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Pharmaceutical compound
2C-E, also known as 4-ethyl-2,5-dimethoxyphenethylamine, is a psychedelic drug of the phenethylamine and 2C families. It is taken orally. The drug acts
2C-E
Airborne early warning and control aircraft
piston-engined E-1 Tracer, which was rapidly becoming obsolete. The aircraft's performance has been upgraded with the E-2B and E-2C versions, where most
Grumman_E-2_Hawkeye
Psychedelic drug
(α-methyl-2C-B) DOM (α-methyl-2C-D) 4C-B (α-ethyl-2C-B) β-Methyl-2C-B (BMB) BOH-2C-B (BOHB; β-hydroxy-2C-B) BOB (β-methoxy-2C-B) βk-2C-B (β-keto-2C-B) 2C-DB
2C-B
Family of phenethylamine psychedelics
including 2C-C, 2C-D, 2C-E, 2C-I, and 2C-T-2 among others, are inactive as monoamine releasing agents and reuptake inhibitors. Most of the 2C drugs are
2C_(psychedelics)
Naturally occurring psychedelic compound
most important phenethylamine compounds together with mescaline, 2C-E, 2C-T-7, and 2C-T-2. Bryan Wynter produced Mars Ascends after trying the substance
Mescaline
Pharmaceutical compound
2C-D has been described. Analogues of 2C-D include 2C-B, 2C-E, 2C-P, other 2Cs, DOM (α-methyl-2C-D), Ariadne (4C-D; α-ethyl-2C-D), 5C-D (α-propyl-2C-D)
2C-D
Pharmaceutical compound
chemical synthesis of 2C-P has been described. Analogues of 2C-P include 2C-D, 2C-E, 2C-Bu, 2C-iP, 2C-iBu, DOPR, and 4C-P, among others. 2C-P was first described
2C-P
Psychedelic designer drug
2C-E-FLY is a recreational designer drug with psychedelic effects of the phenethylamine, 2C, and FLY families. It is slightly less potent than 2C-E or
2C-E-FLY
Pharmaceutical compound
2C-G, or 2C-G-0, also known as 3,4-dimethyl-2,5-dimethoxyphenethylamine or as 3-methyl-2C-D, is a psychedelic phenethylamine of the 2C family. First synthesized
2C-G
Pharmaceutical compound
2C-I, also known as 4-iodo-2,5-dimethoxyphenethylamine, is a psychedelic drug of the phenethylamine and 2C families. It is taken orally. 2C-I was first
2C-I
Pharmaceutical compound
These drugs include 2C-B, 2C-C, 2C-D, 2C-E, and 2C-I, among others. The N-methyl derivative of 2C-H, N-methyl-2C-H, has reduced activational potency
2C-H
Reciprocating internal combustion engine
Camry/Vista 1983-1985 The 2C was a long running diesel engine, with some models (e.g. Corona, Townace, Liteace) receiving the turbo version 2C-T which provided
Toyota_C_engine
Psychedelic drug
psychedelic drug of the phenethylamine and 2C families. It was first synthesized in the laboratory of David E. Nichols. Later, it was tested in humans and
2C-TFM
Hallucinogenic class of psychoactive drug
the 2C drugs like 2C-B, 2C-E, and 2C-I, the DOx drugs like DOM, DOB, DOI, certain MDxx drugs like MDA and MDMA (weak psychedelics), FLY drugs like 2C-B-FLY
Psychedelic_drug
Psychedelic drug
tolerance (see Subsect. E.III). Canal CE, Olaghere da Silva UB, Gresch PJ, Watt EE, Sanders-Bush E, Airey DC (April 2010). "The serotonin 2C receptor potently
Dimethyltryptamine
March 2024. Retrieved 29 March 2024. "DXM & 2C-B - Erowid Exp - 'Nexuswalk - A Beautiful Mix of DXM and 2C-B'". erowid.org. Retrieved 18 April 2023. Pergolizzi
List_of_drug_combinations
Species of psychoactive cactus
S. E. & Malenka, R. C. (2001). "Addiction and the brain: The neurobiology of compulsion and its persistence." Neuroscience. 2;696 K B Nolte and R E Zumwalt
Peyote
Chemical compound found in some species of mushrooms
doi:10.1016/j.aca.2004.08.071. Lindenblatt H, Krämer E, Holzmann-Erens P, Gouzoulis-Mayfrank E, Kovar KA (May 1998). "Quantitation of psilocin in human
Psilocybin
Synthetic hallucinogen
25I-NBOMe, also known as 2C-I-NBOMe, Cimbi-5, and shortened to "25I", is a psychedelic drug of the phenethylamine, 2C, and NBOMe (25-NB) families. Since
25I-NBOMe
South American psychoactive decoction
non-religious adaptations, and the development of ayahuasca analogues (i.e., variants) using local or synthetic ingredients. While DMT is internationally
Ayahuasca
Psychedelic drug
2C-B-FLY is a psychedelic and designer drug of the phenethylamine, 2C, and FLY families. It was first described in 1995 by Aaron Monte, Professor of Chemistry
2C-B-FLY
Weight loss medication
No. 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists
Phentermine
Monoamine neurotransmitter
receptors, including the serotonin 5-HT1 (1A, 1B, 1D, 1E, 1F), 5-HT2 (2A, 2B, 2C), 5-HT3, 5-HT4, 5-HT5 (5A, 5B), 5-HT6, and 5-HT7 receptors. Except for the
Serotonin
Pharmaceutical compound
2C-C, also known as 4-chloro-2,5-dimethoxyphenethylamine, is a psychedelic drug of the phenethylamine and 2C families. It is taken orally. 2C-C was first
2C-C
Medication mainly used for depression and smoking cessation
PMC 5947828. PMID 29377409. Livingstone-Banks J, Norris E, Hartmann-Boyce J, West R, Jarvis M, Chubb E, et al. (October 2019). "Relapse prevention interventions
Bupropion
Muscle relaxant medication
43 nM), adrenergic α-1A (5.6 and 34 nM), α-2B (Ki = 21 and 150 nM) and α-2C (Ki = 21 and 48 nM,); H1 (1.3 and 5.6 nM); and M1 (7.9 and 30 nM). Like CBP
Cyclobenzaprine
Pharmaceutical compound
compound of the 2C-T series of psychedelic phenethylamines, with derivatives such as 2C-T-2, 2C-T-4, 2C-T-7, and 2C-T-21, among many others. 2C-T was first
2C-T
Psychedelic drug
The DEA performed a chromatographic analysis of blotter paper containing 2C-C which showed that the paper contained a much greater concentration of the
LSD
Class of chemical compounds
David E. Nichols and colleagues at Purdue University by 1995. 2C-B-FLY 2C-B-ButterFLY (2C-B-MOTH) 2C-B-DragonFLY (2C-B-DFLY) 2C-B-5-hemiFLY 2C-C-FLY 2C-I-FLY
FLY_(psychedelics)
Psychoactive drug, often called ecstasy
LSD, psilocybin mushrooms, 2C-B, and ketamine. The combination with LSD is called "candy-flipping". The combination with 2C-B is called "nexus flipping"
MDMA
Psychedelic phenthylamine drug
2C-T-7, also known as 4-propylthio-2,5-dimethoxyphenethylamine or as Blue Mystic or 7th Heaven, is a psychedelic drug of the phenethylamine and 2C families
2C-T-7
Common name for more than 1,000 species of flowering plants in the family Convolvulaceae
cold. Some species are strictly annual (e.g. Ipomoea nil), producing many seeds, and some perennial species (e.g. I. indica) are propagated by cuttings
Morning_glory
Pharmaceutical compound
2C-Te, also known as 2,5-dimethoxy-4-methyltellurophenethylamine, is a chemical compound of the phenethylamine and 2C families. It is the analogue of
2C-Te
Chemical compound
βk-2C-B, or bk-2C-B, also known as 4-bromo-2,5-dimethoxy-β-ketophenethylamine or as β-keto-2C-B, is a psychedelic drug of the phenethylamine and 2C family
Βk-2C-B
Antidepressant medication
characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors". Naunyn-Schmiedeberg's Arch. Pharmacol. 370 (2): 114–23. doi:10
Trazodone
Pharmaceutical compound
2C-G-5, also known as 3,4-norbornyl-2,5-dimethoxyphenethylamine, is a psychedelic drug of the phenethylamine and 2C families. It is one of several homologues
2C-G-5
Antidepressant medication
Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists
Mirtazapine
Pharmaceutical compound
2C-T-2, also known as 4-ethylthio-2,5-dimethoxyphenethylamine, is a psychedelic drug of the phenethylamine and 2C families. It is taken orally. The drug
2C-T-2
Central nervous system stimulant
can precipitate unpredictable and rapid mood swings, stimulant psychosis (e.g., paranoia, hallucinations, delirium, and delusions), and aggression. Recreationally
Methamphetamine
Medication used for high blood pressure and ADHD
alpha-2 adrenergic radioligand [3H]-MK912 is alpha-2C selective among human alpha-2A, alpha-2B and alpha-2C adrenoceptors". The Journal of Pharmacology and
Guanfacine
Species of fungus
considered a "container" for psilocybin based on how the law is written, i.e., it does not specifically state that psilocybin mushrooms themselves are
Psilocybe_cubensis
Chemical element with atomic number 54 (Xe)
(PDF). Chinese Physics C. 45 (3) 030001. doi:10.1088/1674-1137/abddae. Aprile E, Abe K, Agostini F, Ahmed Maouloud S, Alfonsi M, Althueser L, et al. (August
Xenon
Chemical compound
25E-NBOMe, also known as 2C-E-NBOMe or NBOMe-2C-E, is a derivative of the phenethylamine 2C-E. It acts in a similar manner to related compounds such as
25E-NBOMe
Chemical compound
2C-T-36 (2C-T-TFM) include 2C-T-21 (2C-T-FE), 2C-T-21.5 (2C-T-DFE), 2C-T-22 (2C-T-TFE), 2C-T-28 (2C-T-FP), 2C-T-35 (2C-T-DFM), 2C-T, 2C-TFM, and 2C-TFE, among
2C-T-36
Pharmaceutical compound
2C-5-TOET, also known as 2-methoxy-4-ethyl-5-methylthiophenethylamine or as 5-thio-2C-E, is a chemical compound and possible psychedelic drug of the phenethylamine
2C-5-TOET
Phytocannabinoid discovered in 1940
"Cannabidiol interactions with voltage-gated sodium channels". eLife. 9 e58593. doi:10.7554/eLife.58593. PMC 7641581. PMID 33089780. Nadulski T, Pragst F
Cannabidiol
Mushrooms containing psychoactive indole alkaloids
mushrooms (in that case, among the Mexican [Nahuatl] Indians). Brande E. (1799). "Mr. E. Brande, on a poisonous species of Agaric". The Medical and Physical
Psilocybin_mushroom
Chemical compound
This profile of effects has been described as being analogous to the case of 2C-B. In addition to its use on its own, 4-HO-MET, along with the related tryptamine
4-HO-MET
Subtype of serotonin receptor
with 2C-I, DOIB, 2C-B, 4-HO-DiPT, DOI, 2,5-DMA, DOET, DOM, psilocin, and 2C-H being highly potent and fully efficacious anti-inflammatories; TMA-2, 2C-B-Fly
5-HT2A_receptor
Psychedelic drug
Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 804 - Lists
5-MeO-DMT
Psychedelic drug found in toads, mushrooms and plants
activity and a revised ternary complex mechanism at serotonin 5-HT(2A) and 5-HT(2C) receptors". Synapse. 35 (2): 144–150. doi:10.1002/(SICI)1098-2396(200002
Bufotenin
Entactogen, stimulant, and psychedelic drug of the amphetamine family
robust self-report VAS changes in both MDMA-like (e.g., "closeness to others") and hallucinogen-like (e.g., "familiar things seem unfamiliar", time distortions
3,4-Methylenedioxyamphetamine
Organic chemical that functions both as a hormone and a neurotransmitter
in other words, dopamine signals the perceived motivational prominence (i.e., the desirability or aversiveness) of an outcome, which in turn propels the
Dopamine
Pharmaceutical compound
including of the serotonin 5-HT2A receptor. Analogues of DOM include mescaline, 2C-D, DOET, DOB, DOI, and Ariadne (4C-D), among others. DOM was first synthesized
2,5-Dimethoxy-4-methylamphetamine
2,5-Dimethoxy-4-methylamphetamine
Species of amphibian
troughs. The Colorado River toad is known to breed in artificial water bodies (e.g., flood control impoundments, reservoirs) and as a result, the distributions
Colorado_River_toad
Medication to prevent nausea and vomiting
September 2020. "Zofran Product and Consumer Medicine Information Licence". TGA eBS. Archived from the original on 29 August 2022. Retrieved 28 August 2022
Ondansetron
Atypical antipsychotic medication
Wallace TJ, Zai CC, Brandl EJ, Müller DJ (18 August 2011). "Role of 5-HT(2C) receptor gene variants in antipsychotic-induced weight gain". Pharmacogenomics
Olanzapine
Atypical antipsychotic medication
was sometimes an antagonist (e.g., at 5-HT6), sometimes an inverse agonist (e.g., 5-HT2B), sometimes a partial agonist (e.g., D2S, D3S, D4S, D2L). Aripiprazole
Aripiprazole
Psychoactive substance found in plants in the family Apocynaceae
the synaptogenesis induced by ibogaine is blocked by ketanserin, a 5-HT2A/2C antagonist (Ly et al., 2018). Ly C, Greb AC, Cameron LP, Wong JM, Barragan
Ibogaine
Pharmaceutical compound
2C-Ph, or 2C-Phenyl, also known as 2C-BI-1 or as 2,5-dimethoxy-4-phenylphenethylamine, is a serotonin receptor modulator of the phenethylamine and 2C
2C-Ph
Chemical compound
receptors, including of the serotonin 5-HT2A receptor. Analogues of DOB include 2C-B, DOM, DOI, and Bromo-DragonFLY (DOB-DFLY), among others. DOB was first synthesized
2,5-Dimethoxy-4-bromoamphetamine
2,5-Dimethoxy-4-bromoamphetamine
Sedating antidepressant
receptors[14]–[16]. Landolt HP, Wehrle R (May 2009). "Antagonism of serotonergic 5-HT2A/2C receptors: mutual improvement of sleep, cognition and mood?". The European
Doxepin
Pharmaceutical compound
2C-I-FLY is a psychedelic drug of the phenethylamine, 2C, and FLY families. It is the FLY (benzodifuran) derivative of 2C-I and an analogue of 2C-B-FLY
2C-I-FLY
Medication mainly used to treat gout
number of chromosomes (i.e., tetraploid instead of diploid), and lead to cell nuclei with double the usual number of chromosomes (i.e., tetraploid instead
Colchicine
Species of plant
ISSN 0102-695X. Archived (PDF) from the original on 2010-08-21. Rivera-Arce E, Chávez-Soto MA, Herrera-Arellano A, et al. (February 2007). "Therapeutic
Mimosa_tenuiflora
Chemical class of organic compounds
3-phenylpiperidine, 3-PPP, OSU-6162 (PNU-96391), LPH-5, LPH-48, 2C-B-3PIP, 2C-B-3PIP-NBOMe, 2C-B-3PIP-POMe, and Z3517967757 (Z7757) 2-Phenylmorpholines like
Substituted_phenethylamine
1991 book by Alexander Shulgin and Ann Shulgin
follows: 2C-B (2,5-dimethoxy-4-bromophenethylamine) 2C-E (2,5-dimethoxy-4-ethylphenethylamine) 2C-T-2 (2,5-dimethoxy-4-ethylthiophenethylamine) 2C-T-7 (2
PiHKAL
Pharmaceutical compound
2C-B-AN, also known as 4-bromo-N-(α′-cyanobenzyl)-2,5-dimethoxyphenethylamine or as brolphetaminil, is a psychedelic drug of the phenethylamine, 2C, and
2C-B-AN
Synthetic opioid pain medication
(May 2004). "The inhibitory effects of tramadol on 5-hydroxytryptamine type 2C receptors expressed in Xenopus oocytes". Anesthesia and Analgesia. 98 (5):
Tramadol
Psychoactive drug
Burkhart JP, Burkholder TM, et al. Aminoalkylbenzofurans as serotonin (5-HT(2c)) agonists. 7045545 (US patent). Published 2000-01-19, issued 2006-16-03.
6-APB
SSRI antidepressant
NSAIDs, antiplatelet drugs, anticoagulants, omega-3 fatty acids, vitamin E, and garlic supplements must be careful when taking fluoxetine or other SSRIs
Fluoxetine
Psychedelic drug
(October 2005). "SAR of psilocybin analogs: discovery of a selective 5-HT 2C agonist". Bioorganic & Medicinal Chemistry Letters. 15 (20): 4555–4559. doi:10
Psilocin
CNS stimulant and isomer of amphetamine
anxiety, and irritability, among others. At excessive doses, psychosis (i.e., hallucinations, delusions), addiction, and rapid muscle breakdown may occur
Dextroamphetamine
Psychoactive substance that induces spiritual experiences
2004; Sobiecki 2002, 2008, 2012). Among the amaXhosa, the artificial drug 2C-B is used as entheogen by traditional healers or amagqirha over their traditional
Entheogen
Chemical compound
25E-NBOH (2C-E-NBOH, NBOH-2C-E) is a derivative of the phenethylamine derived hallucinogen 2C-E. It was first developed by Martin Hansen at the University
25E-NBOH
Medication used to treat anxiety disorders
Structures and Bibliographies. Springer. pp. 192–. ISBN 978-1-4757-2085-3. "TGA eBS - Product and Consumer Medicine Information Licence". "Anksilon (Orion Pharma
Buspirone
Genus of plants
original on 5 May 2015. Retrieved 17 November 2015. Nambiar, E.K. Sadanandan; Harwood, Christopher E.; Kien, Nguyen Duc (2015). "Acacia plantations in Vietnam:
Acacia
Pharmaceutical drug
000 people taking mefloquine for malaria prevention, with milder events (e.g., dizziness, headache, insomnia, and vivid dreams) in up to 25%. When some
Mefloquine
Pharmaceutical compound
2C-tBu, or 2C-t-Bu, also known as 4-tert-butyl-2,5-dimethoxyphenethylamine, is a serotonin receptor agonist and putative serotonergic psychedelic of the
2C-tBu
Atypical antipsychotic medication
extrapyramidal side-effect liability. Owing to the risks associated with clozapine (e.g. agranulocytosis, diabetes mellitus, etc.), clinicians often attempt treatment
Quetiapine
Chemical compound
is a psychedelic drug of the phenethylamine, 2C, and N-benzylphenethylamine families related to 2C-B and 25B-NBOMe. It has been sold and encountered
25B-NBOH
Species of fungus
(2): 181–95. doi:10.33585/cmy.64207. Borovička, Jan; Noordeloos, Machiel E.; Gryndler, Milan; Oborník, Miroslav (2010). "Molecular phylogeny of Psilocybe
Psilocybe_cyanescens
Metabolite of the amino acid tryptophan
activity and a revised ternary complex mechanism at serotonin 5-HT(2A) and 5-HT(2C) receptors". Synapse. 35 (2): 144–150. doi:10.1002/(SICI)1098-2396(200002
Tryptamine
Psychoactive drug
and 4C families. It is a close analogue of the psychedelic drugs 2C-D and DOM, with 2C-D having no substitution at the α carbon, DOM having an α-methyl
Ariadne_(drug)
2C-B 2CB-2OCD3 2CB-5OCD3 2C-Bu 2C-C 2C-CN 2C-CP 2C-D 2C-E 2C-EF 2C-F 2C-H 2C-I 2C-iBu 2C-iP 2C-N 2C-P 2C-Se 2C-Se-TFM 2C-tBu 2C-TFE 2C-TFM 2C-YN 2C-V
List_of_psychedelic_drugs
Pharmaceutical compound
other notable 2C psychedelics including 2C-B, 2C-D, 2C-T, 2C-P, and 2C-T-7. The chemical synthesis of 2C-CN has been described. 2C-CN is the 2C parent compound
2C-CN
Chemical compound
4 (2): 147–150. CiteSeerX 10.1.1.688.3796. doi:10.1080/10298420290015827. eISSN 1476-3524. ISSN 1029-8428. OCLC 50166444. PMID 12829415. S2CID 37594882
Adrenochrome
Tricyclic antidepressant
it is frequently used to treat painful paresthesias in the arms and legs (e.g., burning sensations, pins and needles, stabbing pains) caused by damage
Amitriptyline
Pharmaceutical compound
2C-DB, also known as 2,5-dimethoxy-4,6-dibromophenethylamine or as 6-bromo-2C-B, is a psychedelic drug of the phenethylamine and 2C families related to
2C-DB
Drug mixture used mainly to treat ADHD and narcolepsy
cause rapid muscle breakdown, provoke panic attacks, or induce psychosis (e.g., paranoia, delusions, hallucinations). The side effects vary widely among
Adderall
Species of plant
Mediterranean Plant Protection Organization (EPPO). Retrieved 5 February 2026. E. Al-Assmar, Sami (1999). "The Seeds of the Hawaiian Baby Woodrose Are a Powerful
Argyreia_nervosa
Perennial flowering plant in the coffee family Rubiaceae
side of this scar there is a dense, usually furry line of fine trichomes (i.e., plant hairs) usually 0.5–1 mm (0.020–0.039 in) long that are reddish brown
Psychotria_viridis
Species of fungus
2022.01.003. ISSN 1878-6146. PMID 35314062. Windsor, Coleton; Kreynes, Anna E; Chilton, Jeff S; Chioffi, William A; Niebergall, Christopher; Dodds, Kelsey
Psilocybe_azurescens
Mescaline-containing cactus
one reason it is widely cultivated as an ornamental and landscaping plant. E. pachanoi is normally 3–6 m (10–20 ft) tall and has multiple branches, usually
Echinopsis_pachanoi
CHCl3, historical anaesthetic and common solvent
(This had caused me to impose the name "chloroform" upon this substance [i.e., formyl chloride or chloride of formic acid].) In 1835, Dumas prepared the
Chloroform
Chemical compound
effects having not yet been explored. Analogues of 2C-CP include 2C-CPE, 2C-IP, 2C-P, 2C-T-15, 2C-V, and 2C-YN, among others. The drug is a controlled substance
2C-CP
Pharmaceutical compound
lesser-known psychedelic drug of the phenethylamine and 2C families related to 2C-E and 2C-TFM. It was first synthesised by Daniel Trachsel, and is reportedly a
2C-TFE
Fungi of the genus Claviceps
culminating on the one hand in development of drugs both legal (e.g., bromocriptine) and illegal (e.g., LSD), and on the other hand in extensive knowledge of
Ergot
Drug combination prescribed for weight loss; later withdrawn from market
Children". The New York Times. p. 21. Retrieved September 23, 2023. Hayward E (6 May 1997). "Diet to Death". Boston Herald. p. 1. Archived from the original
Fenfluramine/phentermine
Chemical compound
2C-F, also known as 4-fluoro-2,5-dimethoxyphenethylamine, is a psychedelic drug of the phenethylamine and 2C families. It is taken orally. In his book
2C-F
2C E
2C E
2C E
2C E
2C E
2C E
2C E
2C E
2C E