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Protein-coding gene in the species Homo sapiens
Paired amphipathic helix protein Sin3a is a protein that in humans is encoded by the SIN3A gene. The protein encoded by this gene is a transcriptional
SIN3A
Genetic disorder
function of switch‐insensitive 3 transcription regulator family member A (SIN3A). The syndrome was discovered by developmental neuroscientists Josefine
Witteveen–Kolk_syndrome
Protein-coding gene in the species Homo sapiens
Sin3A-associated protein, 30kDa, also known as SAP30, is a protein which in humans is encoded by the SAP30 gene. Histone acetylation plays a key role
SAP30
Protein domain
proteins such as the mSin3A corepressor. Action of histone deacetylase 1 and 2 (HDAC1/2) is induced by the interaction of mSin3A with a multi-protein complex
MSin3_interaction_domain
Protein-coding gene in humans
SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003).[supplied by OMIM] SAP130 has been shown to interact with: CSN1S1, CUL2, Myc, SIN3A,
SAP130
Medical condition
syndrome with or without renal agenesis Noonan syndrome 4 Orofacial cleft 15 SIN3A-related intellectual disability syndrome due to a point mutation Singleton-Merten
High_anterior_hairline
Medical condition
Renpenning syndrome Seckel syndrome 9 Severe X-linked myotubular myopathy SIN3A-related intellectual disability syndrome due to a point mutation
Narrow_face
Gene and protein involved in Huntington's disease
Density 95 RASA1 (RasGAP) Not known Ras GTPase activating protein SH3GL3 Yes Endocytosis SIN3A Yes Transcriptional repressor Sp1 Yes Transcription factor
Huntingtin
Protein-coding gene in the species Homo sapiens
to interact with: GATAD2B, HDAC1, Histone deacetylase 2, MBD3 MIZF, and SIN3A. GRCh38: Ensembl release 89: ENSG00000134046 – Ensembl, May 2017 GRCm38:
Methyl-CpG-binding domain protein 2
Methyl-CpG-binding_domain_protein_2
Protein that regulates the rate of DNA transcription
as co-activators (e.g., COPS5, EP300, BCL3); co-repressors (e.g., NCOR1, SIN3A, TRIM24). However, there are transcription co-regulators that can act as
Transcription_factor
Cancer of the lymphatic system
inhibition of the tumor suppressor p53 which then leads to enhanced oncogenesis. SIN3A, a regulator of MYC, that acts to inhibit MYC by deacetylating it, is often
Burkitt_lymphoma
Protein-coding gene in the species Homo sapiens
357–64. doi:10.1016/S0092-8674(00)80216-0. PMID 9150135. "Entrez Gene: SAP18 Sin3A-associated protein, 18kDa". Michelle L, Cloutier A, Toutant J, Shkreta L
SAP18
Protein-coding gene in the species Homo sapiens
Retinoblastoma-like protein 1, Retinoblastoma-like protein 2, SAP30, SATB1, SIN3A, SIN3B, SPEN, SUDS3, SUV39H1, Sp1 transcription factor, TOP2A, TOP2B, and
HDAC1
Protein-coding gene in the species Homo sapiens
and inhibits pathological scarring. KLF11 has been shown to interact with SIN3A. Krüppel-like factors Maturity onset diabetes of the young GRCh38: Ensembl
KLF11
Protein-coding gene in the species Homo sapiens
transcription factors. SMARCC1 has been shown to interact with: BAZ1B, ING1, SIN3A, SMARCA2, SMARCA4, and SMARCB1. GRCh38: Ensembl release 89: ENSG00000173473
SMARCC1
Protein-coding gene in the species Homo sapiens
MXD1 has been shown to interact with Histone deacetylase 2, SMC3, MLX, SIN3A and MAX. GRCh38: Ensembl release 89: ENSG00000059728 – Ensembl, May 2017
MXD1
Protein found in humans
Promyelocytic leukemia protein RUNX1T1, Retinoic acid receptor alpha, SIN3A, SIN3B, and ZBTB32. Zbtb7 GRCh38: Ensembl release 89: ENSG00000109906 –
Zinc finger and BTB domain-containing protein 16
Zinc_finger_and_BTB_domain-containing_protein_16
Family of zinc finger transcription factors
activity via interaction with the common transcriptional co-repressor, Sin3A. KLFs 15 and 17 are distantly related without any defined protein interaction
Kruppel-like_factors
Protein-coding gene in the species Homo sapiens
a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003).[supplied by OMIM]
SUDS3
DNA-binding protein involved in methylation
methylated CpG sites on the DNA strands. The TRD region then reacts with SIN3A to recruit histone deacetylases (HDAC). There are also unusual, repetitive
MECP2
Protein-coding gene in the species Homo sapiens
known as HBP1, is a human protein. HBP1 has been shown to interact with SIN3A and Retinoblastoma protein. ENSG00000283847 GRCh38: Ensembl release 89:
HBP1
Proteins that help regulate transcription
RCOR (REST corepressor) RCOR1 (RCOR1) RCOR2 (RCOR2) RCOR3 (RCOR3) Sin3 SIN3A (SIN3A) SIN3B (SIN3B) TIF1 (transcriptional intermediary factor 1) TRIM24 Tripartite
Transcription_coregulator
Protein-coding gene in the species Homo sapiens
been shown to interact with: ACTL6A, ARID1B, CEBPB, POLR2A, Prohibitin, SIN3A, SMARCB1, SMARCC1, and SS18. - Nicolaides Baraitser Syndrome (NCBRS) GRCh38:
SMARCA2
Biological processes used in gene regulation
These complexes include Sin3 (named after its characteristic protein mSin3A), Nucleosome Remodelling and Deacetylating complex (NuRD), and Co-REST.
Histone acetylation and deacetylation
Histone_acetylation_and_deacetylation
Protein
The encoded protein is a subunit of the histone deacetylase-dependent SIN3A transcriptional corepressor complex, which functions in diverse cellular
ARID4B
Type of enzymes
a co-repressor complex to promote histone deacetylation upon binding to SIN3A. SUMOylation refers to the addition of Small Ubiquitin-like Modifier (SUMO)
Histone-modifying_enzymes
Protein-coding gene in the species Homo sapiens
protein 2, PHF21A, PPP1R8, RBBP4, RCOR1, RELA, Retinoblastoma protein, SAP30, SIN3A, SMARCA5, SNW1, SUV39H1, Sp1 transcription factor, Sp3 transcription factor
Histone_deacetylase_2
Transcription factor for converting Naive T cells to TFH
DePinho RA, Dejean A (May 1998). "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF
BCL6
MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split". Molecular and Cellular Biology
MORF4L1
Protein found in humans
co-repressor 2, P53, RPL11, Retinoblastoma protein, Retinoic acid receptor alpha, SIN3A, SKI protein, STAT3, Serum response factor and Small ubiquitin-related modifier
Promyelocytic leukemia protein
Promyelocytic_leukemia_protein
Protein-coding gene in the species Homo sapiens
with: CTBP1, HDAC1, HDAC7A, Histone deacetylase 5, IKZF2, IKZF3, IKZF4, SIN3A, Cereblon SIN3B. GATA2 GRCh38: Ensembl release 89: ENSG00000185811 – Ensembl
IKZF1
Topics referred to by the same term
Witteveen-Kolk syndrome is a rare genetic disorder caused by mutation on the SIN3A gene in the long arm of chromosome 15 This disambiguation page lists articles
Witteveen_(disambiguation)
Protein-coding gene in the species Homo sapiens
(April 2001). "PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors". Molecular and
Non-POU domain-containing octamer-binding protein
Non-POU_domain-containing_octamer-binding_protein
Group of lymphomas
and 5) in ~40% of cases one or more of various other genes such as MLL2, SIN3A, ARID1A, EP300, CREBBP, and TBL1XR1) that have chromatin remodeling activity
Marginal_zone_lymphoma
Protein-coding gene in the species Homo sapiens
BTG2, Myocyte-specific enhancer factor 2A Nuclear receptor co-repressor 1, SIN3A, and SUV39H1. Histone deacetylase GRCh38: Ensembl release 89: ENSG00000048052
HDAC9
Protein-coding gene in the species Homo sapiens
Histone H2B, AKT1, PFKL, KMT2E/MLL5, MAPT/TAU, Host cell factor C1, and SIN3A. O-GlcNAc transferase is a part of a host of biological functions within
Protein_O-GlcNAc_transferase
Protein-coding gene in the species Homo sapiens
to interact with NFKB1, RELA, RELB, BTRC, RPS27A, BCL3, MAP3K8, NFKBIA, SIN3A, SUMO1, Tat. Mutations in the TANGO2 gene may cause defects in mitochondrial
TANGO2
Protein-coding gene in the species Homo sapiens
Sin3-interaction domain MNT (gene) has been shown to interact with MLX, SIN3A and MAX. GRCh38: Ensembl release 89: ENSG00000070444 – Ensembl, May 2017
MNT_(gene)
Protein-coding gene in the species Homo sapiens
CREBBP, CCNE1, ESR1, FANCA, HSP90B1, ING1, Myc, NR3C1, P53, POLR2A, PHB, SIN3A, SMARCB1, SMARCC1, SMARCC2, SMARCE1, STAT2, and STK11. GRCh38: Ensembl release
SMARCA4
Protein-coding gene in the species Homo sapiens
has been shown to interact with: CBFA2T3, EP300, GATA1, LDB1, LMO1, LMO2, SIN3A, Sp1 transcription factor, and TCF3. GRCh38: Ensembl release 89: ENSG00000162367
TAL1
Protein found in humans
Histone deacetylase 1 (HDAC1) through mSin3a protein phosphorylation. This reduces the ability of the HDAC1/mSin3a complex to bind to the IL-2 promoter
Cyclin-dependent_kinase_5
Protein-coding gene in the species Homo sapiens
Imbalzano AN, Kingston RE (March 2001). "Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes". Genes Dev. 15
POLR2A
Protein-coding gene in the species Homo sapiens
with: BAP1, CREB3, GABPA, HDAC1, HDAC2, MLL, OGT, PDCD2, POU2F1, PPP1CA, SIN3A, SP1, SUDS3, WDR5, and ZBTB17. GRCh38: Ensembl release 89: ENSG00000172534
Host_cell_factor_C1
Protein-coding gene in humans
makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain". Mol. Cell. Biol. 21 (19): 6470–83.
RUNX1T1
American pharmacologist, neurobiologist (born 1948)
R (October 1999). "Transcriptional repression by REST: recruitment of Sin3A and histone deacetylase to neuronal genes". Nature Neuroscience. 2 (10):
Raymond_Dingledine
Protein-coding gene in the species Homo sapiens
to interact with: CREB binding protein, DMAP1, HDAC1, P53, PCNA, SAP30, SIN3A, SMARCA4, and SMARCC1. GRCh38: Ensembl release 89: ENSG00000153487 – Ensembl
ING1
Protein-coding gene in the species Homo sapiens
tract-binding protein-associated splicing factor) within the PER complex recruits SIN3A, a scaffold for assembly of transcriptional inhibitory complexes and rhythmically
KDM5A
P81133 14806 SIM2 HGNC:10883; Q14190 14807 SIMC1 HGNC:24779; Q8NDZ2 14808 SIN3A HGNC:19353; Q96ST3 14809 SIN3B HGNC:19354; O75182 14810 SINHCAF HGNC:30702;
List of human protein-coding genes 7
List_of_human_protein-coding_genes_7
Protein-coding gene in the species Homo sapiens
Atouf F, Holdener BC, Mandel G, Kouzarides T (2000). "The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex". J. Biol
RCOR1
Protein-coding gene in the species Homo sapiens
of the human luteinizing hormone receptor gene by histone deacetylase-mSin3A complex". The Journal of Biological Chemistry. 277 (36): 33431–8. doi:10
Transcription_factor_Sp1
Protein-coding gene in the species Homo sapiens
with: BRCA1, CREBBP, GATAD2B, HDAC1, HDAC2, HDAC3, MTA2, RB, SAP30, and SIN3A. GRCh38: Ensembl release 89: ENSG00000162521 – Ensembl, May 2017 GRCm38:
RBBP4
Protein-coding gene in the species Homo sapiens
cell line) Promoter FOXA1 HepG2 (human liver cancer cell line) Promoter SIN3A HepG2 (human liver cancer cell line) Promoter SP1 HepG2 (human liver cancer
ZNF337
Non-coding RNA in the species Homo sapiens
(Apr 2001). "PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors". Molecular and
SFPQ
Protein-coding gene in the species Homo sapiens
this gene localizes primarily to the nucleus, and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two
BRMS1
British-born American toxicologist and academic
uncovering both expected players (AHR, ARNT, CYP1A1) and novel factors such as Sin3A. They further demonstrated that activation of AHR/ARNT transcriptional activity
Oliver_Hankinson
Protein-coding gene in the species Homo sapiens
PMID 15632006. Tong Y, Aune T, Boothby M (February 2005). "T-bet antagonizes mSin3a recruitment and transactivates a fully methylated IFN-gamma promoter via
TBX21
Protein found in humans
PMID 11571228. Sharma M, Sun Z (2002). "5'TG3' interacting factor interacts with Sin3A and represses AR-mediated transcription". Mol. Endocrinol. 15 (11): 1918–28
Homeobox_protein_TGIF1
Protein-coding gene in the species Homo sapiens
Imbalzano AN, Kingston RE (March 2001). "Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes". Genes Dev. 15
SMARCB1
Protein found in humans
F, Holdener BC, Mandel G, Kouzarides T (March 2000). "The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex". The Journal
RE1-silencing transcription factor
RE1-silencing_transcription_factor
Protein-coding gene in the species Homo sapiens
humans is encoded by the PHF12 gene. PHF12 has been shown to interact with SIN3A. GRCh38: Ensembl release 89: ENSG00000109118 – Ensembl, May 2017 GRCm38:
PHF12
Protein-coding gene in the species Homo sapiens
CABIN1 has been shown to interact with: Amphiphysin, MEF2B, MEF2D, and SIN3A. ENSG00000281670 GRCh38: Ensembl release 89: ENSG00000099991, ENSG00000281670
CABIN1
Protein-coding gene in the species Homo sapiens
PMID 12665801. S2CID 23783563. Pal S, Yun R, Datta A, et al. (2003). "mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in
Protein arginine methyltransferase 5
Protein_arginine_methyltransferase_5
Protein-coding gene in the species Homo sapiens
interact with: BRCA1, GATAD2B, HDAC1, MTA2, Retinoblastoma protein, SAP30, and SIN3A. GRCh38: Ensembl release 89: ENSG00000102054 – Ensembl, May 2017 GRCm38:
RBBP7
Protein found in humans
HDAC4 HDAC5 HDAC10 MeCP2 NR4A1 POU2F1 PPARD PGR PML RBPJ RELA RUNX1T1 RARA SIN3A SNW1 SPEN SRF TBL1X THRB VDR ZBTB16 GRCh38: Ensembl release 89: ENSG00000196498
Nuclear receptor co-repressor 2
Nuclear_receptor_co-repressor_2
Protein-coding gene in the species Homo sapiens
makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain". Mol. Cell. Biol. 21 (19): 6470–83.
HDAC8
Enzyme-coding gene in humans
interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B". Biochem. J. 369 (Pt 3): 651–7. doi:10.1042/BJ20020854. PMC 1223118.
SETDB1
Protein-coding gene in the species Homo sapiens
Deltour S, Guerardel C, Leprince D (2000). "Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional
HIC1
Protein found in humans
makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain". Mol. Cell. Biol. 21 (19): 6470–83.
CBFA2T3
Protein and gene in humans
gene and contain binding sites for transcription factors RCOR1, MILLT1, SIN3A, NFIC, STAT3, JUNB, FOS, EGR1, PHB2, RUNX3, and SRF. Many of these transcription
TMEM155
Protein-coding gene in the species Homo sapiens
MRGX, and MRG15 in Transcriptional Repression via Associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split". Mol. Cell. Biol. 22 (22): 7868–76
MORF4L2
Protein-coding gene in humans
makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain". Molecular and Cellular Biology. 21
HDAC3
(1997). "Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase". Cell. 89 (3): 373–380. doi:10.1016/S0092-8674(00)80218-4
Nuclear_receptor_coregulators
Protein found in humans
makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain". Mol. Cell. Biol. 21 (19): 6470–83.
Nuclear receptor co-repressor 1
Nuclear_receptor_co-repressor_1
Protein found in humans
transcription via the basic transcription element box by interacting with mSin3A and HDAC-1 co-repressors and competing with Sp1". The Journal of Biological
KLF13
Protein-coding gene in humans
2003). "Identification and characterization of three new components of the mSin3A corepressor complex". Molecular and Cellular Biology. 23 (10): 3456–67.
ARID4A
Protein-coding gene in the species Homo sapiens
Imbalzano AN, Kingston RE (2001). "Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes". Genes Dev. 15
SMARCC2
Protein family
MAR-binding protein that down-regulates Cyclin D1 expression by recruiting HDAC1-mSin3A co-repressor complex at Cyclin D1 promoter locus; SMAR1 is the target of
BEN_domain
Protein-coding gene in the species Homo sapiens
DePinho RA, Dejean A (May 1998). "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF
SIN3B
SIN3A
SIN3A
SIN3A
SIN3A
Girl/Female
Hindu, Indian
Desired
Girl/Female
German, Swedish
Supplanter; Held by the Heel
Boy/Male
Indian, Punjabi, Sikh
Love of Honour
Female
Portuguese
Portuguese form of Latin Madelina, MADALENA means "of Magdala."
Boy/Male
Native American
Cliff.
Girl/Female
Arabic, Muslim
Spring
Boy/Male
Muslim
Good mannered
Boy/Male
Arabic, Indian, Muslim, Sindhi
Acceptable; Admired
Girl/Female
American, Australian, Chinese, Christian
Jay Bird; Victory
Girl/Female
Indian
Love; God
SIN3A
SIN3A
SIN3A
SIN3A
SIN3A