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Type IV intermediate filaments found in the cytoplasm of neurons
Neurofilaments (NF) are classed as type IV intermediate filaments found in the cytoplasm of neurons. They are protein polymers measuring 10 nm in diameter
Neurofilament
Protein-coding gene in the species Homo sapiens
Neurofilament light polypeptide is a protein that in humans is encoded by the NEFL gene. Neurofilament light polypeptide is a member of the intermediate
Neurofilament light polypeptide
Neurofilament_light_polypeptide
Protein
copurifies with other neurofilament subunits, as it was originally discovered, however in some mature neurons it can be the only neurofilament expressed. The
Internexin
Medical condition
of biomarkers, namely one called neurofilament light chain (NFL), in patients with Alzheimer's disease. Neurofilament light chain is a protein that is
Cerebral_atrophy
German neurologist and multiple sclerosis researcher
sclerosis. His group contributed to the clinical establishment of serum neurofilament light chain (NfL) as a biomarker of neuroaxonal injury in MS measurable
Jens_Kuhle
Protein-coding gene in the species Homo sapiens
Neurofilament medium polypeptide (NF-M) is a protein that in humans is encoded by the NEFM gene. Neurofilaments are type IV intermediate filament heteropolymers
NEFM
American biotechnology company
on degeneration. Another class of antibody to neurofilament NF-L was shown to bind only neurofilaments in healthy neurons and their processes but failed
EnCor_Biotechnology
Portion of a brain cell containing its nucleus
perikarya and axonal and dendritic processes and are called neurofilaments. The neurofilaments become cross linked with certain fixatives and when impregnated
Soma_(biology)
Nineteenth letter in the Greek alphabet
PMID 9846894 – via EuropeMC. M, Sjögren; E, Englund (2004). "Negative neurofilament light and tau immunostaining in frontotemporal dementia". Dementia and
Tau
Rare neurodegenerative disease
towards a slowing of progression, as well as a significant reduction in neurofilament light chain, a putative ALS biomarker thought to indicate neuronal damage
ALS
Protein-coding gene in the species Homo sapiens
Neurofilament, heavy polypeptide (NEFH) is a protein that in humans is encoded by the NEFH gene. It is the gene for a heavy protein subunit that is combined
NEFH
Neuromuscular disease
Additionally, mutations in proteins involved in axonal integrity, such as neurofilament light chain (NF-L), dynamin 2 (DNM2), ganglioside-induced differentiation-associated
Charcot–Marie–Tooth_disease
Neurological disorder
recessive neurological disorder that causes disorganization of neurofilaments. Neurofilaments form a structural framework that helps to define the shape and
Giant_axonal_neuropathy
Medical condition
extremities, early-onset high foot arch, and swelling of the nerve axons with neurofilament accumulation. Additional findings include gait anomalies, muscle cramps
Autosomal dominant Charcot–Marie–Tooth disease type 2 with giant axons
Autosomal_dominant_Charcot–Marie–Tooth_disease_type_2_with_giant_axons
Medical condition
Alzheimer's disease Pick's disease with Pick bodies Lewy body dementias Neurofilament inclusion body disease Creutzfeldt–Jakob disease Frontotemporal degeneration
Corticobasal_syndrome
Aortic valve implantation technique
neuroimaging afterwards. Further, levels of the neuroaxonal damage biomarker neurofilament light chain are elevated in blood plasma after TAVI. Whereas clinical
Transcatheter aortic valve replacement
Transcatheter_aortic_valve_replacement
Protein-coding gene in the species Homo sapiens
from peripherin protein dimers), but it can also heteropolymerize with neurofilaments in several neuronal types. This protein in humans is encoded by the
Peripherin
Terminally differentiated cell incapable of regeneration
antibody to MAP2 (green), Neurofilament NF-H (red) and DNA (blue). MAP2 is found in neuronal dendrites, while the neurofilament is found predominantly in
Permanent_cell
Gene of the species Homo sapiens
Beta-keratin Type 3 Desmin GFAP Peripherin Vimentin Type 4 Internexin Nestin Neurofilament NEFL NEFM NEFH Synemin Syncoilin Type 5 Nuclear lamins A/C B1 B2 Microtubules
KRIT1
Secretion from the glands of nurse bees
mRNA expression of glial cell line-derived neurotrophic factor and neurofilament H in the hippocampus of the adult mouse brain". Biosci. Biotechnol.
Royal_jelly
Clusters of neurons in the peripheral nervous system
stage of day 7) after incubation overnight in NGF growth medium stained with anti-neurofilament antibody. Note the axons growing out of the ganglion.
Ganglion
Pathologic finding in microscopy
Micrograph of the anterior horn of the spinal cord showing motor neurons with central chromatolysis. Neurofilament immunostain.
Central_chromatolysis
Protein-coding gene in humans
Beta-keratin Type 3 Desmin GFAP Peripherin Vimentin Type 4 Internexin Nestin Neurofilament NEFL NEFM NEFH Synemin Syncoilin Type 5 Nuclear lamins A/C B1 B2 Microtubules
Filamin-A
Toxin harmful to nervous tissue
the cytoskeleton through inhibition of neurofilament transport. This is particularly destructive as neurofilaments are used in basic cell structure and
Neurotoxin
Combat sport and martial art
damage. The Gothenburg study[needs context] analyzed temporary levels of neurofilament light in cerebrospinal fluid which they conclude is evidence of damage
Boxing
Structural fibrous protein
Beta-keratin Type 3 Desmin GFAP Peripherin Vimentin Type 4 Internexin Nestin Neurofilament NEFL NEFM NEFH Synemin Syncoilin Type 5 Nuclear lamins A/C B1 B2 Microtubules
Keratin
Spherical inclusion commonly found in damaged neurons
defining protein α-synuclein along with other proteins, such as ubiquitin, neurofilament protein, and alpha B crystallin. There is evidence that a particular
Lewy_body
Irregular beating of the atria of the heart
score. The addition of blood based biomarkers such as NT-proBNP and neurofilament light chain improves risk prediction significantly. A CHA2DS2-VASc score
Atrial_fibrillation
Disease that damages the myelin sheaths around nerves
neurons, the roles of proteins showing loss of nerve tissue such as neurofilaments, tau, and N-acetylaspartate are under investigation. Improvement in
Multiple_sclerosis
Topics referred to by the same term
NEFL may refer to: Neurofilament light polypeptide North Eastern Football League, an Australian rules football competition in South Australia New England
NEFL
Network of filamentous proteins that forms the internal framework of cells
intermediate filaments. In neurons the intermediate filaments are known as neurofilaments. Each type is formed by the polymerization of a distinct type of protein
Cytoskeleton
Medical condition of the brain
higher than those found in healthy controls. One biomarker for PSP is neurofilament light chain (NfL), a non-specific marker of axonal damage. NfL levels
Progressive supranuclear palsy
Progressive_supranuclear_palsy
Mitochondrially inherited degeneration of retinal nerve cells
visual evoked potentials. Neuron-specific enolase and axonal heavy chain neurofilament blood markers may predict conversion to affected status.[citation needed]
Leber's hereditary optic neuropathy
Leber's_hereditary_optic_neuropathy
Human chromosome
nibrin NDRG1: N-myc downstream regulated gene 1 NEF3: neurofilament 3 (150kDa medium) NEFL: neurofilament, light polypeptide 68kDa ODF1: outer dense fiber
Chromosome_8
Mammalian protein found in homo sapiens
Beta-keratin Type 3 Desmin GFAP Peripherin Vimentin Type 4 Internexin Nestin Neurofilament NEFL NEFM NEFH Synemin Syncoilin Type 5 Nuclear lamins A/C B1 B2 Microtubules
KIF18B
Protein-coding gene in humans
substance anterograde axonal transport spermatogenesis response to ethanol neurofilament cytoskeleton organization heart contraction embryo implantation locomotory
SOD1
Protein found in humans
axon. Seven genes encode for the heavy (NF-H), medium (NF-M) and light neurofilament (NF-L) proteins, nestin and α-internexin in nerve cells, synemin α and
Nestin_(protein)
Dementia involving the frontal or temporal lobes
Irwin DJ, et al. (May 2021). "ATN incorporating cerebrospinal fluid neurofilament light chain detects frontotemporal lobar degeneration". Alzheimer's
Frontotemporal_dementia
Dissolution of a neuron's Nissl bodies
neuron, where normal-looking Nissl bodies may be present. Hyperplasia of neurofilaments is frequently observed, however the extent varies. The number of autophagic
Chromatolysis
Neural stem cell culture system
in neuroepithelial stem cells. The cells were not immunoreactive for neurofilament, neuron-specific enolase (NSE), and glial fibrillary acidic protein
Neurosphere
Group of brain diseases induced by prions
in particular, measurement of the 14-3-3 protein, tau protein, and neurofilament light chain, all of which increase in prion diseases; 3) Magnetic resonance
Transmissible spongiform encephalopathy
Transmissible_spongiform_encephalopathy
Chemical compound
cytoskeleton. The disorganization causes the neurofilaments to dissociate from microtubules, the neurofilaments then segregate towards the perimeter of the
IDPN_(chemical)
Mammalian protein found in humans
during the DNA synthesis. Immunofluorescent antibody staining against neurofilament (green) and Ki-67 (red) in a mouse embryo 12.5 days after fertilization
Proliferation marker protein Ki-67
Proliferation_marker_protein_Ki-67
Protein-coding gene in the species Homo sapiens
Beta-keratin Type 3 Desmin GFAP Peripherin Vimentin Type 4 Internexin Nestin Neurofilament NEFL NEFM NEFH Synemin Syncoilin Type 5 Nuclear lamins A/C B1 B2 Microtubules
MYL6B
Rare neuroendocrine tumour
chromogranin A, synaptophysin, neuron specific enolase, serotonin, neurofilament and Neural cell adhesion molecule; they are S-100 protein negative.
Paraganglioma
Protein-coding gene in the species Homo sapiens
Beta-keratin Type 3 Desmin GFAP Peripherin Vimentin Type 4 Internexin Nestin Neurofilament NEFL NEFM NEFH Synemin Syncoilin Type 5 Nuclear lamins A/C B1 B2 Microtubules
PLEKHA7
Family of motor proteins
Beta-keratin Type 3 Desmin GFAP Peripherin Vimentin Type 4 Internexin Nestin Neurofilament NEFL NEFM NEFH Synemin Syncoilin Type 5 Nuclear lamins A/C B1 B2 Microtubules
Myosin
Topics referred to by the same term
neuropathy, a rare neurological disorder that causes disorganization of neurofilaments Hereditary neuropathy with liability to pressure palsy (HNPP), a peripheral
Neuropathy_(disambiguation)
Medical diagnostic method
circulating microRNA Some blood tests have been proposed based in circulating neurofilament light chain (NFL), in RNA profiling or in the MRZ reaction. Another
McDonald_criteria
British neurologist and neuroscientist
functional impairment, yet there was evidence of elevated levels of neurofilament light protein, suggestive of very early neuronal damage, in those closest
Sarah_Tabrizi
Proteins interacting with microtubules
Beta-keratin Type 3 Desmin GFAP Peripherin Vimentin Type 4 Internexin Nestin Neurofilament NEFL NEFM NEFH Synemin Syncoilin Type 5 Nuclear lamins A/C B1 B2 Microtubules
Microtubule-associated protein
Microtubule-associated_protein
Development of memory in children
chitinase-3-like protein 1 (YKL-40), fatty acid binding protein 3 (FABP3), and neurofilament light (NFL), and their findings suggest that tauopathy and FABP3 tended
Memory_development
Protein family
Beta-keratin Type 3 Desmin GFAP Peripherin Vimentin Type 4 Internexin Nestin Neurofilament NEFL NEFM NEFH Synemin Syncoilin Type 5 Nuclear lamins A/C B1 B2 Microtubules
Plakin
Protein-coding gene in the species Homo sapiens
protein 90/ postsynaptic density-95-associated protein (SAPAP) with neurofilaments". Genes Cells. 5 (3): 203–10. doi:10.1046/j.1365-2443.2000.00318.x.
DLGAP2
Macromolecular complex
Beta-keratin Type 3 Desmin GFAP Peripherin Vimentin Type 4 Internexin Nestin Neurofilament NEFL NEFM NEFH Synemin Syncoilin Type 5 Nuclear lamins A/C B1 B2 Microtubules
Arp2/3_complex
Protein-coding gene in humans
Beta-keratin Type 3 Desmin GFAP Peripherin Vimentin Type 4 Internexin Nestin Neurofilament NEFL NEFM NEFH Synemin Syncoilin Type 5 Nuclear lamins A/C B1 B2 Microtubules
KRT31
Protein-coding gene in the species Homo sapiens
Beta-keratin Type 3 Desmin GFAP Peripherin Vimentin Type 4 Internexin Nestin Neurofilament NEFL NEFM NEFH Synemin Syncoilin Type 5 Nuclear lamins A/C B1 B2 Microtubules
KRT85
Protein found in humans
Beta-keratin Type 3 Desmin GFAP Peripherin Vimentin Type 4 Internexin Nestin Neurofilament NEFL NEFM NEFH Synemin Syncoilin Type 5 Nuclear lamins A/C B1 B2 Microtubules
Keratin_16
Mammalian protein found in Homo sapiens
Beta-keratin Type 3 Desmin GFAP Peripherin Vimentin Type 4 Internexin Nestin Neurofilament NEFL NEFM NEFH Synemin Syncoilin Type 5 Nuclear lamins A/C B1 B2 Microtubules
Unconventional_myosin-VI
Primary cell of the nervous system
neuron is supported by a complex mesh of structural proteins called neurofilaments, which together with neurotubules (neuronal microtubules) are assembled
Neuron
interconnected axon networks and express tetanus toxin receptors and neurofilament proteins. By 10–14 days of exposure to retinoic acid, NTERA-2 cells
NTERA-2
Cytoskeletal protein
Beta-keratin Type 3 Desmin GFAP Peripherin Vimentin Type 4 Internexin Nestin Neurofilament NEFL NEFM NEFH Synemin Syncoilin Type 5 Nuclear lamins A/C B1 B2 Microtubules
Spectrin
Protein-coding gene in the species Homo sapiens
Beta-keratin Type 3 Desmin GFAP Peripherin Vimentin Type 4 Internexin Nestin Neurofilament NEFL NEFM NEFH Synemin Syncoilin Type 5 Nuclear lamins A/C B1 B2 Microtubules
MYL6
Protein-coding gene in the species Homo sapiens
Beta-keratin Type 3 Desmin GFAP Peripherin Vimentin Type 4 Internexin Nestin Neurofilament NEFL NEFM NEFH Synemin Syncoilin Type 5 Nuclear lamins A/C B1 B2 Microtubules
MYO1E
Type III intermediate filament protein
Beta-keratin Type 3 Desmin GFAP Peripherin Vimentin Type 4 Internexin Nestin Neurofilament NEFL NEFM NEFH Synemin Syncoilin Type 5 Nuclear lamins A/C B1 B2 Microtubules
Vimentin
Type III intermediate filament protein
Beta-keratin Type 3 Desmin GFAP Peripherin Vimentin Type 4 Internexin Nestin Neurofilament NEFL NEFM NEFH Synemin Syncoilin Type 5 Nuclear lamins A/C B1 B2 Microtubules
Glial fibrillary acidic protein
Glial_fibrillary_acidic_protein
Protein-coding gene in the species Homo sapiens
Beta-keratin Type 3 Desmin GFAP Peripherin Vimentin Type 4 Internexin Nestin Neurofilament NEFL NEFM NEFH Synemin Syncoilin Type 5 Nuclear lamins A/C B1 B2 Microtubules
Myosin-2
Medical condition
Neuron-specific enolase (NSE) positive, NSE negative, synaptophysin negative, neurofilament negative, TUJ1 positive, and nestin positive have been expressed in
Astroblastoma
Protein found in humans
neurons TDP-43 has also been shown in humans to be a low molecular weight neurofilament (hNFL) mRNA-binding protein. It has also shown to be a neuronal activity
TAR_DNA-binding_protein_43
Protein-coding gene in the species Homo sapiens
Beta-keratin Type 3 Desmin GFAP Peripherin Vimentin Type 4 Internexin Nestin Neurofilament NEFL NEFM NEFH Synemin Syncoilin Type 5 Nuclear lamins A/C B1 B2 Microtubules
MYH6
American scientist and academic
L. (2022). Salivary S100 calcium-binding protein beta (S100B) and neurofilament light (NfL) after acute exposure to repeated head impacts in collegiate
Steven_L._Small
Chinese traditional medicine brand
Yiyong; Guo, Liankui (2005). "Effect of Guilingji on expression of neurofilament protein in cerebral cortex and corpus striatum". Chinese Journal of
Guangyuyuan
Type of brain tumor
Synaptophysin → - Chromogranin → - NSE (neuron-specific enolase) → ++ NFP (neurofilament protein) → - CD56/N-CAM (neural cell adhesion molecule) → ++ S100 →
Papillary tumors of the pineal region
Papillary_tumors_of_the_pineal_region
Peptide, Brain Nerve Growth Factors Neuroendocrine Secretory Protein 7B2 Neurofilament Proteins Neurogranin Neuronal Apoptosis-Inhibitory Protein Neuronal
Nerve_tissue_protein
Protein-coding gene in the species Homo sapiens
Beta-keratin Type 3 Desmin GFAP Peripherin Vimentin Type 4 Internexin Nestin Neurofilament NEFL NEFM NEFH Synemin Syncoilin Type 5 Nuclear lamins A/C B1 B2 Microtubules
SPTBN2
British neurologist
disease. Wild's research since 2017 has focused on the potential of neurofilament light and mutant huntingtin protein as biomarkers for Huntington's disease
Edward_Wild_(neuroscientist)
Cluster of neurons in a dorsal root of a spinal nerve
7) after incubation overnight in NGF growth medium stained with anti-neurofilament antibody. Neurites growing out of the ganglion are visible. A spinal
Dorsal_root_ganglion
Protein-coding gene in the species Homo sapiens
Beta-keratin Type 3 Desmin GFAP Peripherin Vimentin Type 4 Internexin Nestin Neurofilament NEFL NEFM NEFH Synemin Syncoilin Type 5 Nuclear lamins A/C B1 B2 Microtubules
TUBA1C
Protein-coding gene in the species Homo sapiens
Beta-keratin Type 3 Desmin GFAP Peripherin Vimentin Type 4 Internexin Nestin Neurofilament NEFL NEFM NEFH Synemin Syncoilin Type 5 Nuclear lamins A/C B1 B2 Microtubules
Filamin-C
Largest known protein in human muscles
Beta-keratin Type 3 Desmin GFAP Peripherin Vimentin Type 4 Internexin Nestin Neurofilament NEFL NEFM NEFH Synemin Syncoilin Type 5 Nuclear lamins A/C B1 B2 Microtubules
Titin
Protein-coding gene in the species Homo sapiens
Beta-keratin Type 3 Desmin GFAP Peripherin Vimentin Type 4 Internexin Nestin Neurofilament NEFL NEFM NEFH Synemin Syncoilin Type 5 Nuclear lamins A/C B1 B2 Microtubules
MYL7
American medical researcher (1923–2008)
Carleton (1985). "Hypothesis: interference with axonal transport of neurofilament as a common pathogenetic mechanism in certain diseases of the central
Daniel_Carleton_Gajdusek
Medical condition
concentrations, and elevated levels of the proteins Tau, amyloid beta (Aβ42), neurofilament light chain (NFL), and glial fibrillary acidic protein (GFAP), but the
Superficial_siderosis
Medical condition
unaffected parts too. Neurofilaments have also been studied as a way to diagnose PMA and other motor neurons diseases. Neurofilaments are a type of filament
Progressive_muscular_atrophy
Microtubule minus-end binding human protein
Beta-keratin Type 3 Desmin GFAP Peripherin Vimentin Type 4 Internexin Nestin Neurofilament NEFL NEFM NEFH Synemin Syncoilin Type 5 Nuclear lamins A/C B1 B2 Microtubules
Calmodulin-regulated spectrin-associated protein 3
Calmodulin-regulated_spectrin-associated_protein_3
Protein domain
Beta-keratin Type 3 Desmin GFAP Peripherin Vimentin Type 4 Internexin Nestin Neurofilament NEFL NEFM NEFH Synemin Syncoilin Type 5 Nuclear lamins A/C B1 B2 Microtubules
Talin_(protein)
Protein found in humans
Beta-keratin Type 3 Desmin GFAP Peripherin Vimentin Type 4 Internexin Nestin Neurofilament NEFL NEFM NEFH Synemin Syncoilin Type 5 Nuclear lamins A/C B1 B2 Microtubules
Lamin_B1
Protein-coding gene in humans
Beta-keratin Type 3 Desmin GFAP Peripherin Vimentin Type 4 Internexin Nestin Neurofilament NEFL NEFM NEFH Synemin Syncoilin Type 5 Nuclear lamins A/C B1 B2 Microtubules
KRT74
Long projection on a neuron that conducts signals to other neurons
arrangements of microtubules and type IV intermediate filaments known as neurofilaments. The axon hillock is the area formed from the cell body of the neuron
Axon
Type of physical injury
instability. After fighting, boxers show raised cerebrospinal fluid levels of neurofilament light chain and total tau then they did after three months with no boxing
Sports-related traumatic brain injury
Sports-related_traumatic_brain_injury
Protein-coding gene in Homo sapiens
Beta-keratin Type 3 Desmin GFAP Peripherin Vimentin Type 4 Internexin Nestin Neurofilament NEFL NEFM NEFH Synemin Syncoilin Type 5 Nuclear lamins A/C B1 B2 Microtubules
KRT77
Eukaryotic motor protein
Beta-keratin Type 3 Desmin GFAP Peripherin Vimentin Type 4 Internexin Nestin Neurofilament NEFL NEFM NEFH Synemin Syncoilin Type 5 Nuclear lamins A/C B1 B2 Microtubules
Kinesin
Protein-coding gene in the species Homo sapiens
Beta-keratin Type 3 Desmin GFAP Peripherin Vimentin Type 4 Internexin Nestin Neurofilament NEFL NEFM NEFH Synemin Syncoilin Type 5 Nuclear lamins A/C B1 B2 Microtubules
Tubulin_beta-4B_chain
Protein-coding gene in the species Homo sapiens
Beta-keratin Type 3 Desmin GFAP Peripherin Vimentin Type 4 Internexin Nestin Neurofilament NEFL NEFM NEFH Synemin Syncoilin Type 5 Nuclear lamins A/C B1 B2 Microtubules
Myosin-7
Turkish physician and author (born 1972)
their findings that psoriasis patients had unusually high levels of neurofilament and Tau protein, which act as a skeleton in the nerve cells in these
Gökhan_Okan
Protein-coding gene in the species Homo sapiens
Beta-keratin Type 3 Desmin GFAP Peripherin Vimentin Type 4 Internexin Nestin Neurofilament NEFL NEFM NEFH Synemin Syncoilin Type 5 Nuclear lamins A/C B1 B2 Microtubules
Ankyrin-1
Protein-coding gene in the species Homo sapiens
protein-containing complex binding Cellular component cytoplasm cell body neurofilament cytoskeleton nuclear envelope synaptic vesicle spindle chromosome microtubule
NDEL1
Biomarker proxy outcome measure
Lussier FZ, et al. (March 2023). "Potential Utility of Plasma P-Tau and Neurofilament Light Chain as Surrogate Biomarkers for Preventive Clinical Trials"
Surrogate_endpoint
Microtubules in nervous tissue neurons
Neurotubules are microtubules found in neurons in nervous tissues. Along with neurofilaments and microfilaments, they form the cytoskeleton of neurons. Neurotubules
Neurotubule
Mammalian protein found in Homo sapiens
Stetzkowski-Marden F, Pradel LA (April 1991). "Interaction domains of neurofilament light chain and brain spectrin". Biochem. J. 275 (Pt 2): 521–7. doi:10
Microtubule-associated protein 2
Microtubule-associated_protein_2
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