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Chemical compound
Trypanothione is an unusual form of glutathione containing two molecules of glutathione joined by a spermidine (polyamine) linker. It is found in parasitic
Trypanothione
Medication used to treat sleeping sickness
mechanism of action is not fully understood, its covalent binding to trypanothione to form the toxic Mel T complex is thought to play a large role. Melarsoprol
Melarsoprol
Class of enzymes
In enzymology, a trypanothione synthase (EC 6.3.1.9) is an enzyme that catalyzes the chemical reaction glutathione + glutathionylspermidine + ATP ⇌ {\displaystyle
Trypanothione_synthase
Enzyme
glutathione reduction is performed by either the thioredoxin or the trypanothione system, respectively. Glutathione plays a key role in maintaining proper
Glutathione_reductase
Molecule that blocks enzyme activity
an enzyme in more than one way. For example, in the figure showing trypanothione reductase from the human protozoan parasite Trypanosoma cruzi, two molecules
Enzyme_inhibitor
Trypanothione-disulfide reductase (EC 1.8.1.12) is an enzyme that catalyzes the chemical reaction trypanothione disulfide + NADPH H+ H+ trypanothione
Trypanothione-disulfide reductase
Trypanothione-disulfide_reductase
Chemical element with atomic number 28 (Ni)
PMID 15012109. Greig N; Wyllie S; Vickers TJ; Fairlamb AH (2006). "Trypanothione-dependent glyoxalase I in Trypanosoma cruzi". Biochemical Journal. 400
Nickel
American Physician and scientist
chaperones : Hsp90 and cyclophilin; and, On trypanosomal enzymes : trypanothione and glutationylspermidine synthetases (1995) Doctoral advisor Christopher
Kari_Nadeau
British biochemist (born 1947)
parasites, and named it trypanothione. This thiol metabolite is quite different from its human equivalent, glutathione. Trypanothione allows the parasites
Alan_Fairlamb
Compound that inhibits the oxidation of other molecules
the Actinomycetes, bacillithiol in some gram-positive bacteria, or by trypanothione in the Kinetoplastids. Vitamin E is the collective name for a set of
Antioxidant
ligase EC 6.3.1.8: glutathionylspermidine synthase EC 6.3.1.9: trypanothione synthase EC 6.3.1.10: adenosylcobinamide-phosphate synthase EC 6.3.1
List_of_EC_numbers_(EC_6)
Protein-coding gene in the species Homo sapiens
(isomerizing). In some instances, the glutathionyl moiety may be supplied by trypanothione, the analog of glutathione in parasitic protozoa such as the trypanosomes
Lactoylglutathione_lyase
Class of enzymes
C, Fairlamb AH (1992). "Purification of glutathionylspermidine and trypanothione synthetases from Crithidia fasciculata". Protein Sci. 1 (7): 874–83
Glutathionylspermidine synthase
Glutathionylspermidine_synthase
Indian immunologist and nanotechnologist
nanotechnology-based vaccine and drug delivery, Owais is the author of two books, Trypanothione reductase: a potential anti-leishmanial drug target and Antimicrobial
Owais_Mohammad
Type of green fluorescent protein
(January 2020). "A tryparedoxin-coupled biosensor reveals a mitochondrial trypanothione metabolism in trypanosomes". eLife. 9: –53227. doi:10.7554/eLife.53227
RoGFP
Class of enzymes
eukaryotes including humans. This TxR is related to glutathione reductase, trypanothione reductase, mercuric reductase and lipoamide dehydrogenase. In the following
Thioredoxin_reductase
Pharmaceutical compound
has potent antitrypanosomal activity. It lowers intracellular GSH and trypanothione levels and inhibits trypanosomal ornithine decarboxylase with its α
Cynaropicrin
now EC 1.8.1.11 asparagusate reductase EC 1.6.4.8: now EC 1.8.1.12 trypanothione-disulfide reductase EC 1.6.4.9: now EC 1.8.1.13 bis-γ-glutamylcystine
List_of_EC_numbers_(EC_1)
Luxembourgish chemist (1952–2020)
biosynthesis (malaria); t-RNA guanine transglycosylase (shigellosis); trypanothione reductase (African sleeping sickness). Supramolecular nanosystems and
François_Diederich
TRYPANOTHIONE
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Girl/Female
Danish American German Hebrew Greek French
Female
Greek
(ΣαπφειÏη) Variant form of Greek Sapphira, derived from the word sappheiros, SAPPHEIRE means "sapphire."Â
Boy/Male
Tamil
Aveekshith | அவிகà¯à®·à®¿à®¤
Vayu Deva
Girl/Female
Arabic
Pride
Male
German
Variant spelling of German Raginmund, REGINMUND means "wise protector."
Male
Portuguese
Portuguese form of Hebrew Adam, ADÃO means "earth" or "red."
Boy/Male
Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Sanskrit, Telugu
Bracelet; Son of Baali
Surname or Lastname
English
English : patronymic from Lown 1.
Boy/Male
Tamil
Mahashaktimaya | மஹாஷகà¯à®¤à®¿à®®à®¾à®¯à®¾
One who has boundless energies
Biblical
changed; sleeping
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