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Transcription factor gene of the SOX family
as SOX2, is a transcription factor that is essential for maintaining self-renewal, or pluripotency, of undifferentiated embryonic stem cells. Sox2 has
SOX2
Medical condition
anophthalmia is mutated SOX2 gene. Sox2 anophthalmia syndrome is caused by a mutation in the Sox2 gene that does not allow it to produce the Sox2 protein that regulates
Anophthalmia
Transformation of a stem cell to a more specialized cell
pluripotent cells. Virally induced expression of four transcription factors Oct4, Sox2, c-Myc, and Klf4 (Yamanaka factors) is sufficient to create pluripotent (iPS)
Cellular_differentiation
Pluripotent stem cell generated directly from a somatic cell
in 2006 that the introduction of four specific genes (named c-Myc, Oct4, Sox2 and KLF4), collectively known as Yamanaka factors, encoding transcription
Induced_pluripotent_stem_cell
Chemical compound
inhibitor of TGFβR1, also known as ALK5. As a mimetic of the effects of the SOX2 protein, it has gained attention in the fields of stem cell research and
RepSox
Mammalian protein found in Homo sapiens
promote differentiation, but are also controlled by levels of Sox2. A decrease in Sox2 accompanies increased levels of Oct-4 to promote a mesendodermal
Oct-4
Epigenetic phenomenon
with Sox2 for the expression of FGF4 which could aid in differentiation. Sox2 is a gene used in maintaining pluripotency in stem cells. Oct4 and Sox2 work
Reprogramming
SOX2 overlapping transcript (SOX2OT) is a long non-coding RNA, containing at least 5 exons. The SOX2 gene, an important regulator of neurogenesis, lies
SOX2OT
Ability of a cell to differentiate into other cell types
pioneered in 2006 using mouse fibroblasts and four transcription factors, Oct4, Sox2, Klf4 and c-Myc; this technique, called reprogramming, later earned Shinya
Cell_potency
Unspecialized biological cell that can become specialized
factors and cell surface proteins. The transcription factors Oct-4, Nanog, and Sox2 form the core regulatory network that ensures the suppression of genes that
Stem_cell
Birth defect of the eye
SIX3 SIX6 SMOC1 SNX3 SOX2 SRD5A3 STRA6 TBC1D20 TBC1D32 TBX22 TCOF1 TENM3 TFAP2A TMEM98 TMEM67 TMX3 VAX1 VSX2 YAP1 ZEB2 ZIC2 SOX2 has been implicated in
Microphthalmia
Medical condition
affected. In addition to HESX1, mutations in OTX2, SOX2 and PAX6 have been implicated in SOD. SOX2 mutations in SOD patients are associated with severe
Septo-optic_dysplasia
Marker in embryonic stem cells
preventing differentiation. Cooperative regulation of Rex1 is seen with Sox2 and Nanog. Oct3/4 can both repress and activate the Rex1 promoter. In cells
Rex1
Class of ray-finned bony fishes
Sanketi, Bhargav; Kurpios, Natasza; McCune, Amy (2020). "Changing in Nkx2.1, Sox2, Bmp4, and Bmp16 expression underlying the lung-to-gas bladder evolutionary
Actinopterygii
Chronic disease caused by bacterial infection
pluripotent stem cells are generated by the transcription factors Myc, Oct3/4, Sox2, and Klf4. A notable study conducted by Charles Shepard used mice to find
Leprosy
Japanese stem cell researcher (born 1962)
early embryo, but could in the end reduce it to four transcription factors – Sox2, Oct4, Klf4 and c-Myc. The 2012 Nobel Prize in Physiology or Medicine was
Shinya_Yamanaka
Type of stem cell
overexpressing in the primed pluripotent stem cell a reprogramming factor Klf4, or Sox2 and Klf4 (SK cocktail). Klf4 alone can reset mouse primed cells, but SK is
Epiblast-derived_stem_cell
Transcription factor gene of the SOX family
group) DNA-binding domain and functions primarily in neurogenesis. SOX1, SOX2 and SOX3, members of the SOX gene family (specifically the SOXB1 group),
SOX1
Developmental disorder involving the eye
syndrome MCOPS2 BCOR XLR XLD oculofaciocardiodental syndrome MCOPS3 SOX2 AD SOX2 anophthalmia syndrome, anophthalmia/microphthalmia-esophageal atresia
Syndromic_microphthalmia
Family of transcription factors
are also important in processes such as neuronal development. For example, Sox2 and Sox3 are involved in the transition of epithelial granule cells in the
SOX_gene_family
Early embryonic mass that gives rise to the fetus
do not turn on the Cdx2 gene, and express high levels of Oct4, Nanog, and Sox2. These genes suppress Cdx2 and the inside cells maintain pluripotency generate
Inner_cell_mass
Body-covering structure of birds
expressed or induced in bird feet, such as the scale-feather converters Sox2, Zic1, Grem1, Spry2, and Sox18. Feathers and scales are made up of two distinct
Feather
Australian geneticist (born 1969)
Sinclair's group published that three Yamanaka transcription factors, Oct4, Sox2, and Klf4, when delivered together in a virus, could safely reverse the age
David_A._Sinclair
Transient embryonic layer of tissue containing neural stem cells
The VZ and SVZ are indicated by immunohistochemical labelling of Sox2 and Tbr2 gene expression in the embryonic mouse forebrain at embryonic day 13.5.
Ventricular_zone
David Suter, Swiss cell biologist
They investigated whether fluctuations in the expression levels of OCT4 and SOX2, two master regulators of pluripotency, impact the differentiation potential
David_Suter_(biologist)
treatment upon reflux of a large excess of thionyl chloride or thionyl bromide (SOX2) in the presence of a small amount of a nitrogen base, such as a tertiary
Darzens_halogenation
Type of cancer
expression levels of both receptors. A recent study also suggested a role for SOX2 as an independent prognostic biomarker that can be used to identify patients
Ewing_sarcoma
Primary layer of cells in embryonic development
factors: Sox2 and Oct4 proteins. These transcription factors cause the pluripotent mouse embryonic stem cells to select a germ layer fate. Sox2 promotes
Germ_layer
Endocrine gland of the brain
Tulsidas; Pevny, Larysa Halyna; Martinez-Barbera, Juan Pedro (October 2013). "Sox2+ Stem/Progenitor Cells in the Adult Mouse Pituitary Support Organ Homeostasis
Pituitary_gland
Division or infraclass of fishes
C.; Sanketi, B. D.; Kurpios, N.; McCune, A. (2020). "Changes in Nkx2.1, Sox2, Bmp4, and Bmp16 expression underlying the lung-to-gas bladder evolutionary
Teleost
Modification. M-phase cytoplasts from hESCs contain dispersed Oct-4, Nanog, and SOX2, which play a role in nuclear reprogramming. In Animal cells, the spindle
Cytoplast
Process in developmental biology
first transfected with pluripotent reprogramming factors temporarily (Oct4, Sox2, Nanog, etc.) before being transfected with the desired inhibitory or activating
Transdifferentiation
stem cells. It is expressed during coexpression of Oct3/4, c-Myc, Klf4, and SOX2, four genes identified to be important in embryonic stem cell self-renewal
F-box_protein_15
Large edible flatfishes
halibut is located on chromosome 9 and it is likely to be bmpr1ba. The gene sox2 is likely to play the same role in the Greenland halibut. The North Pacific
Halibut
Receptor organ for hearing
specific genes, many of which have been identified in previous research (SOX2, GATA3, EYA1, FOXG1, BMP4, RAC1, and more), to undergo such differentiation
Organ_of_Corti
Endogenous tag expressed in different cells along neurogenesis and differentiated cells
neural lineages. Usual markers used for neural stem cells include Nestin and SOX2. Although Nestin it is expressed predominantly in stem cells of the central
Neuronal_lineage_marker
Commercial Scrumwise x Commercial ScrumWorks Pro CollabNet x Commercial SOX2 RM Engineers Consulting GmbH x Commercial Specification Wizard MeetAdd x
Requirements engineering tools
Requirements_engineering_tools
fibroblasts → cardiomyocytes (Oct4, Sox2, Klf4, JI1 and Bmp4) Fibroblasts → neural stem/progenitor cells (Oct4, Sox2, c-Myc, Klf4) Transdifferentiation
Examples of in vitro transdifferentiation by initial epigenetic activation phase approach
Examples_of_in_vitro_transdifferentiation_by_initial_epigenetic_activation_phase_approach
Specialised epithelial tissue in the nasal cavity that detects odours
regulated downstream expression of transcription factors, such as Pax6, Dlx3, Sox2, and others, within the presumptive olfactory placode are crucial for sub-regionalization
Olfactory_epithelium
Long chain of protein monomers
Human neural stem cells stained for Sox2, in green, and vimentin, in red. Vimentin is a type III intermediate filament (IF) protein.
Protein_filament
American public health researcher
Trotter; Yoshihiro Komatsu; Yuji Mishina; Trevor K Archer (October 2008). "Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells". Molecular
Trevor_K._Archer
Family of transcription factors involved in anatomical development
regulates critical pluripotency associated genes such as OCT4, NANOG and SOX2 (Oct4 and Sox2 are Yamanaka factors) by occupying and activating their promoters
FOX_proteins
Human chromosome
SERP1: Stress-associated endoplasmic reticulum protein 1 SOX2: transcription factor SOX2OT: SOX2 overlapping transcript SPG14 encoding protein Spastic paraplegia
Chromosome_3
Renewal or physiological repair of damaged nerve tissue
); RBPJ-k blocks the Notch pathway and elicits a neurogenic program and Sox2 can also increase reprogramming efficiency by causing a dedifferentiation
Neuroregeneration
Medical condition
NFE2L2 (15%). Common oncogene copy number amplifications have been found in SOX2, PDGFRA, EGFR, FGFR1 and CCND1. Deletions were observed in tumor suppressors
Squamous-cell carcinoma of the lung
Squamous-cell_carcinoma_of_the_lung
Protein-coding gene in the species Homo sapiens
Gleason D, et al. (2010). "Candidate gene sequencing of LHX2, HESX1, and SOX2 in a large schizencephaly cohort". Am. J. Med. Genet. A. 152A (11): 2736–42
HESX1
Small molecules that inhibit the Hedgehog signaling pathway
activate the expression of multiple genes including Myc, Bcl-2, NANOG, and SOX2. Targets of GLIs include genes involved in cell proliferation, apoptosis
Hedgehog_pathway_inhibitor
Belgian physician
of cancer stem cells in skin cancers expressing Sox2, they demonstrated by lineage ablation that Sox2 cancer stem cells are essential for tumor initiation
Cédric_Blanpain
Endogenous non-cancerous pluripotent stem cell
pluripotency indicators such as alkaline phosphatase reactivities, Nanog, Oct3/4, Sox2 and PAR4. One of remarkable properties of Muse cells is that they are capable
Muse_cell
Family of regulator genes
cells to return to a 'stem-like' state alongside transcription factors Oct4, Sox2 and Klf4. It has since been shown that it is possible to generate iPSCs without
Myc
pluripotent-like stem cells (DPPSC). These cells are SSEA4+, OCT3/4+, NANOG+, SOX2+, LIN28+, CD13+, CD105+, CD34-, CD45-, CD90+, CD29+, CD73+, STRO1+, and CD146-
Dental_pulp_stem_cell
Congenital discontinuity of the oesophagus
EA/TEF risk genes have been discovered include the transcriptional regulators SOX2, MYCN, CHD7, FANCB, and members of FOX transcription factor family. Others
Esophageal_atresia
Star-shaped organisms
larval sea star nervous system by wounding induced respecification to the Sox2 lineage". eLife. 11 e72983. doi:10.7554/eLife.72983. ISSN 2050-084X. PMC 8809897
Starfish_regeneration
Anterior part of the gastrointestinal tract
hox genes, the morphogen sonic hedgehog, and transcription factors such as sox2 and sox9. Recent research has suggested that most foregut malformations are
Foregut
RC1 antigen Rex-1 Sca-1 SCF Sialyl-lactotetra Side Population (SP) SOX10 SOX2 SOX9 SP phenotype SSEA-1 SSEA-3 SSEA-4 Stat3 Stat5 Stella Stra8 Stro-1 Tartrate-resistant
Stem_cell_marker
Protein-coding gene in the species Homo sapiens
(June 2006). "Developmental malformations of the eye: the role of PAX6, SOX2 and OTX2". Clinical Genetics. 69 (6): 459–70. doi:10.1111/j.1399-0004.2006
Orthodenticle_homeobox_2
Species of fern
in Male Albino Rats: The miR-145 Expression of the PI-3K/Akt/p53 and Oct4/Sox2/Nanog Pathways". Molecules. 28 (14). January 2023. ISSN 1420-3049. Archived
Adiantum_pedatum
Group of transposable elements
increases somatic mosaicism. This phenomenon is negatively regulated by Sox2, which is downregulated in NPCs, and by MeCP2 and methylation of the L1 5'
LINE1
Type of pluripotent blastocystic stem cell
embryonic stem cells, can be induced by the delivery of four factors (Oct3/4, Sox2, c-Myc, and Klf4) to differentiated cells. Utilizing the four genes previously
Embryonic_stem_cell
Gene at the top of a regulation hierarchy
Canonical examples of master regulators include Oct-4 (also called POU5F1), SOX2, and NANOG, all transcription factors involved in maintaining pluripotency
Master_regulator_gene
Protein
function is probably mediated through direct control by FOXO1 of OCT4 and SOX2 gene expression through occupation and activation of their respective promoters
Forkhead_box_protein_O1
Human protein and coding gene
vesicle and concentration combination of BMP4 and Msx2 together active Sox2 and the Sox2 is essential for lens differentiation. Injection of Noggin into lens
Bone_morphogenetic_protein_4
Protein-coding gene in humans
proliferation. When Cul4b deletion was limited to the epiblast (only in Sox2-expressing tissue), it was possible to generate living mice. Mice that do
CUL4B
Protein involved in the pancreas and duodenum differentiation
dependent on Pdx1 expression. It is a ParaHox gene, which together with Sox2 and Cdx2, determines the correct cellular differentiation in the proximal
PDX1
Family of zinc finger transcription factors
[KLF4] is one of the so-called magic four transcription factors, KLF4, Oct4, SOX2 and MYC. KLF5, like KLF3, is important in adipocytes and KLF6 is an important
Kruppel-like_factors
American baseball league
Montgomery Grey Sox, 4g-1g 1926: Birmingham Black Barons1 defeated Memphis Red Sox2, 5g-2g (3 ties) 1932: Cole's American Giants1 defeated Nashville Elite Giants2
Negro Southern League (1920–1936)
Negro_Southern_League_(1920–1936)
Protein-coding gene in the species Homo sapiens
proteins such as Nanog and sex determining region Y (SRY)-box 2 protein (Sox2). Together these proteins can affect each other's expression patterns as
SALL4
Genomic analysis technique
significant participation of major pluripotency factors such as OCT4, NANOG, and SOX2 in the interaction network during somatic cell reprogramming. Since then
Hi-C (genomic analysis technique)
Hi-C_(genomic_analysis_technique)
undifferentiated embryonic state, which relies on the transcription factors Oct4, Sox2, Myc, and Klf4. cellular senescence centimorgan (cM) A unit for measuring
Glossary of cellular and molecular biology (0–L)
Glossary_of_cellular_and_molecular_biology_(0–L)
Class of immune system proteins
vector. This retroviral expression of four transcriptional factors (Oct4, Sox2, Klf4 and c-Myc; OSKM) induces pluripotency in somatic cells. This is supported
Toll-like_receptor
German-American neurobiologist
Cheah, Kathryn S. E.; Pevny, Larysa H.; Kelley, Matthew W. (2008-11-25). "Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation
Bernd_Fritzsch
Medical condition from optic nerve damage
that AAV2-induced transient expression of the reprogramming genes Oct4, Sox2, and Klf4 (OSK) could reverse retinal aging and restore visual function in
Non-arteritic anterior ischemic optic neuropathy
Non-arteritic_anterior_ischemic_optic_neuropathy
American neurologist
James A.; Kosik, Kenneth S. (15 May 2009). "MicroRNA-145 Regulates OCT4, SOX2, and KLF4 and Represses Pluripotency in Human Embryonic Stem Cells". Cell
Kenneth_S._Kosik
Medical condition
(CPHD) in childhood. These are HESX1, PROP1, POU1F1, LHX3, LHX4, TBX19, SOX2 and SOX3. Each transcription factor acts in particular groups of cells. Therefore
Hypopituitarism
Generating of neurons from neural stem cells in adults
measure specific stem cell stages. For example, stem cells requires the sox2 gene to maintain pluripotency and is used to detect enduring concentrations
Adult_neurogenesis
Development and arrangement of teeth
doi:10.1002/bies.200900151. PMC 3034446. PMID 20730948. Martin et al. (2016) Sox2+ progenitors in sharks link taste development with the evolution of regenerative
Dentition
British biologist of Polish descent
T, Marioni JC, Zernicka-Goetz M (March 2016). "Heterogeneity in Oct4 and Sox2 Targets Biases Cell Fate in 4-Cell Mouse Embryos". Cell. 165 (1): 61–74.
Magdalena_Żernicka-Goetz
Catalytic subunit of the enzyme telomerase
into a stem cell-like state by the introduction of four factors (Oct3/4, Sox2, Klf4, and c-Myc). iPS cells have the ability to self-renew indefinitely
Telomerase reverse transcriptase
Telomerase_reverse_transcriptase
Protein-coding gene in the species Homo sapiens
morphological state. Also, SIX3 plays a strategic role in the activation of SOX2. SIX3 has also been proven to play a role in repression of selected members
SIX3
Transcription factor gene of the SOX family
Other cofactors have been identified, such as SP1, OCT6, NMI, FOXD3 and SOX2. The interaction between SOX10 and NMI seems to be coexpressed in glial cells
SOX10
The field gained significant interest once four transcription factors Oct4/Sox2/cMyc/Klf4 were found to reprogram cells from a differentiated state into
Artificial transcription factor
Artificial_transcription_factor
Protein-coding gene in the species Homo sapiens
subunit of the LSD1 complex that regulates ESC property and substitutes for SOX2 in reprogramming somatic cells to pluripotency". Stem Cells. 29 (5). Dayton
RCOR2
Project to catalogue genetic mutations responsible for cancer
neck squamous cell carcinomas and had frequent amplifications of CCND1, SOX2 and TP63; adenocarcinomas were similar to chromosomally unstable gastric
The_Cancer_Genome_Atlas
1,132-amino acid
protein, stimulates the expression of at least 4 relevant genes, MYC, TP63, SOX2, and MYB in cultured cells. All four of these genes are oncogenes, i.e.,
Nuclear protein in testis gene
Nuclear_protein_in_testis_gene
Mammalian protein found in humans
thought to function in concert with other factors such as POU5F1 (Oct-4) and SOX2 to establish ESC identity. These cells offer an important area of study because
Homeobox_protein_NANOG
"non-canonical" microRNA targets in the coding regions of the mouse Nanog, Oct4 and Sox2. Most of these targets are not conserved in the human orthologues of these
RNA22
Group of proteins
eukaryotic organisms. SOX gene family Sex-Determining Region Y Protein SOX1, SOX2, etc. TCF/LEF family (T cell factor/lymphoid enhancer factor family) LEF1
High-mobility_group
Q53LP3 15529 SOWAHD HGNC:32960; A6NJG2 15530 SOX1 HGNC:11189; O00570 15531 SOX2 HGNC:11195; P48431 15532 SOX3 HGNC:11199; P41225 15533 SOX4 HGNC:11200; Q06945
List of human protein-coding genes 7
List_of_human_protein-coding_genes_7
pluripotent-like states also opens new avenues for regenerative therapies. Oct3/4, Sox2, and Nanog, all of which are involved in maintaining stem cell pluripotency
Intracrine_signaling
Thickened portion of ectoderm which serves as the precursor to the lens
a necessary transcription factor for the thickness of the lens placode. SOX2 is a transcription factor that works alongside Pax6 to develop the lens placode
Lens_placode
Protein-coding gene in the species Homo sapiens
(2015-10-22). "Novel Function of Lysine Methyltransferase G9a in the Regulation of Sox2 Protein Stability". PLOS ONE. 10 (10) e0141118. Bibcode:2015PLoSO..1041118L
EHMT1
Ferguson KM, Bressan RB, Blin C, et al. (April 2017). "Elevated FOXG1 and SOX2 in glioblastoma enforces neural stem cell identity through transcriptional
Epigenetic regulation of neurogenesis
Epigenetic_regulation_of_neurogenesis
Mechanisms that form the digestive system in the human embryo
transcription factors to be expressed in different regions of the gut tube. Thus, SOX2 specifies the esophagus and stomach; PDX1 specifies the duodenum; CDXC specifies
Development of the human digestive system
Development_of_the_human_digestive_system
Stage in embryonic development
blastula embryos for an expansion of the region of the ectodermal marker Sox2 and diminution of the expression of the mesodermal marker Xbra. Ectodermin
Ectoderm_specification
Protein-coding gene
induced pluripotent stem cells. The three transcription factors Oct3/4, Sox2 and Klf4 are essential for reprogramming but are extremely inefficient on
GLIS1
ENSG00000203883 HMG/Sox Known motif – High-throughput in vitro [849] ATCAATGHWATTGAT SOX2 ENSG00000181449 HMG/Sox Known motif – High-throughput in vitro [850] HATCAATANCATTGATH
List of human transcription factors
List_of_human_transcription_factors
English geneticist
coordinates the expression of other eye development genes, including the SOX2 and Orthodenticle homeobox 2 (OTX2) genes which are mutated in microphthalmia
Veronica_van_Heyningen
Protein-coding gene in the species Homo sapiens
PMID 19301122. S2CID 8614063. Nonaka D (May 2009). "Differential expression of SOX2 and SOX17 in testicular germ cell tumors". American Journal of Clinical Pathology
SOX17
cells. Studies have shown that radial glia in the SGZ express nestin and Sox2, biomarkers associated with neural stem cells, and that isolated radial glia
Subgranular_zone
General cell type
by multiple factors including transcription factors such as FOXJ1, FOXA3, Sox2, and p53, proteins such as LEF-1, and interleukins IL-1α and IL-33, as well
Basal_cell
SOX2
SOX2
SOX2
SOX2
Girl/Female
Australian, British, Dutch, English, French, German, Greek, Italian, Swedish
Rock; Female Version of Peter; Stone
Boy/Male
Hindu, Indian, Kannada, Malayalam, Marathi, Telugu
Handsome
Girl/Female
Arabic, Muslim
Name of a Sahabiyah (RA)
Girl/Female
Muslim
Jasmine or flower (1)
Girl/Female
Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Telugu
Beautiful
Boy/Male
Tamil
Srivathsa | à®·à¯à®°à¯€Â வாதà¯à®¸à®¾Â
God of srimaha Vishnu, Lakshmi(goddess of wealth
Girl/Female
Indian
Wealth
Boy/Male
British, English
Sea Lover
Girl/Female
Bengali, Indian
Good Looking
Boy/Male
Hindi Muslim
Devoted; true.
SOX2
SOX2
SOX2
SOX2
SOX2