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Protein-coding gene in the species Homo sapiens
subunit, mitochondrial (SDHB) also known as iron-sulfur subunit of complex II (Ip) is a protein that in humans is encoded by the SDHB gene. The succinate
SDHB
Enzyme
The first two subunits, a flavoprotein (SDHA) and an iron-sulfur protein (SDHB), form a hydrophilic head where enzymatic activity of the complex takes place
Succinate_dehydrogenase
Agriculture is a significant sector in California's economy, producing nearly US$59.4 billion in revenue in 2023[update]. There are more than 400 commodity
Agriculture_in_California
Tumor of the adrenal medulla which secretes adrenal hormones
diagnostic workup. Loss of SDHB staining is indicative of SDHx-related pathogenesis and is particularly noted in tumors with SDHB pathogenic variants. Inhibin
Pheochromocytoma
Protein superfamily
LYR tripeptide—a motif frequently found in mitochondrial proteins such as SDHB, NDUFAF3, or mitochondrial ribosomal proteins—but that lack the additional
LYRM_protein
Protein-coding gene in the species Homo sapiens
other transmembrane subunit is SDHC. The SDHC/SDHD dimer is connected to the SDHB electron transport subunit which, in turn, is connected to the SDHA subunit
SDHD
Rare neuroendocrine tumour
SDHC (previously PGL3) and SDHB have been identified as causing familial head and neck paragangliomas. Mutations of SDHB play an important role in familial
Paraganglioma
Protein found in humans
other transmembrane subunit is SDHD. The SDHC/SDHD dimer is connected to the SDHB electron transport subunit which, in turn, is connected to the SDHA subunit
Succinate dehydrogenase complex subunit C
Succinate_dehydrogenase_complex_subunit_C
Study of cell metabolism in the development of cancer
patients for SDH mutation testing in early stages of cancer. The absence of SDHB in IHC staining would be linked to the presence of SDH oncogene mutations
Oncometabolism
Medical condition
SDH plays a key role in metabolism; the catalytic end, made up of SDHA and SDHB oxidizes succinate to fumarate in the tricarboxylic acid (TCA) cycle. The
Mitochondrial complex II deficiency
Mitochondrial_complex_II_deficiency
Multiple neoplasia syndrome
gene pathway involving the succinate dehydrogenase subunits SDHD, SDHC and SDHB. OMIM - Online Mendelian Inheritance in Man. Carney Triad (OMIM 604287) Carney
Carney_triad
Protein-coding gene in the species Homo sapiens
and promotes the maturation of the SDHB subunit of the SDH catalytic dimer. The iron-sulfur (Fe-S) protein subunit SDHB is required for functional succinate
SDHAF1
Engineering services consulting firm
Redevelopment. In 2019 the SDHB released the official design plans for the redevelopment of Dunedin Hospital. On 17 May 2019, the SDHB announced that WSP Opus
WSP_New_Zealand
Muscle disorders caused by mitochondrial dysfunction
reductase deficiency; succinate dehydrogenase deficiency) SDHA, SDHAF1, SDHD, SDHB AR PS252011 cytochrome b of complex III (MTCYB); Exercise intolerance; multisystem
Mitochondrial_myopathy
Energy-producing metabolic pathway
succinate dehydrogenase [ubiquinone] iron–sulfur subunit mitochondrial (SDHB); succinate dehydrogenase complex subunit C (SDHC); and succinate dehydrogenase
Electron_transport_chain
Antelope of southwest and south Africa
in genes related to the mitochondrial electron transport chain (NDUFA10, SDHB, UQCRC2 and ATP5F1B). Two mutations unique to the Antilopinae (SUOX and NLN)
Springbok
Benign tumor of the autonomic nervous system
somatic mosaic origin, such as RET proto-oncogene, CDKN1B, Neurofibromin, SDHB, SDHC, SDHD, VHL, and EPAS1, in association with Pacak-Zhuang syndrome. Pathologically
Ganglioneuroma
American scientist and medical doctor
to study neuroendocrine tumors. In 2020, he co-developed RS0, the first SDHB-mutant, SDH-deficient pheochromocytoma model. Tischler served as President
Arthur_S._Tischler
Inherited genetic condition that predisposes a person to cancer
(succinate:ubiquinone oxidoreductase) subunit genes (SDHD, SDHAF2, SDHC, SDHB). PGL-1 is associated with SDHD mutation, and most PGL-1 individuals with
Hereditary_cancer_syndrome
New Zealand epidemiologist
Society Te Apārangi. Retrieved 17 June 2023. Houlahan, Mike (9 June 2022). "SDHB meets for last time before restructure". Otago Daily Times. Retrieved 24
Moana_Theodore
Human chromosome
encoding protein Sterile alpha motif domain containing 11 SDC3: Syndecan-3 SDHB (1p36) SFPQ (1p34): encoding protein Splicing factor proline and glutamine
Chromosome_1
Protein-coding gene in humans
ubiquinol). Electrons removed from succinate transfer to SDHA, transfer across SDHB through iron sulphur clusters to the SDHC/SDHD subunits on the hydrophobic
SDHA
Gene which maintains basic cellular functions
metabolism SDHA NM_004168 Succinate Dehydrogenase subunit A SDHAF2 NM_017841 SDHB NM_002973 Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH)
Housekeeping_gene
New Zealand politician (1950–2021)
shock entrant in SDHB race". Otago Daily Times. Retrieved 27 August 2019. Houlahan, Mike (13 October 2019). "Cull and Chambers top SDHB poll". Otago Daily
Dave_Cull
Chemical compound
Anastasios N.; Karaoglanidis, George S. (2013). "Differential Effect of SdhB Gene Mutations on the Sensitivity to SDHI Fungicides in Botrytis cinerea"
Fluxapyroxad
Protein that responds to low oxygen
transfer in the succinate dehydrogenase complex due to mutations in the SDHB or SDHD genes can cause a build-up of succinate that inhibits HIF prolyl-hydroxylase
Hypoxia-inducible_factor
Australian pathologist & professor (born 1972)
Clinicopathologic Series of 36 Tumors From 27 Patients". "Immunohistochemistry for SDHB Divides Gastrointestinal Stromal Tumors (GISTs) into 2 Distinct Types". Cancer
Anthony_Gill_(professor)
Iron–sulfur proteins that mediate electron transfer in metabolic reactions
via four Cys residues.[citation needed] 2Fe–2S: AOX1; FDX1; FDX2; NDUFS1; SDHB; XDH; 4Fe–4S: ABCE1; DPYD; NDUFS8; Mortenson LE, Valentine RC, Carnahan JE
Ferredoxin
Ongoing COVID-19 vaccine programme in New Zealand
District Health Board (SDHB) confirmed that mass COVID-19 vaccination clinics would be opened in Dunedin and Invercargill. The SDHB also confirmed that it
COVID-19 vaccination in New Zealand
COVID-19_vaccination_in_New_Zealand
widespread resistance to SDHIs here. They find several etiologies, with various sdhB alleles producing the resistance. H272R resistance to boscalid, H272R or
Agriculture_in_Maryland
Human disease (cancer)
pathway involving the succinate dehydrogenase (SDH) subunits SDHD, SDHC and SDHB. Approximately 85% GISTs are associated with an abnormal c-KIT pathway. c-KIT
Gastrointestinal stromal tumor
Gastrointestinal_stromal_tumor
RNA family
one without. Genes known to contain IREs include FTH1, FTL, TFRC, ALAS2, Sdhb, ACO2, Hao1, SLC11A2 (encoding DMT1), NDUFS1, SLC40A1 (encoding the ferroportin)
Iron_response_element
Mitochondrial protein involved in iron–sulfur cluster biosynthesis
including 79 co-complex interactions. ISCU appears to interact with ISCS, NUP62, SDHB, HPRT1, CCDC172, GOLGA2, IKZF1, KRT40, AGTRAP, NECAB2, FAM9B, BANP, LNX1
ISCU
Species of beetle
Taxon identifiers Cephaloleia trilineata Wikidata: Q2085259 BioLib: 796703 CoL: SDHB EoL: 27518505 GBIF: 6272992 ITIS: 843101 Open Tree of Life: 3371969
Cephaloleia_trilineata
Q9NX18 14442 SDHAF3 HGNC:21752; Q9NRP4 14443 SDHAF4 HGNC:20957; Q5VUM1 14444 SDHB HGNC:10681; P21912 14445 SDHC HGNC:10682; Q99643 14446 SDHD HGNC:10683; O14521
List of human protein-coding genes 7
List_of_human_protein-coding_genes_7
2015 flood in Otago, New Zealand
Health Board (SDHB) also established an emergency operations centre to ensure that staff were able to travel safely to and from work. The SDHB also assisted
2015_Otago_flood
Human NKAPD1 Protein
"Simple and rapid characterization of novel large germline deletions in SDHB, SDHC and SDHD-related paraganglioma". Clinical Genetics. 91 (4): 536–544
NKAPD1
New Zealand politician (born 1966)
minutes, with Coleman telling Mr Garbutt the Southern District Health Board (SDHB) was his ''number 1'' priority in respect of its budget woes. Coleman announced
Jonathan_Coleman_(politician)
Former health board in New Zealand
2020. Retrieved 3 May 2020. "Grant hopes new structure will 'future-proof' SDHB". Stuff. 3 December 2019. Retrieved 14 November 2020. "Statistical area 1
Southern District Health Board
Southern_District_Health_Board
260660; TBX15 Cowden syndrome; 158350; PTEN Cowden-like syndrome; 612359; SDHB Cowden-like syndrome; 612359; SDHD CPT deficiency, hepatic, type IA; 255120;
List_of_OMIM_disorder_codes
Medical condition
cause HDGC, but possible associated genes include CTNNA1, BRCA2, STK11, SDHB, PRSS1, ATM, MSR1, and PALB2. Surgical removal of the stomach (gastrectomy)
Hereditary diffuse gastric cancer
Hereditary_diffuse_gastric_cancer
November 2013. Retrieved 18 April 2020. Goodwin, Eileen (19 March 2015). "New SDHB chairman, Butterfield to go". Otago Daily Times. Retrieved 18 April 2020
List of chairpersons of district health boards
List_of_chairpersons_of_district_health_boards
Protein-coding gene in the species Homo sapiens
the succinate dehydrogenase heterotetrmer, i.e., the SDHD, SDHA, SDHC, and SDHB genes (inactivation of any one of these genes causes paraganglioma cells
SUCNR1
SDHB
SDHB
SDHB
SDHB
Boy/Male
Bengali, Hindu, Indian, Kannada, Telugu
An Ancient King
Boy/Male
Bengali, Hindu, Indian
Anything that is Made out of Mud; A Pot Made by Soil; Made out of Earth
Girl/Female
African, American, Australian, British, Chinese, Christian, Danish, English, French, Indian, Jamaican, Spanish
Precious Green Stone; The Most Beautiful Stone; Green Gemstone
Boy/Male
Hindu, Indian
A Chief; Leader; Head of Group
Surname or Lastname
Americanized form of German Gehr.English
Americanized form of German Gehr.English : perhaps a variant of Geary 3.Hungarian : from a reduced form of the personal name Gergely, Latin Gregorius (see Gregory).
Girl/Female
Hindu
Melodious, A musical Raag
Girl/Female
Italian Latin
Blond.
Boy/Male
Hindu, Indian
Beautiful
Biblical
essence; being; generation
Boy/Male
Arabic, Muslim
Sword of Allah
SDHB
SDHB
SDHB
SDHB
SDHB