known as Gemini-Agena Target Vehicle (GATV), was an uncrewed spacecraft used by NASA during its Gemini
Agena_target_vehicle
Medication producing effects similar to progesterone
progestogenic activity but rather due to off-target activities (e.g., androgenic activity, glucocorticoid activity, antimineralocorticoid activity). At high
Progestogen_(medication)
protein-dependent and -independent contributions to the in vivo off-target activity of zinc finger nucleases". Nucleic Acids Res. 39 (1): 381–92. doi:10
Recombinant AAV mediated genome engineering
Recombinant_AAV_mediated_genome_engineering
Research tool in genomics
the possible PAM sites are identified and selected for. On- and off-target activity should be analysed, as should GC content, and homopolymer stretches
Genome-wide CRISPR-Cas9 knockout screens
Genome-wide_CRISPR-Cas9_knockout_screens
Synthetic hallucinogen
Persson M, Laus A, Pottie E, Cannaert A, Tocco G, et al. (May 2023). "Off-target activity of NBOMes and NBOMe analogs at the µ opioid receptor". Arch Toxicol
25I-NBOMe
2014 film by Christopher Landon
Paranormal Activity: The Marked Ones is a 2014 American found footage supernatural horror film written and directed by Christopher Landon. It is a spin-off and
Paranormal Activity: The Marked Ones
Paranormal_Activity:_The_Marked_Ones
American microbiologist
Nelson, D. C. Bensen, and K. J. Shaw. 2013. Distinguishing on-target versus off-target activity in early antibacterial drug discovery using a macromolecular
Karen_Joy_Shaw
Television show filmed in Vancouver
Human Target is an American spy action television series that was broadcast by Fox in the United States. Based loosely on the Human Target comic book character
Human_Target_(2010_TV_series)
and phage-induced directed evolution of Cas9 to engineer reduced off-target activity". PLOS ONE. 15 (4) e0231716. Bibcode:2020PLoSO..1531716C. doi:10
Mutagenesis (molecular biology technique)
Mutagenesis_(molecular_biology_technique)
Baseball stadium in Minneapolis, Minnesota
Target Field is a baseball stadium in the historic warehouse district of downtown Minneapolis. Since its opening in 2010, the stadium has been the ballpark
Target_Field
Brevity code for NATO communications
elevation information on a potential target.** [A/A] [A/S] [AIR-MAR] CEASE [activity] Discontinue stated activity (e.g., CEASE BUZZER, LASER, SPARKLE,
Multi-service tactical brevity code
Multi-service_tactical_brevity_code
Chemical compound
9.08,11]dodecane-3-ol with sigma (s) receptor ligands modulates off-target activity and subtype selectivity". Bioorg. Med. Chem. Lett. 21 (12): 3622–3626
NE-100
Sexual stimulation of one's own genitals
psychological benefits have been attributed to a healthy attitude toward sexual activity in general and to masturbation in particular. Masturbation is considered
Masturbation
Connected or disconnected state for equipment and services
refer to either computing activities performed while disconnected from the Internet, or alternatives to Internet activities (such as shopping in brick-and-mortar
Online_and_offline
Pharmaceutical compound
Compound 22 was also screened for off-target activity at 47 targets at a concentration of 10 μM. The screened targets included monoamine receptors, monoamine
Compound 22 (TAAR1 antagonist)
Compound_22_(TAAR1_antagonist)
Pharmaceutical compound
model of multiple sclerosis. Originally believed to be selective, off-target activities of WOBE437 have subsequently been identified and described. WOBE437
WOBE437
unprecedented actions targeting American law firms and lawyers that had previously represented positions adverse to Trump. This targeting of political opponents
Targeting of law firms and lawyers under the second Trump administration
Targeting_of_law_firms_and_lawyers_under_the_second_Trump_administration
Chemical compound
progesterone receptor, the biological target of progestogens like progesterone. It has no other important hormonal activity. The medication is a prodrug of
Allylestrenol
Neurosurgical treatment
symptoms and activities of daily living, but found studies to be too heterogenous or insufficient to compare the targets for dyskinesia, daily off time, quality
Deep_brain_stimulation
Military doctrinal concept
collection methods. This includes warning (to include ballistic missile activity), targeting analysis, threat capability assessment, situational awareness, battle
Intelligence, surveillance, target acquisition, and reconnaissance
Intelligence,_surveillance,_target_acquisition,_and_reconnaissance
Use of AI by the Israel Defense Forces in the Gaza war
the IDF said "more than 12,000" targets in Gaza had been identified by its target administration division. The activities of the division, formed in 2019
AI-assisted targeting in the Gaza Strip
AI-assisted_targeting_in_the_Gaza_Strip
the Trump administration took a series of actions using the government to target his political opponents and civil society. News outlets described his actions
Targeting of political opponents and civil society under the second Trump administration
Targeting_of_political_opponents_and_civil_society_under_the_second_Trump_administration
US AI military intelligence program
military intelligence workflows, specifically in intelligence, surveillance, target acquisition, and reconnaissance as well as in geospatial intelligence. It
Project_Maven
Covert and paramilitary unit of the CIA
The raid was launched based on a CIA Special Activities Division's intelligence collection and close target reconnaissance effort that located the leader
Special_Activities_Center
Laws criminalising certain sexual acts
enforced to target against sexual activities between individuals of the opposite sex, and have mostly been used to target against sexual activities between
Sodomy_law
Philippine Navy tanker
Philippine and U.S. forces hit the target ship during the activity. It sank around 10:49 a.m. at about 15 kilometers off Laoag City, Ilocos Norte Province
BRP_Lake_Caliraya
Temporary housing company
Target Hospitality (formerly Target Logistics and Target Lodging) is a company that provides workforce lodging and other temporary, modular housing used
Target_Hospitality
Shooting sport
known as clay target shooting, is a shooting sport involving shooting at special flying targets known as "clay pigeons" or "clay targets" with a shotgun
Clay_pigeon_shooting
Antibiotic medication
and shows activity against a wide range of both Gram-positive and Gram-negative bacteria. Minocycline shows a number of off-target activities in addition
Minocycline
Division of the nervous system supplying internal organs, smooth muscle and glands
functions include control of respiration, cardiac regulation, vasomotor activity, and certain reflex actions such as coughing, sneezing, swallowing and
Autonomic_nervous_system
Processes through which companies combine or transfer ownership
environment The buyer buys the assets of the target company. The cash the target receives from the sell-off is paid back to its shareholders by dividend
Mergers_and_acquisitions
Pharmaceutical compound
sustained efficacy in a rat model of Parkinson's disease and limited off-target activity". British Journal of Pharmacology bph.70351. doi:10.1111/bph.70351
Matsupexole
Combination drug
progestogens in breast cancer may be more related to their off-target activity than their progestogenic activity. In accordance, a study found that the effectiveness
Estradiol valerate/gestonorone caproate
Estradiol_valerate/gestonorone_caproate
Group of people toward which an organization has decided to aim its marketing efforts
as the focus of its activities, in which case, it would normally identify a primary target and a secondary target. Primary target markets are those market
Target_market
Chemical compound
glucocorticoid, or antimineralocorticoid activities, and hence is a pure progestogen with no off-target activity. Clinical studies have found that, on the
Algestone_acetophenide
Microbial protein found in Streptococcus pyogenes M1 GAS
Researchers identified that Cas9 activity depends on two RNA molecules: CRISPR RNA (crRNA), which guides the enzyme to target DNA sequences, and trans-activating
Cas9
1966 NASA crewed space flight
failed to eject from the docking target due to a launch preparation error. Cernan performed a two-hour extravehicular activity, during which it was planned
Gemini_9A
Water sports or aquatic sports are sports activities conducted on waterbodies and can be categorized according to the degree of immersion by the participants
List_of_water_sports
Attacking player position in football
participate in the build-up of attacking plays. The term "target forward" or "target man" or "target striker" is often used to describe a particular type of
Forward (association football)
Forward_(association_football)
Attempt to transform the established social order and its structures
this tool as an element of strategic subversion. The targets of cultural subversive activities are traditionally film, literature, popular music, educational
Subversion
Comic strip character from The Beano
activities and attitudes. From his first appearance in 1953, Walter became the target of Dennis' pranks and misbehaviour, but he would brush it off.
Walter_the_Softy
Automotive vehicle capable of driving across difficult terrain beyond sealed roads
and other low-traction terrains. Off-road vehicles are widely used in various contexts, from recreational activities to practical applications like agriculture
Off-road_vehicle
King of Italy from 1878 to 1900
target: CITEREFPerniconeOttanelli2018 (help); Kemp 2018, p. 62 sfnm error: no target: CITEREFKemp2018 (help); Simon 2022, p. 19 sfnm error: no target:
Umberto_I_of_Italy
Advanced persistent threat operated by the Chinese government
to a target, they put a strong emphasis on stealth, almost exclusively relying on living-off-the-land techniques and hands-on-keyboard activity. Volt
Volt_Typhoon
Analytical technique to study proteins
der Wel, Tom; Soethoudt, Marjolein (2017-06-09). "Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474". Science
Activity-based_proteomics
Pharmaceutical compound
prevention but as having serious side effects due to undesirable off-target activities. Whereas methysergide is functionally an agonist of the serotonin
XC-101
Using a bow to shoot arrows
Archery is the sport, practice, or skill of using a bow to shoot arrows at a target. The word comes from the Latin arcus, meaning bow. Historically, archery
Archery
Dislike of anything that is perceived to be foreign or strange
suspicion of one group's activities by members of the other group, a desire to eliminate the presence of the group that is the target of suspicion, and fear
Xenophobia
1946 nuclear weapon tests at Bikini Atoll
raised at Bikini. She was towed to California and sunk again, as a target ship off the coast, two years later. Three other ships, all in sinking condition
Operation_Crossroads
South Korean biochemist (born 1964)
Jungjoon; Kim, Jin-Soo (30 June 2015). "Measuring and Reducing Off-Target Activities of Programmable Nucleases Including CRISPR-Cas9". Molecules and
Kim_Jin-soo_(biologist)
Chemical compound
with numerous other serotonin receptors and targets. However, BOL-148 reportedly shows less off-target activity compared to LSD. In animals, BOL-148 shows
BOL-148
United States government units targeted by the Department of Government Efficiency
focused on the Public Building Service (PBS) as they target offices to RIF. 600 employees were laid off on March 3 and on March 5, in one of PBS regions,
US federal agencies targeted by DOGE
US_federal_agencies_targeted_by_DOGE
1986 nuclear accident in the Soviet Union
of soil activity in ~ 200 kBq/m2 to dairy milk activity in Bq/L, that had ever been reported, with the transfer, from initial land activity into milk
Chernobyl_disaster
American defector and former airman (born 1979)
specific target. From January 2014 through May 2015, Witt used fraudulent Facebook accounts to investigate intelligence personnel and prepare "target packages"
Monica_Witt
Extrajudicial assassination by governments
Executive Order 12036 Executive Order 12333 High-value target International counter-terrorism activities of the CIA Justifiable homicide Kill authorizations
Targeted_killing
Estrogen medication
the ERs, estetrol is anticipated to have a low risk of undesirable off-target activity and associated side effects. Furthermore, estetrol showed no inhibition
Estetrol_(medication)
validate molecular targets. While early definitions for chemical probes, including criteria for potency, selectivity, and cellular activity, focused on reversible
Chemical_probe
Chemical compound
A, Pottie E, Cannaert A, Tocco G, Gréen H, Stove CP (May 2023). "Off-target activity of NBOMes and NBOMe analogs at the µ opioid receptor". Arch Toxicol
25iP-NBOMe
2025 United States District Court case
E.K. v. Department of Defense Education Activity is a case pending in the U.S District Court for the Eastern District of Virginia brought by the American
E.K. v. Department of Defense Education Activity
E.K._v._Department_of_Defense_Education_Activity
Chemical compound
Persson M, Laus A, Pottie E, Cannaert A, Tocco G, et al. (May 2023). "Off-target activity of NBOMes and NBOMe analogs at the µ opioid receptor". Arch Toxicol
25B-NBOMe
Pharmaceutical discovery procedure
biological activity without knowledge of the biological target. Only after an active substance was identified was an effort made to identify the target. This
Drug_discovery
Planning technique
trade-offs must be made between different alternatives for different targets: for example, performance over costs and even target over target. At this
Technology_roadmap
Sexual activity involving the anus and rectum
penile–anal penetration, and anal sex to denote any form of anal sexual activity, especially between pairings as opposed to anal masturbation. While anal
Anal_sex
Abandoned drug for bipolar depression
activity, and reversed stress-induced reinstatement of cocaine-seeking behavior. However, PF-04455242 also showed a variety of other weak off-target activities
PF-04455242
Chemical compound
proteins are likely to bind." A 2017 research article suggested the off-target activity of BIA 10-2474 may affect lipid metabolism in neurones. According
BIA_10-2474
Sex act
Fisting (also known as fist fucking (FF) and handballing) is a sexual activity that involves inserting one or more hands into the rectum (anal fisting)
Fisting
OFF TARGET-ACTIVITY
OFF TARGET-ACTIVITY
Boy/Male
Gujarati, Hindu, Indian
Target
Male
Greek
(ἸαÏÎδ) Greek form of Hebrew Yered, IARET means "descent." In the bible, this is the name of the father of Enoch. The English form is Jared.
Female
Welsh
Welsh name TARREN means "from the knoll."
Female
Welsh
Welsh form of Greek Margarites, MARGED means "pearl."
Female
Hungarian
Hungarian and Scandinavian form of Greek Margarites, MARGIT means "pearl."
Male
English
 Variant spelling of English Garrett, GARRET means "spear ruler."
Surname or Lastname
English and French
English and French : metonymic occupational name for a boatman, from Middle English, Old French barge ‘boat’, ‘barge’.Dutch : variant of Berg.
Male
English
English surname transferred to unisex forename use, GARNET means "garnet (the gem)," derived from a Middle English altered form of Old French (pome) grenate, "fruit full of seeds," the same source from which came the name of the precious stone.Â
Boy/Male
Hindu, Indian
Target
Boy/Male
Hindu, Indian
Target
Male
English
English byname for a quarrelsome person. It became a surname, then transferred to a forename, derived from Middle English barat, a derivative of barater, BARRET means "to haggle," hence "haggler."
Surname or Lastname
English
English : from Old French argent ‘silver’, hence probably a nickname for someone with silver-gray hair, or possibly an occupational nickname for a silversmith or moneyer.
Surname or Lastname
English
English : topographic name for someone who lived by a market, Middle English market.
Surname or Lastname
French
French : humorous nickname for a man with shapely legs, from jarrett ‘hock’.French : variant spelling of Garet, which has various explanations: from Old French garet ‘shelter’, a derivative of garer ‘to protect’, hence a metonymic occupational name for a herdsman or a topographic name for someone who lived by a covered shelter for animals, or a habitational name for someone from a place named with this word, for example in Allier and Puy-de-Dôme; or alternatively from a pet form of any of the various Germanic personal names beginning with the element geri, gari ‘spear’ or ward ‘guard’, ‘protect’.English : variant spelling of Garrett.
Surname or Lastname
English
English : variant of Taggart.Possibly an altered spelling of French Target, a nickname for someone who carried a square buckler, Old French targe.
Girl/Female
British, English, French, Greek, Latin
Sweet; Beautiful; Intelligent
Surname or Lastname
English (Suffolk, of Norman origin)
English (Suffolk, of Norman origin) : nickname for someone with silvery hair, a variant of Argent, with the French definite article l(e).French : metonymic occupational name for a silversmith, from French argent ‘silver’.
Surname or Lastname
English and French
English and French : in medieval times this did not denote a rank in the army, but was an occupational name for a servant, Middle English, Old French sergent (Latin serviens, genitive servientis, present participle of servire ‘to serve’). The surname probably originated for the most part in this sense, but the word also developed various more specialized meanings, being used for example as a technical term for a tenant by military service below the rank of a knight, and as the name for any of certain administrative and legal officials in different localities, which may also have contributed to the development of the surname. The sense ‘non-commissioned officer’ did not arise until the 16th century.William Sargent (1624–1717) came to Gloucester, MA, from Devon, England before 1678. Many of his descendants distinguished themselves in the civil and military affairs of the colonies and some in literary or artistic paths, notably the portrait painter John Singer Sargent (1856–1925).
Male
Swedish
Swedish and Norwegian form of Old Norse Þorgeirr, TORGER means "Thor's spear."Â
Female
English
Pet form of French Marguerite, MARGOT means "pearl."
OFF TARGET-ACTIVITY
OFF TARGET-ACTIVITY
Boy/Male
American, British, English
Lives at the Buck Meadow
Girl/Female
French English
Of the ashes.
Boy/Male
Hindu, Indian, Tamil
Prince
Girl/Female
American, Australian, Christian, French, Irish, Welsh
Small Valley; Pure; Holy; Valley; Clean; From the Glen
Boy/Male
Indian, Sanskrit
Method; Law
Boy/Male
Tamil
Balgopal | பாலகோபால
Baby Krishna, Infant Krishna
Boy/Male
American, Australian, British, Celtic, Chinese, Christian, English, Jamaican
Hilltop; Mount; Variant of Brent; Settlement Associated with Bryni; Fire; Flame
Male
German
 Pet form of German Ulrich, UTZ means "prosperity and power." Compare with another form of Utz.
Boy/Male
Indian, Tamil
Another Name for God Murugan
Boy/Male
Hindu
OFF TARGET-ACTIVITY
OFF TARGET-ACTIVITY
OFF TARGET-ACTIVITY
OFF TARGET-ACTIVITY
OFF TARGET-ACTIVITY
n.
The pattern or arrangement of a series of hits made by a marksman on a butt or mark; as, he made a good target.
n.
A public place (as an open space in a town) or a large building, where a market is held; a market place or market house; esp., a place where provisions are sold.
n.
Exchange, or purchase and sale; traffic; as, a dull market; a slow market.
n.
A butt or mark to shoot at, as for practice, or to test the accuracy of a firearm, or the force of a projectile.
n.
The price for which a thing is sold in a market; market price. Hence: Value; worth.
n.
The manager of a barge.
n.
A conspicuous disk attached to a switch lever to show its position, or for use as a signal.
n.
A shield or target.
n.
The privelege granted to a town of having a public market.
n.
A turret; a watchtower.
n.
A large, roomy boat for the conveyance of passengers or goods; as, a ship's barge; a charcoal barge.
v. t.
To coat with parget; to plaster, as walls, or the interior of flues; as, to parget the outside of their houses.
n.
A small tart.
n.
A kind of small shield or buckler, used as a defensive weapon in war.
n.
The sliding crosspiece, or vane, on a leveling staff.
n.
A smooth soft covering resembling or suggesting a carpet.
adv.
Denoting the action of removing or separating; separation; as, to take off the hat or cloak; to cut off, to pare off, to clip off, to peel off, to tear off, to march off, to fly off, and the like.
a.
meeting a curve or surface at a point and having at that point the same direction as the curve or surface; -- said of a straight line, curve, or surface; as, a line tangent to a curve; a curve tangent to a surface; tangent surfaces.
v. t.
To cover with, or as with, a carpet; to spread with carpets; to furnish with a carpet or carpets.
a.
Furnished, armed, or protected, with a target.