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Protein-coding gene in Homo sapiens
hMSH6 (human MSH6). The MSH6 protein is a member of the Mutator S (MutS) family of proteins that are involved in DNA damage repair. Defects in hMSH6 are
MSH6
Autosomal dominant genetic condition associated with a high risk of cancer in the colon
repair pathway: People with MSH6 mutations are more likely to be Amsterdam criteria II-negative. The presentation with MSH6 is slightly different from
Hereditary nonpolyposis colorectal cancer
Hereditary_nonpolyposis_colorectal_cancer
Protein-coding gene in the species Homo sapiens
DNA mismatch repair (MMR) protein, MSH2, which forms a heterodimer with MSH6 to make the human MutSα mismatch repair complex. It also dimerizes with MSH3
MSH2
Group of diseases involving cell growth
in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6". Carcinogenesis. 27 (12): 2402–08. doi:10.1093/carcin/bgl079. PMC 2612936
Cancer
Medical condition
sebaceous tumors. The genes affected are MLH1, MSH2, and more recently, MSH6, and are involved in DNA mismatch repair. Muir–Torre syndrome is characterized
Muir–Torre_syndrome
Cancer of the colon or rectum
events, hypermutated tumors display mutated forms of ACVR2A, TGFBR2, MSH3, MSH6, SLC9A9, TCF7L2, and BRAF. The common theme among these genes, across both
Colorectal_cancer
Cancer medication
cytoreduction of tumors with temozolomide and then selection or induction of mutant MSH6, MSH2, MLH1, or PMS2 proteins and cells which are MMRd and temozolomide resistant
Temozolomide
Complete set of nucleic acid sequences for humans
1:3500 APC Lynch syndrome 5–10% of all cases of bowel cancer MLH1, MSH2, MSH6, PMS2 Fanconi anemia 1:130000 births FANCC Neurological conditions Huntington's
Human_genome
System for fixing base errors of DNA replication
mismatch site. In eukaryotes, MutS homologs form two major heterodimers: Msh2/Msh6 (MutSα) and Msh2/Msh3 (MutSβ). The MutSα pathway is involved primarily in
DNA_mismatch_repair
Tumor or other abnormal growth of tissue
in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6". Carcinogenesis. 27 (12): 2402–8. doi:10.1093/carcin/bgl079. PMC 2612936
Neoplasm
Male reproductive organ cancer
particularly early-onset prostate cancer – including BRCA1, ATM, NBS1, MSH2, MSH6, PMS2, CHEK2, RAD51D, and PALB2. Additionally, variants in the genome near
Prostate_cancer
Genetic characteristic
pathogenic variants in DNA mismatch repair genes such as MLH1, MSH2, and MSH6. Inheriting these mutations impairs the body's ability to correct DNA replication
Genetic_predisposition
Study of DNA modifications that do not change its sequence
H2O2 for 30 minutes causes the mismatch repair protein heterodimer MSH2-MSH6 to recruit DNA methyltransferase 1 (DNMT1) to sites of some kinds of oxidative
Epigenetics
Inherited genetic condition that predisposes a person to cancer
genetic mutations in DNA mismatch repair (MMR) genes, notably MLH1, MSH2, MSH6 and PMS2. In addition to colorectal cancer many other cancers are increased
Hereditary_cancer_syndrome
Malignancy that develops from epithelial cells
in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6". Carcinogenesis. 27 (12): 2402–2408. doi:10.1093/carcin/bgl079. PMC 2612936
Carcinoma
Cellular mechanism
H2O2 for 30 minutes causes the mismatch repair protein heterodimer MSH2-MSH6 to recruit DNA methyltransferase 1 (DNMT1) to sites of some kinds of oxidative
DNA_repair
Protein found in humans
MSH3 leading to high levels of MutSβ and degradation of the partnerless MSH6 protein which normally complexes with MSH2 to form MutSα. MSH3 has been shown
MSH3
Multiple dominant or recessive 1:14,500-123,000 Lynch syndrome MSH2, MLH1, MSH6, PMS2, PMS1, TGFBR2, MLH3 1:279 Lipoprotein lipase deficiency recessive 1:1
List_of_genetic_disorders
Urinary system cancer that begins in the urinary bladder
syndrome is caused by mutations in DNA mismatch repair genes MLH1, MSH2, MSH6 or PMS2; see main article Hereditary nonpolyposis colorectal cancer (HNPCC)
Bladder_cancer
Uterine cancer that is located in tissues lining the uterus
mistakes in the DNA. Other genes mutated in Lynch syndrome include MSH2, MSH6, and PMS2, which are also mismatch repair genes. Women with Lynch syndrome
Endometrial_cancer
Cancer syndrome
constitutional mismatch repair-deficiency (CMMR-D), it has been mapped to MLH1, MSH2, MSH6 or PMS2. Monoallelic mutations of these genes are observed in the condition
Mismatch repair cancer syndrome
Mismatch_repair_cancer_syndrome
Protein family
Tony; Alani, Eric (1999-06-04). "A Mutation in the MSH6 Subunit of the Saccharomyces cerevisiae MSH2-MSH6 Complex Disrupts Mismatch Recognition *". Journal
MutS-1
Condition of genetic hypermutability
tumors in Lynch syndrome are caused by germline mutations in MLH1, MSH2, MSH6, and PMS2. MSI has been evident in the cause of sebaceous carcinomas. Sebaceous
Microsatellite_instability
Malignant tumor of oil glands in the skin
MTS results from defects in DNA mismatch repair genes, MLH1, MSH2, and MSH6, leading to a buildup of unstable microsatellite sequences and replication
Sebaceous_carcinoma
Human chromosome
phosphoprotein 10 MSH2: mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) MSH6: mutS homolog 6 (E. coli) MTHFD2: Bifunctional methylenetetrahydrofolate
Chromosome_2
Cancer originating in or on the ovary
therapy. Other genes that have been associated with ovarian cancer are BRIP1, MSH6, RAD51C and RAD51D. CDH1, CHEK2, PALB2 and RAD50 have also been associated
Ovarian_cancer
Topics referred to by the same term
related to skin pigmentation DNA mismatch repair genes: MSH2 MSH3 MSH4 MSH5 MSH6 Multiple system atrophy Mycothiol, an unusual thiol that is found in Actinobacteria
MSH
Damaging changes to a biological cell
in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6". Carcinogenesis. 27 (12): 2402–2408. doi:10.1093/carcin/bgl079. PMC 2612936
Cell_damage
Protein family around which DNA winds to form nucleosomes
of H3 lysine 36 (H3K36me3) H3K36me3 has the ability to recruit the MSH2-MSH6 (hMutSα) complex of the DNA mismatch repair pathway. Consistently, regions
Histone
Gene known for its role in breast cancer
repair. BRCA1 interacts with the DNA mismatch repair protein MSH2. MSH2, MSH6, PARP, and some other proteins involved in single-strand repair are reported
BRCA1
Tumor of the glial cells of the brain or spine
in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6". Carcinogenesis. 27 (12): 2402–8. doi:10.1093/carcin/bgl079. PMC 2612936
Glioma
positioned nucleotides. Another gene involved in DNA mismatch repair is Msh6. Both the Msh6 and Msh2 mutant mice develop gastrointestinal cancer but the tumours
Mouse model of colorectal and intestinal cancer
Mouse_model_of_colorectal_and_intestinal_cancer
Death of a cell mediated by intracellular program, often as part of development
a dual role for each repair process are: (1) DNA mismatch repair, MSH2, MSH6, MLH1 and PMS2; (2) base excision repair, APEX1 (REF1/APE), poly(ADP-ribose)
Programmed_cell_death
Formation of cancer
in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6". Carcinogenesis. 27 (12): 2402–8. doi:10.1093/carcin/bgl079. PMC 2612936
Carcinogenesis
Growth found in bowel wall
biologists have linked the syndrome to specific genes such as hMSH2, hMSH1, hMSH6, and hPMS2. Peutz–Jeghers syndrome is an autosomal dominant syndrome that
Colorectal_polyp
Mammalian protein found in Homo sapiens
endonuclease 1 GADD45A GADD45G HDAC1 HUS1 ING1 KCTD13 KIAA0101 Ku70 Ku80 MCL1 MSH3 MSH6 MUTYH P21 POLD2 POLD3 POLDIP2 POLH POLL RFC1 RFC2 RFC3 RFC4 RFC5 Ubiquitin
Proliferating cell nuclear antigen
Proliferating_cell_nuclear_antigen
Enzyme that creates mutations in DNA
the MutSα(alpha) complex. MutSα is a heterodimer consisting of MSH2 and MSH6. This heterodimer is able to recognize mostly single-base distortions in
Activation-induced cytidine deaminase
Activation-induced_cytidine_deaminase
Protein-coding gene in humans
seven DNA mismatch repair proteins in humans are MLH1, MLH3, MSH2, MSH3, MSH6, PMS1 and PMS2. In addition, there are Exo1-dependent and Exo1-independent
MLH1
Protein-coding gene in the species Homo sapiens
interactions with mismatch repair protein complexes MLH1, MSH2, MSH3, and MSH6. Also, it has known interaction in the following repair mechanisms: nucleotide
RAD9A
Medical condition
10-27% risk of ovarian cancer. Other identified genes include: MLH1, MSH2, MSH6, PMS2: mutations in genes that lead to Lynch Syndrome put individuals at
Hereditary breast–ovarian cancer syndrome
Hereditary_breast–ovarian_cancer_syndrome
Accumulation of mutations
genetic mutations. Deficiency of DNA repair proteins PMS2, MLH1, MSH2, MSH3, MSH6 or BRCA2 can cause up to 100-fold increases in mutation frequency Epigenetic
Somatic_evolution_in_cancer
Cell death resulting from a deficiency of or interaction between in two or more genes
in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6". Carcinogenesis. 27 (12): 2402–8. doi:10.1093/carcin/bgl079. PMC 2612936
Synthetic_lethality
High frequency of mutations within the genome of a cellular lineage
in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6". Carcinogenesis. 27 (12): 2402–8. doi:10.1093/carcin/bgl079. PMC 2612936
Genome_instability
microsatellite instability: Signature 6, 15, 20 and 26. Loss of function MLH1, MSH2, MSH6 or PMS2 genes cause defective DNA mismatch repair. Signature 10 has a transcriptional
Mutational_signatures
Analysis of tissue to identify colorectal cancer characteristics
syndrome is made by looking for specific genetic mutations in genes MLH1, MSH2, MSH6, and PMS2. Immunohistochemical testing can also be used to guide treatment
Histopathology of colorectal adenocarcinoma
Histopathology_of_colorectal_adenocarcinoma
Biological process
and the insertion-deletion loop. Humans employ the MutSα heterodimer (MSH2/MSH6) to recognize the base mismatch. Once the mismatch is found, Exo1 carries
Mutagenesis
Medical condition
Companion Reviews and Search Terms XPG - Companion Reviews and Search Terms MSH6 - Companion Reviews and Search Terms MUTYH - Companion Reviews and Search
DNA repair-deficiency disorder
DNA_repair-deficiency_disorder
Medical condition
with mutations in any of the four DNA mismatch repair genes (MLH1, MSH2, MSH6, PMS2), or the EpCAM gene. The relative risks of men vs. women with these
Male_breast_cancer
Cytoplasmic biomolecular condensates of proteins and RNA occurring in cells under stress
Protein 2 MOV10 MOV-10 Mov10 RISC Complex RNA Helicase yes MSH6 MSH6 DNA mismatch repair protein Msh6 MSI1 Musashi-1 Musashi RNA Binding Protein 1 yes MSI2
Stress_granule
CAGGTATGC CAGGCATGC Intervening sequence, RNA processing,No amino acid change MSH6 Intron 9 TTTTTAATTTTAAGG TTTTTAATTTTGAGG Intervening sequence, RNA processing
Shapiro–Senapathy_algorithm
HGNC:7326; P20585 9903 MSH4 HGNC:7327; O15457 9904 MSH5 HGNC:7328; O43196 9905 MSH6 HGNC:7329; P52701 9906 MSI1 HGNC:7330; O43347 9907 MSI2 HGNC:18585; Q96DH6
List of human protein-coding genes 5
List_of_human_protein-coding_genes_5
Finnish human geneticist (1933–2020)
genes were cloned and shown to cause Lynch syndrome: MSH2 (2p), MLH1 (3p); MSH6 (2p) and PMS2 (7p). Dr. de la Chapelle's group contributed to the cloning
Albert_de_la_Chapelle
Single-molecule imaging technique
Basis for One-Dimensional DNA Scanning by the Mismatch Repair Complex Msh2-Msh6". Molecular Cell. 28 (3): 359–370. doi:10.1016/j.molcel.2007.09.008. PMC 2953642
DNA_curtain
Protein-coding gene in the species Homo sapiens
down-regulation, at the protein level, of MMR proteins Mlh1, Msh2, Pms2, and Msh6 by 5.8-, 5.6-, 2.6-, and 2.7-fold, respectively. In colorectal cancers with
MBD4
Protein-coding gene in humans
(1999). "Prevalence of germline mutations of hMLH1, hMSH2, hPMS1, hPMS2, and hMSH6 genes in 75 French kindreds with nonpolyposis colorectal cancer". Hum. Genet
PMS1
Field of study in cancer research
miR-101), DNA-PK (miR-101), ATR (miR-185), Wip1 (miR-16), MLH1, MSH2 and MSH6 (miR-155), ERCC3 and ERCC4 (miR-192) and UNG2 (mir-16, miR-34c and miR-199a)
Cancer_epigenetics
Protein-coding gene in the species Homo sapiens
germline mutations in DNA repair proteins involved in MMR (MSH2, MLH1, MSH6, and PMS2) have been described in Lynch syndrome (LS), which is characterized
POLD1
ICK Endometrial cancer; 608089; MLH3 Endometrial cancer, familial; 608089; MSH6 Endplate acetylcholinesterase deficiency; 603034; COLQ Enhanced S-cone syndrome;
List_of_OMIM_disorder_codes
MSH6
MSH6
MSH6
MSH6
Male
English
 Anglicized form of Greek Daniēl (Hebrew Daniyel), DANIEL means "God is my judge." In the bible, this is the name of the hero of the Book of Daniel, who was cast into a den of lions but saved by God. Anglicized form of Scottish Gaelic Domhnall, meaning "world ruler."
Girl/Female
Arabic
Princess; Lady
Girl/Female
American, Australian, British, English
Harvester; Abbreviation of Teresa
Girl/Female
Hindu
Beautiful
Girl/Female
Arabic, Malaysian
Brilliant of Whiteness
Girl/Female
Hindu
Means sober, Polite, Well behaved
Male
English
Pet form of English Dennis, DYE means "follower of Dionysos."
Boy/Male
African
Ghanian name given to a child born on Tuesday.
Boy/Male
English American Latin
Highly praiseworthy.' From a Roman clan name. This abbreviation of Anthony and its variants has...
Girl/Female
Indian, Telugu
New Future
MSH6
MSH6
MSH6
MSH6
MSH6