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Class of corticosteroids
are in turn a class of steroid hormones. Glucocorticoids are corticosteroids that bind to the glucocorticoid receptor that is present in almost every
Glucocorticoid
Receptor to which cortisol and other glucocorticoids bind
The glucocorticoid receptor (GR or GCR) also known by its gene name NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the steroid receptor for
Glucocorticoid_receptor
Drug class
Topical glucocorticoids are the topical forms of glucocorticoids. Topical glucocorticoids are used in the treatment of many skin conditions. They provide
Topical_glucocorticoids
Corticosteroid medication
Methylprednisolone, sold under the brand name Medrol among others, is a synthetic glucocorticoid, primarily prescribed for its anti-inflammatory and immunosuppressive
Methylprednisolone
Human disease
Glucocorticoid deficiency is a condition where the body does not produce enough glucocorticoid hormones. Symptoms of glucocorticoid deficiency (having
Glucocorticoid_deficiency
Medical condition
Generalized glucocorticoid resistance or Chrousos syndrome is an extraordinarily rare genetic disorder that can run in families or be sporadic. It is characterized
Generalized glucocorticoid resistance
Generalized_glucocorticoid_resistance
Steroid medication
Prednisone is a glucocorticoid medication mostly used to suppress the immune system and decrease inflammation in conditions such as asthma, COPD, and rheumatologic
Prednisone
Vertebrate natural glucocorticoid hormone
Cortisol is a steroid hormone in the glucocorticoid class of hormones and a stress hormone. When used as medication, it is known as hydrocortisone. Cortisol
Cortisol
Class of pharmaceutical drugs
that act to reduce the effects of glucocorticoids, primarily cortisol, in the body. They include direct glucocorticoid receptor antagonists such as mifepristone
Antiglucocorticoid
Class of experimental drugs
Selective glucocorticoid receptor modulators (SEGRMs) and selective glucocorticoid receptor agonists (SEGRAs) formerly known as dissociated glucocorticoid receptor
Selective glucocorticoid receptor modulator
Selective_glucocorticoid_receptor_modulator
Protein family
isoforms encoded by the genes SGK1, SGK2, and SGK3. The name Serum/glucocorticoid-regulated kinase refers to the first cloning of a SGK family member
SGK
Corticosteroid medication
Dexamethasone is a fluorinated glucocorticoid medication used to treat rheumatic problems, a number of skin diseases, severe allergies, asthma, chronic
Dexamethasone
Medical condition
Glucocorticoid remediable aldosteronism also describable as aldosterone synthase hyperactivity, is an autosomal dominant disorder in which the increase
Glucocorticoid remediable aldosteronism
Glucocorticoid_remediable_aldosteronism
HippoCampus
has helped further the understanding of neuronal signal potentiation. Glucocorticoid signaling plays a major role in the development of the hippocampus.
Glucocorticoids in hippocampal development
Glucocorticoids_in_hippocampal_development
Class of steroid hormones
their synthetic analogues. The two main classes of corticosteroids – glucocorticoids and mineralocorticoids – are involved in a wide range of physiological
Corticosteroid
Symptoms from excessive exposure to glucocorticoids such as cortisol
is a collection of signs and symptoms due to prolonged exposure to glucocorticoids such as cortisol. Signs and symptoms may include high blood pressure
Cushing's_syndrome
Endocrine gland
produces three main types of steroid hormones: mineralocorticoids, glucocorticoids, and androgens. Mineralocorticoids (such as aldosterone) produced in
Adrenal_gland
Membrane glucocorticoid receptors (mGRs) are a group of receptors which bind and are activated by glucocorticoids such as cortisol and corticosterone,
Membrane glucocorticoid receptor
Membrane_glucocorticoid_receptor
Medical condition
Glucocorticoid deficiency 1 is an adrenocortical failure characterized by low levels of plasma cortisol produced by the adrenal gland despite high levels
Glucocorticoid_deficiency_1
Medical condition
symptoms have been found in some individuals who have been exposed to glucocorticoid medication, often dispensed in the form of asthma, arthritis, and anti-inflammatory
Steroid_dementia_syndrome
Medical condition
glucocorticoids (a class of steroid hormones) analogous to Cushing's syndrome but involving mainly the axial skeleton. The synthetic glucocorticoid prescription
Steroid-induced_osteoporosis
Corticosteroid medication
pregnancy is occasionally associated with harm to the baby. It is a glucocorticoid made from hydrocortisone (cortisol). Prednisolone was discovered and
Prednisolone
estrogen response elements (EREs) androgen response elements (AREs) glucocorticoid response elements (GREs) Type 2 NR response elements: direct repeat
Response_element
Glucocorticoid and mineralocorticoid hormone Cortisol supplied as a medication
acting specifically as both a glucocorticoid and as a mineralocorticoid. That is, it is an agonist of the glucocorticoid and mineralocorticoid receptors
Hydrocortisone
Chemical compound
Meprednisone is a glucocorticoid. It is a methylated derivative of prednisone. Glucocorticoid Corticosteroid Elks J (1990). "Meprednisone". The Dictionary
Meprednisone
Medical condition
congenital or acquired, and its symptoms are clinically similar to those of glucocorticoid deficiency. Symptoms consist of weight loss, diminished appetite, muscle
Adrenocorticotropic hormone deficiency
Adrenocorticotropic_hormone_deficiency
Medical emergency due to insufficient steroid production
mechanisms underlying an adrenal crisis involve the loss of endogenous glucocorticoids' typical inhibitory effect on inflammatory cytokines. When someone
Adrenal_crisis
Medical condition
Corticosteroid-induced lipodystrophy (CIL) is a condition of abnormal fat deposition caused by corticosteroid medications. Fat accumulates in the facial
Corticosteroid-induced lipodystrophy
Corticosteroid-induced_lipodystrophy
Protein-coding gene in the species Homo sapiens
Serine/threonine-protein kinase Sgk1 also known as serum and glucocorticoid-regulated kinase 1 is an enzyme that in humans is encoded by the SGK1 gene
SGK1
Relationship between stress and performance
stress hormones (glucocorticoids, GC) and human cognition revealed that memory performance vs. circulating levels of glucocorticoids does manifest an
Yerkes–Dodson_law
Protein-coding gene in the species Homo sapiens
humans is encoded by the NCOA2 gene. NCoA-2 is also frequently called glucocorticoid receptor-interacting protein 1 (GRIP1), steroid receptor coactivator-2
Nuclear receptor coactivator 2
Nuclear_receptor_coactivator_2
Genetic disorder in which the adrenal glands produce excess aldosterone
can be treated with steroid medications called glucocorticoids, so it is also known as glucocorticoid remediable aldosteronism (GRA). In familial hyperaldosteronism
Familial_hyperaldosteronism
Chemical compound
Clobetasol is a synthetic glucocorticoid corticosteroid. A propionate ester of clobetasol, clobetasol propionate, has also been marketed, and is far more
Clobetasol
Class of enzymes
cortisone) to active cortisol, or vice versa, thus regulating the access of glucocorticoids to the steroid receptors. cortisol + NADP+ H+ H+ cortisone
11β-Hydroxysteroid dehydrogenase
11β-Hydroxysteroid_dehydrogenase
Insufficient production of steroid hormones by the adrenal glands
adrenal glands—also referred to as the adrenal cortex—normally secrete glucocorticoids (primarily cortisol), mineralocorticoids (primarily aldosterone), and
Adrenal_insufficiency
Steroid medication
Triamcinolone is a glucocorticoid used to treat certain skin diseases, allergies, and rheumatic disorders among others. It is also used to prevent worsening
Triamcinolone
Antifungal chemical compound
suppression of glucocorticoid synthesis in the treatment of Cushing's syndrome. However, in the treatment of prostate cancer, concomitant glucocorticoid administration
Ketoconazole
Set of physiological feedback interactions
adrenal cortex: It produces glucocorticoid hormones (mainly cortisol in humans) in response to stimulation by ACTH. Glucocorticoids in turn, act back on the
Hypothalamic–pituitary–adrenal axis
Hypothalamic–pituitary–adrenal_axis
Drug class
inhibitors, namely non- steroidal anti- inflammatory drugs (NSAIDs) and glucocorticoids. In the following sections, the medical uses, side effects, contraindications
Prostaglandin_inhibitors
Glucocorticoid medication
sold under the brand names Flovent and Flonase among others, is a glucocorticoid steroid medication. When inhaled it is used for the long term management
Fluticasone_propionate
Chemical compound
Prednisolone sodium phosphate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. "Prednisolone sodium phosphate". Drug Information
Prednisolone_sodium_phosphate
Chemical compound
high-affinity agonist ligand for the glucocorticoid receptor and consequently is classified as a glucocorticoid. It is sometimes abbreviated "CVZ". Schlechte
Cortivazol
Protein-coding gene in the species Homo sapiens
Glucocorticoid modulatory element-binding protein 2 is a protein that in humans is encoded by the GMEB2 gene. This gene is a member of KDWK gene family
GMEB2
Investigational drug
treatment of Duchenne muscular dystrophy. It is a non-steroidal selective glucocorticoid receptor modulator. "Tegacorat - Grunenthal GmbH". AdisInsight. Springer
Tegacorat
target organ response to the major products of the adrenal cortex, glucocorticoids (principally cortisol in man), and mineralocorticoids (principally
Corticosteroid_receptor
Mineralocorticoid medication
unknown. Fludrocortisone is mostly a mineralocorticoid, but it also has glucocorticoid effects. Fludrocortisone was patented in 1953. It is on the World Health
Fludrocortisone
Form of arthritis causing swollen joints
drugs (NSAIDs), colchicine, and glucocorticoids. While glucocorticoids and NSAIDs work equally well, glucocorticoids may be safer. Repeated attacks can
Gout
Index of chemical compounds with the same molecular formula
acetonide, a synthetic glucocorticoid corticosteroid that was never brought to market. Fluorometholone acetate, a synthetic glucocorticoid corticosteroid and
C24H31FO5
Chemical compound
fallopian tube cancer, or primary peritoneal cancer. Relacorilant is a glucocorticoid receptor antagonist. It is taken by mouth. The most common adverse reactions
Relacorilant
Cortex of the adrenal gland
hyperpolarized to permit Ca2+ channels entry. Glucocorticoids are produced mainly in the zona fasciculata. Glucocorticoids are steroid hormones that are necessary
Adrenal_cortex
Pharmaceutical drug
the class of glucocorticoids, which are steroids synthesized in the adrenal cortex of the kidneys. In order to illustrate its glucocorticoid activity, the
Topical_hydrocortisone
Group of protein families
sexual characteristics and muscle growth. 4. Glucocorticoid receptors (GRs): GRs bind to glucocorticoids like cortisol and regulate gene expression in
Steroid_hormone_receptor
Nuclear receptor that mediates the effects of the mineralocorticoid hormone Aldosterone
2. MR is a receptor with equal affinity for mineralocorticoids and glucocorticoids. It belongs to the nuclear receptor family where the ligand diffuses
Mineralocorticoid_receptor
Steroid medication
increased hair growth and skin irritation. Betamethasone belongs to the glucocorticoid class of medication. It is a stereoisomer of dexamethasone, the two
Betamethasone
Chemical compound
to glucocorticoid release in the body. Since elevated glucocorticoid levels are a characteristic marker of chronic stress, blocking glucocorticoid signalling
SAFit2
Steroid medication
Mometasone and its derivate mometasone furoate are steroids (specifically, glucocorticoids), medications used to treat certain skin conditions, hay fever, and
Mometasone
Pharmaceutical compound
first-in-class medication. Crinecerfont is indicated as adjunctive treatment to glucocorticoid replacement to control androgens in people aged four years of age and
Crinecerfont
Chemical compound
similarly to ketoconazole, is known to act as an antagonist of the glucocorticoid receptor. Miconazole is also known to bind to tubulin and inhibit its
Miconazole
Chemical compound
of many other endogenous steroids, including androgens, estrogens, glucocorticoids, and mineralocorticoids, as well as neurosteroids. 17α-OHP is an agonist
17α-Hydroxyprogesterone
Chemical compound
6α-methyl-9α-fluoro-11β,17α-dihydroxypregna-1,4-diene-3,20-dione, is a synthetic glucocorticoid which is used in the treatment of inflammatory eye diseases. The C17α
Fluorometholone
Chemical compound
Fluocinonide is a potent glucocorticoid used topically as an anti-inflammatory agent for the treatment of skin disorders such as eczema and seborrhoeic
Fluocinonide
Corticosteroid precursor and metabolite of cortisol
(including abscesses). Cortisone is a corticosteroid, functioning as both a glucocorticoid and mineralocorticoid. Cortisone itself is inactive and instead acts
Cortisone
This is a list of corticosteroids (glucocorticoids and mineralocorticoids) or derivatives of cortisol (hydrocortisone). Most esters of these corticosteroids
List_of_corticosteroids
Molecular biological process
transcription. An example of transrepression is the ability of the glucocorticoid receptor to inhibit the transcriptional promoting activity of the AP-1
Transrepression
Male genetic disorder in which the subject has abnormally large testicles
treated using glucocorticoid. Using glucocorticoid at the beginning of macroorchidism can help reduce the abnormal testicular size. Glucocorticoid treatment
Macroorchidism
American biochemist
genomic sequences to which the glucocorticoid receptor (GR) binds in order to control gene transcription termed "glucocorticoid response elements". In science
Keith_Yamamoto
Chemical compound
Meclorisone (developmental code name NSC-92353) is a synthetic glucocorticoid corticosteroid which was never marketed. Elks J (14 November 2014). The Dictionary
Meclorisone
Protein-coding gene in the species Homo sapiens
adrenocorticotropic hormone (ACTH) in the adrenal gland leading to stimulation of glucocorticoid synthesis. Human MRAP is found mainly in the adrenal gland and adipose
Melanocortin 2 receptor accessory protein
Melanocortin_2_receptor_accessory_protein
Chemical compound
form is generally regarded as safe in pregnancy. Beclometasone is a glucocorticoid. Beclomethasone, as beclomethasone dipropionate, was first patented
Beclometasone
Swiss neuroscientist
Switzerland. He is known for his pioneering research into the use of glucocorticoids (cortisol) in the treatment of PTSD and phobias. He is understood to
Dominique_de_Quervain
Medical condition
use of glucocorticoids in a patient who may or may not have had diabetes in the past. Steroid diabetes is caused by the use of glucocorticoids. Traditional
Steroid-induced_diabetes
Protein-coding gene in the species Homo sapiens
Glucocorticoid modulatory element-binding protein 1 is a protein that in humans is encoded by the GMEB1 gene. This gene is a member of KDWK gene family
GMEB1
Medical condition
involves hormone replacement therapy to provide adequate levels of glucocorticoids and mineralocorticoids. Regular monitoring is necessary to optimize
Congenital adrenal hyperplasia due to 21-hydroxylase deficiency
Congenital_adrenal_hyperplasia_due_to_21-hydroxylase_deficiency
Endocrine disorder
damage or destruction of the adrenal cortex. These deficiencies include glucocorticoid and mineralocorticoid hormones as well. These are adrenal dysgenesis
Addison's_disease
Chemical reaction
pollutants, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids, fatty acid derivatives, retinoids, and bile acids. These linkages
Glucuronidation
Pharmaceutical drug
Deflazacort, sold under the brand name Calcort among others, is a glucocorticoid belonging to acetonides or O-isopropylidene derivative. It is used as
Deflazacort
Medication
of progestogens like progesterone. It has very weak androgenic and glucocorticoid activity and no other important hormonal activity. The medication is
Desogestrel
Contagious disease caused by SARS-CoV-2
themselves at home and wear a face mask. As of November 2020 use of the glucocorticoid dexamethasone had been strongly recommended in those severe cases treated
COVID-19
Medical condition
100-fold elevations of corticosterone have enough weak glucocorticoid activity to prevent glucocorticoid deficiency and adrenal crisis. Genetic females affected
Congenital adrenal hyperplasia due to 17α-hydroxylase deficiency
Congenital_adrenal_hyperplasia_due_to_17α-hydroxylase_deficiency
Chemical compound
Hydrocortisone 17-butyrate is a form of hydrocortisone butyrate. Glucocorticoid Corticosteroid Brogden, R.N.; Pinder, R.M.; Sawyer, Phyllis R.; Speight
Hydrocortisone_17-butyrate
Medical condition
shown suppression of cortisol by over 30%. These tests are based on the glucocorticoid sensitivity of pituitary adenomas compared to non-pituitary tumors.
Cushing's_disease
Chemical compound
thrush in people with neutropenia. Clotrimazole may be compounded with a glucocorticoid, such as betamethasone, in a topical cream for the treatment of tinea
Clotrimazole
Type of corticosteroid medication
inhaled form is generally safe in pregnancy. Budesonide chiefly acts as a glucocorticoid. Budesonide was initially patented in 1973. Commercial use as an asthma
Budesonide
Chemical compound
(developmental code name RU-24476), or locicortone, is a synthetic glucocorticoid corticosteroid which was never marketed. Negwer M, Scharnow HG (2001)
Locicortolone
Genetic disorders of the adrenal gland
disorders involve excessive or deficient production of hormones such as glucocorticoids, mineralocorticoids, or sex steroids, and can alter development of
Congenital adrenal hyperplasia
Congenital_adrenal_hyperplasia
M3 gene doping); S6 stimulants; S7 narcotics; S8 cannabinoids; S9 glucocorticoids; P1 beta-blockers. Blood doping is the injection of red blood cells
List of drugs banned by the World Anti-Doping Agency
List_of_drugs_banned_by_the_World_Anti-Doping_Agency
Protein-coding gene in the species Homo sapiens
is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response
SGK2
Protein-coding gene in the species Homo sapiens
necrosis factor receptor superfamily member 18 (TNFRSF18), also known as glucocorticoid-induced TNFR-related protein (GITR) or CD357. GITR is encoded and tnfrsf18
TNFRSF18
Pandemic caused by SARS-CoV-2
treatment in hospital. In those with low oxygen levels, use of the glucocorticoid dexamethasone is recommended to reduce mortality. Noninvasive ventilation
COVID-19_pandemic
Basophilic cell in anterior pituitary that produces pro-opiomelanocortin
Adrenocorticotropin hormone stimulates the adrenal cortex to release glucocorticoids and plays an important role in the stress response. The primary function
Corticotropic_cell
Chemical compound
Betamethasone valerate is a synthetic glucocorticoid ester. It is the 17-valerate ester of betamethasone. Betamethasone valerate is often used to treat
Betamethasone_valerate
Chemical compound
Paramethasone acetate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. It is the acetate ester of paramethasone. Paramethasone
Paramethasone_acetate
Chemical compound
or simply tetrahydrocorticosterone (THB or THCC), is an endogenous glucocorticoid hormone. 5α-Dihydrocorticosterone Tetrahydrodeoxycorticosterone
Tetrahydrocorticosterone
Middle and widest zone of the adrenal cortex
fasciculata chiefly produces glucocorticoids (mainly cortisol in humans), which regulate the metabolism of glucose. Glucocorticoid production is stimulated
Zona_fasciculata
Human monoclonal antibody
in men with osteoporosis at high risk for fracture; the treatment of glucocorticoid-induced osteoporosis in men and women at high risk for fracture; to
Denosumab
Chemical compound
Hydrocortisone sodium phosphate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. v t e
Hydrocortisone_phosphate
Chemical compound
Fluticasone is a manufactured glucocorticoid used to treat nasal congestion. Both the esters, fluticasone propionate (sold as Flovent) and fluticasone
Fluticasone
Medicinal chemical compound, steroid
acetonide is a corticosteroid. It is specifically a glucocorticoid, or an agonist of the glucocorticoid receptor, that is about five times as potent as cortisol
Triamcinolone_acetonide
Medical condition
can be divided into:[citation needed] mineralocorticoid deficiency, glucocorticoid deficiency, sex steroid deficiency, and damage to gonads caused by lipid
Lipoid congenital adrenal hyperplasia
Lipoid_congenital_adrenal_hyperplasia
Chemical compound
11β-hydroxyl group. 11β-HSD2 is responsible for the inactivation of the glucocorticoids cortisol and corticosterone (into cortisone and 11-dehydrocorticosterone
Fluoxymesterone
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