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Human protein
Urokinase, also known as urokinase-type plasminogen activator (uPA), is a serine protease present in humans and other animals. The human urokinase protein
Urokinase
Mammalian protein found in Homo sapiens
The Urokinase receptor, also known as urokinase plasminogen activator surface receptor (uPAR) or CD87 (Cluster of Differentiation 87), is a protein encoded
Urokinase_receptor
Soluble urokinase plasminogen activator receptor (suPAR) (NCBI Accession no. AAK31795) is a protein and the soluble form of uPAR. uPAR is expressed mainly
Soluble urokinase plasminogen activator receptor
Soluble_urokinase_plasminogen_activator_receptor
Chemical compound
with weak potency (IC50 = 87 mM), and it can block the active-site of urokinase plasminogen activator (uPA) with high specificity (Ki = 2 mM), one of
Tranexamic_acid
German nephrologist (born 1971)
pathogenesis of kidney diseases. Reiser discovered the role of suPAR (soluble urokinase plasminogen activator receptor) as a global, circulating risk factor for
Jochen_Reiser
Type of protein
formed during blood clotting. There are two main plasminogen activators: urokinase (uPA) and tissue plasminogen activator (tPA). Tissue plasminogen activators
Plasminogen_activator
Process of formation of blood clots
Thrombophilia Urokinase Activates plasminogen Quebec platelet disorder Plasminogen activator inhibitor-1 PAI-1 Inactivates tPA and urokinase (endothelial
Coagulation
Human protein
the principal inhibitor of tissue-type plasminogen activator (tPA) and urokinase (uPA), the activators of plasminogen and hence fibrinolysis (the physiological
Plasminogen activator inhibitor-1
Plasminogen_activator_inhibitor-1
Life-threatening response to infection
better patient outcomes. A 2012 systematic review found that soluble urokinase-type plasminogen activator receptor (SuPAR) is a nonspecific marker of
Sepsis
Pharmaceutical drug
failure, as determined by blood levels of a protein called suPAR (soluble urokinase plasminogen activator receptor) of at least 6 ng per ml." In November
Anakinra
Chemical compound
Mesupron) is a drug which acts as an inhibitor of the serine protease enzyme urokinase. It is under development as a potential treatment agent for pancreatic
Upamostat
Liquid by-product of animal metabolism
Kumar, A. (2006). "Urokinase separation from cell culture broth of a human kidney cell line and comparison with urine-derived urokinase". International Journal
Urine
Medical condition
disorder is characterized by large amounts of the fibrinolytic enzyme urokinase-type plasminogen activator (uPA) in platelets. This causes accelerated
Quebec_platelet_disorder
Process that prevents blood clots from growing
into the clot when it is formed. Tissue plasminogen activator (t-PA) and urokinase are the agents that convert plasminogen to the active plasmin, thus allowing
Fibrinolysis
Ly6 also known as lymphocyte antigen 6 or urokinase-type plasminogen activator receptor (uPAR) is family of proteins that share a common structure but
Ly6
Breakdown (lysis) of blood clots formed in blood vessels, using medication
[citation needed] Some fibrinolytics are: Streptokinase (Kabikinase) Urokinase Recombinant tissue plasminogen activators (rtPA) Alteplase (Activase or
Thrombolysis
Coagulation factor protein found in humans
coagulation factor that inactivates tissue plasminogen activator and urokinase. It is present in most cells, especially monocytes/macrophages. PAI-2
Plasminogen activator inhibitor-2
Plasminogen_activator_inhibitor-2
Phenotype of senescent cells which secrete certain substances
microRNA, DNA fragments, chemokines, and other bioactive factors. Soluble urokinase plasminogen activator surface receptor is part of SASP, and has been used
Senescence-associated secretory phenotype
Senescence-associated_secretory_phenotype
enzyme-linked immunosorbent assay (ELISA) that measures the amount of soluble urokinase plasminogen activator receptor (suPAR) in blood. Elevated plasma suPAR
Suparnostic
Class of prescription drugs in India
TRIPOTASSIUM DICITRATE BISMUTHATE 518. TROMANTADINE HYDROCHLORIDE 519. UROKINASE 520. VALSARTAN 521. VASOPRESSIN 522. VECURONIUM BROMIDE 523. VENLAFAXINE
Schedule_H
American immunologist and microbiologist
receive a patent in molecular biology, for a new production method of urokinase. Nicol was born in Little Rock, Kentucky. Her parents were Daniel Eugene
Evelyn_Nicol
Autonomous protein domains
varying number of copies in some plasma proteins including prothrombin and urokinase-type plasminogen activator, which are serine proteases belonging to MEROPS
Kringle_domain
Protein family
variable inhibition of the blood peptidases Factor Xa, thrombin, and urokinase-type plasminogen activator. MEROPS entry for ecotin MEROPS peptidase family
Ecotin
Catheter intended for long periods of use
complications may include catheter occlusion, phlebitis and bleeding. Urokinase or low-dose tissue plasminogen activator (tPA) may be required to break
Peripherally inserted central catheter
Peripherally_inserted_central_catheter
Medical condition
Organization (WHO): One study has proposed that elevated levels of soluble urokinase-type plasminogen activator receptor (SuPAR) in seminal plasma might be
Male accessory gland infection
Male_accessory_gland_infection
Acronym for lipoxygenase interaction product
humanin, and a cleaved soluble fragment (amino acids 274–388) from the urokinase receptor; and d) other SPMs including resolvins RvD1, RvD2, RvD5, AT-RvD1
Lipoxin
American medical researcher and vascular surgeon
Complications In Endovascular Therapy 1998, paper, A comparison of recombinant urokinase with vascular surgery as initial treatment for acute arterial occlusion
Kenneth_Ouriel
Enzyme
Saruplase is a fibrinolytic enzyme. It is closely related to urokinase. Bär FW, Vermeer F, Michels R, et al. (1995). "Saruplase in Myocardial Infarction"
Saruplase
remodelling. Tissue plasminogen activator (tPA), and urokinase plasminogen activator (urokinase, uPA) are serine proteases which cleave and activate plasminogen
Proteases_in_angiogenesis
Presence of blood in urine
retention. Blood clots that remain in the bladder are digested by urinary urokinase producing fibrin fragments. These fibrin fragments are natural anticoagulants
Hematuria
Enzyme in human blood that degrades clots and other proteins
plasminogen activator. Urokinase plasminogen activator receptor (uPAR) is a cofactor for plasminogen activation by urokinase plasminogen activator. The
Plasmin
Restriction in blood supply to tissues
g., recombinant tissue plasminogen activator (tPA), streptokinase, or urokinase). A percutaneous catheter inserted into the femoral artery and threaded
Ischemia
Natural regrowth of damaged liver tissue
mechanical stress causes epithelial cells to express an increased activity of urokinase plasminogen activator (uPA). Increased uPA activity initiates conversion
Liver_regeneration
Heparin Rivaroxaban Warfarin Alteplase Reteplase Streptokinase Tenecteplase Urokinase Loop diuretics: bumetanide ethacrynic acid furosemide torsemide Thiazide
List of cardiac pharmaceutical agents
List_of_cardiac_pharmaceutical_agents
Restoring blood flow post-heart attack
effective. Currently available thrombolytic agents include streptokinase, urokinase, and alteplase (recombinant tissue plasminogen activator, rtPA). More
Reperfusion_therapy
related infection and a decrease of the use of thrombolytic agents like urokinase or tissue plasminogen activator (t-PA). Taurolidine/heparin (Defencath)
Catheter_lock_solution
Chemical compound
it increases activity of the enzymes tissue plasminogen activator and urokinase, which are involved in the blood clotting cascade. It has been researched
TM5441
Tear of the inner lining of the vertebral artery
blood clots. This is achieved by the administration of a drug (such as urokinase or alteplase) that activates plasmin, an enzyme that occurs naturally
Vertebral_artery_dissection
Protein-coding gene in the species Homo sapiens
to a DNA element involved in the phorbol ester induction of the human urokinase gene". EMBO J. 11 (1): 205–13. doi:10.1002/j.1460-2075.1992.tb05043.x
REL
Chemical compound
thereby increasing activity of the enzymes tissue plasminogen activator and urokinase, which are involved in the blood clotting cascade. Inhibition of PAI-1
Tiplasinin
Type of drug intended to protect the brain after stroke onset
stroke outcome in this individual patient data meta-analysis. 9 0 0 17 Urokinase 1976 Thrombolytic 53 12 13 1 0 18 Atorvastatin 2015 Statin considered
Cerebroprotectant
Enzyme involved in breakdown of extracellular matrix
A, English WR, Resnati M, et al. (2003). "Metalloproteases cleave the urokinase-type plasminogen activator receptor in the D1-D2 linker region and expose
Matrix_metallopeptidase_12
Protein
the extracellular matrix. The Somatomedin B domain interacts with the urokinase receptor, and this interaction has been implicated in cell migration and
Vitronectin
Biological catalysts used in production
Pharmaceutical Lymphatic cancer therapeutic Ficin Pharmaceutical Digestive aid Urokinase Pharmaceutical Anticoagulant β-Lactamase Pharmaceutical Penicillin allergy
Industrial_enzymes
Mammalian protein found in Homo sapiens
suppressor. Notably, LRP1 functions in clearing proteases such as plasmin, urokinase-type plasminogen activator, and metalloproteinases, which contributes
LRP1
Topics referred to by the same term
Particle Attribution, a mechanism to prevent ambiguity in XML Schema Urokinase, an enzyme involved in the biology of humans and other animals Ulipristal
Upa
Enzyme involved in blood coagulation in humans
OF UROKINASE TYPE PLASMINOGEN ACTIVATOR 1c5n: STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE
Thrombin
Protein superfamily
the small globular protein lymphocyte antigen 6 (LY6) family and the urokinase plasminogen activator receptor (uPAR). Other receptors with LU domains
Three-finger_protein
Protein domain
domain of vitronectin has been demonstrated to interact with both the urokinase receptor and the plasminogen activator inhibitor-1 (PAI-1) and the conserved
Somatomedin_B
Danish physician-scientist (born 1963)
reached first-in-human clinical use. Examples include first-in-humans with urokinase plasminogen activator receptor (uPAR)-PET, a marker of cancer aggressiveness
Andreas_Kjær_(scientist)
Protein found in humans
"Mannose 6-Phosphate/Insulin-like Growth Factor–II Receptor Targets the Urokinase Receptor to Lysosomes via a Novel Binding Interaction". J. Cell Biol.
Insulin-like growth factor 2 receptor
Insulin-like_growth_factor_2_receptor
Protein-coding gene in the species Homo sapiens
(2003). "Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell surface and inhibits cell migration"
LRP1B
Blood accumulation in the pleural cavity
unavailable, an alternative is fibrinolytic therapy such as streptokinase or urokinase given directly into the pleural space seven to ten days after the injury
Hemothorax
Anticoagulant enzyme
that cannot be dissolved by other compounds, such as streptokinase and urokinase.[citation needed] The processes of blood anticoagulation by hementin includes
Hementin
American biochemist (born c. 1955)
487–98. PMID 2222810 Degen SJ, Heckel JL, Reich E, Degen JL. The murine urokinase-type plasminogen activator gene. Biochemistry. 26: 8270–9. PMID 2831940
Sandra_J._F._Degen
Health issue in China
of dividing neuroprotectors in stroke. The clinical therapy test with urokinase and defibrase for cerebral infarction in China is effective and relatively
Stroke_in_China
Low-density lipoprotein containing apolipoprotein(a)
of pericellular plasminogen activation by apolipoprotein(a): Roles of urokinase plasminogen activator receptor and integrins αMβ2 and αVβ3". Atherosclerosis
Lipoprotein(a)
Mammalian protein found in Homo sapiens
SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR 1ezq: CRYSTAL STRUCTURE OF HUMAN COAGULATION
Factor_X
Topics referred to by the same term
Plau may refer to: Urokinase Plau am See, Germany Plau am See (Amt) Pław, Poland Henrik Plau (born 1988), Norwegian actor Plaus This disambiguation page
Plau
Protein-coding gene in the species Homo sapiens
of other proteases, including matrix metalloproteinase, urokinase (serine protease urokinase plasminogen activator), and cathepsin D, and thus it has
Cathepsin_B
Protein-coding gene in the species Homo sapiens
"Novel mutations in the gene encoding secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related protein-1 (SLURP-1) and description
SLURP1
Primary type of cell found in the epidermis
Shen, Y Guo, C Du, M Wilczynska, S Hellström, T Ny, Mice Deficient in Urokinase-Type Plasminogen Activator Have Delayed Healing of Tympanic Membrane Perforations
Keratinocyte
Protein-coding gene in the species Homo sapiens
shown to cleave and activate hepatocyte growth factor/scatter factor, and urokinase plasminogen activator, which suggest the function of this protease as
ST14
dual therapy combination of mutant prourokinase (the precursor form of urokinase) and a small dose of tPA [Tissue Plasminogen Activator]. TSI is developing
Thrombolytic Science International
Thrombolytic_Science_International
Drug classification – antithrombotic agents
B01AD01 Streptokinase B01AD02 Alteplase B01AD03 Anistreplase B01AD04 Urokinase B01AD05 Fibrinolysin B01AD06 Brinase B01AD07 Reteplase B01AD08 Saruplase
ATC_code_B01
American cell biologist
Bernstein, AM; Twining, SS; Warejcka, DJ; Tall, E; Masur, SK (2007). "Urokinase receptor cleavage: a crucial step in fibroblast-to-myofibroblast differentiation"
Sandra_K._Masur
Blood purification procedure using the abdominal peritoneum
frequently used treatments such as routine peritoneal lavage or use of urokinase. The use of preventative nasal mupirocin is of unclear effect with respect
Peritoneal_dialysis
Extracellular metalloprotease expressed by S. aureus
staphylocoagulation, aureolysin is responsible for the activation of urokinase, and inactivation of α2-antiplasmin and plasminogen activator inhibitor-1
Aureolysin
Protein-coding gene in the species Homo sapiens
isoforms containing epitope v9 and subsequently suppresses expression of urokinase-type plasminogen activator in human chondrosarcoma cells". The Journal
SPINT2
Genus of bacteria
Coppi, Marco; Rossolini, Gian Maria; Giuliani, Claudia (July 2023). "A urokinase-associated outbreak of Ralstonia mannitolilytica bloodstream infections
Ralstonia
Protein-coding gene in the species Homo sapiens
CV, Kim HR (2005). "Platelet-Derived Growth Factor D Is Activated by Urokinase Plasminogen Activator in Prostate Carcinoma Cells". Mol. Cell. Biol. 25
PDGFD
Protein family
Lin CY (November 2000). "Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine protease"
Matriptase
Type of molecule that may be able to induce death of senescent cells
drug dasatinib and the experimental small molecule navitoclax. Soluble urokinase plasminogen activator surface receptor have been found to be highly expressed
Senolytic
Croatian cell and molecular biologist
of Zagreb. Her dissertation in 2002 was titled The expression of the urokinase plasminogen activator gene in bladder carcinoma cell lines. Her doctoral
Jadranka_Lončarek
Greek-American pathologist
derived from release of HGF from hepatic extracellular matrix mediated by urokinase activation and coinciding with liver regeneration signals. These studies
George_Michalopoulos
Human protein
communicated by malignant cells smothers tumor invasion by hindering urokinase-sort plasminogen activator, and restrains tumor development and metastasis
Protein_C_inhibitor
Thrombolytic medication
catheter occlusion, such as tenecteplase, reteplase, and recombinant urokinase, offer the advantage of shorter dwell times than alteplase. A person should
Alteplase
Mammalian protein found in Homo sapiens
evidence for a role in the regulation of the mesenchymal cell phenotype and urokinase expression". Developmental Dynamics. 214 (1): 92–100. doi:10
Hepatocyte growth factor receptor
Hepatocyte_growth_factor_receptor
Human glycoprotein
suppressing the production of proMMP-1 and proMMP, prostaglandin H2 synthase-2, urokinase, CXC chemokine, pro-inflammatory cytokines, inducible nitric oxide synthase
Ulinastatin
Phenomenon characterized by the cessation of cell division
alternative means to senolytic drugs for the elimination of senescent cells. Urokinase receptors have been found to be highly expressed on senescent cells, leading
Cellular_senescence
Protein-coding gene in humans
gene--phylogenetic and functional relationship with blood coagulation factor XII, urokinase, and tissue-type plasminogen activator". Eur. J. Biochem. 258 (2): 355–61
HGFAC
Adult and pediatric nephrologist
articles, according to Microsoft Academic. Wei, Changli, et al. “Circulating Urokinase Receptor as a Cause of Focal Segmental Glomerulosclerosis.” Nature Medicine
Minnie_Sarwal
Soviet and Russian biochemist (born 1946)
particular, a lot of research was focused on the role of urokinase-type plasminogen activator (Urokinase, uPA) in angiogenesis and vessel remodeling. It was
Vsevolod_Tkachuk
CendR elements can be activated by proteolytic cleavage (e.g. by furin, urokinase type plasminogen activator, and other proteases of suitable substrate
CendR
proteinase. EC 3.4.23.21, rhizopuspepsin EC 3.4.99.26: Transferred entry: urokinase. Now EC 3.4.21.68, t-plasminogen activator EC 3.4.99.27: Deleted entry:
List_of_EC_numbers_(EC_3)
Enzyme in humans
WT, Petty HR (October 2002). "Molecular proximity of seprase and the urokinase-type plasminogen activator receptor on malignant melanoma cell membranes:
Fibroblast activation protein, alpha
Fibroblast_activation_protein,_alpha
Protein-coding gene in the species Homo sapiens
and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates". The Journal of Biological Chemistry
Protease-activated_receptor_2
receive a patent in molecular biology, for a new production method of urokinase. Ogonna Nnamani is a physician and a resident in plastic and reconstructive
List of African-American women in medicine
List_of_African-American_women_in_medicine
Protein-coding gene in the species Homo sapiens
"Identification of a novel nucleus protein involved in the regulation of urokinase in 95D cells". Acta Biochim. Biophys. Sin. (Shanghai). 37 (5): 303–9.
RSL1D1
Protein-coding gene in the species Homo sapiens
Capozzoli M, et al. (1999). "Urokinase receptor interacts with alpha(v)beta5 vitronectin receptor, promoting urokinase-dependent cell migration in breast
Integrin_beta_5
Protein-coding gene in the species Homo sapiens
DJ (1998). "Ligand binding to macrophage scavenger receptor-A induces urokinase-type plasminogen activator expression by a protein kinase-dependent signaling
MSR1
Protein domain
small globular proteins such as CD59 antigen, LYNX1, SLURP1, and SLURP2. Urokinase plasminogen activator surface receptor InterPro: IPR003631 Cell-surface
LU_domain
receive a patent in molecular biology, for a new production method of urokinase Victoria Chibuogu Nneji computer scientist, design and innovation strategist
List of African-American women in STEM fields
List_of_African-American_women_in_STEM_fields
Italian medical scientist
"Differentiation-enhanced binding of the amino-terminal fragment of human urokinase plasminogen activator to a specific receptor on U937 monocytes". Proceedings
Francesco_Blasi
Protein family
(CLEC13D), CD206, MMR MRC2 Macrophage mannose receptor 2 C-type mannose receptor 2, Urokinase-type plasminogen activator receptor-associated protein, CD280
Mannose_receptor
Protein-coding gene in the species Homo sapiens
cobratoxin. As a prototoxin, LYPD6B also belongs to the protein family of Ly-6/urokinase plasminogen activator receptor (Ly6/uPAR). It has a 3-fingered motif secondary
LYPD6B
Electric current produced in living cells
(2013). "CFTR suppresses tumor progression through miR-193b targeting urokinase plasminogen activator (uPA) in prostate cancer". Oncogene. 32 (18): 2282–2291
Developmental_bioelectricity
Protein-coding gene in the species Homo sapiens
with numerous proteases involved in angiogenesis, including plasminogen, urokinase, matrix metalloproteinase, thrombin, cathepsin, and elastase. Thrombospondin-1
Thrombospondin_1
Mammalian protein found in Homo sapiens
Koshelnick Y, Ehart M, Hufnagl P, Heinrich PC, Binder BR (Nov 1997). "Urokinase receptor is associated with the components of the JAK1/STAT1 signaling
Glycoprotein_130
Protein-coding gene in humans
the proteolytic process of the precursors of tumor necrosis factors and urokinase plasminogen activators. MMP7 cleaves cell surface proteins, promotes adhesion
MMP7
UROKINASE
UROKINASE
UROKINASE
UROKINASE
Girl/Female
Arabic, Muslim
Blossom
Boy/Male
Hindu, Indian
Protected by God
Boy/Male
Muslim/Islamic
Sun of religion
Boy/Male
American, British, Danish, Dutch, English, Finnish, French, German, Greek, Hindu, Indian, Latin, Swedish
Brave as a Lion; Strong Like a Lion; Lion Man; Man Like a Man
Male
Scottish
Scottish form of Old French Hugues, HEW means "heart," "mind," or "spirit."Â
Surname or Lastname
Probably an altered spelling of German Kobs or Kops.English
Probably an altered spelling of German Kobs or Kops.English : patronymic from Cobb.
Girl/Female
Indian
A songbird
Boy/Male
Muslim
Lion, Famous
Girl/Female
Indian
Hindu Holly Book Saama Vedha
Boy/Male
American, Australian, British, English
Lives in the Valley; Small Valley
UROKINASE
UROKINASE
UROKINASE
UROKINASE
UROKINASE