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Thiolactones are a class of heterocyclic compounds in organic chemistry. They are analogs of the more common lactones in which an oxygen atom is replaced
Thiolactone
Chemical compound
Homocysteine thiolactone (HTL) is an organosulfur compound with the formula H2NCHC(O)SCH2CH2. It is the thiolactone (intramolecular thioester) of homocysteine
Homocysteine_thiolactone
Antiplatelet medication
thiophene ring is converted to a thiolactone. This thiolactone is then oxidized by a cytochrome P450 into a thiolactone S-oxide, that is unstable and opens
Clopidogrel
Chemical compound
for methionine synthase. Homocysteine can cyclize to give homocysteine thiolactone, a five-membered heterocycle. Because of this "self-looping" reaction
Homocysteine
Medication used to prevent formation of blood clots
intestine and carboxylesterase 1 in the liver to a likewise inactive thiolactone, which is then converted by CYP3A4 and CYP2B6, and to a minor extent
Prasugrel
Chemical reaction
to the thiolactone intermediate 1. Shimizu and Seki realized the efficient synthesis of (+)-biotin via the Fukuyama coupling of the thiolactone 1 and an
Fukuyama_coupling
Cyclic carboxylic ester
Lactam, a cyclic amide Lactim, a cyclic imide Lactide, a cyclic diester Thiolactone Halolactonization Phthalein Ester "lactones", Compendium of Chemical
Lactone
Drug class of antiplatelet agents
starts in the intestines where it is metabolized by esterase into a thiolactone, this inactive intermediate then undergoes CYP-mediated ring opening
Adenosine diphosphate receptor inhibitor
Adenosine_diphosphate_receptor_inhibitor
Type of regulator gene
transcriptional quorum-sensing (QS) system activated by an autoinducing, thiolactone-containing cyclic peptide (AIP). Agr occurs in 4 allelic subtypes that
Accessory_gene_regulator
Industrial synthesis of chemical substance
ring closure was also achieved by converting the thiolactone-thiolactame intermediate HE-40u to thiolactone-thioiminoester HE-45u by S-methylation of the
Vitamin_B12_total_synthesis
Protein-coding gene in the species Homo sapiens
biological function is hydrolysis of the reactive electrophile homocysteine thiolactone. Another of its activities is metabolic inactivation of the glycopeptide
Bleomycin_hydrolase
Chemical compound
trifluoromethyl groups. That compound has a half-life of 8 hours at 25 °C. Α-Thiolactones can be produced via oxygen transfer from a nitrone to a thioketene. α-Propiolactone
Acetolactone
Chemical to treat chronic bronchitis
acid: a novel mucolytic agent of the class of homocysteine thiolactone derivatives". Il Farmaco; Edizione Scientifica. 41 (1): 69–79. PMID 3956722
Erdosteine
Study of compounds with carbon to zinc bonds
(+)-biotin. In this case, the Fukuyama coupling takes place with the thiolactone: The Barbier reaction involves nucleophilic addition of a carbanion equivalent
Organozinc_chemistry
Chemical compound
especially when exposed to light (due to both the furan ring and the thiolactone group in the molecule). Kadethrin at Sigma-Aldrich John E. Casida (1980)
Kadethrin
Chemical compound
Citiolone is a drug used in liver therapy. It is a derivative of the amino acid homocysteine. Citilone has also been studied with regard to hypothermia
Citiolone
Organosulfur compounds of the form R–SC(=O)–R′
protein for degradation. Oxidation of the sulfur atom in thioesters (thiolactones) is postulated in the bioactivation of the antithrombotic prodrugs ticlopidine
Thioester
Protein-coding gene in the species Homo sapiens
hydrolysing a wide variety of substrates, such as lactones, including thiolactones and pharmaceutical agents such as statins. PON1 substrates also include
PON1
Overview of and topical guide to organic chemistry
Enals Enamines Enols Enolates Esters Lactones Sulfonates Thioesters Thiolactones Ethers Epoxides Silyl Ethers Thioethers Glycosides Glycosylamines Heterocyclic
Outline_of_organic_chemistry
THIOLACTONE
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Biblical
desiring God
Female
Spanish
Portuguese and Spanish form of Greek Euphêmia, EUFÉMIA means "Well I speak."
Boy/Male
Tamil
Large quantity
Girl/Female
Arabic
Beauty
Male
English
Variant spelling of English Jamar, probably JAMAAR means either "to change" or "happy and healthy."Â
Boy/Male
Indian, Kannada, Tamil
God Shiva; Skilled in the Arts
Girl/Female
Indian
Opening, Introduction, Dawn
Girl/Female
Teutonic American Dutch German
Firm defender.
Boy/Male
English Muslim
Hooded.
Girl/Female
Indian
Name of an Instrument
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