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Group of prokaryotic enzymes
Sortase refers to a group of prokaryotic enzymes that modify surface proteins by recognizing and cleaving a carboxyl-terminal sorting signal. For most
Sortase
Sortase A (EC 3.4.22.70, SrtA, SrtA protein, SrtA sortase) is an enzyme. This enzyme catalyses a cell wall sorting reaction, in which a surface protein
Sortase_A
Sortases are membrane anchored enzyme that sort these surface proteins onto the bacterial cell surface and anchor them to the peptidoglycan. There are
Sortase_B
Enzyme
A protein-sorting transpeptidase is an enzyme, such as the sortase SrtA of Staphylococcus aureus, that cleaves one or more target proteins produced by
Protein-sorting transpeptidase
Protein-sorting_transpeptidase
Species of bacterium
Nikghalb, Kevyan D. (2018). "Expanding the Scope of Sortase-Mediated Ligations by Using Sortase Homologues". ChemBioChem. 19 (7): 185–195. doi:10.1002/cbic
Streptococcus_pneumoniae
Type of chemical bond between 2 amino acids
aspect that distinguishes sortases in general is that they have a very specific targeting for their substrate, as sortases have generally two functions
Isopeptide_bond
Species of Gram-positive bacterium
Protein A Protein A is anchored to staphylococcal peptidoglycan pentaglycine bridges (chains of five glycine residues) by the transpeptidase sortase A. Protein
Staphylococcus_aureus
Family of integral membrane proteins
PEP-CTERM. The name derives from a predicted role analogous to sortase, despite the lack of any detectable sequence homology, and a strong association of exosortase
Exosortase
Endopeptidase enzyme
motif of surface proteins similar to Sortase. However, LPXTGase differs significantly from Sortase in several ways: a) it is glycosylated, b) it contains
LPXTGase
German-born American microbiologist (1961–2019)
bacteria are cleaved between the T and G residue in the LPXTG sortase signal by the enzyme sortase (the enzyme was not discovered yet, but was later shown by
Olaf_Schneewind
Production of peptides
spontaneous isopeptide bond formation and sortase ligation. In order to optimize synthesis of long peptides, a method was developed in Medicon Valley for
Peptide_synthesis
Species of bacterium
Laura; Ferrarini, Alberto; Delledonne, Massimo (2013-07-02). "Role of sortase-dependent pili of Bifidobacterium bifidum PRL2010 in modulating bacterium–host
Bifidobacterium_bifidum
Protein family
common in gram-positive cocci. They are named for a C-terminal motif used by the sortase. There is also a LPXTGase. LPXTG Pili in Gram-positive bacteria
Pilin
Protein family
protein-sorting domain. Thus, archaeosortase appears to be a transpeptidase, like sortase, rather than a simple protease. Archaeosortases are related to exosortases
Archaeosortase
American Microbiologist
wife and son. He earned a PhD from the University of Chicago investigating the biochemistry and biological role of sortase, a transpeptidase that links
Luciano_Marraffini
Proteinaceous hair-like appendage on the surface of bacteria
(hence the name "toxin mediated pilus"). Bacterial nanowires Flagellum Sortase P fimbriae PilZ domain "pilus" at Dorland's Medical Dictionary Brinton
Pilus
Class of enzymes
degrade proteins. These proteases share a common catalytic mechanism that involves a nucleophilic cysteine thiol in a catalytic triad or dyad. Discovered
Cysteine_protease
Biological classification system
and a domain in RNA polymerases β and σ. [G] Endospores. [H] Gram-positive Bacteria: hypertrophy of the wall peptidoglycan, sortase enzyme and a loss
Cavalier-Smith's system of classification
Cavalier-Smith's_system_of_classification
Bacterial taxonomy
and a domain in RNA polymerases β and σ. [G] Endospores. [H] Gram-positive Bacteria: hypertrophy of the wall peptidoglycan, sortase enzyme and a loss
Eurybacteria
Species of bacterium
"Porphyromonas gingivalis Type IX Secretion Substrates Are Cleaved and Modified by a Sortase-Like Mechanism". PLOS Pathogens. 11 (9) e1005152. doi:10.1371/journal
Porphyromonas_gingivalis
Biological mechanism for routing proteins
covalent attachment to the bacterial cell wall. A specialized enzyme, sortase, cleaves the target protein at a characteristic recognition site near the protein
Protein_targeting
could be developed by using as a target the enzyme responsible of linking such proteins to cell wall, that is the Sortase A (SrtA), rather than any single
Antivirulence
Topics referred to by the same term
a liver enzyme D-Glutamyl transpeptidase A protein-sorting transpeptidase (e.g. sortase), that cleaves a C-terminal sorting signal from its target protein(s)
Transpeptidase
SARS coronavirus main proteinase EC 3.4.22.70: sortase A EC 3.4.22.71: sortase B EC 3.4.23.1: pepsin A EC 3.4.23.2: pepsin B EC 3.4.23.3: gastricsin EC
List_of_EC_numbers_(EC_3)
Protein engineering technology
step. An early example, involved the stabilization of the transpeptidase Sortase A which resulted in INCYPRO-stabilized variants with activity under elevated
In situ cyclization of proteins
In_situ_cyclization_of_proteins
Topics referred to by the same term
Massachusetts State Road and Tollway Authority, a government agency of the U.S. state of Georgia Sortase A, an enzyme, abbreviated as SrtA This disambiguation
SRTA
Set of three coordinated amino acids
orbital makes it larger (by 0.4 Å) and softer, allows it to form longer bonds (dC-X and dX-H by 1.3-fold), and gives it a lower pKa (by 5 units). Serine
Catalytic_triad
Smoothened (SMO). TDsmURFP was purified from E. coli and attached to SMO by sortase-mediated conjugation for fluorescence-activated cell sorting (FACS). This
SmURFP
mutate as a mature cell. Ploegh and his colleagues have been able to use sortase to cut erythrocyte surface proteins, allowing the binding of biotin and
Hidde_Ploegh
Vaccine that prevents infection from all strains of coronaviruses
uses a ferritin nanoparticle with prefusion-stabilized spike antigens from the Wuhan strain. Another candidate is RBD–scNP, which is a sortase A-conjugated
Universal_coronavirus_vaccine
Chang C, Wu C, Jooya N, Joachimiak A, Das A, Ton-That H (2015). "A Disulfide Bond-forming Machine Is Linked to the Sortase-mediated Pilus Assembly Pathway
List of bacterial disulfide oxidoreductases
List_of_bacterial_disulfide_oxidoreductases
Infrakingdom of bacteria
and a domain in RNA polymerases β and σ. [G] Endospores. [H] Gram-positive Bacteria: hypertrophy of the wall peptidoglycan, sortase enzyme and a loss
Gracilicutes
Type of molecules produced by a pathogen that might cause potential harmful effects
an example of a virulence factor from a fungus. Other virulence factors include factors required for biofilm formation (e.g. sortases) and integrins
Virulence_factor
virulence factor assembly pathways, including Sortase A and wall teichoic acid biosynthesis. Clubb is a professor of chemistry, biochemistry, and molecular
Robert_T._Clubb
Chemical compound
Bio Mater. 2018, 1 (6), 1823−182 Lipid Modification of Proteins through Sortase-Catalyzed Transpeptidation. J. Am. Chem. Soc. 2008, 130 (48), 16338−16343
O-Octadecylhydroxylamine
American bacteriologist and immunologist
transpeptidase sortase by Olaf Schneewind, a former member of his lab. By the late 1990s, Fischetti was exploring the impact of phage lysins, a novel form
Vincent_Fischetti
Kornberger, Petra; Skerra, Arne (1 March 2014). "Sortase-catalyzed in vitro functionalization of a HER2-specific recombinant Fab for tumor targeting
Gelonin
American biochemist
the use of chemical ligation (NCL) and enzyme-mediated ligation using Sortase A (SrtA), non-native cargos that contain functionalities that don't naturally
Bradley_L._Pentelute
SORTASE A
SORTASE A
Surname or Lastname
Southern French and German
Southern French and German : from Occitan astor ‘goshawk’ (from Latin acceptor, variant of accipiter ‘hawk’), used as a nickname characterizing a predacious or otherwise hawklike man. The name was taken to southwestern Germany by 17th-century Waldensian refugees from their Alpine valleys above Italian Piedmont.English : variant spelling of Aster.Astor is the name of a famous American family of industrialists and newspaper owners. John Jacob Astor I (1763–1848) was born at Walldorf near Heidelberg, Germany, the son of a butcher. He followed his brother Henry to New York and made a fortune in the fur trade, which was greatly increased by his descendants in industry, hotels, and newspapers. They built the Waldorf-Astoria Hotel in New York. The great-grandson of John Jacob I, William Waldorf Astor (1848–1919), moved to England in 1890, becoming an influential newspaper proprietor and taking British citizenship in 1899. In 1917 he was created Viscount Astor of Hever. His son, the 2nd Viscount (1879–1952), married Nancy Shaw (née Langhorne) (1879–1964), daughter of a VA planter. She became the first woman to sit in the British House of Commons as a member of Parliament.
Surname or Lastname
Americanized spelling of French Hary.English
Americanized spelling of French Hary.English : variant spelling of Airey.
Surname or Lastname
English and Scottish
English and Scottish : from the Old Norse personal name Ãsketill, composed of the elements áss ‘god’ + ketill ‘kettle’, ‘helmet’ (see Haskell). This name was in use both among Scandinavian settlers in northern England and among the Normans.
Surname or Lastname
English, French, and German
English, French, and German : from the personal name Austin, a vernacular form of Latin Augustinus, a derivative of Augustus. This was an extremely common personal name in every part of Western Europe during the Middle Ages, owing its popularity chiefly to St. Augustine of Hippo (354–430), whose influence on Christianity is generally considered to be second only to that of St. Paul. Various religious orders came to be formed following rules named in his honor, including the ‘Austin canons’, established in the 11th century, and the ‘Austin friars’, a mendicant order dating from the 13th century. The popularity of the personal name in England was further increased by the fact that it was borne by St. Augustine of Canterbury (died c. 605), an Italian Benedictine monk known as ‘the Apostle of the English’, who brought Christianity to England in 597 and founded the see of Canterbury.German : from a reduced form of the personal name Augustin.This was the name of a merchant family that became well established in eastern MA in the 17th century, notably in Charlestown. Richard Austin came from England and landed at Boston in 1638, and his son Anthony was clerk of Suffield, CT, in 1674. The surname is very common in England as well as America; this Richard Austin was only one of a number of bearers who brought it to North America.
Surname or Lastname
English (Hampshire and Dorset)
English (Hampshire and Dorset) : of uncertain origin, perhaps representing a patronymic from a personal name such as those that appeared in Old English as Ægel and Ædel (see Aylesworth and Ayling).
Surname or Lastname
Swedish and Norwegian
Swedish and Norwegian : from ask ‘ash tree’, applied either as a habitational name from a place named with this word or as an ornamental name.English : habitational name from a place in North Yorkshire named Aske, from Old English as æsc ‘ash tree’, later replaced by the Old Norse cognate askr.
Girl/Female
Bengali, Indian
Daughter of Sage Kashyap and Surase
Boy/Male
Sikh
One who sings praises of the Lord, Love, Pyar, Never shortage of money
Surname or Lastname
Americanized spelling of Dutch Acker.English
Americanized spelling of Dutch Acker.English : variant of Alker, which has two possible origins: either from a Middle English survival of the Old English personal name Ealhhere meaning ‘altar army’; or a habitational name from Altcar in Lancashire, named from the Celtic river name Alt (meaning ‘muddy river’) + Old Norse kiarr ‘marsh’.
Surname or Lastname
English (Midlands and Lancashire)
English (Midlands and Lancashire) : topographic name for someone living ‘at the clearing or meadow’, Middle English ater lee (from Old English lēah ‘woodland clearing’). Compare Atlee.
Surname or Lastname
English (Lancashire and Cheshire)
English (Lancashire and Cheshire) : variant spelling of Axon.
Surname or Lastname
English and Scottish
English and Scottish : topographic or habitational name for residence on or near land covered with ash trees. There are minor places called Ashland(s) in Hampshire and Leicestershire, Staffordshire, and Galloway. Asland, a river name in Lancashire, refers to the lower reaches of what is more generally known as the Douglas river. It is named from Old Norse askr ‘ash’ + Old English lanu ‘lane’.Americanized form of Norwegian Ask(e)land (see Askeland).Probably an Americanized form of the common French Canadian name Asselin. Compare Ashline.In the U.S., Ashland is the name of two counties and at least thirteen cities, towns, and villages. Most, perhaps all, were named after Ashland in Lexington, KY, home of Henry Clay (1777–1852), who is said to have named his estate from a characteristic feature of the site, not from anyone’s surname.
Surname or Lastname
French (Aubé)
French (Aubé) : from the Old French personal name Aube, a variant of Albert. This is a common surname in VT.English (of Norman origin) : nickname from Old French aube, albe ‘white’ (i.e. blond), from Latin albus. Compare Albin.
Surname or Lastname
English and Swedish
English and Swedish : variant of Aslin.
Surname or Lastname
English (mainly Sussex and Hampshire)
English (mainly Sussex and Hampshire) : topographic name denoting someone dwelling by an ash tree, from Middle English asche ‘ash tree’ + the habitational suffix -er.Jewish : from the Hebrew personal name Asher ‘blessed’.Americanized spelling of German Ascher.
Girl/Female
Bengali, Hindu, Indian, Marathi
Daughter of Sage Kashyap and Surase
Surname or Lastname
Respelling of German Austel, from a pet form of August.English
Respelling of German Austel, from a pet form of August.English : possibly a variant of Astle. There is a place in Cornwall called St. Austell (from the dedication of its church to a certain St. Austol), but this is unlikely to be the source of the surname.
Boy/Male
Sikh
One who sings praises of the Lord, Love, Pyar, Never shortage of money
Surname or Lastname
English (mainly East Anglia and southern counties)
English (mainly East Anglia and southern counties) : unexplained.Possibly a shortened form of Mac Avey, a variant of McEvoy and McVey.Possibly an altered form of French Hévé.Alternatively, perhaps, an Americanized form of German Ewig.
Boy/Male
Hindu, Indian, Punjabi, Sikh
Love; Pyar; Never Shortage of Money; Popular
SORTASE A
SORTASE A
Boy/Male
Native American
He keeps watch.
Girl/Female
Arabic, Muslim
Gift; Restless
Boy/Male
Tamil
Calf, Gentleness, Wife
Girl/Female
Gujarati, Hindu, Indian, Kannada
Meaning of Life
Boy/Male
Muslim
Increase
Surname or Lastname
English
English : possibly a variant of Mares.
Surname or Lastname
English, Welsh, or Irish
English, Welsh, or Irish : variant spelling of Pierce.
Boy/Male
Muslim/Islamic
Safety
Surname or Lastname
English
English : variant of Blankenship.
Girl/Female
Hindu
SORTASE A
SORTASE A
SORTASE A
SORTASE A
SORTASE A
n.
That in which anything is packed; bagging, as for hops.
n.
A prayer book or breviary; a portass.
n.
Amount or extent of deficiency, as determined by some requirement or standard; as, a shortage in money accounts.
a.
Pertaining to a sort.
n.
A board or group of moldings running round a room on a level with the tops of the chair backs.
n.
See Portass.
a.
Borne not erect, but diagonally athwart an escutcheon; as, a cross portate.
v. t.
To join or fasten by a tenon and mortise; as, to mortise a beam into a post, or a joist into a girder.
a.
Uncomfortable; out of sorts.
n.
See Portass.
n.
a mortise for a key or cotter.
imp. & p. p.
of Mortise
n.
See Portass.
n.
A cornice, or series of moldings, on the top of the base of a pedestal, podium, etc. See Illust. of Column.
p. pr. & vb. n.
of Mortise
n.
A close garnment with straight sleeves, and skirts reaching to the ankles, and buttoned in front from top to bottom; especially, the black garment of this shape worn by the clergy in France and Italy as their daily dress; a cassock.
a.
Having a surbase, or molding above the base.
v. i.
Suitableness; agreement.
n.
See Portass.
v. t.
Alt. of Torase